Longitudinal measures of cognition in the Ts65Dn mouse: Refining windows and defining modalities for therapeutic intervention in Down syndrome.

No abstract is available for this paper.

• Publication year

  2016

• Venue

  Experimental Neurology

• Publication date

  2016-05-01

• Fields of study

  Biology, Medicine, Psychology

• Identifiers
  DOI 10.1016/j.expneurol.2016.02.005PMID 26854932PMCID PMC5716476
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Working memory , processing speed , and set-shifting in children with developmental coordination disorder and attention-deficit-hyperactivity disorder

  2017cited by this paper
• A new cognitive evaluation battery for Down syndrome and its relevance for clinical trials

  2015cited by this paper
• Pre-reproductive maternal enrichment influences rat maternal care and offspring developmental trajectories: behavioral performances and neuroplasticity correlates

  2015influential reference
• Down syndrome and Alzheimer's disease: Common pathways, common goals

  2015cited by this paper
• Beneficial effects of the β-secretase inhibitor GRL-8234 in 5XFAD Alzheimer's transgenic mice lessen during disease progression.

  2015cited by this paper
• Relationship between motor skill competency and executive function in children with Down's syndrome.

  2015cited by this paper
• An anti-pyroglutamate-3 Aβ vaccine reduces plaques and improves cognition in APPswe/PS1ΔE9 mice.

  2015cited by this paper
• Executive functions among youth with Down Syndrome and co-existing neurobehavioural disorders.

  2015cited by this paper
• Negative life events predict performance on an executive function task in young adults with developmental disabilities.

  2015cited by this paper
• Motor Performance of Children With Down Syndrome and Typical Development at 2 to 4 and 26 Months

  2015cited by this paper
• Excitation/inhibition balance and learning are modified by Dyrk1a gene dosage.

  2014cited by this paper
• Rule-based category learning in Down syndrome.

  2014cited by this paper
• Obstructive sleep apnea syndrome and cognition in Down syndrome

  2014cited by this paper
• Nest building is impaired in the Ts65Dn mouse model of Down syndrome and rescued by blocking 5HT2a receptors.

  2014cited by this paper
• Human chromosome 21 orthologous region on mouse chromosome 17 is a major determinant of Down syndrome-related developmental cognitive deficits.

  2014cited by this paper
• Using mice to model Alzheimer's dementia: an overview of the clinical disease and the preclinical behavioral changes in 10 mouse models

  2014cited by this paper
• Assessing spatial learning and memory in rodents.

  2014cited by this paper
• Overexpression of Dyrk1A Is Implicated in Several Cognitive, Electrophysiological and Neuromorphological Alterations Found in a Mouse Model of Down Syndrome

  2014cited by this paper
• Linking the Developmental and Degenerative Theories of Schizophrenia: Association Between Infant Development and Adult Cognitive Decline

  2014cited by this paper
• Monoacylglycerol Lipase Inhibitor JZL184 Improves Behavior and Neural Properties in Ts65Dn Mice, a Model of Down Syndrome

  2014cited by this paper
• Water T-maze: a useful assay for determination of repetitive behaviors in mice.

  2013cited by this paper
• Immunization targeting a minor plaque constituent clears β-amyloid and rescues behavioral deficits in an Alzheimer's disease mouse model.

  2013cited by this paper
• Atypical aging in Down syndrome.

  2013influential reference
• Systematic review of cognitive development across childhood in Down syndrome: implications for treatment interventions: Cognitive development in Down syndrome

  2013cited by this paper
• Normalization of Dyrk1A expression by AAV2/1-shDyrk1A attenuates hippocampal-dependent defects in the Ts65Dn mouse model of Down syndrome.

  2013cited by this paper
• Systematic review of cognitive development across childhood in Down syndrome: implications for treatment interventions.

  2013cited by this paper
• Early interactions with mother and peers independently build adult social skills and shape BDNF and oxytocin receptor brain levels.

