Variation of peptide transporter (PepT1 and HPT1) expression in Caco-2 cells as a function of cell origin.

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Journal of Pharmacy and Science

• Publication date

  2004-07-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/JPS.20062PMID 15176063
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Transport Characteristics of Ceftibuten, a New Cephalosporin Antibiotic, via the Apical H+/Dipeptide Cotransport System in Human Intestinal Cell Line Caco-2: Regulation by Cell Growth

  2004cited by this paper
• Do cell culture conditions influence the carrier-mediated transport of peptides in Caco-2 cell monolayers?

  2003cited by this paper
• Spatial expression patterns of peptide transporters in the human and rat gastrointestinal tracts, Caco-2 In Vitro cell culture model, and multiple human tissues

  2001cited by this paper
• Evaluation of absorption enhancement for a potent cyclopeptidic alpha(nu)beta(3)-antagonist in a human intestinal cell line (Caco-2).

  2000cited by this paper
• Formation of Multilayers in the Caco-2 Cell Culture Model: A Confocal Laser Scanning Microscopy Study

  2000cited by this paper
• Evaluation of absorption enhancement for a potent cyclopeptidic ανβ3-antagonist in a human intestinal cell line (Caco-2)

  2000cited by this paper
• P-Glycoprotein (P-gp) mediated efflux in Caco-2 cell monolayers: the influence of culturing conditions and drug exposure on P-gp expression levels.

  1998cited by this paper
• The fundamental variables of the biopharmaceutics classification system (BCS): a commentary.

  1998cited by this paper
• The fundamental variables of the biopharmaceutics classification system (BCS): a commentary.

  1998cited by this paper
• Substrate upregulation of the human small intestinal peptide transporter, hPepT1

  1998cited by this paper
• Evidence for Diminished Functional Expression of Intestinal Transporters in Caco-2 Cell Monolayers at High Passages

  1997cited by this paper
• A human colonic cell line sharing similarities with enterocytes as a model to examine oral absorption: advantages and limitations of the Caco-2 model.

  1997cited by this paper
• The Influence of Culture Time and Passage Number on the Morphological and Physiological Development of Caco-2 Cells

  1997cited by this paper
• Transport properties are not altered across Caco-2 cells with heightened TEER despite underlying physiological and ultrastructural changes.

  1996cited by this paper
• Transepithelial Transport Properties of Peptidomimetic Thrombin Inhibitors in Monolayers of a Human Intestinal Cell Line (Caco-2) and Their Correlation to in Vivo Data

  1995cited by this paper
• A Theoretical Basis for a Biopharmaceutic Drug Classification: The Correlation of in Vitro Drug Product Dissolution and in Vivo Bioavailability

  1995cited by this paper
• Passive diffusion of weak organic electrolytes across Caco-2 cell monolayers: uncoupling the contributions of hydrodynamic, transcellular, and paracellular barriers.

  1995cited by this paper
• Heterogeneity in the human intestinal cell line Caco-2 leads to differences in transepithelial transport

  1995cited by this paper
• Regional expression and dietary regulation of rat small intestinal peptide and amino acid transporter mRNAs.

  1995cited by this paper
• Riboprobe expression cassettes for measuring IGF-I, beta-actin and glyceraldehyde 3-phosphate dehydrogenase transcripts.

  1994cited by this paper
• Transcellular transport of oral cephalosporins in human intestinal epithelial cells, Caco-2: interaction with dipeptide transport systems in apical and basolateral membranes.

  1994cited by this paper
• Transepithelial Transport and Metabolism of Thyrotropin-Releasing Hormone (TRH) in Monolayers of a Human Intestinal Cell Line (Caco-2): Evidence for an Active Transport Component?

  1994cited by this paper
• Transport mechanisms responsible for the absorption of loracarbef, cefixime, and cefuroxime axetil into human intestinal Caco-2 cells.

  1994cited by this paper
• Association of intestinal peptide transport with a protein related to the cadherin superfamily.

  1994cited by this paper
• Sodium Caprate Elicits Dilatations in Human Intestinal Tight Junctions and Enhances Drug Absorption by the Paracellular Route

  1993cited by this paper
• Transepithelial glycylsarcosine transport in intestinal Caco-2 cells mediated by expression of H(+)-coupled carriers at both apical and basal membranes.

  1993cited by this paper
• Passive Transepithelial Absorption of Thyrotropin-Releasing Hormone (TRH) via a Paracellular Route in Cultured Intestinal and Renal Epithelial Cell Lines

  1993cited by this paper
• Transepithelial transport of oral cephalosporins by monolayers of intestinal epithelial cell line Caco-2: specific transport systems in apical and basolateral membranes.

  1992cited by this paper
• Characterization of the human colon carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeability.

