Quercetin decreases the activity of matrix metalloproteinase-2 and ameliorates vascular remodeling in renovascular hypertension.

No abstract is available for this paper.

• Publication year

  2018

• Venue

  Atherosclerosis

• Publication date

  2018-03-01

• Fields of study

  Medicine, Chemistry, Environmental Science

• Identifiers
  DOI 10.1016/j.atherosclerosis.2018.01.031PMID 29425960
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Matrix metalloproteinase-2 knockout prevents angiotensin II-induced vascular injury

  2017cited by this paper
• Reactive oxygen species derived from NAD(P)H oxidase play a role on ethanol-induced hypertension and endothelial dysfunction in rat resistance arteries

  2016cited by this paper
• Effects of Quercetin on Blood Pressure: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials

  2016cited by this paper
• Reduced levels of potential circulating biomarkers of cardiovascular diseases in apparently healthy vegetarian men.

  2016cited by this paper
• Matrix Metalloproteinase 2 as a Potential Mediator of Vascular Smooth Muscle Cell Migration and Chronic Vascular Remodeling in Hypertension

  2016cited by this paper
• Alpha1beta1 and integrin-linked kinase interact and modulate angiotensin II effects in vascular smooth muscle cells.

  2015cited by this paper
• Quercetin Improves Postischemic Recovery of Heart Function in Doxorubicin-Treated Rats and Prevents Doxorubicin-Induced Matrix Metalloproteinase-2 Activation and Apoptosis Induction

  2015cited by this paper
• NADPH Oxidases in Vascular Pathology

  2014cited by this paper
• Quercetin Inhibits Left Ventricular Hypertrophy in Spontaneously Hypertensive Rats and Inhibits Angiotensin II-Induced H9C2 Cells Hypertrophy by Enhancing PPAR-γ Expression and Suppressing AP-1 Activity

  2013cited by this paper
• Quercetin reduces oxidative stress and inhibits activation of c-Jun N-terminal kinase/activator protein-1 signaling in an experimental mouse model of abdominal aortic aneurysm

  2013cited by this paper
• Nebivolol attenuates prooxidant and profibrotic mechanisms involving TGF-β and MMPs, and decreases vascular remodeling in renovascular hypertension.

  2013cited by this paper
• Tempol inhibits TGF-β and MMPs upregulation and prevents cardiac hypertensive changes.

  2013cited by this paper
• Acute ethanol intake induces superoxide anion generation and mitogen-activated protein kinase phosphorylation in rat aorta: a role for angiotensin type 1 receptor.

  2012cited by this paper
• Time course involvement of matrix metalloproteinases in the vascular alterations of renovascular hypertension.

  2012cited by this paper
• Inward remodeling of resistance arteries requires reactive oxygen species-dependent activation of matrix metalloproteinases.

  2011cited by this paper
• Reactive oxygen species and vascular biology: implications in human hypertension

  2011cited by this paper
• Matrix metalloproteinase (MMP)‐2 proteolysis of calponin contributes to vascular hypocontractility in endotoxemic rats

  2011cited by this paper
• Anti-inflammatory, anti-proliferative and anti-atherosclerotic effects of quercetin in human in vitro and in vivo models.

  2011cited by this paper
• Matrix metalloproteinase inhibitor properties of tetracyclines: therapeutic potential in cardiovascular diseases.

  2011cited by this paper
• Extracellular matrix alterations in hypertensive vascular remodeling.

  2010cited by this paper
• Quercetin restores plasma nitrite and nitroso species levels in renovascular hypertension

  2010cited by this paper
• Imbalance between matrix metalloproteinases and tissue inhibitor of metalloproteinases in hypertensive vascular remodeling.

  2010cited by this paper
• Antioxidant treatment reduces matrix metalloproteinase-2-induced vascular changes in renovascular hypertension.

  2009cited by this paper
• Activation and modulation of 72kDa matrix metalloproteinase-2 by peroxynitrite and glutathione.

  2009cited by this paper
• The plastic nature of the vascular wall: a continuum of remodeling events contributing to control of arteriolar diameter and structure.

  2009cited by this paper
• Vitamin C improves the effect of a new nitric oxide donor on the vascular smooth muscle from renal hypertensive rats.

  2008cited by this paper
• Metalloproteinase inhibition ameliorates hypertension and prevents vascular dysfunction and remodeling in renovascular hypertensive rats.

