A classification algorithm for predicting progression from normal cognition to mild cognitive impairment across five cohorts: The preclinical AD consortium

We established a method for diagnostic harmonization across multiple studies of preclinical Alzheimer's disease and validated the method by examining its relationship with clinical status and cognition.

• Publication year

  2017

• Venue

  Alzheimer's & Dementia

• Publication date

  2017-05-30

• Fields of study

  Medicine, Psychology

• Identifiers
  DOI 10.1016/j.dadm.2017.05.003PMID 28653035PMCID 5476965
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Randomized controlled trials in mild cognitive impairment

  2017cited by this paper
• Structural Equations With Latent Variables

  2016cited by this paper
• Tau imaging: early progress and future directions.

  2015cited by this paper
• Application of Latent Variable Methods to the Study of Cognitive Decline When Tests Change over Time

  2015cited by this paper
• Effects of education and race on cognitive decline: An integrative study of generalizability versus study-specific results.

  2015cited by this paper
• Harmonizing Measures of Cognitive Performance Across International Surveys of Aging Using Item Response Theory

  2015cited by this paper
• The A4 Study: Stopping AD Before Symptoms Begin?

  2014cited by this paper
• Calibration and Validation of an Innovative Approach for Estimating General Cognitive Performance

  2014cited by this paper
• Calibrating Longitudinal Cognition in Alzheimer's Disease Across Diverse Test Batteries and Datasets

  2014cited by this paper
• Neuropsychological Criteria for Mild Cognitive Impairment Improves Diagnostic Precision, Biomarker Associations, and Progression Rates

  2014cited by this paper
• Emergence of Mild Cognitive Impairment in Late Middle-Aged Adults in the Wisconsin Registry for Alzheimer's Prevention

  2014cited by this paper
• Cognitive changes preceding clinical symptom onset of mild cognitive impairment and relationship to ApoE genotype.

  2014cited by this paper
• Developing an international network for Alzheimer research: The Dominantly Inherited Alzheimer Network.

  2012cited by this paper
• Toward defining the preclinical stages of Alzheimer's disease: Recommendations from the National Institute on Aging‐Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

  2011cited by this paper
• Sources of variability in estimates of the prevalence of Alzheimer's disease in the United States

  2011cited by this paper
• Cognitive decline in prodromal Alzheimer disease and mild cognitive impairment.

  2011cited by this paper
• The diagnosis of dementia due to Alzheimer's disease: Recommendations from the National Institute on Aging‐Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

  2011cited by this paper
• Testing the Right Target and Right Drug at the Right Stage

  2011cited by this paper
• The diagnosis of mild cognitive impairment due to Alzheimer's disease: Recommendations from the National Institute on Aging‐Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

  2011cited by this paper
• Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade.

  2010cited by this paper
• The Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging: methodology and baseline characteristics of 1112 individuals recruited for a longitudinal study of Alzheimer's disease

  2009cited by this paper
• Longitudinal study of the transition from healthy aging to Alzheimer disease.

  2009cited by this paper
• Prodromal Alzheimer's disease: Successive emergence of the clinical symptoms

  2008cited by this paper
• Editorial Comment on ‘Prevalence of Dementia in the United States: The Aging, Demographics, and Memory Study’ by Plassman et al.

  2007cited by this paper
• Antecedent Biomarkers of Alzheimer’s Disease: The Adult Children Study

  2005cited by this paper
• Longitudinal Models of Growth and Survival Applied to the Early Detection of Alzheimer’s Disease

  2005cited by this paper
• Middle-Aged Children of Persons With Alzheimer’s Disease: APOE Genotypes and Cognitive Function in the Wisconsin Registry for Alzheimer’s Prevention

  2005cited by this paper
• Neuropsychological tests accurately predict incident Alzheimer disease after 5 and 10 years

  2005cited by this paper
• Behavioral Characterization of Mild Cognitive Impairment

  2002cited by this paper
• One-year age changes in MRI brain volumes in older adults.

  2000cited by this paper
• Test Theory: A Unified Treatment

  1999cited by this paper
• Mild Cognitive Impairment Clinical Characterization and Outcome

  1999cited by this paper
• SPECIES RICHNESS OF PARASITE ASSEMBLAGES: Evolution and Patterns

  1997cited by this paper
• The effect of different diagnostic criteria on the prevalence of dementia.

