Calmodulin antagonist W-7 inhibits de novo synthesis of cholesterol and suppresses secretion of de novo synthesized and preformed lipids from cultured hepatocytes.

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Biochimica et Biophysica Acta

• Publication date

  2004-06-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/J.BBALIP.2004.02.002PMID 15158760
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Complexity in the Secretory Pathway: The Assembly and Secretion of Apolipoprotein B-containing Lipoproteins*

  2002cited by this paper
• An Unexpected Requirement for PhosphatidylethanolamineN-Methyltransferase in the Secretion of Very Low Density Lipoproteins*

  2002cited by this paper
• Mobilisation of triacylglycerol stores.

  2000cited by this paper
• Cloning and expression of a cDNA encoding a hepatic microsomal lipase that mobilizes stored triacylglycerol.

  1999cited by this paper
• Activation of caspase-3-like proteases in apoptosis induced by sphingosine and other long-chain bases in Hep3B hepatoma cells.

  1999cited by this paper
• Manipulation of cholesterol and cholesteryl ester synthesis has multiple effects on the metabolism of apolipoprotein B and the secretion of very-low-density lipoprotein by primary hepatocyte cultures.

  1999cited by this paper
• Use of cytosolic triacylglycerol hydrolysis products and of exogenous fatty acid for the synthesis of triacylglycerol secreted by cultured rat hepatocytes.

  1998cited by this paper
• Transport of cholesterol from the endoplasmic reticulum to the plasma membrane is constitutive in CaCo-2 cells and differs from the transport of plasma membrane cholesterol to the endoplasmic reticulum.

  1998cited by this paper
• Phosphatidylcholine biosynthesis is required for secretion of truncated apolipoprotein Bs from McArdle RH7777 cells only when a neutral lipid core is formed.

  1997cited by this paper
• A Two-site Model for ApoB Degradation in HepG2 Cells*

  1997cited by this paper
• Intracellular degradation of newly synthesized apolipoprotein B.

  1997cited by this paper
• Role of cholesterol in regulating apolipoprotein B secretion by the liver.

  1996cited by this paper
• Inhibition of acyl-CoA: cholesterol acyltransferase decreases apolipoprotein B-100-containing lipoprotein secretion from HepG2 cells.

  1996cited by this paper
• Contribution of de novo fatty acid synthesis to very low density lipoprotein triacylglycerols: evidence from mass isotopomer distribution analysis of fatty acids synthesized from [2H6]ethanol.

  1996cited by this paper
• Effect of chlorpromazine on the synthesis of neutral lipids and phospholipids from [3H]glycerol in the primordial human placenta.

  1995cited by this paper
• Triacylglycerol-rich lipoprotein cholesterol is derived from the plasma membrane in CaCo-2 cells.

  1995cited by this paper
• Esterification of plasma membrane cholesterol and triacylglycerol-rich lipoprotein secretion in CaCo-2 cells: possible role of p-glycoprotein.

  1995cited by this paper
• Evidence for a lack of regulation of the assembly and secretion of apolipoprotein B-containing lipoprotein from HepG2 cells by cholesteryl ester.

  1994cited by this paper
• Synthesis and secretion of hepatic apolipoprotein B-containing lipoproteins.

  1994cited by this paper
• Influence of triacylglycerol biosynthesis rate on the assembly of apoB-100-containing lipoproteins in Hep G2 cells.

  1993cited by this paper
• Impaired biosynthesis of phosphatidylcholine causes a decrease in the number of very low density lipoprotein particles in the Golgi but not in the endoplasmic reticulum of rat liver.

  1993cited by this paper
• Prostaglandins suppress VLDL secretion in primary rat hepatocyte cultures: relationships to hepatic calcium metabolism.

  1992cited by this paper
• The lipolysis/esterification cycle of hepatic triacylglycerol. Its role in the secretion of very-low-density lipoprotein and its response to hormones and sulphonylureas.

  1992cited by this paper
• Calmodulin antagonists chlorpromazine and W‐7 inhibit exogenous cholesterol esterification and sphingomyelinase activity in human skin fibroblast cultures. Similarities between drug‐induced and niemann‐pick type C lipidoses

  1992cited by this paper
• Regulation of hepatic secretion of very low density lipoprotein by dietary cholesterol.

  1992cited by this paper
• Perturbation of cellular calcium blocks exit of secretory proteins from the rough endoplasmic reticulum.

  1990cited by this paper
• Regulation of apoB secretion from HepG2 cells: evidence for a critical role for cholesteryl ester synthesis in the response to a fatty acid challenge.

  1990cited by this paper
• Apolipoprotein B is both integrated into and translocated across the endoplasmic reticulum membrane. Evidence for two functionally distinct pools.

  1990cited by this paper
• Effect of trifluoperazine on cholesterol metabolism of smooth muscle cells exposed to hypercholesterolemic medium in vitro.

  1990cited by this paper
• Cholesterol is required for secretion of very-low-density lipoprotein by rat liver.

  1989cited by this paper
• Contribution of cytoplasmic storage triacylglycerol to VLDL-triacylglycerol in isolated rat hepatocytes.

  1989cited by this paper
• The active synthesis of phosphatidylcholine is required for very low density lipoprotein secretion from rat hepatocytes.

  1988cited by this paper
• Calcium/calmodulin-mediated action of calcitonin on lipid metabolism in rats.

  1988cited by this paper
• Trifluoperazine increases fatty acid turnover in phospholipids in cultured human fibroblasts

  1988cited by this paper
• Calmodulin antagonists suppress cholesterol synthesis by inhibiting sterol delta 24 reductase.

