N‐terminal guanidinylation of the cyclic 1,4‐ureido‐deltorphin analogues: the synthesis, receptor binding studies, and resistance to proteolytic digestion

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Journal of Peptide Science

• Publication date

  2015-06-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1002/psc.2762PMID 25755050
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Delta-Opioid Receptor Analgesia Is Independent of Microglial Activation in a Rat Model of Neuropathic Pain

  2014cited by this paper
• Synthesis, biological activity and resistance to proteolytic digestion of new cyclic dermorphin/deltorphin analogues.

  2013cited by this paper
• N-terminal guanidinylation of TIPP (Tyr-Tic-Phe-Phe) peptides results in major changes of the opioid activity profile.

  2013cited by this paper
• Chronic inflammatory injury results in increased coupling of delta opioid receptors to voltage-gated Ca2+ channels

  2013cited by this paper
• Cyclization in opioid peptides.

  2013cited by this paper
• Peptides as therapeutics with enhanced bioactivity.

  2012cited by this paper
• Co‐administration of &dgr;‐ and &mgr;‐opioid receptor agonists promotes peripheral opioid receptor function

  2010cited by this paper
• Coexpression of δ- and μ-opioid receptors in nociceptive sensory neurons

  2010cited by this paper
• Opioid switching and rotation in primary care: implementation and clinical utility

  2009cited by this paper
• Enkephalin derivative, cyclo[Nepsilon,Nbeta-carbonyl-D-Lys2, Dap5] enkephalinamide (cUENK6), induces a highly potent antinociception in rats.

  2009cited by this paper
• Management of cancer pain: ESMO clinical recommendations.

  2009cited by this paper
• N‐(ureidoethyl)amides of cyclic enkephalin analogs

  2009cited by this paper
• Influence of TRPV1 on diabetes-induced alterations in thermal pain sensitivity

  2008cited by this paper
• Intrathecal antinociceptive interaction between the NMDA antagonist ketamine and the opioids, morphine and biphalin

  2008cited by this paper
• Down-regulation of mu opioid receptor expression within distinct subpopulations of dorsal root ganglion neurons in a murine model of bone cancer pain.

  2008cited by this paper
• Management of cancer pain: ESMO clinical recommendations.

  2008cited by this paper
• Ureido group containing cyclic dermorphin(1–7) analogues: synthesis, biology and conformation

  2007cited by this paper
• Management of cancer pain: ESMO clinical recommendations.

  2007cited by this paper
• Morphine and Pain-Related Stimuli Enhance Cell Surface Availability of Somatic δ-Opioid Receptors in Rat Dorsal Root Ganglia

  2006cited by this paper
• Utilization of Combined Chemical Modifications to Enhance the Blood-Brain Barrier Permeability and Pharmacological Activity of Endomorphin-1

  2006cited by this paper
• CNS drug delivery: Opioid peptides and the blood-brain barrier

  2006cited by this paper
• Morphine and pain-related stimuli enhance cell surface availability of somatic delta-opioid receptors in rat dorsal root ganglia.

  2006cited by this paper
• Abbreviated nomenclature for cyclic and branched homo- and hetero-detic peptides.

  2005cited by this paper
• Interactions between delta and mu opioid agonists in assays of schedule-controlled responding, thermal nociception, drug self-administration, and drug versus food choice in rhesus monkeys: studies with SNC80 [(+)-4-[(alphaR)-alpha-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-die

  2005cited by this paper
• p‐Nitrophenoxycarbonyl derivatives of Boc‐protected diaminoalkanes in the synthesis of enkephalin peptidomimetics

  2005cited by this paper
• Cyclic enkephalin and dermorphin analogues containing a carbonyl bridge

  2005cited by this paper
• Interactions between δ and μ Opioid Agonists in Assays of Schedule-Controlled Responding, Thermal Nociception, Drug Self-Administration, and Drug versus Food Choice in Rhesus Monkeys: Studies with SNC80 [(+)-4-[(αR)-α-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethylbenzamide

  2005cited by this paper
• The cardiovascular and renal effects of a highly potent mu-opioid receptor agonist, cyclo[N epsilon,N beta-carbonyl-D-Lys2,Dap5]enkephalinamide.

