The heterotrimeric kinesin-2 complex interacts with and regulates GLI protein function

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Journal of Cell Science

• Publication date

  2015-03-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1242/jcs.162552PMID 25588831PMCID PMC4342584
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• POPX2 phosphatase regulates the KIF3 kinesin motor complex

  2014cited by this paper
• The PPFIA1-PP2A protein complex promotes trafficking of Kif7 to the ciliary tip and Hedgehog signaling

  2014influential reference
• The Kinesin-4 Protein KIF7 Regulates Mammalian Hedgehog Signaling by Organizing the Cilia Tip Compartment

  2014influential reference
• Intraflagellar transport complex structure and cargo interactions

  2013cited by this paper
• Kinesin-2: a family of heterotrimeric and homodimeric motors with diverse intracellular transport functions.

  2013cited by this paper
• The mechanisms of Hedgehog signalling and its roles in development and disease

  2013cited by this paper
• Hedgehog signaling from the primary cilium to the nucleus: an emerging picture of ciliary localization, trafficking and transduction.

  2013cited by this paper
• Positive and Negative Regulation of Gli Activity by Kif7 in the Zebrafish Embryo

  2013cited by this paper
• IFT25 links the signal-dependent movement of Hedgehog components to intraflagellar transport.

  2012cited by this paper
• Neural-specific Sox2 input and differential Gli-binding affinity provide context and positional information in Shh-directed neural patterning.

  2012cited by this paper
• Mechanistic differences in the transcriptional interpretation of local and long-range Shh morphogen signaling.

  2012cited by this paper
• Kif7 regulates Gli2 through Sufu-dependent and -independent functions during skin development and tumorigenesis

  2012cited by this paper
• Complex Interactions Between Genes Controlling Trafficking in Primary Cilia

  2011cited by this paper
• Association of the testis-specific TRIM/RBCC protein RNF33/TRIM60 with the cytoplasmic motor proteins KIF3A and KIF3B

  2011influential reference
• Kif7 promotes hedgehog signaling in growth plate chondrocytes by restricting the inhibitory function of Sufu

  2011influential reference
• Regulation of mammalian Gli proteins by Costal 2 and PKA in Drosophila reveals Hedgehog pathway conservation

  2011influential reference
• The Retrograde IFT Machinery of C. elegans Cilia: Two IFT Dynein Complexes?

  2011cited by this paper
• Gli proteins in development and disease.

  2011cited by this paper
• Overlapping roles and collective requirement for the coreceptors GAS1, CDO, and BOC in SHH pathway function.

  2011cited by this paper
• Hedgehog Signaling and the Gli Code in Stem Cells, Cancer, and Metastases

  2011cited by this paper
• Intraflagellar transport protein 122 antagonizes Sonic Hedgehog signaling and controls ciliary localization of pathway components

  2011cited by this paper
• The primary cilium: a signalling centre during vertebrate development

  2010cited by this paper
• Suppressor of fused and Spop regulate the stability, processing and function of Gli2 and Gli3 full-length activators but not their repressors

  2010influential reference
• Kinetics of Hedgehog-Dependent Full-Length Gli3 Accumulation in Primary Cilia and Subsequent Degradation

  2010cited by this paper
• A mechanism for vertebrate Hedgehog signaling: recruitment to cilia and dissociation of SuFu–Gli protein complexes

  2010cited by this paper
• Intraflagellar transport: it's not just for cilia anymore.

  2010cited by this paper
• The mammalian Cos2 homolog Kif7 plays an essential role in modulating Hh signal transduction during development.

  2009cited by this paper
• Protein phosphatase Dusp26 associates with KIF3 motor and promotes N-cadherin-mediated cell–cell adhesion

  2009cited by this paper
• Mouse Kif7/Costal2 is a cilia-associated protein that regulates Sonic hedgehog signaling

  2009cited by this paper
• The Kinesin Protein Kif7 Is a Critical Regulator of Gli Transcription Factors in Mammalian Hedgehog Signaling

  2009influential reference
• Tubby-like protein 3 (TULP3) regulates patterning in the mouse embryo through inhibition of Hedgehog signaling.

  2009cited by this paper
• Intraflagellar transport is required for polarized recycling of the TCR/CD3 complex to the immune synapse

  2009cited by this paper
• Gli2 trafficking links Hedgehog-dependent activation of Smoothened in the primary cilium to transcriptional activation in the nucleus

  2009cited by this paper
• Kinesin superfamily motor proteins and intracellular transport

  2009cited by this paper
• Intraflagellar transport (IFT) role in ciliary assembly, resorption and signalling.

