Inhibition of DNA Polymerase by β-D-Arabinosylcytosine and Reversal of Inhibition by Deoxycytidine-5′-triphosphate∗

No abstract is available for this paper.

• Publication year

  1968

• Venue

  Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine

• Publication date

  1968-02-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.3181/00379727-127-32708PMID 5689918
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Formation of Inosine-5′-Monophosphate by a Kinase in Cell-Free Extracts of Ehrlich Ascites Cells in Vitro∗

  1968cited by this paper
• Further studies on the metabolic effects of 9-beta-D-arabinofuranosyl-9-H-purine-6-thiol.

  1967cited by this paper
• Inhibitory effects of the arabinosides of 6-mercaptopurine and cytosine on purine and pyrimidine metabolism.

  1966cited by this paper
• Regulation of mammalian deoxyribonucleotide biosynthesis by nucleotides as activators and inhibitors.

  1966cited by this paper
• Enzymatic synthesis of deoxyribonucleotides. X. Reduction of purine ribonucleotides; allosteric behavior and substrate specificity of the enzyme system from Escherichia coli B.

  1966cited by this paper
• A proposed mechanism for the action of 9-beta-D-arabinofuranosyladenine as an inhibitor of the growth of some ascites cells.

  1966cited by this paper
• THE REVERSAL OF CYTOSINE ARABINOSIDE ACTIVITY IN VIVO BY DEOXYCYTIDINE.

  1964cited by this paper
• A proposed mechanism of action of 1-beta-D-arabinofuranosyl-cytosine as an inhibitor of the growth of leukemic cells.

  1962cited by this paper
• Protein measurement with the Folin phenol reagent.

  1951cited by this paper

• (±)-2-Cyclohexyl-5-methoxy-2H-chromene, a Synthetic 5‑Methoxyflavone Derivative, Is a Selective DNA Polymerase‑β Inhibitor with Neuroprotective Activity against β‑Amyloid Toxicity

  2025cites this paper
• Marine-Derived Anticancer Agents Targeting Apoptotic Pathways: Exploring the Depths for Novel Cancer Therapies

  2024cites this paper
• Effects of Chemotherapy on Fertility Preservation in Patients with Tumors of the Hematopoietic and Lymphoid Tissues

  2022cites this paper
• Phase I and Pharmacologic Trial of Cytosine Arabinoside with the Selective Checkpoint 1 Inhibitor Sch 900776 in Refractory Acute Leukemias

  2012cites this paper
• Differential Sensitivities of Human Melanoma Cells Grown in Vitro to Arabinosylcytosine l

  2006cites this paper
• Enzymatic Phosphorylation of 1-ß-D-Arabinofuranosylcy tosine1

  2006cites this paper
• Potentiation of Cytotoxicity of l-/?-D-Arabinofuranosylcytosine for K562 Human Leukemic Cells by Cadeguomycin1

  2006cites this paper
• The Effect of 1-@-D-Arabinofuranosylcytosine on the Immune Response of Mice to Sheep Red Blood Cells1

  2006cites this paper
• Direct Relationship of Marrow Cell Growth and 1-/?-D-Arabinofuranosy Icytosine Metabolism1

  2006cites this paper
• Metabolism of pyrimidine analogues and their nucleosides.

  1990cites this paper
• Potentiation of cytotoxicity of 1-beta-D-arabinofuranosylcytosine for K562 human leukemic cells by cadeguomycin.

  1987cites this paper
• Direct relationship of marrow cell growth and 1-beta-D-arabinofuranosylcytosine metabolism.

  1984cites this paper
• Effect of Cytosine Arabinoside Ointment on Herpes Zoster

  1984cites this paper
• Prediction of response of acute nonlymphocytic leukaemia to therapy with ‘high dose’ cytosine arabinoside

  1984cites this paper
• A neurochemical study of developmental impairment of the brain caused by the administration of cytosine arabinoside during the fetal or neonatal period of rats

  1983cites this paper
• Synergistic and antagonistic interactions of methotrexate and 1-beta-D-arabinofuranosylcytosine in hepatoma cells. The modulating effect of purines.

