Evaluating Fmoc-amino acids as selective inhibitors of butyrylcholinesterase

No abstract is available for this paper.

• Publication year

  2016

• Venue

  Amino Acids

• Publication date

  2016-08-13

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1007/s00726-016-2310-4PMID 27522651PMCID PMC5802362
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Advances in Fmoc solid‐phase peptide synthesis

  2016cited by this paper
• 3-Oxoisoxazole-2(3H)-carboxamides and isoxazol-3-yl carbamates: Resistance-breaking acetylcholinesterase inhibitors targeting the malaria mosquito, Anopheles gambiae.

  2015cited by this paper
• Cholinesterase inhibitors for Parkinson's disease: a systematic review and meta-analysis

  2014cited by this paper
• Discovery, biological evaluation, and crystal structure of a novel nanomolar selective butyrylcholinesterase inhibitor.

  2014cited by this paper
• Long-term efficacy and toxicity of cholinesterase inhibitors in the treatment of Alzheimer disease.

  2014cited by this paper
• Status of acetylcholinesterase and butyrylcholinesterase in Alzheimer's disease and type 2 diabetes mellitus.

  2014cited by this paper
• Modulation of inflammatory pathways by the immune cholinergic system

  2013cited by this paper
• Preparation and Characterization of Magnetic Chitosan Microcapsules

  2013cited by this paper
• Acetylcholinesterase and Butyrylcholinesterase Inhibitory Activities of β-Carboline and Quinoline Alkaloids Derivatives from the Plants of Genus Peganum.

  2013cited by this paper
• Aryl methylcarbamates: potency and selectivity towards wild-type and carbamate-insensitive (G119S) Anopheles gambiae acetylcholinesterase, and toxicity to G3 strain An. gambiae.

  2013cited by this paper
• Natural products as sources of new lead compounds for the treatment of Alzheimer's disease.

  2013cited by this paper
• Divergent structure-activity relationships of structurally similar acetylcholinesterase inhibitors.

  2013cited by this paper
• Nature as a source of metabolites with cholinesterase‐inhibitory activity: an approach to Alzheimer's disease treatment

  2013cited by this paper
• Design, synthesis and biological evaluation of organophosphorous-homodimers as dual binding site acetylcholinesterase inhibitors.

  2013cited by this paper
• A review on cholinesterase inhibitors for Alzheimer’s disease

  2013cited by this paper
• From protein to peptides: a spectrum of non-hydrolytic functions of acetylcholinesterase.

  2012cited by this paper
• Probing the Peripheral Site of Human Butyrylcholinesterase

  2012cited by this paper
• Re-engineering aryl methylcarbamates to confer high selectivity for inhibition of Anopheles gambiae versus human acetylcholinesterase.

  2012cited by this paper
• Developmental aspects of the cholinergic system.

  2011cited by this paper
• Homo- and hetero-dimers of inactive organophosphorous group binding at dual sites of AChE.

  2011cited by this paper
• Targeting Acetylcholinesterase: Identification of Chemical Leads by High Throughput Screening, Structure Determination and Molecular Modeling

  2011cited by this paper
• Isosorbide-2-benzyl carbamate-5-salicylate, a peripheral anionic site binding subnanomolar selective butyrylcholinesterase inhibitor.

  2010cited by this paper
• Acetylcholinesterase: from 3D structure to function.

  2010cited by this paper
• Solid phase peptide synthesis utilizing 9-fluorenylmethoxycarbonyl amino acids.

  2009cited by this paper
• Synthesis of novel phosphorothioates and phosphorodithioates and their differential inhibition of cholinesterases.

  2009cited by this paper
• Tetrahydrofurobenzofuran cymserine, a potent butyrylcholinesterase inhibitor and experimental Alzheimer drug candidate, enzyme kinetic analysis

  2008cited by this paper
• Acetylcholinesterase and apoptosis

  2008cited by this paper
• Dialkyl phenyl phosphates as novel selective inhibitors of butyrylcholinesterase.

  2007cited by this paper
• Recent developments in cholinesterases inhibitors for Alzheimer's disease treatment.

