Metformin inhibits the radiation-induced invasive phenotype of esophageal squamous cell carcinoma.

No abstract is available for this paper.

• Publication year

  2016

• Venue

  International Journal of Oncology

• Publication date

  2016-11-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.3892/ijo.2016.3676PMID 27599468
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The impact of metformin and salinomycin on transforming growth factor β-induced epithelial-to-mesenchymal transition in non-small cell lung cancer cell lines.

  2016cited by this paper
• Metformin inhibits thyroid cancer cell growth, migration, and EMT through the mTOR pathway

  2015cited by this paper
• Fractionated Ionizing Radiation Promotes Epithelial-Mesenchymal Transition in Human Esophageal Cancer Cells through PTEN Deficiency-Mediated Akt Activation

  2015influential reference
• Metformin may function as anti-cancer agent via targeting cancer stem cells: the potential biological significance of tumor-associated miRNAs in breast and pancreatic cancers.

  2014cited by this paper
• Inhibition of mTOR pathway attenuates migration and invasion of gallbladder cancer via EMT inhibition

  2014cited by this paper
• Cancer stem cells, the epithelial to mesenchymal transition (EMT) and radioresistance: potential role of hypoxia.

  2013cited by this paper
• DKK1 promotes hepatocellular carcinoma cell migration and invasion through β-catenin/MMP7 signaling pathway

  2013cited by this paper
• EPIDEMIOLOGY OF ESOPHAGEAL CANCER

  2013cited by this paper
• Metformin inhibits growth and enhances radiation response of non-small cell lung cancer (NSCLC) through ATM and AMPK

  2013cited by this paper
• Hypoxia-inducing factors as master regulators of stemness properties and altered metabolism of cancer- and metastasis-initiating cells

  2013cited by this paper
• Epidemiology of esophageal cancer.

  2013cited by this paper
• The relevance of the TGF-β Paradox to EMT-MET programs.

  2013cited by this paper
• Metformin in cancer: translational challenges.

  2012cited by this paper
• Establishment of animal model for the analysis of cancer cell metastasis during radiotherapy

  2012cited by this paper
• Metformin, an Antidiabetic Agent Reduces Growth of Cutaneous Squamous Cell Carcinoma by Targeting mTOR Signaling Pathway †

  2012influential reference
• Novel radiosensitizing anticancer therapeutics.

  2012cited by this paper
• Ionizing radiation promotes migration and invasion of cancer cells through transforming growth factor-beta-mediated epithelial-mesenchymal transition.

  2011influential reference
• Evidence for biological effects of metformin in operable breast cancer: a pre-operative, window-of-opportunity, randomized trial

  2011cited by this paper
• Global cancer statistics

  2011cited by this paper
• Survival after neoadjuvant chemotherapy or chemoradiotherapy for resectable oesophageal carcinoma: an updated meta-analysis.

  2011cited by this paper
• Low doses ionizing radiation enhances the invasiveness of breast cancer cells by inducing epithelial-mesenchymal transition.

  2011cited by this paper
• Evaluation of metformin in early breast cancer: a modification of the traditional paradigm for clinical testing of anti-cancer agents

  2011cited by this paper
• Metformin Associated With Lower Cancer Mortality in Type 2 Diabetes: ZODIAC-16

  2010cited by this paper
• Metformin against TGFβ-induced epithelial-to-mesenchymal transition (EMT): From cancer stem cells to aging-associated fibrosis

  2010cited by this paper
• Ionizing radiation activates AMP-activated kinase (AMPK): a target for radiosensitization of human cancer cells.

  2010cited by this paper
• Metformin regulates breast cancer stem cello ntogeny by transcriptional regulation of the epithelial-mesenchymal transition (EMT) status

  2010cited by this paper
• Activation of senescence and aging characteristics by mitochondrially generated ROS: How are they linked?

  2010cited by this paper
• Regulation of the stability of cell surface E-cadherin by the proteasome.

  2009cited by this paper
• Metformin Associated With Lower Cancer Mortality in Type 2 Diabetes

  2009cited by this paper
• TGF-β-induced epithelial to mesenchymal transition

  2009cited by this paper
• Epithelial-mesenchymal transitions in development and disease.

  2009cited by this paper
• Metformin, Sulfonylureas, or Other Antidiabetes Drugs and the Risk of Lactic Acidosis or Hypoglycemia

  2008cited by this paper
• Activation of the PI3-K/AKT pathway and implications for radioresistance mechanisms in head and neck cancer.

  2008cited by this paper
• Cell size and invasion in TGF-β–induced epithelial to mesenchymal transition is regulated by activation of the mTOR pathway

  2007cited by this paper
• Metformin inhibits mammalian target of rapamycin-dependent translation initiation in breast cancer cells.