  2008cited by this paper
• Quercetin reduces blood pressure in hypertensive subjects.

  2007cited by this paper
• TGF-beta signaling in vascular fibrosis.

  2007cited by this paper
• TGF-β signaling in vascular fibrosis

  2007cited by this paper
• Quercetin downregulates NADPH oxidase, increases eNOS activity and prevents endothelial dysfunction in spontaneously hypertensive rats

  2006cited by this paper
• Stretch-induced phosphorylation of focal adhesion kinase in endothelial cells: role of mitochondrial oxidants.

  2006cited by this paper
• Matrix metalloproteinases regulate migration, proliferation, and death of vascular smooth muscle cells by degrading matrix and non-matrix substrates.

  2006cited by this paper
• Oxidative-nitrosative stress in hypertension.

  2005cited by this paper
• Different Involvement of Extracellular Matrix Components in Small and Large Arteries During Chronic NO Synthase Inhibition

  2005cited by this paper
• Atheroprotective effects of antioxidants through inhibition of mitogen-activated protein kinases.

  2004cited by this paper
• Transinactivation of the epidermal growth factor receptor tyrosine kinase and focal adhesion kinase phosphorylation by dietary flavonoids: effect on invasive potential of human carcinoma cells.

  2004cited by this paper
• Quercetin exerts multiple inhibitory effects on vascular smooth muscle cells: role of ERK1/2, cell-cycle regulation, and matrix metalloproteinase-9.

  2003cited by this paper
• Mechanical Stretch Enhances mRNA Expression and Proenzyme Release of Matrix Metalloproteinase‐2 (MMP‐2) via NAD(P)H Oxidase‐Derived Reactive Oxygen Species

  2003cited by this paper
• Oxidative stress and cardiovascular injury: Part II: animal and human studies.

  2003cited by this paper
• Quercetin glucuronide prevents VSMC hypertrophy by angiotensin II via the inhibition of JNK and AP-1 signaling pathway.

  2002cited by this paper
• Norepinephrine-induced aortic hyperplasia and extracellular matrix deposition are endothelin-dependent

  2001cited by this paper
• Antihypertensive effects of the flavonoid quercetin in spontaneously hypertensive rats

  2001cited by this paper
• Structure-antioxidant activity relationships of flavonoids and phenolic acids.

  1996cited by this paper
• Reactive oxygen species produced by macrophage-derived foam cells regulate the activity of vascular matrix metalloproteinases in vitro. Implications for atherosclerotic plaque stability.

  1996cited by this paper
• Dietary antioxidant flavonoids and risk of coronary heart disease: the Zutphen Elderly Study.

  1993cited by this paper

• Identification of Bioactive Ingredients and Mechanistic Pathways of Xuefu Zhuyu Decoction in Ventricular Remodeling: A Network Pharmacology, Molecular Docking and Molecular Dynamics Simulations.

  2025cites this paper
• Gel Zymography for the Evaluation of Matrix Metalloproteinase-2 and -9 in Aorta and Kidney Tissues.

  2025cites this paper
• Bioactivity and biomedical applications of pomegranate peel extract: a comprehensive review

  2025cites this paper
• The Role of Quercetin, a Flavonoid in the Management of Pathogenesis Through Regulation of Oxidative Stress, Inflammation, and Biological Activities

  2025cites this paper
• Quercetin as a Multi‐Target Natural Therapeutic in Aging‐Related Diseases: Systemic Molecular and Cellular Mechanisms

  2025cites this paper
• Wine polyphenols in the prevention of metabolic syndrome: a critical review of multitarget mechanisms and translational perspectives.

  2025cites this paper
• Antagonism of the complement receptor reduces oxidative stress and matrix metalloproteinase (MMP)-2 activity in the aortas of mice with angiotensin-II-induced hypertension.

  2025cites this paper
• Nanotechnology and flavonoids: Current research and future perspectives on cardiovascular health

  2024cites this paper
• The role of oxidative stress in aortic dissection: a potential therapeutic target

  2024cites this paper
• Quercetin ameliorates atherosclerosis by inhibiting inflammation of vascular endothelial cells via Piezo1 channels.

