Target engagement and histopathology of neuraxial resiniferatoxin in dog.

No abstract is available for this paper.

• Publication year

  2017

• Venue

  Veterinary Anaesthesia and Analgesia

• Publication date

  2017-12-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.vaa.2017.10.005PMID 29361418
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Safety Evaluation of CNS Administered Biologics-Study Design, Data Interpretation, and Translation to the Clinic.

  2016cited by this paper
• Intrathecal resiniferatoxin in a dog model: efficacy in bone cancer pain

  2015cited by this paper
• Complement activation associated with polysorbate 80 in beagle dogs.

  2013cited by this paper
• Hypersensitivity reaction to human papillomavirus vaccine due to polysorbate 80

  2012cited by this paper
• Evaluation of the Adult Nervous System in Preclinical Studies

  2011cited by this paper
• The vanilloid agonist resiniferatoxin for interventional-based pain control.

  2011influential reference
• [Anaphylactoid reactions induced by polysorbate 80 on Beagle dogs].

  2011cited by this paper
• Development of a canine nociceptive thermal escape model.

  2008cited by this paper
• Intrathecal delivery of resiniferatoxin (RTX) reduces detrusor overactivity and spinal expression of TRPV1 in spinal cord injured animals.

  2008cited by this paper
• Physiologic and Antinociceptive Effects of Intrathecal Resiniferatoxin in a Canine Bone Cancer Model

  2005cited by this paper
• Inhibition by spinal mu- and delta-opioid agonists of afferent-evoked substance P release.

  2005cited by this paper
• Inhibition by Spinal μ- and δ-Opioid Agonists of Afferent-Evoked Substance P Release

  2005cited by this paper
• Deletion of vanilloid receptor 1-expressing primary afferent neurons for pain control.

  2004cited by this paper
• The capsaicin receptor: a heat-activated ion channel in the pain pathway

  1997cited by this paper
• Antinociception produced by capsaicin: spinal or peripheral mechanism?

  1990cited by this paper
• Resiniferatoxin and its analogs provide novel insights into the pharmacology of the vanilloid (capsaicin) receptor.

  1990cited by this paper
• A spinal mechanism of action is involved in the antinociception produced by the capsaicin analogue NE 19550 (olvanil)

  1990cited by this paper
• Opioid modulation of capsaicin-evoked release of substance P from rat spinal cord in vivo.

  1989cited by this paper
• Micturition in the unanesthetized rat: effects of intrathecal capsaicin, N-vanillylnonanamide, 6-hydroxydopamine and 5,6-dihydroxytryptamine.

  1988cited by this paper
• Release of substance P from the cat spinal cord.

  1987cited by this paper
• Calcitonin gene-related peptide (CGRP) in capsaicin-sensitive substance P-immunoreactive sensory neurons in animals and man: distribution and release by capsaicin.

  1987cited by this paper
• Action of intrathecal capsaicin and its structural analogues on the content and release of spinal substance P: selectivity of action and relationship to analgesia.

  1984influential reference
• Pulmonary and respiratory tract receptors.

  1982cited by this paper
• Effect of capsaicin pretreatment on capsaicin-evoked release of immunoreactive somatostatin and substance P from primary sensory neurons

  1981cited by this paper
• In vitro release of substance P from spinal cord slices by capsaicin congeners.

  1981cited by this paper
• Identification by high-performance liquid chromatography of immunoreactive substance P released from isolated rat spinal cord.

  1980cited by this paper
• Intrathecal morphine inhibits substance P release from mammalian spinal cord in vivo

  1980cited by this paper
• Capsaicin-evoked release of substance P from primary sensory neurons.

  1979cited by this paper
• Intrathecal capsaicin depletes substance P in the rat spinal cord and produces prolonged thermal analgesia.

  1979influential reference
• Stimulation and desensitization of the hypothalamic heat‐sensitive structures by capsaicin in rats

  1970cited by this paper

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  2023cites this paper
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  2023influential citation
• Pain Treatment in the Companion Canine Model to Validate Rodent Results and Incentivize the Transition to Human Clinical Trials

  2021influential citation
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  2021cites this paper
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  2020cites this paper
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  2018cites this paper
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  2018cites this paper