The Janus nature of heme.

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Natural product reports (Print)

• Publication date

  2007-05-30

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1039/B604195GPMID 17534526
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Structure-based hypothesis on the activation of the CO-sensing transcription factor CooA.

  2007cited by this paper
• The role of the heme propionates in heme biochemistry.

  2006cited by this paper
• QM/MM modeling of compound I active species in cytochrome P450, cytochrome C peroxidase, and ascorbate peroxidase

  2006cited by this paper
• Heme Is a Carbon Monoxide Receptor for Large-Conductance Ca2+-Activated K+ Channels

  2005cited by this paper
• Role of electrostatics and salt bridges in stabilizing the compound I radical in ascorbate peroxidase.

  2005cited by this paper
• Structural basis for novel delta-regioselective heme oxygenation in the opportunistic pathogen Pseudomonas aeruginosa.

  2004cited by this paper
• Activation of heme-regulated eukaryotic initiation factor 2alpha kinase by nitric oxide is induced by the formation of a five-coordinate NO-heme complex: optical absorption, electron spin resonance, and resonance raman spectral studies.

  2004cited by this paper
• Structural basis for the mechanism of Ca(2+) activation of the di-heme cytochrome c peroxidase from Pseudomonas nautica 617.

  2004cited by this paper
• Crystal structure of human heme oxygenase-1 in a complex with biliverdin.

  2004cited by this paper
• Electrostatic control of the tryptophan radical in cytochrome c peroxidase.

  2004cited by this paper
• Quantum mechanical/molecular mechanical investigation of the mechanism of C-H hydroxylation of camphor by cytochrome P450cam: theory supports a two-state rebound mechanism.

  2004cited by this paper
• Activation Mechanism of the CO Sensor CooA

  2003cited by this paper
• CO binding study of mouse heme-regulated eIF-2alpha kinase: kinetics and resonance Raman spectra.

  2003cited by this paper
• Peripheral heme substituents control the hydrogen-atom abstraction chemistry in cytochromes P450

  2003cited by this paper
• Haem can bind to and inhibit mammalian calcium-dependent Slo1 BK channels

  2003cited by this paper
• Crystal structure of the ascorbate peroxidase–ascorbate complex

  2003cited by this paper
• NO-induced activation mechanism of the heme-regulated eIF2alpha kinase.

  2002cited by this paper
• NO-Induced Activation Mechanism of the Heme-Regulated eIF2α Kinase

  2002cited by this paper
• CooA: a heme-containing regulatory protein that serves as a specific sensor of both carbon monoxide and redox state.

  2001cited by this paper
• Structure of the CO sensing transcription activator CooA

  2000cited by this paper
• Two heme-binding domains of heme-regulated eukaryotic initiation factor-2alpha kinase. N terminus and kinase insertion.

  2000cited by this paper
• Molecular mechanism of heme signaling in yeast: the transcriptional activator Hap1 serves as the key mediator

  1999cited by this paper
• Formation of a pterin radical in the reaction of the heme domain of inducible nitric oxide synthase with oxygen.

  1999cited by this paper
• Structural characterization of nitric oxide synthase isoforms reveals striking active-site conservation

  1999cited by this paper
• Structure of nitric oxide synthase oxygenase dimer with pterin and substrate.

  1998cited by this paper
• Crystal structure of constitutive endothelial nitric oxide synthase: a paradigm for pterin function involving a novel metal center.

  1998cited by this paper
• Heme-regulated eIF-2alpha kinase purifies as a hemoprotein.

  1998cited by this paper
• Identification of two electron-transfer sites in ascorbate peroxidase using chemical modification, enzyme kinetics, and crystallography.

  1998cited by this paper
• Energetics of Cation Radical Formation at the Proximal Active Site Tryptophan of Cytochrome c Peroxidase and Ascorbate Peroxidase

  1998cited by this paper
• Protein Radicals in Enzyme Catalysis.

  1998cited by this paper
• Crystal structure of horseradish peroxidase C at 2.15 Å resolution

  1997cited by this paper
• An engineered cation site in cytochrome c peroxidase alters the reactivity of the redox active tryptophan.

  1996cited by this paper
• Crystal structure of recombinant pea cytosolic ascorbate peroxidase.

  1995cited by this paper
• Identification of a porphyrin pi cation radical in ascorbate peroxidase compound I.

  1995cited by this paper
• Carbon monoxide-induced activation of gene expression in Rhodospirillum rubrum requires the product of cooA, a member of the cyclic AMP receptor protein family of transcriptional regulators

  1995cited by this paper
• Crystal structure of the fungal peroxidase from Arthromyces ramosus at 1.9 A resolution. Structural comparisons with the lignin and cytochrome c peroxidases.

  1994cited by this paper
• The crystal structure of manganese peroxidase from Phanerochaete chrysosporium at 2.06-A resolution.

