Age-Dependent Increase in Ischemic Brain Injury in Wild-Type Mice and in Mice Lacking the Inducible Nitric Oxide Synthase Gene

No abstract is available for this paper.

• Publication year

  1999

• Venue

  Journal of Cerebral Blood Flow and Metabolism

• Publication date

  1999-06-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1097/00004647-199906000-00009PMID 10366196
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Reduction of CuZn-Superoxide Dismutase Activity Exacerbates Neuronal Cell Injury and Edema Formation after Transient Focal Cerebral Ischemia

  1997cited by this paper
• Increased Susceptibility to Ischemic Brain Damage in Transgenic Mice Overexpressing the Amyloid Precursor Protein

  1997cited by this paper
• Delayed Reduction of Ischemic Brain Injury and Neurological Deficits in Mice Lacking the Inducible Nitric Oxide Synthase Gene

  1997cited by this paper
• Effect of age in rodent models of focal and forebrain ischemia.

  1996cited by this paper
• Enlarged Infarcts in Endothelial Nitric Oxide Synthase Knockout Mice are Attenuated by Nitro-L-Arginine

  1996cited by this paper
• Inducible nitric oxide synthase gene expression in vascular cells after transient focal cerebral ischemia.

  1996cited by this paper
• Gene-targeting studies of mammalian behavior: is it the mutation or the background genotype?

  1996cited by this paper
• Effects of aging and chronic hypertension on cerebral blood flow and cerebrovascular CO2 reactivity in the rat.

  1995cited by this paper
• Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase.

  1995cited by this paper
• Rodent models of focal ischemia.

  1995cited by this paper
• Experimental stroke and neuroprotection in the aging rat brain.

  1995cited by this paper
• Inhibition of inducible nitric oxide synthase ameliorates cerebral ischemic damage.

  1995cited by this paper
• Rodent models of focal ischemia.

  1995cited by this paper
• Oxidative damage and mitochondrial decay in aging.

  1994cited by this paper
• Transgenic and Knock‐out Mice: Models of Neurological Disease

  1994cited by this paper
• Oxygen Radicals in Focal Cerebral Ischemia

  1994cited by this paper
• Human Copper‐Zinc Superoxide Dismutase Transgenic Mice Are Highly Resistant to Reperfusion Injury After Focal Cerebral Ischemia

  1994cited by this paper
• Effect of Brain Edema on Infarct Volume in a Focal Cerebral Ischemia Model in Rats

  1993cited by this paper
• Oxidants, antioxidants, and the degenerative diseases of aging.

  1993cited by this paper
• Gene targeting: a practical approach.

  1993influential reference
• Embolic Stroke in Aged Rats

  1991cited by this paper
• Rodent models of cerebral ischemia.

  1989cited by this paper
• The Quantification of Cerebral Infarction following Focal Ischemia in the Rat: Influence of Strain, Arterial Pressure, Blood Glucose Concentration, and Age

  1988cited by this paper
• A study on the microvasculature of the cerebral cortex. Fundamental architecture and its senile change in the frontal cortex.

  1986cited by this paper
• Rat middle cerebral artery occlusion: evaluation of the model and development of a neurologic examination.

  1986cited by this paper
• Experimental Design: Procedures for the Behavioral Sciences

  1969cited by this paper

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  2023cites this paper
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  2019cites this paper
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  2019cites this paper
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  2018cites this paper
• Ischemic stroke across sexes: what is the status quo?

  2018cites this paper
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  2017cites this paper
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  2017cites this paper
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  2016cites this paper
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  2016cites this paper
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  2015cites this paper
• Inflammation in ischemic stroke: mechanisms, consequences and possible drug targets.

  2014cites this paper
• Progranulin Deficiency Promotes Post-Ischemic Blood–Brain Barrier Disruption

  2013cites this paper
• Estrogens: Protective or Risk Factors in the Injured Brain?

  2013cites this paper
• Multiple Origins of Sex Differences in Brain

  2013cites this paper
• Sex, stroke, and inflammation: the potential for estrogen-mediated immunoprotection in stroke.

  2013cites this paper
• Comparison of Glial Activation in the Hippocampal CA1 Region Between The Young and Adult Gerbils After Transient Cerebral Ischemia

  2012cites this paper
• Ablation of Neurogenesis Attenuates Recovery of Motor Function after Focal Cerebral Ischemia in Middle-Aged Mice

  2012cites this paper
• Recovery from ischemia in the middle-aged brain: a nonhuman primate model.

  2012cites this paper
• Restoration of dietary-fat induced blood–brain barrier dysfunction by anti-inflammatory lipid-modulating agents

  2012cites this paper
• Neuroprotective effects of estrogens following ischemic stroke.

  2009influential citation
• Inflammatory and Hemodynamic Changes in the Cerebral Microcirculation of Aged Rats after Global Cerebral Ischemia and Reperfusion

  2008cites this paper
• Inducible nitric oxide synthase and estradiol exhibit complementary neuroprotective roles after ischemic brain injury.

  2008cites this paper
• Age alters cerebrovascular inflammation and effects of estrogen.

  2007cites this paper
• Complex actions of sex steroids in adipose tissue, the cardiovascular system, and brain: Insights from basic science and clinical studies.

  2006cites this paper
• Astrocytic-Inducible Nitric Oxide Synthase in the Ischemic Developing Human Brain

  2006cites this paper
• Neuroprotective effects of scutellarin on rat neuronal damage induced by cerebral ischemia/reperfusion

  2005cites this paper
• Increased oxidative protein and DNA damage but decreased stress response in the aged brain following experimental stroke.

  2005cites this paper
• Neuronal Nitric Oxide Synthase and Ischemia-Induced Neurogenesis

  2005influential citation
• Genetically modified animals in molecular stroke research.

  2004cites this paper
• Suppression of oxidative neuronal damage after transient middle cerebral artery occlusion in mice lacking interleukin-1.

  2003cites this paper
• The eicosanoid pathway and brain aging

  2003cites this paper
• Brain nitric oxide and its dual role in neurodegeneration/neuroprotection: understanding molecular mechanisms to devise drug approaches.

  2003cites this paper
• Nitric oxide and nitric oxide synthases in the fetal cerebral cortex of rats following transient uteroplacental ischemia.

  2002cites this paper
• Effects of aminoguanidine on cerebral ischemia in mice: comparison between mice with and without inducible nitric oxide synthase gene.

  2002cites this paper
• Role of Inducible Nitric Oxide Synthase and Cyclooxygenase-2 in the Mechanisms of Ischemic Brain Injury

  2001cites this paper
• [Aging and neurodegeneration: molecular and cellular bases].

  2000cites this paper
• Gene-dosing effect and persistence of reduction in ischemic brain injury in mice lacking inducible nitric oxide synthase.

  2000cites this paper
• Neuroprotection and functional alterations in mice over-expressing heat shock protein 70i.

  2000cites this paper
• Age-Related Differences in Acute Physiologic Response to Focal Traumatic Brain Injury in Piglets

  2000cites this paper
• Inflammation and Stroke: Putative Role for Cytokines, Adhesion Molecules and iNOS in Brain Response to Ischemia

  2000cites this paper
• On ischemic brain injury in genetically altered mice.

  1999cites this paper
• Ginsberg On Ischemic Brain Injury in Genetically Altered Mice 2583

  1999cites this paper