Age-related carbonylation of fibrocartilage structural proteins drives tissue degenerative modification.

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Chemistry and Biology

• Publication date

  2013-07-25

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.chembiol.2013.06.006PMID 23890010PMCID PMC3758909
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Oxidative Stress and Metabolic Syndrome

  2014influential reference
• The molecular basis of intervertebral disc degeneration.

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• The Naked Mole-Rat Response to Oxidative Stress: Just Deal with It

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  2012influential reference
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  2011cited by this paper
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• The aging stress response.

  2010cited by this paper
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  2010influential reference
• Cellular strategies for controlling protein aggregation

  2010cited by this paper
• The Role of Oxidative Stress in the Aging Process

  2010cited by this paper
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  2010cited by this paper
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  2010cited by this paper
• Oxidative stress and metabolic syndrome.

  2009cited by this paper
• Reactive oxygen species： A double-edged sword in oncogenesis

  2009cited by this paper
• Oxidized proteins: Mechanisms of removal and consequences of accumulation

  2009cited by this paper
• Is there more to aging than mitochondrial DNA and reactive oxygen species?

  2009cited by this paper
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  2009cited by this paper
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• An integrated view of oxidative stress in aging: basic mechanisms, functional effects, and pathological considerations.

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• Protein oxidation and aging

  2006cited by this paper
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  2004cited by this paper
• Use of biomarkers of oxidative stress in research studies.

  2004cited by this paper
• Role of oxidant species in aging.

  2004cited by this paper
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  2004cited by this paper
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• Chondrocyte apoptosis increases with age in the articular cartilage of adult animals

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• Experimental verification and theoretical prediction of cartilage interstitial fluid pressurization at an impermeable contact interface in confined compression.

  1998influential reference
• Linkage of chondrocyte apoptosis and cartilage degradation in human osteoarthritis.

  1998cited by this paper
• Collagen Crosslinks in Human Lumbar Intervertebral Disc Aging

  1998cited by this paper
• Reactive oxygen-mediated protein oxidation in aging and disease.

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  1995cited by this paper
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  1995cited by this paper
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  1995cited by this paper
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  1994cited by this paper
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  1994cited by this paper
• Structure elucidation of a senescence cross-link from human extracellular matrix. Implication of pentoses in the aging process.

  1989cited by this paper
• Age-related changes in oxidized proteins.

  1987cited by this paper
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  1984cited by this paper

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