  2007cited by this paper
• ARP, the cleavable C-terminal peptide of “readthrough” acetylcholinesterase, promotes neuronal development and plasticity

  2007cited by this paper
• Crystal Structure of Human Butyrylcholinesterase and of Its Complexes with Substrate and Products*

  2003cited by this paper
• Fast calculation of van der Waals volume as a sum of atomic and bond contributions and its application to drug compounds.

  2003influential reference
• Kinetic and structural studies on the interaction of cholinesterases with the anti-Alzheimer drug rivastigmine.

  2002cited by this paper
• Alternative Splicing and Neuritic mRNA Translocation Under Long-Term Neuronal Hypersensitivity

  2002cited by this paper
• Acetylthiocholine binds to asp74 at the peripheral site of human acetylcholinesterase as the first step in the catalytic pathway.

  2000cited by this paper
• Substrate binding to the peripheral site of acetylcholinesterase initiates enzymatic catalysis. Substrate inhibition arises as a secondary effect.

  1999cited by this paper
• Differences in active-site gorge dimensions of cholinesterases revealed by binding of inhibitors to human butyrylcholinesterase.

  1999cited by this paper
• Structural roles of acetylcholinesterase variants in biology and pathology.

  1999cited by this paper
• Differences in active site gorge dimensions of cholinesterases revealed by binding of inhibitors to human butyrylcholinesterase.

  1997influential reference
• Detection, delineation, measurement and display of cavities in macromolecular structures.

  1994influential reference
• Amino acid residues controlling acetylcholinesterase and butyrylcholinesterase specificity.

  1993cited by this paper
• Three distinct domains in the cholinesterase molecule confer selectivity for acetyl- and butyrylcholinesterase inhibitors.

  1993cited by this paper
• Excavations into the active-site gorge of cholinesterases.

  1992cited by this paper
• Atomic structure of acetylcholinesterase from Torpedo californica: a prototypic acetylcholine-binding protein

  1991cited by this paper
• Reassessment of Ellman's reagent.

  1983cited by this paper
• Enzyme kinetics: Behavior and analysis of rapid equilibrium and steady‐state enzyme systems. Author: Irwin H. Segal (University of California, Davis). Published by Wiley‐Interscience, New York, 1975. Price: $24.50. No. of pages: 957

  1976cited by this paper
• A new and rapid colorimetric determination of acetylcholinesterase activity.

  1961cited by this paper
• Effect of anticholinesterases on conduction.

  1948cited by this paper
• On the specificity of cholinesterase.

  1948cited by this paper

• In Silico Analysis of 9H-(Fluorenyl) Methyl Lysine Carbamate Derivatives as Butyrylcholinesterase Inhibitors

  2025cites this paper
• The Synthesis and in vitro Study of 9-fluorenylmethoxycarbonyl Protected Non-Protein Amino Acids Antimicrobial Activity

  2024cites this paper
• Antioxidant, Anti-Alzheimer’s, anticancer, and cytotoxic properties of peanut oil: in vitro, in silico, and GC-MS analysis

  2024cites this paper
• Unnatural Phosphorus‐Containing α‐Amino Acids and Their N‐FMOC Derivatives: Synthesis and In Vitro Investigation of Anticholinesterase Activity

  2024cites this paper
• Synthesis and Evaluation of Fmoc-Amino Esters and Amides Bearing a Substrate Like Quaternary Ammonium Group as Selective Butyrylcholinesterase Inhibitors.

  2023cites this paper
• Unexpected dihydropyridinium derivatives using a multicomponent reaction containing unprotected amino acids

  2021cites this paper
• Synthesis, experimental and in silico studies of N-fluorenylmethoxycarbonyl-O-tert-butyl-N-methyltyrosine, coupled with CSD data: a survey of interactions in the crystal structures of Fmoc-amino acids.

  2020cites this paper
• Synthesis, biochemical evaluation, and molecular modeling of organophosphate-coumarin hybrids as potent and selective butyrylcholinesterase inhibitors.

  2020cites this paper
• DHF-BAHPC Molecule Exerts Ameliorative Antioxidant Status and Reduced Cadmium-Induced Toxicity in Zebrafish (Danio rerio) Embryos.

  2020cites this paper
• Current Perspectives Applications of artificial intelligence in drug discovery for neurological diseases

  year unknowncites this paper