Optimizing tamoxifen-inducible Cre/loxp system to reduce tamoxifen effect on bone turnover in long bones of young mice.

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Bone

• Publication date

  2015-12-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/j.bone.2015.07.034PMID 26232373PMCID PMC4640982
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Estrogen Modulates Bone Morphogenetic Protein-Induced Sclerostin Expression Through the Wnt Signaling Pathway

  2015cited by this paper
• Strategies to achieve conditional gene mutation in mice.

  2014cited by this paper
• Reproducibility of Results in Preclinical Studies: A Perspective From the Bone Field

  2014cited by this paper
• Effect of sequential treatments with alendronate, parathyroid hormone (1-34) and raloxifene on cortical bone mass and strength in ovariectomized rats.

  2014cited by this paper
• The role of estrogen and androgen receptors in bone health and disease

  2013cited by this paper
• Maternal and offspring pools of osteocalcin influence brain development and functions.

  2013cited by this paper
• Estrogen Receptor α Mediates Proliferation of Osteoblastic Cells Stimulated by Estrogen and Mechanical Strain, but Their Acute Down-regulation of the Wnt Antagonist Sost Is Mediated by Estrogen Receptor β*

  2013cited by this paper
• Mouse and human lung fibroblasts regulate dendritic cell trafficking, airway inflammation, and fibrosis through integrin αvβ8-mediated activation of TGF-β.

  2011cited by this paper
• The development of an inducible androgen receptor knockout model in mouse to study the post-meiotic effects of androgens on germ cell development

  2011cited by this paper
• Inhibition of the Progesterone Nuclear Receptor during the Bone Linear Growth Phase Increases Peak Bone Mass in Female Mice

  2010cited by this paper
• Inducible Cre mice.

  2009cited by this paper
• A global double‐fluorescent Cre reporter mouse

  2007cited by this paper
• Increased bone mass in male and female mice following tamoxifen administration

  2007cited by this paper
• Raloxifene enhances vertebral mechanical properties independent of bone density.

  2006cited by this paper
• Tamoxifen stimulates cancellous bone formation in long bones of female mice.

  2005cited by this paper
• Transgenic mice expressing a ligand-inducible cre recombinase in osteoblasts and odontoblasts: a new tool to examine physiology and disease of postnatal bone and tooth.

  2004cited by this paper
• Tamoxifen-inducible glia-specific Cre mice for somatic mutagenesis in oligodendrocytes and Schwann cells.

  2003cited by this paper
• Use of Type I Collagen Green Fluorescent Protein Transgenes to Identify Subpopulations of Cells at Different Stages of the Osteoblast Lineage

  2002cited by this paper
• Efficient recombination in diverse tissues by a tamoxifen-inducible form of Cre: a tool for temporally regulated gene activation/inactivation in the mouse.

  2002cited by this paper
• Reduction of vertebral fracture risk in postmenopausal women with osteoporosis treated with raloxifene: results from a 3-year randomized clinical trial. Multiple Outcomes of Raloxifene Evaluation (MORE) Investigators.

  1999cited by this paper
• Temporally and spatially regulated somatic mutagenesis in mice.

  1998cited by this paper
• The short term effects of tamoxifen on bone turnover in older women.

  1995cited by this paper
• Conditional site-specific recombination in mammalian cells using a ligand-dependent chimeric Cre recombinase.

  1995cited by this paper
• Tamoxifen reduces bone turnover and prevents lumbar spine and proximal femoral bone loss in early postmenopausal women.

  1993cited by this paper

• Multifunctional LepR⁺ skeletal stem/progenitor cells for bone and marrow homeostasis.

  2026cites this paper
• Decoding tamoxifen on idiopathic pulmonary fibrosis: integrating network toxicology and multi-omics.

  2025cites this paper
• Modulation of Heat Shock Proteins Levels in Health and Disease: An Integrated Perspective in Diagnostics and Therapy

  2025cites this paper
• Effects of tamoxifen on fetal cartilage development, adult cartilage metabolism and endochondral ossification in mice.

