Response of the human detrusor to stretch is regulated by TREK‐1, a two‐pore‐domain (K2P) mechano‐gated potassium channel

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Journal of Physiology

• Publication date

  2014-07-15

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1113/jphysiol.2014.271718PMID 24801307PMCID PMC4214657
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2005influential reference
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  1995influential reference
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  1994cited by this paper
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