  1981cites this paper
• Elevated Monoamine Levels in the Cerebral Hemispheres of Microencephlic Rats Treated Prenatally with Methylazoxymethanol or Cytosine Arabinoside

  1980cites this paper
• Antiviral agents as adjuncts in cancer chemotherapy.

  1980cites this paper
• Deoxycytidine kinase and cytosine nucleoside deaminase activities in synchronized cultures of normal rat kidney cells.

  1978cites this paper
• Inhibitors of bacterial DNA polymerases

  1977cites this paper
• [Protection of the mouse digestive tract from the toxic effect of cytosine-arabinoside].

  1977cites this paper
• Cytosine arabinoside-induce transplacental dysgenetic hydrocephalus in mice.

  1977cites this paper
• Kinetics of inhibition of deoxynucleotide-polymerizing enzyme activities from normal and leukemic human cells by 9-beta-D-arabinofuranosyladenine 5'-triphosphate and 1-beta-D-arabinofuranosylcytosine 5'-triphosphate.

  1977cites this paper
• The Specific Treatment of Virus Diseases

  1977cites this paper
• The mechanism of action of inhibitors of DNA synthesis.

  1977cites this paper
• Effects of 2'-deoxycoformycin, 9-beta-D-arabinofuranosyladenine 5'-phosphate, and 1-beta-D-arabinofuranosylcytosine triple combination therapy on intracerebral leukemia 1210.

  1977cites this paper
• Effects of 5-fluorodeoxyuridine on cell viability and uptake of deoxycytidine and (3H)cytosine arabinoside in L5178Y cells.

  1976cites this paper
• Flow microfluorimetric analysis of sensitive and resistant leukemia L1210 following 1-beta-D-arabinofuranosylcytosine in vivo.

  1976cites this paper
• On the mechanism of erythropoietin-induced differentiation. XV. Induced transcription restricted by cytosine arabinoside.

  1976cites this paper
• The lethality of aranucleotides.

  1976cites this paper
• Clinical Pharmacology of Arabinosylcytosine

  1975cites this paper
• Drug Interactions in Cancer Chemotherapy

  1975cites this paper
• Developmental abnormality of the retina caused by postnatal administration of cytosine arabinoside.

  1975cites this paper
• Cytarabine and its effect on cerebellum of suckling mouse.

  1975cites this paper
• BIOCHEMICAL AND PHARMACOLOGICAL PRINCIPLES OF COMBINATION CHEMOTHERAPY

  1975cites this paper
• In vivo chain elongation of hepatic DNA: 1-beta-D-arabinofuranosyl cytosine sensitive steps.

  1975cites this paper
• Biochemical aspects of drug combinations.

  1974cites this paper
• Schedule-dependent synergism for the combination of 1-beta-D-arabinofuranosylcytosine and daunorubicin.

  1974cites this paper
• Mechanisms of Resistance

  1974cites this paper
• Effect of ara-CTP on DNA replication and repair in isolated hepatocyte nuclei.

  1974cites this paper
• Studies of the mechanism of induction of infectious murine leukemia virus from AKR mouse embryo cell lines by 5-iododeoxyuridine and 5-bromodeoxyuridine.

  1973cites this paper
• Mathematical simulation of the interaction of drugs that inhibit deoxyribonucleic acid biosynthesis.

  1973cites this paper
• The Gross and Biochemical Effects of 1-β-D-Arabinofuranosyl Cytosine on an Actinobolin-Resistant Strain of Streptococcus faecalis 1

  1973cites this paper
• Schedule dependence of the lethal effects of 6-azauridine and cytosine arabinoside on murine leukemia cels (L5178Y) in culture.

  1973cites this paper
• Enhanced antitumor effect of cytosine arabinoside given in a schedule dictated by kinetic studies in vivo.

  1973cites this paper
• Enhancement of the antiproliferative action of 1- -D-arabinofuranosylcytosine by methotrexate in murine leukemic cells (L5178Y).

  1973cites this paper
• 9 – The Effects of Antitumor Drugs on the Cell Cycle

  1973cites this paper
• Somatic Crossing over in GLYCINE MAX (L.) Merrill: Effect of Some Inhibitors of DNA Synthesis on the Induction of Somatic Crossing over and Point Mutations.

  1973cites this paper
• Phenotypic expression of drug resistance in hybrid cells.

