Polyglutamine Domains Are Substrates of Tissue Transglutaminase: Does Transglutaminase Play a Role in Expanded CAG/Poly‐Q Neurodegenerative Diseases?

No abstract is available for this paper.

• Publication year

  1997

• Venue

  Journal of Neurochemistry

• Publication date

  1997-07-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1046/j.1471-4159.1997.69010431.xPMID 9202340
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  1996cited by this paper
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• Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice.

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• An expanded CAG repeat sequence in spinocerebellar ataxia type 7.

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• Peptides containing glutamine repeats as substrates for transglutaminase-catalyzed cross-linking: relevance to diseases of the nervous system.

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  1996cited by this paper
• Incorporation of glutamine repeats makes protein oligomerize: implications for neurodegenerative diseases.

  1995cited by this paper
• Substrate Requirements for Transglutaminases

  1995cited by this paper
• Purification and characterization of rat brain transglutaminase.

  1995cited by this paper
• Human genetic diseases due to codon reiteration: relationship to an evolutionary mechanism.

  1993cited by this paper
• Covalent modification of synapsin I by a tetanus toxin-activated transglutaminase.

  1993cited by this paper
• γ‐Glutamylaminotransferase and Transglutaminase in Subcellular Fractions of Rat Cortex and in Cultured Astrocytes

  1992cited by this paper
• Tetanus toxin potently stimulates tissue transglutaminase. A possible mechanism of neurotoxicity.

  1992cited by this paper
• Apoptosis: molecular mechanisms in programmed cell death.

  1991cited by this paper
• A Role for Transglutaminase in Neurotransmitter Release by Rat Brain Synaptosomes

  1986cited by this paper
• Decreased pyruvate dehydrogenase complex activity in Huntington and Alzheimer brain

  1983cited by this paper
• Association of putrescine, spermidine, spermine, and GABA with structural elements of brain cells

  1976cited by this paper
• Transglutaminase: mechanistic features of the active site as determined by kinetic and inhibitor studies.

  1966cited by this paper
• Protein measurement with the Folin phenol reagent.

  1951cited by this paper

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  2013cites this paper
• Transglutaminase 2: biology, relevance to neurodegenerative diseases and therapeutic implications.

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  2009cites this paper
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  2005cites this paper
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