  1997cited by this paper
• The Clinical Dementia Rating (CDR)

  1993cited by this paper
• Normal Human Aging: The Baltimore Longitudinal Study of Aging

  1986cited by this paper
• Normal Human Aging: The Baltimore Longitudinal Study on Aging

  1984cited by this paper

• Impacts of Environmental Distractions and Interruptions on Unsupervised Digital Cognitive Assessments in Older Adults: Cognitive Ecological Momentary Assessment Study

  2025influential citation
• Temporal modeling and AT profiles in the early phase of Alzheimer's disease

  2025cites this paper
• MRI Distance Measures as a Predictor of Subsequent Clinical Status During the Preclinical Phase of Alzheimer's Disease and Related Disorders

  2025cites this paper
• Higher interleukin-6 (IL-6) is associated with decline in psychomotor processing speed but not executive functioning in older adults: Gender-specific effects.

  2025cites this paper
• Predictors and outcomes of fluctuations in the clinical dementia rating scale

  2024cites this paper
• Sensory and motor deficits as contributors to early cognitive impairment

  2024cites this paper
• Alzheimer’s disease genetic risk and changes in brain atrophy and white matter hyperintensities in cognitively unimpaired adults

  2024cites this paper
• Dual-task gait has prognostic value for cognitive decline in Parkinson's disease.

  2024cites this paper
• Longitudinal normative standards for cognitive tests and composites using harmonized data from two Wisconsin AD‐risk‐enriched cohorts

  2024cites this paper
• A genome-wide search for pleiotropy in more than 100,000 harmonized longitudinal cognitive domain scores

  2023cites this paper
• Deep phenotyping and genomic data from a nationally representative study on dementia in India

  2023cites this paper
• Alzheimer’s disease genetic risk and cognitive reserve in relationship to long-term cognitive trajectories among cognitively normal individuals

  2023cites this paper
• Prevalence of DSM-5 mild and major neurocognitive disorder in India: Results from the LASI-DAD

  2023cites this paper
• Amyloid beta-specic T cell response is enhanced in individuals with mild cognitive impairment

  2023cites this paper
• Application and validation of an algorithmic classification of early impairment in cognitive performance

  2023cites this paper
• Categorical predictive and disease progression modeling in the early stage of Alzheimer's disease.

  2022cites this paper
• Dual Task Performance Is Associated with Amyloidosis in Cognitively Healthy Adults

  2022cites this paper
• Sharper in the morning: Cognitive time of day effects revealed with high-frequency smartphone testing

  2021influential citation
• Learning From Clinical Consensus Diagnosis in India to Facilitate Automatic Classification of Dementia: Machine Learning Study

  2021cites this paper
• Comparison of the predictive accuracy of multiple definitions of cognitive impairment for incident dementia: a 20-year follow-up of the Whitehall II cohort study

  2021cites this paper
• Linear linking for related traits (LLRT): A novel method for the harmonization of cognitive domains with no or few common items.

  2021cites this paper
• Diagnostic Stability of Mild Cognitive Impairment, and Predictors of Reversion to Normal Cognitive Functioning

  2020cites this paper
• Online Clinical Consensus Diagnosis of Dementia: Development and Validation.

  2020cites this paper
• The role of tau and neuroinflammation in Progressive Supranuclear Palsy and Alzheimer's Disease

  2019cites this paper
• Identifying Changepoints in Biomarkers During the Preclinical Phase of Alzheimer’s Disease

  2019cites this paper
• Plasma Markers of Inflammation Linked to Clinical Progression and Decline During Preclinical AD

  2019cites this paper
• A Birth Cohort Analysis of Amnestic Mild Cognitive Impairment Incidence in the Einstein Aging Study (EAS) Cohort

  2019cites this paper
• A harmonized longitudinal biomarkers and cognition database for assessing the natural history of preclinical Alzheimer's disease from young adulthood and for designing prevention trials

  2019cites this paper
• ATN profiles among cognitively normal individuals and longitudinal cognitive outcomes

  2019cites this paper
• Essential Dynamic Transformation as Specific Highly Characterizable Indices of Progression of the Initial Mild Cognitive Impairment Phase of Alzheimer Patients

  2018cites this paper
• Identifying Changepoints in Biomarkers During the Preclinical Phase of AD

  2018cites this paper
• Sex, amyloid, and APOE ε4 and risk of cognitive decline in preclinical Alzheimer's disease: Findings from three well‐characterized cohorts

  2018cites this paper
• Personality Change in the Preclinical Phase of Alzheimer Disease

  2017cites this paper
• The Wisconsin Registry for Alzheimer's Prevention: A review of findings and current directions

  2017cites this paper