  2007cited by this paper
• Irradiation-induced epithelial-mesenchymal transition (EMT) related to invasive potential in endometrial carcinoma cells.

  2007cited by this paper
• Faculty Opinions recommendation of Cell size and invasion in TGF-beta-induced epithelial to mesenchymal transition is regulated by activation of the mTOR pathway.

  2007cited by this paper
• Increased Cancer-Related Mortality for Patients With Type 2 Diabetes Who Use Sulfonylureas or Insulin

  2006cited by this paper
• Metformin and reduced risk of cancer in diabetic patients

  2005cited by this paper
• Radiation and the microenvironment – tumorigenesis and therapy

  2005cited by this paper
• Stress and Radiation-Induced Activation of Multiple Intracellular Signaling Pathways1

  2003cited by this paper
• Sublethal irradiation promotes migration and invasiveness of glioma cells: implications for radiotherapy of human glioblastoma.

  2001cited by this paper
• Chemoradiotherapy of Locally Advanced Esophageal Cancer: Long-term Follow-up of a Prospective Randomized Trial (RTOG 85-01)

  1999cited by this paper
• Chemoradiotherapy of locally advanced esophageal cancer: long-term follow-up of a prospective randomized trial (RTOG 85-01). Radiation Therapy Oncology Group.

  1999cited by this paper
• Regulation of matrix metalloproteinase expression in tumor invasion

  1999cited by this paper

• Unraveling the underlying mechanisms of cancer stem cells in therapeutic resistance for optimizing treatment strategies

  2025cites this paper
• The multifaceted role of agents counteracting metabolic syndrome: A new hope for gastrointestinal cancer therapy.

  2025cites this paper
• Metformin suppresses esophageal cancer progression through the radiation‑induced cellular senescence of cancer‑associated fibroblasts

  2024cites this paper
• Current findings on the antitumor effects of metformin on esophageal squamous cell carcinoma (Review)

  2024influential citation
• Metformin in Esophageal Carcinoma: Exploring Molecular Mechanisms and Therapeutic Insights

  2024cites this paper
• Radioprotective countermeasures for radiation injury (Review)

  2023cites this paper
• Engine shutdown: migrastatic strategies and prevention of metastases.

  2023cites this paper
• Targeting the SOX2/PARP1 complex to intervene in the growth of esophageal squamous cell carcinoma.

  2022cites this paper
• Neoadjuvant therapy for resectable pancreatic cancer: a narrative review

  2022influential citation
• Metformin and Cancer Hallmarks: Molecular Mechanisms in Thyroid, Prostate and Head and Neck Cancer Models

  2022cites this paper
• Metformin Inhibits Esophageal Squamous Cell Carcinoma Viability and Mobility in vitro through Down-regulation of Long Non-coding RNA CCAT1 and SPRY4-IT1

  2021cites this paper
• A phase I study of preoperative (neoadjuvant) chemotherapy with gemcitabine plus nab-paclitaxel for resectable pancreatic cancer.

  2020cites this paper
• Metformin Combined with 4SC-202 Inhibited the Migration and Invasion of OSCC via STAT3/TWIST1

  2020cites this paper
• Mechanisms of metformin inhibiting cancer invasion and migration.

  2020cites this paper
• OTT_A_268851 11019..11029

  2020cites this paper
• Metformin inhibits TGF‑β1‑induced epithelial‑mesenchymal transition and liver metastasis of pancreatic cancer cells.

  2020cites this paper
• Impact of metformin on survival outcome of esophageal squamous cell carcinomas patients undergoing surgical resection: a multicenter retrospective study

  2020cites this paper
• Genome-wide copy number variation analysis identified ANO1 as a novel oncogene and prognostic biomarker in esophageal squamous cell cancer.

  2019cites this paper
• Metformin enhances radiosensitivity in hepatocellular carcinoma by inhibition of specificity protein 1 and epithelial-to-mesenchymal transition

  2019cites this paper
• Antitumor effects of metformin are a result of inhibiting nuclear factor kappa B nuclear translocation in esophageal squamous cell carcinoma

  2018cites this paper
• K‐ras mutation promotes ionizing radiation‐induced invasion and migration of lung cancer in part via the Cathepsin L/CUX1 pathway

  2018cites this paper
• Effects of radiation on the metastatic process

  2018influential citation
• Blocking epithelial-to-mesenchymal transition in glioblastoma with a sextet of repurposed drugs: the EIS regimen

  2017cites this paper
• Altered expression of E-Cadherin-related transcription factors indicates partial epithelial-mesenchymal transition in aggressive meningiomas.

  2017cites this paper