Rolipram attenuates MK-801-induced deficits in latent inhibition.

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Behavioral Neuroscience

• Publication date

  2005-04-01

• Fields of study

  Medicine, Psychology

• Identifiers
  DOI 10.1037/0735-7044.119.2.595PMID 15839805
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Effects of antipsychotic drugs on latent inhibition: sensitivity and specificity of an animal behavioral model of clinical drug action

  2005cited by this paper
• The effects of phencyclidine on latent inhibition in taste aversion conditioning: differential effects of preexposure and conditioning.

  2005cited by this paper
• Latent inhibition of cued fear conditioning: an NMDA receptor‐dependent process that can be established in the presence of anisomycin

  2004cited by this paper
• Sensorimotor Gating Deficits in Transgenic Mice Expressing a Constitutively Active Form of Gsα

  2004cited by this paper
• Latent inhibition is spared by N-methyl-D-aspartate (NMDA)-induced ventral hippocampal lesions, but is attenuated following local activation of the ventral hippocampus by intracerebral NMDA infusion.

  2004cited by this paper
• Regulation of hippocampal synaptic plasticity by cyclic AMP-dependent protein kinases.

  2003cited by this paper
• Systemic administration of MK-801 produces an abnormally persistent latent inhibition which is reversed by clozapine but not haloperidol

  2003cited by this paper
• Ketamine-induced changes in rat behaviour: A possible animal model of schizophrenia.

  2003cited by this paper
• A mouse model of Rubinstein-Taybi syndrome: Defective long-term memory is ameliorated by inhibitors of phosphodiesterase 4

  2003cited by this paper
• Latent inhibition disruption by MK-801 in a conditioned taste-aversion paradigm.

  2003cited by this paper
• Glutamate receptor function in learning and memory.

  2003cited by this paper
• The "two-headed" latent inhibition model of schizophrenia: modeling positive and negative symptoms and their treatment

  2003cited by this paper
• The role of NMDA glutamate receptors, PKA, MAPK, and CAMKII in the hippocampus in extinction of conditioned fear

  2003cited by this paper
• Input dysfunction, schizotypy, and genetic models of schizophrenia.

  2002cited by this paper
• Cyclic nucleotide phosphodiesterases and their role in endocrine cell signaling.

  2002cited by this paper
• The influence of selective lesions to components of the hippocampal system on the orientating response, habituation and latent inhibition

  2002cited by this paper
• Review: Protein Kinase Signal Transduction Cascades in Mammalian Associative Conditioning

  2002cited by this paper
• Effects of a phosphodiesterase IV inhibitor rolipram on microsphere embolism‐induced defects in memory function and cerebral cyclic AMP signal transduction system in rats

  2002cited by this paper
• MK-801 disrupts acquisition of contextual fear conditioning but enhances memory consolidation of cued fear conditioning

  2002cited by this paper
• Integrative role for serotonergic and glutamatergic receptor mechanisms in the action of NMDA antagonists: potential relationships to antipsychotic drug actions on NMDA antagonist responsiveness.

  2002cited by this paper
• Latent inhibition and schizophrenia: Pavlovian conditioning of autonomic responses.

  2002cited by this paper
• Rolipram depresses [3H]2-deoxyglucose uptake in mouse brain and heart in vivo

  2002cited by this paper
• Nicotine enhances latent inhibition and ameliorates ethanol-induced deficits in latent inhibition.

  2001cited by this paper
• The changing roles and targets for animal models of schizophrenia.

  2001cited by this paper
• Clinical features of latent inhibition in schizophrenia.

  2001cited by this paper
• Role of Ca2+‐stimulated adenylyl cyclases in LTP and memory formation

  2001cited by this paper
• Characterization of r-[11C]rolipram for PET imaging of phosphodieterase-4: in vivo binding, metabolism, and dosimetry studies in rats.

  2001cited by this paper
• Basolateral amygdala lesions disrupt latent inhibitionin rats.

  2001cited by this paper
• The cAMP-dependent protein kinase substrate Rap1 in platelets from patients with obsessive compulsive disorder or schizophrenia.

  2001cited by this paper
• Molecular mechanisms of memory acquisition, consolidation and retrieval.

  2001cited by this paper
• Effects of rolipram on scopolamine-induced impairment of working and reference memory in the radial-arm maze tests in rats

  2000cited by this paper
• The delayed effects of DTG and MK-801 on latent inhibition in a conditioned taste-aversion paradigm.