  2025cites this paper
• Cellular senescence by loss of Men1 in osteoblasts is critical for age‐related osteoporosis

  2024cites this paper
• Expression of nicastrin, NICD1, and Hes1 in NCSTN knockout mice: implications for hidradenitis suppurativa, Alzheimer’s, and liver cancer

  2024cites this paper
• Genetic targeting of lymphatic endothelial cells in mice: current strategies and future perspectives.

  2024cites this paper
• A review of tamoxifen administration regimen optimization for Cre/loxp system in mouse bone study.

  2023cites this paper
• Warning regarding hematological toxicity of tamoxifen activated CreERT2 in young Rosa26CreERT2 mice

  2023cites this paper
• Perspective: The current state of Cre driver mouse lines in skeletal research: Challenges and opportunities.

  2023cites this paper
• Depletion of microglial BDNF increases susceptibility to the behavioral and synaptic effects of chronic unpredictable stress.

  2023cites this paper
• Short-term tamoxifen administration improves hepatic steatosis and glucose intolerance through JNK/MAPK in mice

  2023cites this paper
• Treatment with PB125^® Increases Femoral Long Bone Strength in 15-Month-Old Female Hartley Guinea Pigs

  2023cites this paper
• Clonal tracking in cancer and metastasis

  2023cites this paper
• Loss of PKCδ/Prkcd prevents cartilage degeneration in joints but exacerbates hyperalgesia in an experimental osteoarthritis mouse model.

  2023cites this paper
• The Utility of Preclinical Models in Understanding the Bone Health of Transgender Individuals Undergoing Gender-Affirming Hormone Therapy

  2023cites this paper
• Postnatal Tamoxifen Exposure Induces Long-Lasting Changes to Adipose Tissue in Adult Mice

  2023cites this paper
• Osteocyte RANKL Drives Bone Resorption in Mouse Ligature‐Induced Periodontitis

  2023cites this paper
• Loading-Induced Bone Formation is Mediated by Wnt1 Induction in Osteoblast-Lineage Cells

  2022cites this paper
• Induced inactivation of Wnt16 in young adult mice has no impact on osteoarthritis development

  2022influential citation
• Genetic complementation screening and molecular docking give new insight on phosphorylation-dependent Mastl kinase activation

  2022cites this paper
• Sensory Neuron-Specific Deletion of Tropomyosin Receptor Kinase A (TrkA) in Mice Abolishes Osteoarthritis (OA) Pain via NGF/TrkA Intervention of Peripheral Sensitization

  2022cites this paper
• Ablation of Discoidin Domain Receptor 1 Provokes an Osteopenic Phenotype by Regulating Osteoblast/Osteocyte Autophagy and Apoptosis

  2022cites this paper
• Inactivation of AR or ERα in extrahypothalamic neurons does not affect osteogenic response to loading in male mice.

  2022cites this paper
• Effects of tamoxifen alone and in combination with risperidone on hyperlocomotion, hippocampal structure and bone in ketamine-induced model of psychosis in rats

  2022cites this paper
• Deficiency of Mineralization-Regulating Transcription Factor Trps1 Compromises Quality of Dental Tissues and Increases Susceptibility to Dental Caries

  2022cites this paper
• Tamoxifen administration alters gastrointestinal motility in mice

  2022cites this paper
• Wnt5a plays a critical role in anal opening in mice at an early stage of embryonic development

  2022cites this paper
• Critical Role of Estrogens on Bone Homeostasis in Both Male and Female: From Physiology to Medical Implications

  2021cites this paper
• Critical Role of Estrogens on Bone Homeostasis in Both Male and Female: From Physiology to Medical Implications.

  2021cites this paper
• Activation of creER recombinase in the mouse calvaria induces local recombination without effects on distant skeletal segments

  2021cites this paper
• Sites of Cre‐recombinase activity in mouse lines targeting skeletal cells

  2021cites this paper
• Mitochondrial dysfunction in adult midbrain dopamine neurons triggers an early immune response

  2021cites this paper
• The use of mice in diabetes research: The impact of physiological characteristics, choice of model and husbandry practices

  2021cites this paper
• Low‐Dose Tamoxifen Induces Significant Bone Formation in Mice

  2020influential citation
• Contributions of Dickkopf‐1 to Obesity‐Induced Bone Loss and Marrow Adiposity

  2020cites this paper
• Generating Beta-Cell-Specific Transgenic Mice Using the Cre-Lox System.