  2013cited by this paper
• Aging and intellectual disability: insights from mouse models of Down syndrome.

  2013cited by this paper
• Neurodevelopmental and psychiatric issues in Down’s syndrome: assessment and intervention

  2013cited by this paper
• Cognitive flexibility among individuals with Down syndrome: assessing the influence of verbal and nonverbal abilities.

  2013cited by this paper
• Non-spatial pre-training in the water maze as a clinically relevant model for evaluating learning and memory in experimental TBI.

  2013cited by this paper
• Impairment of nesting behaviour in 3xTg-AD mice.

  2013cited by this paper
• Early-occurring proliferation defects in peripheral tissues of the Ts65Dn mouse model of Down syndrome are associated with patched1 over expression

  2012cited by this paper
• The in vivo Down syndrome genomic library in mouse.

  2012cited by this paper
• Phenotypic effects of repeated psychosocial stress during adolescence in mice mutant for the schizophrenia risk gene neuregulin-1: a putative model of gene × environment interaction.

  2012cited by this paper
• Low sociability in BTBR T+tf/J mice is independent of partner strain.

  2012cited by this paper
• Hippocampal-Dependent Spatial Memory in the Water Maze is Preserved in an Experimental Model of Temporal Lobe Epilepsy in Rats

  2011cited by this paper
• Molecular characterization of the translocation breakpoints in the Down syndrome mouse model Ts65Dn

  2011cited by this paper
• The use of mouse models to understand and improve cognitive deficits in Down syndrome

  2011cited by this paper
• Identification of the translocation breakpoints in the Ts65Dn and Ts1Cje mouse lines: relevance for modeling down syndrome

  2011cited by this paper
• Learning to walk changes infants' social interactions.

  2011cited by this paper
• α-Tocopherol suppresses lipid peroxidation and behavioral and cognitive impairments in the Ts65Dn mouse model of Down syndrome.

  2011cited by this paper
• Animal models of prefrontal-executive function.

  2011cited by this paper
• International trends of Down syndrome 1993-2004: Births in relation to maternal age and terminations of pregnancies.

  2010cited by this paper
• Updated National Birth Prevalence estimates for selected birth defects in the United States, 2004-2006.

  2010influential reference
• Developing language in a developing body: the relationship between motor development and language development.

  2010cited by this paper
• Age-related cognitive decline and nesting behavior in an APPswe/PS1 bigenic model of Alzheimer's disease.

  2009cited by this paper
• Does the learning deficit observed under an incremental repeated acquisition schedule of reinforcement in Ts65Dn mice, a model for Down syndrome, change as they age?

  2009cited by this paper
• What is the Most Sensitive Measure of Water Maze Probe Test Performance?

  2009cited by this paper
• A summary of recent research into the development of children with Down's syndrome.

  2008cited by this paper
• Prevention of Developmental Delays in a Down Syndrome Mouse Model

  2008cited by this paper
• Psychomotor development in the first year and mental retardation--a prospective study.

  2008cited by this paper
• Alzheimer's & Dementia: The Journal of the Alzheimer's Association

  2008cited by this paper
• Defects in Embryonic Neurogenesis and Initial Synapse Formation in the Forebrain of the Ts65Dn Mouse Model of Down Syndrome

  2007cited by this paper
• [Neuropsychological impairment in the early Alzheimer's disease].

  2007cited by this paper
• Working memory, processing speed, and set‐shifting in children with developmental coordination disorder and attention‐deficit–hyperactivity disorder

  2007cited by this paper
• Differential regulation of fronto-executive function by the monoamines and acetylcholine.

  2007cited by this paper
• Phenotypic characterization of spatial cognition and social behavior in mice with 'knockout' of the schizophrenia risk gene neuregulin 1.

