A new approach to the medical management of glaucoma, from the bench to the clinic, and beyond: the Proctor Lecture.

No abstract is available for this paper.

• Publication year

  2001

• Venue

  Investigative Ophthalmology and Visual Science

• Publication date

  2001-05-01

• Fields of study

  Medicine

• Identifiers
  PMID 11328718
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• From PGF(2alpha)-isopropyl ester to latanoprost: a review of the development of xalatan: the Proctor Lecture.

  2001cited by this paper
• Accommodation and presbyopia.

  2001cited by this paper
• Regulation of growth and melanogenesis of uveal melanocytes.

  2000cited by this paper
• Melanins, melanogenesis and melanocytes: looking at their functional significance from the chemist's viewpoint.

  2000cited by this paper
• Accommodation dynamics in aging rhesus monkeys.

  1998cited by this paper
• Prostaglandin-induced iris color darkening. An experimental model.

  1998cited by this paper
• Eye color changes past early childhood. The Louisville Twin Study.

  1997cited by this paper
• Pigment cell research: what directions?

  1997cited by this paper
• Textbook of ocular pharmacology

  1997cited by this paper
• Prostaglandins: a new approach to glaucoma management with a new, intriguing side effect.

  1997cited by this paper
• The incidence and time-course of latanoprost-induced iridial pigmentation as a function of eye color.

  1997cited by this paper
• Circadian intraocular pressure management with latanoprost: diurnal and nocturnal intraocular pressure reduction and increased uveoscleral outflow.

  1997cited by this paper
• The color of the human eye: a review of morphologic correlates and of some conditions that affect iridial pigmentation.

  1997cited by this paper
• Around-the-clock intraocular pressure reduction with once-daily application of latanoprost by itself or in combination with timolol.

  1996cited by this paper
• Impact of intraocular pressure on venous outflow from the globe: a hypothesis regarding IOP-dependent vascular damage in normal-tension and hypertensive glaucoma.

  1996cited by this paper
• Impact of intraocular pressure on venous outflow from the globe: a hypothesis regarding IOP-dependent vascular damage in normal-tension and hypertensive glaucoma.

  1996cited by this paper
• Oxidative stress‐induced cataract: mechanism of action

  1995cited by this paper
• Accommodation and presbyopia

  1995cited by this paper
• The Pigmentary System:an Expanded Perspective

  1994cited by this paper
• Decreasing stromal iris pigmentation as a risk factor for age-related macular degeneration.

  1994cited by this paper
• Glaucoma: A Physiologic Perspective with Darwinian Overtones

  1992cited by this paper
• Presence and rapid decline of early morning intraocular pressure peaks in glaucoma patients.

  1990cited by this paper
• The putative and demonstrated miotic effects of prostaglandins in mammals.

  1989cited by this paper
• A physiological approach to glaucoma management: the use of local hormones and the pharmacokinetics of prostaglandin esters.

  1989influential reference
• Functional morphology of accommodation in the raccoon.

  1989cited by this paper
• Presbyopia: An animal model and experimental approaches for the study of the mechanism of accommodation and ocular ageing

  1987cited by this paper
• Prostaglandins. Old concepts and new perspectives.

  1987cited by this paper
• Effects of timolol, epinephrine, and acetazolamide on aqueous flow during sleep.

  1985cited by this paper
• Noninvasive observations on eyes of cats after long-term maintenance of reduced intraocular pressure by topical application of prostaglandin E2.

  1983cited by this paper
• Long-term maintenance of reduced intraocular pressure by daily or twice daily topical application of prostaglandins to cat or rhesus monkey eyes.

  1983cited by this paper
• Species variations in the pathophysiologic responses of vertebrate eyes to a chemical irritant, nitrogen mustard.

  1983cited by this paper
• Paradoxical ocular hypertensive effect of pilocarpine on echothiophate iodide--treated primate eyes.

  1980influential reference
• Transport Functions of the Blood-Retinal Barrier System and the Micro-Environment of the Retina

  1980cited by this paper
• The pathophysiological effects of nitrogen mustard on the rabbit eye. I. The biphasic intraocular pressure response and the role of prostaglandins.

