Endocytosis of Synaptotagmin 1 Is Mediated by a Novel, Tryptophan‐Containing Motif

No abstract is available for this paper.

• Publication year

  2003

• Venue

  Traffic : the International Journal of Intracellular Transport

• Publication date

  2003-07-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1034/j.1600-0854.2003.00101.xPMID 12795692
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Faculty Opinions recommendation of The C(2)B Ca(2+)-binding motif of synaptotagmin is required for synaptic transmission in vivo.

  2003cited by this paper
• Internalization signals in synaptotagmin VII utilizing two independent pathways are masked by intramolecular inhibitions

  2003cited by this paper
• The C2B Ca2+-binding motif of synaptotagmin is required for synaptic transmission in vivo

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• Synaptotagmins I and IV promote transmitter release independently of Ca2+ binding in the C2A domain

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• Ca2+-dependent synaptotagmin binding to SNAP-25 is essential for Ca2+-triggered exocytosis.

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• Cargo Selection in Vesicular Transport: The Making and Breaking of a Coat

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• Synaptotagmin I functions as a calcium regulator of release probability

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• Three-dimensional structure of the synaptotagmin 1 C2B-domain: synaptotagmin 1 as a phospholipid binding machine.

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• synaptotagmin Mutants Reveal Essential Functions for the C2B Domain in Ca2+-Triggered Fusion and Recycling of Synaptic Vesicles In Vivo

  2001cited by this paper
• Endocytotic mechanisms in synapses.

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• A Third Specificity‐Determining Site in μ2 Adaptin for Sequences Upstream of YxxΦ Sorting Motifs

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• Dynamin and Rab5a-dependent Trafficking and Signaling of the Neurokinin 1 Receptor*

  2001influential reference
• The AP2 binding site of synaptotagmin 1 is not an internalization signal but a regulator of endocytosis

  2001cited by this paper
• The C2B domain of synaptotagmin I is a Ca2+-binding module.

  2001cited by this paper
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• Formation of Crystalloid Endoplasmic Reticulum Induced by Expression of Synaptotagmin Lacking the Conserved WHXL Motif in the C Terminus

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• HIV-1 Nef protein binds to the cellular protein PACS-1 to downregulate class I major histocompatibility complexes

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  2000cited by this paper
• Dual interaction of synaptotagmin with mu2- and alpha-adaptin facilitates clathrin-coated pit nucleation.

  2000influential reference
• Synaptotagmin Regulation of Coated Pit Assembly*

  2000cited by this paper
• The C Terminus of SNAP25 Is Essential for Ca2+-dependent Binding of Synaptotagmin to SNARE Complexes*

  2000cited by this paper
• The Carboxyl Terminus of the Cystic Fibrosis Transmembrane Conductance Regulator Binds to AP-2 Clathrin Adaptors*

  2000cited by this paper
• Role of the conserved WHXL motif in the C terminus of synaptotagmin in synaptic vesicle docking.

  2000cited by this paper
• Inhibition of the receptor‐binding function of clathrin adaptor protein AP‐2 by dominant‐negative mutant μ2 subunit and its effects on endocytosis

  1999cited by this paper
• Inhibition of clathrin-coated pit assembly by an Eps15 mutant.

  1999influential reference
• Molecular Bases for the Recognition of Tyrosine-based Sorting Signals

  1999cited by this paper
• Recognition of sorting signals by clathrin adaptors

  1999cited by this paper
• Kinetics of synaptotagmin responses to Ca2+ and assembly with the core SNARE complex onto membranes.

  1999cited by this paper
• Structure of the Janus-faced C2B domain of rabphilin

  1999cited by this paper
• Delineation of the Oligomerization, AP-2 Binding, and Synprint Binding Region of the C2B Domain of Synaptotagmin*

  1998cited by this paper
• A Leucine-based Motif Mediates the Endocytosis of Vesicular Monoamine and Acetylcholine Transporters*

  1998cited by this paper
• Reconstitution of synaptic vesicle biogenesis from PC12 cell membranes.

  1998cited by this paper
• The Medium Subunits of Adaptor Complexes Recognize Distinct but Overlapping Sets of Tyrosine-based Sorting Signals*

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• A structural explanation for the recognition of tyrosine-based endocytotic signals.

  1998cited by this paper
• AP-2/Eps15 Interaction Is Required for Receptor-mediated Endocytosis

  1998influential reference
• Direct Interaction of a Ca2+-binding Loop of Synaptotagmin with Lipid Bilayers*

  1998cited by this paper
• Distinct Saturable Pathways for the Endocytosis of Different Tyrosine Motifs*

  1998cited by this paper
• Solution structures of the Ca2+-free and Ca2+-bound C2A domain of synaptotagmin I: does Ca2+ induce a conformational change?