  1987cited by this paper
• Calmodulin antagonists suppress cholesterol synthesis by inhibiting sterol Δ24 reductasereductase

  1987cited by this paper
• Suppression of triglyceride secretion by epinephrine in isolated rat hepatocytes.

  1986cited by this paper
• Regulation of the translocation of phosphatidate phosphohydrolase between the cytosol and the endoplasmic reticulum of rat liver. Effects of unsaturated fatty acids, spermine, nucleotides, albumin and chlorpromazine.

  1985cited by this paper
• Trifluoperazine and chlorpromazine inhibit phosphatidylcholine biosynthesis and CTP:phosphocholine cytidylyltransferase in HeLa cells.

  1984cited by this paper
• Pharmacological antagonism of calmodulin.

  1983cited by this paper
• Effects of phenothiazines on low density lipoprotein metabolism in cultured human fibroblasts

  1983cited by this paper
• Mechanism of adrenergic stimulation of hepatic ketogenesis.

  1983cited by this paper
• Effect of prostaglandins and hormones on cyclic AMP formation in rat hepatomas and liver tissue.

  1978cited by this paper
• Studies of cAMP metabolism in cultured hepatoma cells: Presence of functional adenylate cyclase despite low camp content and lack of hormonal responsiveness

  1978cited by this paper
• Effects of dibutyryl adenosine 3',5'-monophosphate on hepatic metabolism of free fatty acids.

  1978cited by this paper
• Colchicine-induced inhibition of very low density lipoprotein release by rat liver in vivo.

  1973cited by this paper
• A simple method for the isolation and purification of total lipides from animal tissues.

  1957cited by this paper
• The FASEB Journal express article 10.1096/fj.02-0728fje. Published online July 18, 2003. Inhibitors of hepatic microsomal triacylglycerol hydrolase decrease very low density lipoprotein secretion

  year unknowncited by this paper

• Association between serum albumin to serum creatinine ratio and incident heart failure in patients with chronic kidney disease

  2025cites this paper
• Endothelial activation and stress index and cardiovascular disease among American population-findings from NHANES 1999–2018

  2025cites this paper
• Gastritis and peptic ulcers are associated with the lower levels of plasma lipids: possible involvement of histamine

  2024cites this paper
• Serum creatinine levels, traditional cardiovascular risk factors and 10-year cardiovascular risk in Chinese patients with hypertension

  2023cites this paper
• Association between serum albumin to serum creatinine ratio and mortality risk in patients with heart failure

  2023cites this paper
• Serum total carbohydrates, conjugated carbohydrates and total protein glycation index in diabetes mellitus

  2023cites this paper
• Histamine H1‐ and H2‐receptors participate to provide metabolic energy differently

  2022cites this paper
• Differential distribution of cholesterol pools across arteries under high-cholesterol diet.

  2022cites this paper
• The features of liver glycogen fractions in streptozotocin-induced type-I diabetic rats

  2022cites this paper
• Exploration of Blood Lipoprotein and Lipid Fraction Profiles in Healthy Subjects through Integrated Univariate, Multivariate, and Network Analysis Reveals Association of Lipase Activity and Cholesterol Esterification with Sex and Age

  2021cites this paper
• Fixed-time and continuous assays of very-low-density lipoprotein secretion rate from rat liver: mean vs. instantaneous velocity

  2021cites this paper
• Hypolipemic effects of histamine is due to inhibition of VLDL secretion from the liver: involvement of both H1 and H2-receptors

  2020cites this paper
• Serum Creatinine and Occurrence and Severity of Coronary Artery Disease

  2019cites this paper
• Esterification of HDL-cholesterol is Decreased in Diabetes Mellitus and CAD and Enhanced Following Treatment with Statins

  2018cites this paper
• Iron hypothesis and coronary artery disease in geriatric patients

  2018cites this paper
• The Ratio of Unesterified/esterified Cholesterol is the Major Determinant of Atherogenicity of Lipoprotein Fractions

  2018cites this paper
• Calculation of LDL‐Cholesterol vs. Direct Homogenous Assay

  2017cites this paper
• The Long Term Kinetic of Plasma Lipids and Lipoproteins in Tyloxapol Injected Rats.

  2016cites this paper
• Life Psychosocial Stresses and Coronary Artery Disease

  2016cites this paper
• Liver denervation increases the levels of serum triglyceride and cholesterol via increases in the rate of VLDL secretion.

  2012cites this paper
• Suppression of Cytochrome P450 Reductase (POR) Expression in Hepatoma Cells Replicates the Hepatic Lipidosis Observed in Hepatic POR-Null Mice

  2011cites this paper
• Calmodulin Antagonizes a Calcium-Activated SCF Ubiquitin E3 Ligase Subunit, FBXL2, To Regulate Surfactant Homeostasis

  2011cites this paper
• Cytotoxic effects of antipsychotic drugs implicate cholesterol homeostasis as a novel chemotherapeutic target

  2010cites this paper
• Calmodulin Binds and Stabilizes the Regulatory Enzyme, CTP:Phosphocholine Cytidylyltransferase*

  2007cites this paper
• Apolipoprotein B and triacylglycerol secretion in human triacylglycerol hydrolase transgenic mice Published, JLR Papers in Press, September 18, 2007.

  2007cites this paper
• Serum calcium and phosphorus associate with the occurrence and severity of angiographically documented coronary heart disease, possibly through correlation with atherogenic (apo)lipoproteins

  2006cites this paper