Conventional protein kinase C isoforms and cross‐activation of protein kinase A regulate cardiac Na+ current

We tested the hypothesis that specific isoforms of protein kinase C (PKC) are responsible for modulation of Na+ current (I Na) derived from the human cardiac Na+ channel using activators and inhibitors selective for specific PKCs. Experimental results demonstrated that I Na suppression was mediated by activation of conventional PKCs (cPKCs) and possibly resulted from channel internalization. In the presence of cPKC inhibition, phorbol ester application unexpectedly increased Na+ current, an effect eliminated by inhibition of protein kinase A. These findings demonstrate complex modulation of cardiac I Na by protein kinases and provide further evidence that PKC isoforms have distinct protein targets.

• Publication year

  2001

• Venue

  FEBS Letters

• Publication date

  2001-04-27

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/S0014-5793(01)02380-8PMID 11334883
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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