  1989cited by this paper

• Pharmaceutical excipients that alter intestinal drug Absorption: A systematic review of Excipient–Drug interactions

  2026cites this paper
• DEDICATÓRIA

  2026cites this paper
• Discovery of theaflavins and curcumins as the effective inhibitors of human pancreatic lipase and human carboxylesterase 2 that alleviate the formation of intracellular lipid droplets

  2026cites this paper
• Improving the Accuracy of Permeability Data to Gain Predictive Power: Assessing Sources of Variability in Assays Using Cell Monolayers

  2024cites this paper
• The shape of our gut: Dissecting its impact on drug absorption in a 3D bioprinted intestinal model.

  2023cites this paper
• Validation of Freshly Isolated Rat Renal Cells as a Tool for Preclinical Assessment of Radiolabeled Receptor-Specific Peptide Uptake in the Kidney

  2023cites this paper
• Dairy and plant based protein beverages: In vitro digestion behaviour and effect on intestinal barrier biomarkers.

  2023cites this paper
• Particulate matter 10 exposure affects intestinal functionality in both inflamed 2D intestinal epithelial cell and 3D intestinal organoid models

  2023cites this paper
• Bioavailability of Peptides Derived from the In Vitro Digestion of Human Milk Assessed by Caco-2 Cell Monolayers.

  2022cites this paper
• Navigating Through Cell-Based In vitro Models Available for Prediction of Intestinal Permeability and Metabolism: Are We Ready for 3D?

  2021cites this paper
• LC-Q-TOF/MS based identification and in silico verification of ACE-inhibitory peptides in Giresun (Turkey) hazelnut cakes

  2021cites this paper
• Drug Disposition in the Lower Gastrointestinal Tract: Targeting and Monitoring

  2021cites this paper
• Bioengineered Gastrointestinal Tissues with Fibroblast‐Induced Shapes

  2020cites this paper
• Human small intestinal organotypic culture model for drug permeation, inflammation, and toxicity assays

  2020cites this paper
• Evaluating Human Intestinal Cell Lines for Studying Dietary Protein Absorption

  2018cites this paper
• Evaluation of PepT 1 transport of food-derived antihypertensive 1 peptides , Ile-Pro-Pro and Leu-Lys-Pro using in vitro , ex vivo and 2 in vivo transport models 3 4

  2017cites this paper
• In Vitro Intrinsic Permeability: A Transporter-Independent Measure of Caco-2 Cell Permeability in Drug Design and Development.

  2017cites this paper
• Elucidation of the impact of cell culture conditions of Caco‐2 cell monolayer on barrier integrity and intestinal permeability

  2017cites this paper
• Evaluation of PepT1 transport of food‐derived antihypertensive peptides, Ile‐Pro‐Pro and Leu‐Lys‐Pro using in vitro, ex vivo and in vivo transport models

  2017cites this paper
• Analysis of the Role of Satiety of the Parents during Irradiation in the Assimilation of Substrates of the Protein Origin in two Generations of their Posterity

  2016cites this paper
• Measuring Lipid Bilayer Permeability with Biomimetic Membranes

  2016cites this paper
• Chitosan-based nanoparticles for rosmarinic acid ocular delivery--In vitro tests.

  2016cites this paper
• Caracterização in vitro do metabolismo e da absorção intestinal da casearina X

  2016cites this paper
• Intestinal permeability and P‐glycoprotein‐mediated efflux transport of ticagrelor in Caco‐2 monolayer cells

  2016cites this paper
• Variability of permeability estimation from different protocols of subculture and transport experiments in cell monolayers.

  2015cites this paper
• Towards a fully mechanistic prediction of oral drug absorption: Investigating intestinal transporter abundance and function relationships

  2015cites this paper
• Complex dietary protein improves growth through a complex mechanism of intestinal peptide absorption and protein digestion.

  2015cites this paper
• Development, validation, and application of a novel 7-day Caco-2 cell culture system.

  2014cites this paper
• Chitosan-Based Nanomedicine for Rosmarinic Acid Ocular Delivery

  2014cites this paper
• Application of Caco-2 cell line in herb-drug interaction studies: current approaches and challenges.

  2014cites this paper
• Innovative in vitro method and permeability estimation procedure to predict drug transport across the blood-brain barrier

  2014cites this paper
• Amino acids in oral drug delivery:salts, ion-pairs and transcriptomics

  2013cites this paper
• Drug Discovery and Regulatory Considerations for Improving In Silico and In Vitro Predictions that Use Caco-2 as a Surrogate for Human Intestinal Permeability Measurements

  2013cites this paper
• Streptococcus gallolyticus and colorectal cancer: explorations at the host-pathogen interface

  2012cites this paper
• The effects of intralaboratory modifications to media composition and cell source on the expression of pharmaceutically relevant transporters and metabolizing genes in the Caco-2 cell line.

  2012cites this paper
• Characterization of THLE-Cytochrome P450 (P450) Cell Lines: Gene Expression Background and Relationship to P450-Enzyme Activity

  2012cites this paper
• Shape effect in the design of nanowire-coated microparticles as transepithelial drug delivery devices.

  2012cites this paper
• Improving oral absorption via drug-loaded nanocarriers: absorption mechanisms, intestinal models and rational fabrication.

  2012cites this paper
• Exploring the interplay of physicochemical properties, membrane permeability and giardicidal activity of some benzimidazole derivatives.