  1980cited by this paper
• The pathophysiological effects of nitrogen mustard on the rabbit eye. II. The inhibition of the initial hypertensive phase by capsaicin and the apparent role of substance P.

  1980cited by this paper
• Prostaglandins and thromboxanes.

  1978cited by this paper
• Transport of prostaglandins across the blood-brain and blood-aqueous barriers and the physiological significance of these absorptive transport processes.

  1977cited by this paper
• Intraocular inflammation produced by X-irradiation of the rabbit eye.

  1977cited by this paper
• Prostaglandins and Thromboxanes

  1977cited by this paper
• Prostaglandin and non-prostaglandin mediated breeakdown of the blood-aqueous barrier.

  1977cited by this paper
• Reduction of intraocular pressure by prostaglandins applied topically to the eyes of conscious rabbits.

  1977cited by this paper
• Recent observations concerning the effects of cholinergic drugs on outflow facility in monkeys.

  1977cited by this paper
• Inflammatory effects of endotoxin-like contaminants in commonly used protein preparations.

  1977cited by this paper
• Inhibition of renal prostaglandin metabolism and excretion by probenecid, bromcresol green and indomethacin.

  1976cited by this paper
• Inhibition of pulmonary prostaglandin metabolism by inhibitors of prostaglandin biotransport (probenecid and bromcresol green).

  1975cited by this paper
• Impermeability of rabbit erythrocytes to prostaglandins.

  1975influential reference
• Changes in eye colour during early childhood: sex and genetic differences.

  1975cited by this paper
• The effects of experimental uveitis on anterior uveal prostaglandin transport and aqueous humor composition.

  1974influential reference
• Inactivation of prostaglandin E, by ocular tissues in vitro.

  1974cited by this paper
• Absorptive transport of prostaglandins from intraocular fluids to blood: a review of recent findings.

  1973cited by this paper
• Intraocular fluid dynamics. 3. The site and mechanism of prostaglandin transfer across the blood intraocular fluid barriers.

  1972cited by this paper
• Release of prostaglandins in ocular inflammation in the rabbit.

  1972cited by this paper
• Accumulation and apparent active transport of prostaglandins by some rabbit tissues in vitro

  1972cited by this paper
• Increased intraocular pressure produced by prostaglandins E1 and E2 in the cat eye.

  1970cited by this paper
• The effects of prostaglandins on the intraocular pressure of the rabbit

  1969cited by this paper
• A simple chemical procedure for distinguishing E from F prostaglandins, with application to tissue extracts.

  1968cited by this paper
• Some differences in uveal reactions between cats and rabbits

  1966cited by this paper
• STEADY-STATE CONCENTRATIONS OF POTASSIUM IN THE OCULAR FLUIDS.

  1964cited by this paper
• SMOOTH MUSCLE STIMULATING LIPIDS IN SHEEP IRIS. THE IDENTIFICATION OF PROSTAGLANDIN F 2A. PROSTAGLANDINS AND RELATED FACTORS 21.

  1964cited by this paper
• OCULAR AND CEREBROSPINAL FLUIDS

  1957cited by this paper

• The role of prostanoids in regulatory T cells and their implications in inflammatory diseases and cancers.

  2025cites this paper
• A Narrative Review of Pharmacotherapy of Glaucoma

  2024cites this paper
• The role of primary needle revision after Ahmed glaucoma valve (AGV) implantation

  2020cites this paper
• Discovery to Launch of Anti-allergy (Emadine; Patanol/Pataday/Pazeo) and Anti-glaucoma (Travatan; Simbrinza) Ocular Drugs, and Generation of Novel Pharmacological Tools Such as AL-8810.

