Alternative oxidation by isopenicillin N synthase observed by X-ray diffraction.

No abstract is available for this paper.

• Publication year

  2001

• Venue

  Chemistry and Biology

• Publication date

  2001-12-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1016/S1074-5521(01)00090-4PMID 11755401
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Structural origins of the selectivity of the trifunctional oxygenase clavaminic acid synthase

  2000cited by this paper
• The catalytic pathway of cytochrome p450cam at atomic resolution.

  2000cited by this paper
• Further additions to MolScript version 1.4, including reading and contouring of electron-density maps.

  1999cited by this paper
• Crystal structure of Pseudomonas fluorescens 4-hydroxyphenylpyruvate dioxygenase: an enzyme involved in the tyrosine degradation pathway.

  1999cited by this paper
• The reaction cycle of isopenicillin N synthase observed by X-ray diffraction

  1999cited by this paper
• Time-resolved crystallography.

  1998cited by this paper
• Structure of a cephalosporin synthase

  1998cited by this paper
• New results using Laue diffraction and time-resolved crystallography.

  1998cited by this paper
• Oxygen activating nonheme iron enzymes.

  1998cited by this paper
• SHELXL: high-resolution refinement.

  1997cited by this paper
• The 2-His-1-carboxylate facial triad--an emerging structural motif in mononuclear non-heme iron(II) enzymes.

  1997cited by this paper
• Raster3D: photorealistic molecular graphics.

  1997cited by this paper
• Structure of isopenicillinN synthase complexed with substrate and the mechanism ofpenicillin formation

  1997cited by this paper
• Structure of isopenicillin N synthase complexed with substrate and the mechanism of penicillin formation.

  1997cited by this paper
• Anaerobic crystallisation of an isopenicillin N synthase.Fe(II).substrate complex demonstrated by X-ray studies.

  1996cited by this paper
• Crystal structure of isopenicillin N synthase is the first from a new structural family of enzymes

  1995cited by this paper
• The Practice of Peptide Synthesis

  1994cited by this paper
• Raster3D Version 2.0. A program for photorealistic molecular graphics.

  1994cited by this paper
• The CCP4 suite: programs for protein crystallography.

  1994cited by this paper
• Isopenicilin N synthase: a new mode of reactivity

  1992cited by this paper
• 1 The biosynthesis of ß-lactams

  1992cited by this paper
• Improved methods for building protein models in electron density maps and the location of errors in these models.

  1991cited by this paper
• Isopenicillin N synthase: a new mode of reactivity

  1991cited by this paper
• Isopenicillin N synthase: mechanistic studies

  1990cited by this paper
• Recent advances in the chemistry of β-lactam antibiotics

  1989cited by this paper
• Stereoselektive synthese von D-α-hydroxycarbonsäuren bzw. D-α-hydroxycarbonsäuren enthaltenden depsipeptiden aus L-aminosäuren

  1985cited by this paper

• Isopenicillin N Synthase: Crystallographic Studies

  2021cites this paper
• Principles and current strategies targeting metallo-β-lactamase mediated antibacterial resistance.

  2020cites this paper
• Temperature-Dependent Reactivity of a Non-heme FeIII(OH)(SR) Complex: Relevance to Isopenicillin N Synthase.

  2020cites this paper
• Role of structural ions on the dynamics of the Pseudomonas fluorescens 07A metalloprotease.

  2019cites this paper
• Insights into the Structure and Molecular Mechanisms of β-Lactam Synthesizing Enzymes in Fungi

  2017cites this paper
• Terminally Truncated Isopenicillin N Synthase Generates a Dithioester Product: Evidence for a Thioaldehyde Intermediate during Catalysis and a New Mode of Reaction for Non‐Heme Iron Oxidases

  2017cites this paper
• Olefin cis-Dihydroxylation and Aliphatic C-H Bond Oxygenation by a Dioxygen-Derived Electrophilic Iron-Oxygen Oxidant.

  2015cites this paper
• Demonstration of the heterolytic O-O bond cleavage of putative nonheme iron(II)-OOH(R) complexes for Fenton and enzymatic reactions.

  2014cites this paper
• The enzymes of β-lactam biosynthesis.

  2013cites this paper
• The crystal structure of an isopenicillin N synthase complex with an ethereal substrate analogue reveals water in the oxygen binding site

  2013cites this paper
• The Interaction of Isopenicillin N Synthase with Homologated Substrate Analogues δ‐(L‐α‐Aminoadipoyl)‐L‐homocysteinyl‐D‐Xaa Characterised by Protein Crystallography

  2013cites this paper
• The crystal structure of isopenicillin N synthase with a dipeptide substrate analogue.