  1994cited by this paper
• Three‐dimensional structure of a recombinant peroxidase from Coprinus cinereus at 2.6 Å resolution

  1994cited by this paper
• Cloning of the cDNA of the heme-regulated eukaryotic initiation factor 2 alpha (eIF-2 alpha) kinase of rabbit reticulocytes: homology to yeast GCN2 protein kinase and human double-stranded-RNA-dependent eIF-2 alpha kinase.

  1991cited by this paper
• Identification by ENDOR of Trp191 as the free-radical site in cytochrome c peroxidase compound ES.

  1989cited by this paper
• Lignin-degrading enzyme from Phanerochaete chrysosporium: Purification, characterization, and catalytic properties of a unique H(2)O(2)-requiring oxygenase.

  1984cited by this paper
• Purification and characterization of an extracellular H2O2-requiring diarylpropane oxygenase from the white rot basidiomycete, Phanerochaete chrysosporium.

  1984cited by this paper
• The reaction of hydrogen peroxide with the dimethyl ester heme derivative of cytochrome c peroxidase.

  1982cited by this paper
• The stereochemistry of peroxidase catalysis.

  1980cited by this paper
• Interaction of peroxidases with aromatic peracids and alkyl peroxides. Product analysis.

  1972cited by this paper
• Compounds I of catalase and horse radish peroxidase: pi-cation radicals.

  1971cited by this paper
• Studies on cytochrome c peroxidase. XIV. Recombination of apoenzyme with protoheme dialkyl esters and etioheme.

  1969cited by this paper

• Structure comparison of heme-binding sites in heme protein predicted by AlphaFold3 and AlphaFold2

  2024cites this paper
• Biosensor-based growth-coupling as an evolutionary strategy to improve heme export in Corynebacterium glutamicum

  2024cites this paper
• Aim18p and Aim46p are chalcone isomerase domain–containing mitochondrial hemoproteins in Saccharomyces cerevisiae

  2023cites this paper
• Prediction of Protein Function from Tertiary Structure of the Active Site in Heme Proteins by Convolutional Neural Network

  2023cites this paper
• Aim18p and Aim46p are CHI-domain-containing mitochondrial hemoproteins in Saccharomyces cerevisiae

  2022cites this paper
• Elucidation of the Correlation between Heme Distortion and Tertiary Structure of the Heme-Binding Pocket Using a Convolutional Neural Network

  2022cites this paper
• Global Analysis of Heme Proteins Elucidates the Correlation between Heme Distortion and the Heme-Binding Pocket

  2021cites this paper
• Analysis of Fluctuation in the Heme-Binding Pocket and Heme Distortion in Hemoglobin and Myoglobin

  2021cites this paper
• A BIOPHYSICAL INVESTIGATION OF STABILITY, LIGAND BINDING, AND IRON STATE OF CYP102A1

  2020cites this paper
• Multiplicity spin, structure, and charge of iron-verdohemeoxygenase complex: A comparison study by the DFT method

  2020cites this paper
• Evolving Mechanisms of Disease Tolerance

  2020cites this paper
• Facile synthesis of asymmetric patchy Janus Ag/Cu particles and study of their antifungal activity

  2020cites this paper
• Lipocalin Blc is a potential heme-binding protein

  2020cites this paper
• PyDISH: database and analysis tools for heme porphyrin distortion in heme proteins

  2020cites this paper
• The effects of inflammation induced by LPS and alpha synuclein on iron homeostasis in glial and neuronal cells

  2019cites this paper
• Toxic but tasty – temporal dynamics and network architecture of heme‐responsive two‐component signaling in Corynebacterium glutamicum

  2019cites this paper
• Membrane Topology and Heme Binding of the Histidine Kinases HrrS and ChrS in Corynebacterium glutamicum

  2018cites this paper
• Innate Nutritional Immunity

  2018cites this paper
• Molecular Determinants of Substrate Affinity and Enzyme Activity of a Cytochrome P450BM3 Variant.

  2018cites this paper
• Cross-Talk Between Iron and Glucose Metabolism in the Establishment of Disease Tolerance

  2018cites this paper
• Amphiphilic Ionic Perylenediimides: Structures, Self-Assembly Studies and Biomedical Applications

  2017cites this paper
• Interaction of glyceraldehyde-3-phosphate dehydrogenase and heme: The relevance of its biological function.

  2017cites this paper
• Janus Dendritic Ligands for Nanoparticle Assemblies

  2016cites this paper
• Going with the Electron Flow: Heme Electronic Structure and Electron Transfer in Cytochrome c

  2016cites this paper
• Self-assemblies of amphiphilic homopolymers: synthesis, morphology studies and biomedical applications.

  2015cites this paper
• Evidence for catalytic intermediates involved in generating the chromopyrrolic acid scaffold of rebeccamycin by RebO and RebD.