  2004cited by this paper
• The cardiovascular and renal effects of a highly potent μ-opioid receptor agonist, cyclo[Nε, Nβ-carbonyl-D-Lys2, Dap5]enkephalinamide

  2004cited by this paper
• Reagents for Efficient Conversion of Amines to Protected Guanidines.

  2004cited by this paper
• Opioid receptor binding and in vivo antinociceptive activity of position 3-substituted morphiceptin analogs.

  2004cited by this paper
• Potent side‐chain to side‐chain cyclized dermorphin analogues containing a carbonyl bridge

  2003cited by this paper
• Structure-activity relationships (SAR) of [D-Arg(2)]dermorphin(1-4) analogues, N(alpha)-amidino-Tyr-D-Arg-Phe-X.

  2002cited by this paper
• The terminology of guanidine formation

  2002cited by this paper
• Postoperative Titration of Intravenous Morphine in the Elderly Patient

  2002cited by this paper
• Converting a peptide into a drug: strategies to improve stability and bioavailability.

  2002cited by this paper
• Synthesis and structure-activity relationships of an orally available and long-acting analgesic peptide, N(alpha)-amidino-Tyr-D-Arg-Phe-MebetaAla-OH (ADAMB).

  2002cited by this paper
• Synthesis and Structure−Activity Relationships of an Orally Available and Long-Acting Analgesic Peptide, Nα-Amidino-Tyr-d-Arg-Phe-MeβAla-OH (ADAMB)

  2002cited by this paper
• Effect of guanidino modification and proline substitution on the in vitro stability and blood-brain barrier permeability of endomorphin II.

  2002cited by this paper
• Highly potent side‐chain to side‐chain cyclized enkephalin analogues containing a carbonyl bridge: synthesis, biology and conformation

  2001cited by this paper
• Incomplete cross tolerance and multiple mu opioid peptide receptors.

  2001cited by this paper
• Prolonged morphine treatment targets delta opioid receptors to neuronal plasma membranes and enhances delta-mediated antinociception.

  2001cited by this paper
• Prolonged Morphine Treatment Targets δ Opioid Receptors to Neuronal Plasma Membranes and Enhances δ-Mediated Antinociception

  2001cited by this paper
• Synthesis of a novel side‐chain to side‐chain cyclized enkephalin analogue containing a carbonyl bridge

  1997cited by this paper
• Synergy between μδ-opioid receptors mediates adenosine release from spinal cord synaptosomes

  1996cited by this paper
• Synergy between mu/delta-opioid receptors mediates adenosine release from spinal cord synaptosomes.

  1996cited by this paper
• Co-localization of μ and δ opioid receptors on SK-N-SH cells detected by fluorescence microscopy using labeled anti-idiotypic antibodies

  1993cited by this paper
• Co-localization of mu and delta opioid receptors on SK-N-SH cells detected by fluorescence microscopy using labeled anti-idiotypic antibodies.

  1993cited by this paper
• Antinociceptive interactions of opioid delta receptor agonists with morphine in mice: supra- and sub-additivity.

  1992cited by this paper
• Topographical requirements for delta opioid ligands: common structural features of dermenkephalin and deltorphin.

  1992cited by this paper
• Alternated delta and mu receptor activation: a stratagem for limiting opioid tolerance

  1989cited by this paper
• Synthesis and activity profiles of new dermorphin-(1-4) peptide analogues.

  1987cited by this paper
• Differential effects of leucine and methionine enkephalin on morphine-induced analgesia, acute tolerance and dependence.

  1979cited by this paper

• Structure-activity study of oncocin: On-resin guanidinylation and incorporation of homoarginine, 4-hydroxyproline or 4,4-difluoroproline residues.

  2023cites this paper
• PD-1: A new candidate target for analgesic peptide design.

  2023cites this paper
• Peptidomimetics and Their Applications for Opioid Peptide Drug Discovery

  2022cites this paper
• Evaluation of 1H-Triazole-1-[N,N'-Bis(tert-butoxycarbonyl)]carboxamidine in Solution-Phase and On-Resin Guanidinylation.

  2021cites this paper
• On resin click-chemistry-mediated synthesis of novel enkephalin analogues with potent anti-nociceptive activity

  2019cites this paper
• N-Guanidyl and C-Tetrazole Leu-Enkephalin Derivatives: Efficient Mu and Delta Opioid Receptor Agonists with Improved Pharmacological Properties.

  2019cites this paper
• Cyclic Opioid Peptides.

  2016cites this paper