  2008cited by this paper
• The homodimeric kinesin, Kif17, is essential for vertebrate photoreceptor sensory outer segment development.

  2008cited by this paper
• Chapter Two Intraflagellar Transport (IFT)

  2008cited by this paper
• Genomic characterization of Gli-activator targets in sonic hedgehog-mediated neural patterning

  2007cited by this paper
• Sonic hedgehog Signaling Regulates Gli2 Transcriptional Activity by Suppressing Its Processing and Degradation

  2006cited by this paper
• A genome-wide RNA interference screen in Drosophila melanogaster cells for new components of the Hh signaling pathway

  2005cited by this paper
• The KIF3 motor transports N-cadherin and organizes the developing neuroepithelium

  2005cited by this paper
• A previously unidentified amino-terminal domain regulates transcriptional activity of wild-type and disease-associated human GLI2.

  2005cited by this paper
• Mouse intraflagellar transport proteins regulate both the activator and repressor functions of Gli transcription factors

  2005cited by this paper
• A gradient of Gli activity mediates graded Sonic Hedgehog signaling in the neural tube.

  2005cited by this paper
• Negative regulation of Gli1 and Gli2 activator function by Suppressor of fused through multiple mechanisms.

  2005cited by this paper
• Gli2 and Gli3 Localize to Cilia and Require the Intraflagellar Transport Protein Polaris for Processing and Function

  2005influential reference
• Kinesin‐2 is a Motor for Late Endosomes and Lysosomes

  2005cited by this paper
• Redistribution of the kinesin-II subunit KAP from cilia to nuclei during the mitotic and ciliogenic cycles in sea urchin embryos.

  2004cited by this paper
• Intraflagellar transport (IFT) cargo

  2004cited by this paper
• All mouse ventral spinal cord patterning by hedgehog is Gli dependent and involves an activator function of Gli3.

  2004cited by this paper
• Intraflagellar transport (IFT) cargo: IFT transports flagellar precursors to the tip and turnover products to the cell body

  2004cited by this paper
• Two anterograde intraflagellar transport motors cooperate to build sensory cilia on C. elegans neurons

  2004cited by this paper
• Intraflagellar transport.

  2003cited by this paper
• Hedgehog signalling in the mouse requires intraflagellar transport proteins

  2003influential reference
• Developmental roles and clinical significance of hedgehog signaling.

  2003cited by this paper
• The amino-terminal region of Gli3 antagonizes the Shh response and acts in dorsoventral fate specification in the developing spinal cord.

  2003cited by this paper
• Gli2, but not Gli1, is required for initial Shh signaling and ectopic activation of the Shh pathway.

  2002influential reference
• A mitogen gradient of dorsal midline Wnts organizes growth in the CNS.

  2002cited by this paper
• Identification of a link between the tumour suppressor APC and the kinesin superfamily

  2002influential reference
• Intraflagellar transport

  2002cited by this paper
• Gli1 can rescue the in vivo function of Gli2.

  2001cited by this paper
• Functional Analysis of Mouse Kinesin Motor Kif3C

  2001cited by this paper
• Stirring up Development with the Heterotrimeric Kinesin KIF3

  2000cited by this paper
• Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb.

  2000influential reference
• Expression of the vertebrate Gli proteins in Drosophila reveals a distribution of activator and repressor activities.

  2000cited by this paper
• Regulation of Gli2 and Gli3 activities by an amino-terminal repression domain: implication of Gli2 and Gli3 as primary mediators of Shh signaling.

  1999influential reference
• Nuclear trafficking of Cubitus interruptus in the transcriptional regulation of Hedgehog target gene expression.

  1999cited by this paper
• Gli proteins encode context-dependent positive and negative functions: implications for development and disease.

  1999cited by this paper
• Gli proteins encode context-dependent positive and negative functions: implications for development and disease

  1999cited by this paper
• Mammalian Suppressor-of-Fused modulates nuclear–cytoplasmic shuttling of GLI-1

  1999cited by this paper
• Left-Right Asymmetry and Kinesin Superfamily Protein KIF3A: New Insights in Determination of Laterality and Mesoderm Induction by kif3A− /− Mice Analysis

  1999influential reference
• Diminished Sonic hedgehog signaling and lack of floor plate differentiation in Gli2 mutant mice.