  1998cited by this paper
• Linking cargo to vesicle formation: receptor tail interactions with coat proteins.

  1997cited by this paper
• Tyrosine phosphorylation controls internalization of CTLA-4 by regulating its interaction with clathrin-associated adaptor complex AP-2.

  1997cited by this paper
• Endocytosis of VAMP is facilitated by a synaptic vesicle targeting signal

  1996cited by this paper
• Structural Determinants of Interaction of Tyrosine-based Sorting Signals with the Adaptor Medium Chains*

  1996cited by this paper
• Distinct Ca(2+)-dependent properties of the first and second C2-domains of synaptotagmin I.

  1996cited by this paper
• The targeting of Lamp1 to lysosomes is dependent on the spacing of its cytoplasmic tail tyrosine sorting motif relative to the membrane

  1996cited by this paper
• Sequence requirements for the recognition of tyrosine‐based endocytic signals by clathrin AP‐2 complexes.

  1996cited by this paper
• A Novel Function for the Second C2 Domain of Synaptotagmin

  1996cited by this paper
• Distinct Ca-dependent Properties of the First and Second C-domains of Synaptotagmin I (*)

  1996cited by this paper
• Erratum: Synaptotagmins: C2-domain proteins that regulate membrane traffic (Neuron (1996) 17 (379-388))

  1996cited by this paper
• Synaptotagmins: C2-domain proteins that regulate membrane traffic.

  1996cited by this paper
• Residues Throughout the Cytoplasmic Domain Affect the Internalization Efficiency of P-selectin (*)

  1995cited by this paper
• A targeting signal in VAMP regulating transport to synaptic vesicles.

  1995cited by this paper
• A Role for Acidic Residues in Di-leucine Motif-based Targeting to the Endocytic Pathway (*)

  1995cited by this paper
• Functional Diversity of C2 Domains of Synaptotagmin Family

  1995cited by this paper
• Structure of the first C2 domain of synaptotagmin I: a novel Ca2+/phospholipid-binding fold.

  1995cited by this paper
• Ca2+-dependent and -independent activities of neural and non-neural synaptotagmins

  1995cited by this paper
• An acidic sequence within the cytoplasmic domain of furin functions as a determinant of trans‐Golgi network localization and internalization from the cell surface.

  1995cited by this paper
• Interaction of tyrosine-based sorting signals with clathrin-associated proteins.

  1995cited by this paper
• The effect on synaptic physiology of synaptotagmin mutations in Drosophila.

  1994cited by this paper
• Backbone 1H and 15N resonance assignments of the N-terminal SH3 domain of drk in folded and unfolded states using enhanced-sensitivity pulsed field gradient NMR techniques

  1994cited by this paper
• Calcium-dependent interaction of the cytoplasmic region of synaptotagmin with membranes. Autonomous function of a single C2-homologous domain.

  1994cited by this paper
• Synaptotagmin I is a high affinity receptor for clathrin AP-2: implications for membrane recycling.

  1994cited by this paper
• Synaptotagmin I: a major Ca2+ sensor for transmitter release at a central synapse.

  1994cited by this paper
• Calcium dependence of neurotransmitter release and rate of spontaneous vesicle fusions are altered in Drosophila synaptotagmin mutants.

  1994cited by this paper
• Structural requirements and sequence motifs for polarized sorting and endocytosis of LDL and Fc receptors in MDCK cells

  1994cited by this paper
• Synaptic function is impaired but not eliminated in C. elegans mutants lacking synaptotagmin.

  1993cited by this paper
• Mutational analysis of Drosophila synaptotagmin demonstrates its essential role in Ca(2+)-activated neurotransmitter release.

  1993cited by this paper
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  1993cited by this paper
• Effects of mutant rat dynamin on endocytosis

  1993cited by this paper
• The synaptic vesicle proteins SV2, synaptotagmin and synaptophysin are sorted to separate cellular compartments in CHO fibroblasts

  1993cited by this paper
• Synaptotagmin: a calcium sensor on the synaptic vesicle surface.

  1992cited by this paper
• Domain structure of synaptotagmin (p65)

  1991cited by this paper
• Synaptophysin is sorted from endocytotic markers in neuroendocrine PC12 cells but not transfected fibroblasts.

  1991cited by this paper
• Identification of a synaptic vesicle-specific membrane protein with a wide distribution in neuronal and neurosecretory tissue

  1981influential reference
• Accelerated Publications The C 2 B Domain of Synaptotagmin I Is a Ca 2 +-Binding Module †

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  2022cites this paper
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  2010cites this paper
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  2010cites this paper
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  2010cites this paper
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  2009cites this paper
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  2009cites this paper
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  2009cites this paper
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  2008cites this paper
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