  2012cites this paper
• Potential of Amino Acid/Dipeptide Monoester Prodrugs of Floxuridine in Facilitating Enhanced Delivery of Active Drug to Interior Sites of Tumors: A Two-Tier Monolayer In Vitro Study

  2011cites this paper
• GM1 expression in caco-2 cells: characterisation of a fundamental passage-dependent transformation of a cell line.

  2011cites this paper
• Novel clues on the specific association of Streptococcus gallolyticus subsp gallolyticus with colorectal cancer.

  2011cites this paper
• Conception et caractérisation biologique de systèmes lipidiques destinés à une administration par voie orale

  2010cites this paper
• Drug Transporters and Imatinib Treatment: Implications for Clinical Practice

  2010cites this paper
• Absolute Difference of Hepatobiliary Transporter Multidrug Resistance-Associated Protein (MRP2/Mrp2) in Liver Tissues and Isolated Hepatocytes from Rat, Dog, Monkey, and Human

  2009cites this paper
• Identification of interspecies difference in hepatobiliary transporters to improve extrapolation of human biliary secretion

  2009cites this paper
• Membrane Permeability – Measurement and Prediction in Drug Discovery

  2009cites this paper
• Identificationofinterspecies differenceinhepatobiliary transporterstoimprove extrapolationofhumanbiliary secretion

  2009cites this paper
• Interferon-gamma increases expression of the di/tri-peptide transporter, h-PEPT1, and dipeptide transport in cultured human intestinal monolayers.

  2009cites this paper
• Synthesis and in vitro evaluation of a library of modified endomorphin 1 peptides.

  2008cites this paper
• Comparison of drug transporter gene expression and functionality in Caco-2 cells from 10 different laboratories.

  2008cites this paper
• Ketoconazole and the modulation of multidrug resistance-mediated transport in Caco-2 and MDCKII-MDR1 drug transport models

  2008cites this paper
• Evaluation of Permeability and P-glycoprotein Interactions: Industry Outlook

  2008cites this paper
• Oral absorption of ampicillin: role of paracellular route vs. PepT1 transporter

  2008cites this paper
• Variability in Caco-2 and MDCK cell-based intestinal permeability assays.

  2008cites this paper
• Absolute Difference of Hepatobiliary Transporter MRP2/Mrp2 in Liver Tissues and Isolated Hepatocytes from Rat, Dog, Monkey and Human

  2008cites this paper
• Evaluation of drug-transporter interactions using in vitro and in vivo models.

  2007cites this paper
• Expression of Thirty-six Drug Transporter Genes in Human Intestine, Liver, Kidney, and Organotypic Cell Lines

  2007cites this paper
• Determination of drug absorption parameters in Caco-2 cell monolayers with a mathematical model encompassing passive diffusion, carrier-mediated efflux, non-specific binding and phase II metabolism

  2007cites this paper
• Expression of 36 drug transporter genes in human intestine, liver, kidney, and organotypic cell lines

  2007cites this paper
• Analysis of drug transporter expression in human intestinal Caco‐2 cells by real‐time PCR

  2007cites this paper
• Regional levels of drug transporters along the human intestinal tract: co-expression of ABC and SLC transporters and comparison with Caco-2 cells.

  2006cites this paper
• Caco-2 cell cultures in the assessment of intestinal absorption: Effects of some co-administered drugs and natural compounds in biological matrices

  2006cites this paper
• Comparison of drug transporter levels in normal colon, colon cancer, and Caco-2 cells: impact on drug disposition and discovery.

  2006cites this paper
• Variability in mRNA expression of ABC- and SLC-transporters in human intestinal cells: comparison between human segments and Caco-2 cells.

  2006cites this paper
• Current industrial practices of assessing permeability and P-glycoprotein interaction

  2006cites this paper
• Pharmacophore-based discovery of ligands for drug transporters.

  2006cites this paper
• Delineation of Human Peptide Transporter 1 (hPepT1)-Mediated Uptake and Transport of Substrates with Varying Transporter Affinities Utilizing Stably Transfected hPepT1/Madin-Darby Canine Kidney Clones and Caco-2 Cells

  2005cites this paper
• The Caco-2 cell line as a model of the intestinal barrier: influence of cell and culture-related factors on Caco-2 cell functional characteristics

  2005cites this paper
• DELINEATION OF HPEPT1 MEDIATED UPTAKE AND TRANSPORT OF SUBSTRATES WITH VARYING TRANSPORTER AFFINITIES UTILIZING STABLY TRANSFECTED HPEPT1/MDCK CLONES AND CACO-2 CELLS

  2005cites this paper
• Physiological, Biochemical, and Chemical Barriers to Oral Drug Delivery

  2005cites this paper
• Cell culture-based models for intestinal permeability: a critique.

  2005cites this paper
• Apical/Basolateral Surface Expression of Drug Transporters and its Role in Vectorial Drug Transport

  2005cites this paper
• Do cell culture conditions influence the carrier-mediated transport of peptides in Caco-2 cell monolayers?

  2003cites this paper