  2020cites this paper
• Discovery, characterization and clinical utility of prostaglandin agonists for the treatment of glaucoma

  2019influential citation
• Segmental outflow of aqueous humor in mouse and human

  2017cites this paper
• Effect of topical ophthalmic latanoprost 0.005% solution alone and in combination with diclofenac 0.1% solution in healthy horses: a pilot study

  2017cites this paper
• The Interaction of Nepafenac and Prostaglandin Analogs in Primary Open-angle Glaucoma Patients

  2016cites this paper
• Ocular Hypotensives and Neuroprotectants in Glaucoma

  2016cites this paper
• Best Practices in Reporting Iris Recognition Results

  2014cites this paper
• Continuous IOP Monitoring Devices: The Micro-ocular Glaucoma Holter

  2014cites this paper
• Concept of Glaucoma Pathogenesis

  2014cites this paper
• Daily Pressure Curve

  2014cites this paper
• Early Diagnosis of Intraocular Hypertension: Ibopamine Test

  2014cites this paper
• Glaucoma: Basic and Clinical Perspectives

  2013cites this paper
• The effect of topical latanoprost on anterior segment anatomic relationships in normal dogs.

  2013cites this paper
• Pharmacological therapy for glaucoma

  2013cites this paper
• Sildenafil accelerates anterior chamber refilling after paracentesis in sheep and rabbits.

  2012cites this paper
• Prostanoid receptors.

  2011cites this paper
• International Union of Basic and Clinical Pharmacology. LXXXIII: Classification of Prostanoid Receptors, Updating 15 Years of Progress

  2011cites this paper
• Significance of lipid mediators in corneal injury and repair

  2010cites this paper
• The Drug Discovery Process: How Do New Glaucoma Medications Come to Market?

  2010cites this paper
• Medications Used to Treat Glaucoma

  2010cites this paper
• Pharmacotherapies for glaucoma.

  2010cites this paper
• Molecular Circuits of Resolution in the Eye

  2010cites this paper
• Long-term effects of prostaglandin analogues on the anterior chamber depth of patients with primary open-angle glaucoma

  2009cites this paper
• Prostaglandin Subtype-Selective and Non-Selective IOP-Lowering Comparison in Monkeys

  2009cites this paper
• Corneal Neovascularization and Ocular Irritancy Responses in Dogs Following Topical Ocular Administration of an EP4-Prostaglandin E2 Agonist

  2009cites this paper
• Topical and Oral Ketorolac Administration Increases the Intraocular Pressure-Lowering Effect of Latanoprost

  2008cites this paper
• Enhancing trabecular outflow by disrupting the actin cytoskeleton, increasing uveoscleral outflow with prostaglandins, and understanding the pathophysiology of presbyopia interrogating Mother Nature: asking why, asking how, recognizing the signs, following the trail.

  2008cites this paper
• Highlights of Swedish ophthalmology in the 20th century

  2008cites this paper
• The prostanoid EP2 receptor agonist butaprost increases uveoscleral outflow in the cynomolgus monkey.

  2006cites this paper
• The influence of diclofenac ophthalmic solution on the intraocular pressure-lowering effect of topical 0.5% timolol and 0.005% latanoprost in primary open-angle glaucoma patients.

  2005cites this paper
• Species differences in the effects of prostanoids on MAP kinase phosphorylation, myosin light chain phosphorylation and contraction in bovine and cat iris sphincter smooth muscle.

  2005cites this paper
• Tales of two drugs.

  2005cites this paper
• The Role of Prostaglandin Analogues in the Treatment of Glaucoma in the 21st Century

  2004cites this paper
• Abnormal cell cycle regulation in primary human uveal melanoma cultures

  2004cites this paper
• Effects of prostaglandin F2alpha, latanoprost and carbachol on phosphoinositide turnover, MAP kinases, myosin light chain phosphorylation and contraction and functional existence and expression of FP receptors in bovine iris sphincter.

  2004cites this paper
• [Glaucoma and ocular hypertension: the importance of intraocular pressure in treatment decisions in France].

  2003cites this paper
• Ocular Drug Transfer Following Systemic Drug Administration

  2003cites this paper
• New drugs in glaucoma therapy.

  2003cites this paper
• Vascular activities of prostaglandins and selective prostanoid receptor agonists in human retinal microvessels.

  2002cites this paper
• Prostaglandin postscript: a personal reflection.

  2002cites this paper