  2013cites this paper
• l-Proline-derived ligands to mimic the ‘2-His-1-carboxylate’ triad of the non-haem iron oxidase active site

  2012cites this paper
• Isopenicillin N Synthase Binds δ‐(L‐α‐Aminoadipoyl)‐L‐Cysteinyl‐D‐Thia‐allo‐Isoleucine through both Sulfur Atoms

  2011cites this paper
• On the Stereochemistry of 2-Hydroxyethylphosphonate Dioxygenase

  2011cites this paper
• The crystal structure of isopenicillin N synthase with δ-((L)-α-aminoadipoyl)-(L)-cysteinyl-(D)-methionine reveals thioether coordination to iron.

  2011cites this paper
• Mechanism and Substrate Recognition of 2-Hydroxyethylphosphonate Dioxygenase

  2011cites this paper
• Design and synthesis of a tetradentate '3-amine-1-carboxylate' ligand to mimic the metal binding environment at the non-heme iron(II) oxidase active site.

  2010cites this paper
• Reaction coordinate of isopenicillin N synthase: oxidase versus oxygenase activity.

  2010cites this paper
• Substrate activation by iron superoxo intermediates.

  2010cites this paper
• The crystal structure of an LLL-configured depsipeptide substrate analogue bound to isopenicillin N synthase.

  2010cites this paper
• Crystallographic studies on the binding of selectively deuterated LLD- and LLL-substrate epimers by isopenicillin N synthase.

  2010cites this paper
• Transition States in a Protein Environment - ONIOM QM:MM Modeling of Isopenicillin N Synthesis.

  2009cites this paper
• Structural Studies on the Reaction of Isopenicillin N Synthase with a Sterically Demanding Depsipeptide Substrate Analogue

  2009cites this paper
• Tripodal N,N,O-Ligands for Metalloenzyme Models and Organometallics

  2008cites this paper
• Isopenicillin N synthase mediates thiolate oxidation to sulfenate in a depsipeptide substrate analogue: implications for oxygen binding and a link to nitrile hydratase?

  2008cites this paper
• Interactions of isopenicillin N synthase with cyclopropyl-containing substrate analogues reveal new mechanistic insight.

  2007cites this paper
• Enzymatic C-H activation by metal-superoxo intermediates.

  2007cites this paper
• Determination of reaction intermediate structures in heme proteins.

  2007cites this paper
• A Cyclobutanone Analogue Mimics Penicillin in Binding to Isopenicillin N Synthase

  2007cites this paper
• Non-heme Fe(IV)-oxo intermediates.

  2007cites this paper
• Unexpected Oxidation of a Depsipeptide Substrate Analogue in Crystalline Isopenicillin N Synthase

  2006cites this paper
• Structural studies on 2-oxoglutarate oxygenases and related double-stranded beta-helix fold proteins.

  2006cites this paper
• Iron Proteins with Mononuclear Active Sites

  2006cites this paper
• Macromolecular Crystallography Protocols

  2006cites this paper
• Unique binding of a non-natural L,L,L-substrate by isopenicillin N synthase.

  2005cites this paper
• Design and synthesis of an isopenicillin N synthase mimic

  2005cites this paper
• FeII/alpha-ketoglutarate-dependent hydroxylases and related enzymes.

  2004cites this paper
• Fe(II)/α-Ketoglutarate-Dependent Hydroxylases and Related Enzymes

  2004cites this paper
• Active-site-mediated elimination of hydrogen fluoride from a fluorinated substrate analogue by isopenicillin N synthase.

  2004cites this paper
• Dioxygen activation at mononuclear nonheme iron active sites: enzymes, models, and intermediates.

  2004cites this paper
• Structural studies on the reaction of isopenicillin N synthase with the substrate analogue δ -( L - α -aminoadipoyl)- L -cysteinyl- D - α -aminobutyrate

  2003cites this paper
• Bis(pyrazol-1-yl)acetates as tripodal heteroscorpionate ligands in iron chemistry: syntheses and structures of iron(II) and iron(III) complexes with bpza, bdmpza, and bdtbpza ligands.

  2003cites this paper
• Structural studies on the reaction of isopenicillin N synthase with the substrate analogue delta-(l-alpha-aminoadipoyl)-l-cysteinyl-d-alpha-aminobutyrate.

  2003cites this paper
• Crystallographic studies on the reaction of isopenicillin N synthase with an unsaturated substrate analogue.

  2003cites this paper
• A device for the high-pressure oxygenation of protein crystals.

  2002cites this paper