Opposite effects of GCN5 and PCAF knockdowns on the alternative mechanism of telomere maintenance

Cancer cells can use a telomerase-independent mechanism, known as alternative lengthening of telomeres (ALT), to elongate their telomeres. General control non-derepressible 5 (GCN5) and P300/CBP-associated factor (PCAF) are two homologous acetyltransferases that are mutually exclusive subunits in SAGA-like complexes. Here, we reveal that down regulation of GCN5 and PCAF had differential effects on some phenotypic characteristics of ALT cells. Our results suggest that GCN5 is present at telomeres and opposes telomere recombination, in contrast to PCAF that may indirectly favour them in ALT cells.

• Publication year

  2017

• Venue

  OncoTarget

• Publication date

  2017-02-17

• Fields of study

  Biology, Medicine, Philosophy

• Identifiers
  DOI 10.18632/oncotarget.15447PMID 28412741PMCID 5432255
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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