  2007cited by this paper
• Infant Developmental Milestones and Subsequent Cognitive Function

  2007cited by this paper
• Le déficit neuropsychologique dans la maladie d’Alzheimer débutante

  2007cited by this paper
• The Elusive Nature of Executive Functions: A Review of our Current Understanding

  2007cited by this paper
• Early discrimination reversal learning impairment and preserved spatial learning in a longitudinal study of Tg2576 APPsw mice.

  2007cited by this paper
• Assessing nest building in mice

  2006cited by this paper
• Infant motor development is associated with adult cognitive categorisation in a longitudinal birth cohort study.

  2006cited by this paper
• Executive Function and the Frontal Lobes: A Meta-Analytic Review

  2006cited by this paper
• Morris water maze: procedures for assessing spatial and related forms of learning and memory

  2006cited by this paper
• Mouse Models of Cognitive Disorders in Trisomy 21: A Review

  2006cited by this paper
• Infant developmental milestones: a 31-year follow-up.

  2005cited by this paper
• Down syndrome children often have brain with maturation delay, retardation of growth, and cortical dysgenesis.

  2005cited by this paper
• Experimental parameters affecting the Morris water maze performance of a mouse model of Down syndrome.

  2004influential reference
• The neurobiological basis of spontaneous alternation.

  2002cited by this paper
• Behavioral profiles of inbred strains on novel olfactory, spatial and emotional tests for reference memory in mice

  2002cited by this paper
• Loss of cholinergic phenotype in basal forebrain coincides with cognitive decline in a mouse model of Down's syndrome.

  2000cited by this paper
• Motor dysfunction in a mouse model for Down syndrome.

  1999cited by this paper
• Developmental abnormalities and age-related neurodegeneration in a mouse model of Down syndrome.

  1996cited by this paper
• Cognitive and neurobiologic markers of early Alzheimer disease.

  1996cited by this paper
• Segmental trisomy as a mouse model for Down syndrome.

  1993cited by this paper
• Neuroanatomical correlates of sparing of function after neonatal medial prefrontal cortex lesions in rats.

  1991cited by this paper
• Learning difficulties in infants with Down's syndrome

  1991cited by this paper
• Neonatal frontal lesions in hamsters impair species-typical behaviors and reduce brain weight and neocortical thickness.

  1985cited by this paper
• Reflex-ontogeny and behavioural development of the mouse.

  1965cited by this paper
• DEVELOPMENTAL COMPARISONS OF MENTALLY RETARDED AND NEUROTIC CHILDREN.

  1964cited by this paper

• Charting the future: current and future directions in translational research for individuals with Down syndrome

  2025cites this paper
• Early postnatal GABAB antagonist treatment normalizes inhibitory/excitatory balance in neonatal Ts65Dn mice, a genetic model of down syndrome.

  2025cites this paper
• In and out: Benchmarking in vitro, in vivo, ex vivo, and xenografting approaches for an integrative brain disease modeling pipeline

  2024cites this paper
• Harlequin mice exhibit cognitive impairment, severe loss of Purkinje cells and a compromised bioenergetic status due to the absence of Apoptosis Inducing Factor.

  2024cites this paper
• Emergence of Treadmill Running Ability and Quantitative Assessment of Gait Dynamics in Young Ts65Dn Mice: A Mouse Model for Down Syndrome

  2023cites this paper
• Pleiotropic effects of trisomy and pharmacologic modulation on structural , functional , 1 molecular , and genetic systems in a Down syndrome mouse model 2

  2023cites this paper
• The Impact of Mmu17 Non-Hsa21 Orthologous Genes in the Ts65Dn Mouse Model of Down Syndrome: The Gold Standard Refuted.

  2023cites this paper
• Pleiotropic effects of trisomy and pharmacologic modulation on structural, functional, molecular, and genetic systems in a Down syndrome mouse model

  2023cites this paper
• Delayed postnatal brain development and ontogenesis of behavior and cognition in a mouse model of intellectual disability.

