How lipids influence the mode of action of membrane-active peptides.

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Biochimica et Biophysica Acta

• Publication date

  2007-10-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/J.BBAMEM.2007.06.015PMID 17662236
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2000cited by this paper
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• Conformation-dependent Antibacterial Activity of the Naturally Occurring Human Peptide LL-37*

  1998influential reference
• Anomalous phase behavior of long chain saturated lecithin bilayers.

  1996cited by this paper
• An antimicrobial peptide, magainin 2, induced rapid flip-flop of phospholipids coupled with pore formation and peptide translocation.

  1996cited by this paper
• Acyl chain length dependence in the stability of melittin-phosphatidylcholine complexes. A light scattering and 31P-NMR study.

  1995cited by this paper
• Measurement of chain tilt angle in fully hydrated bilayers of gel phase lecithins.

  1993cited by this paper
• Antibacterial peptides: key components needed in immunity.

  1991cited by this paper
• The actions of melittin on membranes.

  1990cited by this paper
• All-D amino acid-containing channel-forming antibiotic peptides.

  1990cited by this paper
• Structure of the fully hydrated gel phase of dipalmitoylphosphatidylcholine.

  1989cited by this paper
• Structure and thermodynamics of the dihexadecylphosphatidylcholine-water system.

  1987cited by this paper
• A deuterium and phosphorus-31 nuclear magnetic resonance study of the interaction of melittin with dimyristoylphosphatidylcholine bilayers and the effects of contaminating phospholipase A2.

  1987cited by this paper
• Tris buffer causes acyl chain interdigitation in phosphatidylglycerol.

  1987cited by this paper
• Recombinant lipoproteins: implications for structure and assembly of native lipoproteins.

  1986cited by this paper
• Morphological changes of phosphatidylcholine bilayers induced by melittin: vesicularization, fusion, discoidal particles.

  1986cited by this paper
• Area per molecule and distribution of water in fully hydrated dilauroylphosphatidylethanolamine bilayers.

  1986cited by this paper
• Comparative effects of short chain alcohols on lipid phase transitions.

  1985cited by this paper
• Phase transitions and fatty acid spin label behavior in interdigitated lipid phases induced by glycerol and polymyxin.

  1985cited by this paper
• Induction of an interdigitated gel phase in fully hydrated phosphatidylcholine bilayers

  1983cited by this paper
• Choline and acetylcholine induce interdigitation of hydrocarbon chains in dipalmitoylphosphatidylglycerol lamellar phase with stiff chains

  1982cited by this paper
• Polymyxin B induces interdigitation in dipalmitoylphosphatidylglycerol lamellar phase with stiff hydrocarbon chains

  1982cited by this paper
• Lecithin bilayers. Density measurement and molecular interactions.

  1978cited by this paper
• Structure and polymorphism of the hydrocarbon chains of lipids: a study of lecithin-water phases.

  1973cited by this paper
• Electron microscopic study on reassembly of plasma high density apoprotein with various lipids.

  1971cited by this paper

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• Influence of lipid vesicle properties on the function of conjugation dependent membrane active peptides

  2024cites this paper
• Chitosan-coated liposomal systems for delivery of antibacterial peptide LL17-32 to Porphyromonas gingivalis

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• Peptide Meets Membrane: Investigating Peptide-Lipid Interactions using Small-Angle Scattering Techniques

  2023cites this paper
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• Disturbing Lipid Phase Equilibrium in Model Membrane Induced by Lytic Peptides

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  2009influential citation
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