  1973cites this paper
• Depression of thymidylate synthetase activity in response to cytosine arabinoside.

  1972cites this paper
• Cancer chemotherapy. I.

  1972cites this paper
• Mechanism of l-^-D-Arabinofuranosylcytosine-induced Cell Lethalityl

  1972cites this paper
• Interaction of drugs inhibiting different steps in the synthesis of DNA.

  1972cites this paper
• The effects of arabinosylcytosine on cultured human lymphoma cells.

  1972cites this paper
• Chromatid Breakage: Differential Effect of Inhibitors of DNA Synthesis during G2 Phase

  1972cites this paper
• Differential sensitivites of human melanoma cells grown in vitro to arabinosylcytosine.

  1972cites this paper
• Antineoplastic drug effects on spermatogenesis studied by velocity sedimentation cell separation.

  1972cites this paper
• Prediction of the response of patients with acute nonlymphocytic leukemia to cytosine arabinoside (NSC-63878) therapy.

  1972cites this paper
• Combinations of drugs which interact as inhibitors of DNA biosynthesis.

  1972cites this paper
• Mechanism of 1- -D-arabinofuranosylcytosine-induced cell lethality.

  1972cites this paper
• Streckungshemmung durch FUDR bei den Hypokotylen von Sinapis alba

  1971cites this paper
• Enzymatic phosphorylation of 1-beta-D-arabinofuranosylcytosine.

  1971cites this paper
• Chromatid Breakage: Cytosine Arabinoside-Induced Lesions Inhibited by Ultraviolet Irradiation

  1971cites this paper
• Metabolic effets of nucleosides in rat thymus cells in vitro

  1971cites this paper
• Inhibition of DNA synthesis but not of poly-dAT synthesis by the arabinose analogue of cytidine in vitro.

  1971cites this paper
• Hematological toxicity of 1-beta-D-arabinofuranosylcytosine, and its prevention by deoxycytidine, in the mouse.

  1971cites this paper
• Enzymatic Phosphorylation of 1-β-d-Arabinofuranosylcytosine

  1971cites this paper
• The Effect of 1-β-d-Arabinofuranosylcytosine on Growth, Viability, and DNA Synthesis of Mouse L-cells

  1970cites this paper
• Comparison of cytotoxicity and antiviral activity of 1-beta-D-arabino-furanosyl-5-iodocytosine with related compounds.

  1970cites this paper
• Kinetics of 1-beta-D-arabinofuranosylcytosine-induced chromosome breaks.

  1970cites this paper
• 3 Some Pyrimidines of Biological and Medicinal Interest—Part III

  1970cites this paper
• The effect of-beta-D-arabinofuranosylcytosine on growth, viability, and DNA synthesis of mouse L-cells.

  1970cites this paper
• Biochemical and genetic studies of a mutant strain of mouse leukemia L1210 resistant to 1-beta-D-arabinofuranosylcytosine (Cytarabine).

  1969cites this paper
• Biochemie der Regeneration

  1969cites this paper
• Deoxycytidine kinase. I. Distribution in normal and neoplastic tissues and interrelationships of deoxycytidine and 1-beta-D-arabinofuranosylcytosine phosphorylation.

  1969cites this paper
• Some approaches to the therapeutic exploitation of metabolic sites of vulnerability of neoplastic cells.

  1969cites this paper
• Cytosine arabinoside (NSC-63878) given subcutaneously to patients with cancer.

  1969cites this paper
• Studies on the mechanism of action of 1-beta-D-arabinofuranosylcytosine as an inhibitor of DNA synthesis in human leukemic leukocytes.

  1969cites this paper
• Cancer chemotherapy.

  1969cites this paper
• Cytotoxic effects of 1-beta-D-arabinofuranosyl-5-fluorocytosine and of 1-beta-D-arabinofuranosylcytosine in proliferating tissues in mice.

  1969cites this paper
• The effect of 1-beta-D-arabinofuranosylcytosine on the immune response of mice to sheep red blood cells.

  1968cites this paper
• Inhibition of mammalian DNA polymerase by the 5'-triphosphate of 1-beta-d-arabinofuranosylcytosine and the 5'-triphosphate of 9-beta-d-arabinofuranoxyladenine.

  1968cites this paper