  2023cites this paper
• The impact of Mmu17 non-Hsa21 orthologous genes in the Ts65Dn mouse model of Down syndrome: the “gold standard” revisited

  2022cites this paper
• Inhibition of PLK2 activity affects APP and tau pathology and improves synaptic content in a sex-dependent manner in a 3xTg mouse model of Alzheimer's disease.

  2022cites this paper
• Sexually dimorphic DYRK1A overexpression on postnatal day 15 in the Ts65Dn mouse model of Down syndrome: Effects of pharmacological targeting on behavioral phenotypes.

  2022cites this paper
• Neurodevelopment in Down syndrome: Concordance in humans and models

  2022cites this paper
• Enhanced GIRK2 channel signaling in Down syndrome: A feasible role in the development of abnormal nascent neural circuits

  2022cites this paper
• Overexpression of miR-99a in hippocampus leads to impairment of reversal learning in mice.

  2021cites this paper
• Time-dependent diffusion MRI probes cerebellar microstructural alterations in a mouse model of Down syndrome

  2021cites this paper
• Signalling pathways contributing to learning and memory deficits in the Ts65Dn mouse model of Down syndrome

  2021cites this paper
• Longitudinal neuroanatomical and behavioral analyses show phenotypic drift and variability in the Ts65Dn mouse model of Down syndrome

  2020cites this paper
• Modeling Down syndrome in animals from the early stage to the 4.0 models and next.

  2020cites this paper
• Mapping behavioral landscapes in Down syndrome animal models.

  2020cites this paper
• Alterations of specific inhibitory circuits of the prefrontal cortex underlie abnormal network activity in a mouse model of Down syndrome

  2020cites this paper
• Behavioral Phenotyping for Down Syndrome in Mice

  2020cites this paper
• Alterations of specific cortical GABAergic circuits underlie abnormal network activity in a mouse model of Down syndrome

  2020cites this paper
• Neurobiology of Down Syndrome

  2020cites this paper
• Hydroxyurea Improves Spatial Memory and Cognitive Plasticity in Mice and Has a Mild Effect on These Parameters in a Down Syndrome Mouse Model

  2019cites this paper
• Spatiotemporal development of spinal neuronal and glial populations in the Ts65Dn mouse model of Down syndrome

  2019cites this paper
• Spaced training improves learning in Ts65Dn and Ube3a mouse models of intellectual disabilities

  2019cites this paper
• Proteomic analysis of six- and twelve-month hippocampus and cerebellum in a murine Down syndrome model.

  2018influential citation
• Lifespan analysis of brain development, gene expression and behavioral phenotypes in the Ts1Cje, Ts65Dn and Dp(16)1/Yey mouse models of Down syndrome

  2018cites this paper
• Developmental excitatory-to-inhibitory GABA polarity switch is delayed in Ts65Dn mice, a genetic model of Down syndrome.

  2018cites this paper
• Correction of cognitive deficits in mouse models of Down syndrome by a pharmacological inhibitor of DYRK1A

  2018influential citation
• Epigallocatechin gallate: A useful therapy for cognitive disability in Down syndrome?

  2017cites this paper
• Proteomic Analysis of Mature and Middle-Aged Hippocampus and Cerebellum in a Murine Down Syndrome Model

  2017influential citation
• Rodent models in Down syndrome research: impact and future opportunities

  2017cites this paper
• Deleterious Effects of Chronic Folate Deficiency in the Ts65Dn Mouse Model of Down Syndrome

  2017cites this paper
• Age exacerbates abnormal protein expression in a mouse model of Down syndrome.

  2017cites this paper
• Early neurotrophic pharmacotherapy rescues developmental delay and Alzheimer’s-like memory deficits in the Ts65Dn mouse model of Down syndrome

  2017cites this paper
• Absence of Prenatal Forebrain Defects in the Dp(16)1Yey/+ Mouse Model of Down Syndrome

  2016cites this paper