  2024cites this paper
• Elucidating the anti-hypertensive mechanisms of Uncaria rhynchophylla-Alisma plantago-aquatica L: an integrated network pharmacology, cluster analysis, and molecular docking approach

  2024cites this paper
• Natural Products as Regulators against Matrix Metalloproteinases for the Treatment of Cancer

  2024cites this paper
• Quercetin Prevents HSpertension in Dahl Salt-sensitive Rats Fed a High-salt Diet Through Balancing Endothelial Nitric Oxide Synthase and Sirtuin 1.

  2024cites this paper
• Antihypertensive Effects of Quercetin-Rich Marchin-13 in a Dexamethasone-Induced Rat Model

  2024cites this paper
• Antihypertensive mechanism of the medicine food homology compound solution with high ACE inhibition rate based on network pharmacology and molecular docking

  2024cites this paper
• Curcumin Prevents Renal Damage of l‐NAME Induced Hypertension in by Reducing MMP‐2 and MMP‐9

  2024cites this paper
• Unrevealing the mechanisms behind the cardioprotective effect of wheat polyphenolics

  2024cites this paper
• Cardiovascular and Renal Effects Induced by Alpha-Lipoic Acid Treatment in Two-Kidney-One-Clip Hypertensive Rats

  2024cites this paper
• Naringenin and proanthocyanidins pre-treatment decreases synthesis and activity of gelatinases induced by zoledronic acid in a dental implant surface in vitro model.

  2023cites this paper
• PROTEINS TIMP-2, IRISIN AND SITUATION WITH HEMOSTASIS, LIPID METABOLISM AND SEX HORMONES IN FEMALE CARDIOVASCULAR PATIENTS

  2023cites this paper
• Research progress of quercetin in cardiovascular disease

  2023cites this paper
• Quercetin and Heart Health: From Molecular Pathways to Clinical Findings

  2023cites this paper
• Intermittent mild cold stimulation alleviates cold stress-induced pulmonary fibrosis by inhibiting the TGF-β1/Smad signaling pathway in broilers

  2023cites this paper
• META-ANALYSIS OF DEPENDENCE OF THE DEVELOPMENT OF EXPERIMENTAL RENOVASCULAR HYPERTENSION “2 KIDNEYS, 1 CLAMP” ON LIFESTYLE FACTORS

  2023cites this paper
• Recent advances in understanding dietary polyphenols protecting against hypertension

  2023cites this paper
• Bio-Actives from Natural Products with Potential Cardioprotective Properties: Isolation, Identification, and Pharmacological Actions of Apigenin, Quercetin, and Silibinin

  2023cites this paper
• Effect of Qiling Jiaogulan Powder on Pulmonary Fibrosis and Pulmonary Arteriole Remodeling in Low-Temperature-Exposed Broilers

  2022cites this paper
• Cardiovascular protection effect of a Northeastern Brazilian lyophilized red wine in spontaneously hypertensive rats

  2022cites this paper
• Olive cake reduces blood pressure, oxidative stress, aortic endothelial dysfunction and vascular remodeling, in dexamethasone-induced hypertensive rats

  2022cites this paper
• Biosynthesis and Chemopreventive Potential of Jute ( Corchorus capsularis and C. olitorius) Flavonoids and Phylogeny of Flavonoid Biosynthesis Pathways

  2022cites this paper
• Chimonanthus salicifolius attenuated vascular remodeling by alleviating endoplasmic reticulum stress in spontaneously hypertensive rats.

  2022cites this paper
• Development of flavonoid probes and the binding mode of the target protein and quercetin derivatives.

  2022cites this paper
• Nobiletin resolves left ventricular and renal changes in 2K-1C hypertensive rats

  2022cites this paper
• Integrated network pharmacology and experimental verification to explore the action mechanism of the Sangqi Qingxuan formula against hypertensive vascular remodeling

  2022cites this paper
• DNA damage and repair on hematopoietic stem cells: impact of oxidative stress in renovascular hypertension

  2022cites this paper
• Potential Pharmaceutical Applications of Quercetin in Cardiovascular Diseases

  2022influential citation
• Isolated Natural Antioxidants as a new Possible Therapeutic Alternative for the Treatment of Hypertension.