  1998cited by this paper
• Gli2 is required for induction of floor plate and adjacent cells, but not most ventral neurons in the mouse central nervous system.

  1998cited by this paper
• Randomization of left-right asymmetry due to loss of nodal cilia generating leftward flow of extraembryonic fluid in mice lacking KIF3B motor protein.

  1998cited by this paper
• Characterization of the KIF3C neural kinesin-like motor from mouse.

  1998cited by this paper
• Costal2, a novel kinesin-related protein in the Hedgehog signaling pathway.

  1997cited by this paper
• Hedgehog elicits signal transduction by means of a large complex containing the kinesin-related protein costal2.

  1997cited by this paper
• Armadillo repeats in the SpKAP115 subunit of kinesin-II.

  1996cited by this paper
• Biochemical evidence that Patched is the Hedgehog receptor

  1996cited by this paper
• The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog

  1996cited by this paper
• Cloning and characterization of KAP3: a novel kinesin superfamily-associated protein of KIF3A/3B.

  1996influential reference
• Sequence and submolecular localization of the 115-kD accessory subunit of the heterotrimeric kinesin-II (KRP85/95) complex

  1996cited by this paper
• KIF3A/B: a heterodimeric kinesin superfamily protein that works as a microtubule plus end-directed motor for membrane organelle transport

  1995influential reference
• Novel heterotrimeric kinesin-related protein purified from sea urchin eggs

  1993cited by this paper

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  2025cites this paper
• The Hitchdock Domain in Kinesin-2 Tail Enables Adaptor Assembly and Cargo Binding

  2025cites this paper
• Collaborative role of two distinct cilium-specific cytoskeletal systems in driving Hedgehog-responsive transcription factor trafficking

  2025cites this paper
• Hedgehog signaling in tissue homeostasis, cancers and targeted therapies

  2023cites this paper
• The two‐step cargo recognition mechanism of heterotrimeric kinesin

  2023cites this paper
• Cilia proteins getting to work - how do they commute from the cytoplasm to the base of cilia?

  2022cites this paper
• Dual and opposing roles for the kinesin-2 motor, KIF17, in Hedgehog-dependent cerebellar development

  2022cites this paper
• KAP is the neuronal organelle adaptor for Kinesin-2 KIF3AB and KIF3AC

  2022cites this paper
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  2021cites this paper
• Novel alterations in IFT172 and KIFAP3 may induce basal cell carcinoma

  2021cites this paper
• GLI3: a mediator of genetic diseases, development and cancer

  2020cites this paper
• Keratin 17 regulates nuclear morphology and chromatin organization

  2020cites this paper
• Developmental and regenerative paradigms of cilia regulated hedgehog signaling.

  2020cites this paper
• Architecture of the IFT ciliary trafficking machinery and interplay between its components

  2020cites this paper
• Molecular characterisation of putative WNT signalling protein, Leucine zipper and ICAT domain containing (LZIC)

  2020cites this paper
• Silica Perturbs Primary Cilia and Causes Myofibroblast Differentiation during Silicosis by Reduction of the KIF3A-Repressor GLI3 Complex

  2020influential citation
• Common and distinct transcriptional signatures of mammalian embryonic lethality

  2019cites this paper
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  2019cites this paper
• Ciliopathy-Associated Protein Kinase ICK Requires Its Non-Catalytic Carboxyl-Terminal Domain for Regulation of Ciliogenesis

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  2019cites this paper
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• Kinesin-2 heterodimerization alters entry into a processive run along the microtubule but not stepping within the run

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  2018cites this paper
• Spatiotemporal manipulation of ciliary glutamylation reveals its roles in intraciliary trafficking and Hedgehog signaling

  2018cites this paper
• Rab23 and developmental disorders

  2018cites this paper
• The regulation of KIF3A motor subunit by phosphorylation

  2018cites this paper
• Protein Interaction Analysis Provides a Map of the Spatial and Temporal Organization of the Ciliary Gating Zone.

  2017cites this paper
• Microtubule Motors Drive Hedgehog Signaling in Primary Cilia.

  2017cites this paper
• Cell Cycle-Related Kinase (CCRK) regulates ciliogenesis and Hedgehog signaling in mice

  2017cites this paper
• Intraflagellar transport: mechanisms of motor action, cooperation, and cargo delivery

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• Dynamic transcription and expression patterns of KIF3A and KIF3B genes during spermiogenesis in the shrimp, Palaemon carincauda.

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