  2020cites this paper
• Animal Models of Diabetes: Methods and Protocols

  2020cites this paper
• Localization of Gli1+ Expressing Cells in Adult Mouse Molars

  2020influential citation
• Methods in lineage tracing

  2020cites this paper
• Preactivation of β‐catenin in osteoblasts improves the osteoanabolic effect of PTH in type 1 diabetic mice

  2020cites this paper
• Investigating the determinants of mammalian Mastl kinase activation

  2020cites this paper
• Optimization of tamoxifen-induced Cre activity and its effect on immune cell populations

  2020cites this paper
• Even a Low Dose of Tamoxifen Profoundly Induces Adipose Tissue Browning in Female Mice

  2019influential citation
• Inhibition of mesenchymal stromal cells' chemotactic effect to ameliorate paraquat-induced pulmonary fibrosis.

  2019cites this paper
• Chronic pancreatitis fibrogenesis : the role of TGFB pathway inhibitor Smad7 in the fibrosis development

  2019cites this paper
• Expression of a Degradation‐Resistant β‐Catenin Mutant in Osteocytes Protects the Skeleton From Mechanodeprivation‐Induced Bone Wasting

  2019cites this paper
• Analysis of Cre-mediated genetic deletion of Gdf11 in cardiomyocytes of young mice.

  2019cites this paper
• Reduced postnatal expression of cochlear Connexin26 induces hearing loss and affects the developmental status of pillar cells in a dose-dependent manner.

  2019cites this paper
• Advanced glycation end products as biomarkers in systemic diseases: premises and perspectives of salivary advanced glycation end products.

  2019cites this paper
• The use of selective estrogen receptor modulators on bone health in men

  2019influential citation
• Different effects of Wnt/β‐catenin activation and parathyroid hormone on diaphyseal and metaphyseal in the early phase of femur bone healing of mice

  2019cites this paper
• The Role of Wnt Signaling in Bone Mechanotransduction

  2019cites this paper
• Selective inhibition of progesterone receptor in osteochondral progenitor cells, but not in mature chondrocytes, modulated subchondral bone structures.

  2019cites this paper
• Conditional disruption of the osterix gene in chondrocytes during early postnatal growth impairs secondary ossification in the mouse tibial epiphysis

  2019cites this paper
• Tamoxifen affects chronic pancreatitis‐related fibrogenesis in an experimental mouse model: an effect beyond Cre recombination

  2019cites this paper
• Differential effects of type 1 diabetes mellitus and subsequent osteoblastic β-catenin activation on trabecular and cortical bone in a mouse model

  2018cites this paper
• Cell Lineage Tracing of Osteoblasts Within the Periodontal Ligament During Orthodontic Tooth Movement

  2018cites this paper
• Androgen receptor signaling mechanisms in bone

  2018cites this paper
• Investigating the role of CCN2 in a bleomycin model of Idiopathic Pulmonary Fibrosis

  2018cites this paper
• Transgenic Mouse Models in Cancer Research

  2018cites this paper
• Defective autophagy in osteoblasts induces endoplasmic reticulum stress and causes remarkable bone loss

  2018cites this paper
• Inducible Wnt16 inactivation: WNT16 regulates cortical bone thickness in adult mice

  2018cites this paper
• Establishing a Model to Label and Stimulate Cells Active During Motor Behaviour

  2018cites this paper
• Conditional genetic deletion of Ano1 in interstitial cells of Cajal impairs Ca2+ transients and slow waves in adult mouse small intestine.

  2017cites this paper
• A shortened tamoxifen induction scheme to induce CreER recombinase without side effects on the male mouse skeleton.

  2017cites this paper
• Acceleration of Fracture Healing by Overexpression of Basic Fibroblast Growth Factor in the Mesenchymal Stromal Cells

  2017cites this paper