  2022cites this paper
• Quercetin inhibits angiotensin II-induced vascular smooth muscle cell proliferation and activation of JAK2/STAT3 pathway: A target based networking pharmacology approach

  2022cites this paper
• Therapeutic Potential of Select Dietary Compounds in the Management of Hypertension and its Cardiovascular Complications

  2022cites this paper
• Quercetin decreases cardiac hypertrophic mediators and maladaptive coronary arterial remodeling in renovascular hypertensive rats without improving cardiac function

  2022cites this paper
• Matrix metalloproteinase-2 inhibition activity of Plukenetia volubilis L. leaves extract for anti-aging application

  2021cites this paper
• New Insights Toward Nanostructured Drug Delivery of Plant-Derived Polyphenol Compounds: Cancer Treatment and Gene Expression Profiles.

  2021cites this paper
• Potential Use of Quercetin as Protective Agent against Hydroxychloroquine Induced Cardiotoxicity

  2021cites this paper
• Matrix Metalloproteinases and Arterial Hypertension: Role of Oxidative Stress and Nitric Oxide in Vascular Functional and Structural Alterations

  2021cites this paper
• Natural Marine and Terrestrial Compounds as Modulators of Matrix Metalloproteinases-2 (MMP-2) and MMP-9 in Alzheimer’s Disease

  2021cites this paper
• Network Pharmacology Analysis Uncovers the Potential Anti-Hypertensive Mechanisms of Xia Sang Ju Granule

  2020cites this paper
• Phyto-Derived Products as Matrix Metalloproteinases Inhibitors in Cardiovascular Diseases.

  2020cites this paper
• Managing Editor

  2020cites this paper
• Potential Implications of Quercetin and its Derivatives in Cardioprotection

  2020cites this paper
• Prenatal hypoxia predisposes vascular functional and structural changes associated with oxidative stress damage and depressive behavior in adult offspring male rats.

  2020cites this paper
• Preventive Effects of Quercetin against the Onset of Atherosclerosis-Related Acute Aortic Syndromes in Mice

  2020cites this paper
• Systematic Elucidation of the Mechanism of Quercetin against Gastric Cancer via Network Pharmacology Approach

  2020influential citation
• Effect of Kenikir (Cosmos Caudatus) on Malondialdehyde (MDA) and Blood Pressure When Hypertension in Pregnancy : A Systematic Review

  2020influential citation
• Angiotensin Type 1 Receptors and Superoxide Anion Production in Hypothalamic Paraventricular Nucleus Contribute to Capsaicin-Induced Excitatory Renal Reflex and Sympathetic Activation

  2020cites this paper
• Flavonoids: A vital resource in healthcare and medicine

  2020cites this paper
• Interleukin-1β in hypothalamic paraventricular nucleus mediates excitatory renal reflex

  2020cites this paper
• Naringenin Ameliorates Renovascular Hypertensive Renal Damage by Normalizing the Balance of Renin-Angiotensin System Components in Rats

  2019cites this paper
• Oxidative stress and vascular stiffness in hypertension: A renewed interest for antioxidant therapies?

  2019cites this paper
• Matrix metalloproteinase (MMP)-2 activation by oxidative stress decreases aortic calponin-1 levels during hypertrophic remodeling in early hypertension.

  2019cites this paper
• DDDT_A_218606 4215..4223

  2019cites this paper
• The Effect of Glutamine Supplementation on Oxidative Stress and Matrix Metalloproteinase 2 and 9 After Exhaustive Exercise

  2019cites this paper
• Verapamil decreases calpain-1 and matrix metalloproteinase-2 activities and improves hypertension-induced hypertrophic cardiac remodeling in rats.

  2019cites this paper
• The Use of Nutraceuticals to Counteract Atherosclerosis: The Role of the Notch Pathway

  2019cites this paper
• Matrix metalloproteinase in the cardiovascular remodeling of hypertension: current insights and therapeutic potential

  2018cites this paper
• The diagnostic values of circulating miRNAs for hypertension and bioinformatics analysis

  2018cites this paper
• Quercetin affecting gelatinases in rat aortas: Some comments.

  2018cites this paper
• Pharmacological Effect of Quercetin in Hypertension and Its Potential Application in Pregnancy-Induced Hypertension: Review of In Vitro, In Vivo, and Clinical Studies

  2018cites this paper
• Hypertension, augmented activity of matrix metalloproteinases‐2 and ‐9 and angiogenic imbalance in hypertensive pregnancy are attenuated by doxycycline

  2018cites this paper
• Reply to: "Quercetin affects gelatinases in rat aortas: Some comments".

  2018cites this paper