  2015cites this paper
• High‐resolution Raman imaging reveals spatial location of heme oxidation sites in single red blood cells of dried smears

  2015cites this paper
• QM/MM Molecular Dynamics Studies of Metal Binding Proteins

  2014cites this paper
• Raman spectroscopy of proteins: a review

  2013cites this paper
• Computational quantification of the physicochemical effects of heme distortion: redox control in the reaction center cytochrome subunit of Blastochloris viridis.

  2013cites this paper
• Highly sensitive analysis of four hemeproteins by dynamically-coated capillary electrophoresis with chemiluminescence detector using an off-column coaxial flow interface.

  2013cites this paper
• New heme-dioxygen and carbon monoxide adducts using pyridyl or imidazolyl tailed porphyrins.

  2013cites this paper
• Synthesis of sterically hindered xanthene-modified iron corroles with catalase-like activity.

  2013cites this paper
• Porphyrin and heme metabolism and the porphyrias.

  2013cites this paper
• Heme proteins in lactic acid bacteria.

  2013cites this paper
• Methemoglobin generation by 8-aminoquinolines: effect of substitution at 5-position of primaquine.

  2013cites this paper
• Regulation of Virulence by Iron in Gram-Positive Bacteria

  2013cites this paper
• Probing into Homopolymer Self-Assembly: How Does Hydrogen Bonding Influence Morphology?

  2013cites this paper
• Heme Cytotoxicity and the Pathogenesis of Immune-Mediated Inflammatory Diseases

  2012cites this paper
• Catalases versus peroxidases: DFT investigation of H₂O₂ oxidation in models systems and implications for heme protein engineering.

  2012cites this paper
• Crystallographic studies of heme oxygenase complexed with an unstable reaction intermediate, verdoheme.

  2012cites this paper
• Multicofactor proteins: structure,prediction, function

  2011influential citation
• Proton delivery to ferryl heme in a heme peroxidase: enzymatic use of the Grotthuss mechanism.

  2011cites this paper
• Proton-coupled electron transfer reactions at a heme-propionate in an iron-protoporphyrin-IX model compound.

  2011cites this paper
• Anisotropic particles with patchy, multicompartment and Janus architectures: preparation and application.

  2011cites this paper
• P450 enzymes: their structure, reactivity, and selectivity-modeled by QM/MM calculations.

  2010cites this paper
• On the role of water in peroxidase catalysis: a theoretical investigation of HRP compound I formation.

  2010cites this paper
• Regulation and effects of heme-oxygenase-1 expression in chronic inflammation

  2010cites this paper
• Structural analysis of heme proteins: implications for design and prediction

  2010cites this paper
• An analysis of substrate binding interactions in the heme peroxidase enzymes: a structural perspective.

  2010cites this paper
• Nitric oxide synthase stabilizes the tetrahydrobiopterin cofactor radical by controlling its protonation state.

  2010cites this paper
• Nitric oxide blocks cellular heme insertion into a broad range of heme proteins.

  2010cites this paper
• The molecular mechanism of the catalase reaction.

  2009cites this paper
• Towards a Unified View of Substrate Binding in Heme Peroxidases.

  2009cites this paper
• Density functional study of roles of porphyrin ring in electronic structures of heme

  2009cites this paper
• Bacterial heme-transport proteins and their heme-coordination modes.

  2009cites this paper
• What kinds of ferryl species exist for compound II of chloroperoxidase? A dialog of theory with experiment.

  2009cites this paper
• Binding Modes of Aromatic Ligands to Mammalian Heme Peroxidases with Associated Functional Implications

  2009cites this paper
• First half-reaction mechanism of nitric oxide synthase: the role of proton and oxygen coupled electron transfer in the reaction by quantum mechanics/molecular mechanics.

  2009cites this paper
• Inhibition of lactoperoxidase by its own catalytic product: crystal structure of the hypothiocyanate-inhibited bovine lactoperoxidase at 2.3-A resolution.

  2009cites this paper
• Theoretical and experimental studies of the conversion of chromopyrrolic acid to an antitumor derivative by cytochrome P450 StaP: the catalytic role of water molecules.

  2009cites this paper
• Electronic structures of heme a of cytochrome c oxidase in the redox states—Charge density migration to the propionate groups of heme a

  2009cites this paper
• Characterization of SiaA, a streptococcal heme-binding protein associated with a heme ABC transport system.

  2008cites this paper
• Compound I in heme thiolate enzymes: a comparative QM/MM study.

  2008cites this paper
• Electron transfer activation of chromopyrrolic acid by cytochrome p450 en route to the formation of an antitumor indolocarbazole derivative: theory supports experiment.

  2008cites this paper
• Heme electron transfer in peroxidases: the propionate e-pathway.

  2008cites this paper
• The Tuberculosis Prodrug Isoniazid Bound to Activating Peroxidases*

  2008cites this paper
• Engineering the substrate specificity and reactivity of a heme protein: creation of an ascorbate binding site in cytochrome c peroxidase.

  2008cites this paper
• Iron oxidation state modulates active site structure in a heme peroxidase.

  2008cites this paper
• The Janus Nature of Heme

  2007cites this paper