  2000cited by this paper
• Inhibition of Cyclic AMP Phosphodiesterase (PDE4) Reverses Memory Deficits Associated with NMDA Receptor Antagonism

  2000cited by this paper
• The pharmacology of latent inhibition as an animal model of schizophrenia.

  2000cited by this paper
• Blockade of NMDA receptors in the amygdala prevents latent inhibition of fear-conditioning.

  2000cited by this paper
• Abnormal Levels of cAMP-dependent Protein Kinase Regulatory Subunits in Platelets from Schizophrenic Patients

  2000cited by this paper
• Visual search in schizophrenia: latent inhibition and novel pop-out effects.

  2000cited by this paper
• Regulation of cAMP and cGMP signaling: new phosphodiesterases and new functions.

  2000cited by this paper
• Haloperidol reinstates latent inhibition impaired by hippocampal lesions: data and theory.

  2000cited by this paper
• Cellular and Molecular Mechanisms of Learning and Memory

  2000cited by this paper
• Cerebral signal transduction : from first to fourth messengers

  2000cited by this paper
• Imaging of cAMP‐specific phosphodiesterase‐IV: Comparison of [11C]Rolipram and [11C]Ro 20–1724 in rats

  1999cited by this paper
• Neurotransmitter interactions in schizophrenia-therapeutic implications

  1999cited by this paper
• Behavioral effects of family-selective inhibitors of cyclic nucleotide phosphodiesterases.

  1999cited by this paper
• Isolation and characterization of PDE10A, a novel human 3', 5'-cyclic nucleotide phosphodiesterase.

  1999cited by this paper
• Genetic influences on latent inhibition.

  1999cited by this paper
• Neurotransmitter interactions in schizophrenia--therapeutic implications.

  1999cited by this paper
• Behavioral effects of ketamine, an NMDA glutamatergic antagonist, in non-human primates

  1999cited by this paper
• NMDA receptor hypofunction model of schizophrenia.

  1999cited by this paper
• Effects of rolipram on the elevated plus-maze test in rats: a preliminary study

  1999cited by this paper
• Comparison of four components of sensory gating in schizophrenia and normal subjects: a preliminary report.

  1999cited by this paper
• Age-related defects in spatial memory are correlated with defects in the late phase of hippocampal long-term potentiation in vitro and are attenuated by drugs that enhance the cAMP signaling pathway.

  1999cited by this paper
• The neuropathology of schizophrenia. A critical review of the data and their interpretation.

  1999cited by this paper
• Synaptic plasticity: going through phases with LTP.

  1998cited by this paper
• Rolipram, a type IV-specific phosphodiesterase inhibitor, facilitates the establishment of long-lasting long-term potentiation and improves memory.

  1998cited by this paper
• Tetrodotoxin inactivation of the gustatory cortex disrupts the effect of the N-methyl-D-aspartate antagonist ketamine on latent inhibition of conditioned taste aversion in rats.

  1998cited by this paper
• Simulation of psychosis by continuous delivery of phencyclidine from controlled-release polymer implants.

  1998cited by this paper
• The delayed effects of phencyclidine (PCP) disrupt latent inhibition in a conditioned taste aversion paradigm.

  1998cited by this paper
• Positive and negative regulatory mechanisms that mediate long-term memory storage.

  1998cited by this paper
• Ameliorating effects of rolipram on experimentally induced impairments of learning and memory in rodents.

  1997cited by this paper
• Genetic demonstration of a role for PKA in the late phase of LTP and in hippocampus-based long-term memory.

  1997cited by this paper
• A pivotal role for glutamate in the pathogenesis of schizophrenia, and its cognitive dysfunction.

  1997cited by this paper
• Multiplicity within cyclic nucleotide phosphodiesterases.

  1996cited by this paper
• Synaptic plasticity: the basis of particular types of learning.

  1996cited by this paper
• Latent inhibition in schizophrenia.

  1996cited by this paper
• Latent inhibition in humans: data, theory, and implications for schizophrenia.

  1995cited by this paper
• Hippocampal lesions disrupt decrements but not increments in conditioned stimulus processing

  1995cited by this paper
• Effects of the NMDA receptor antagonist ketamine on flavor memory: conditioned aversion, latent inhibition, and habituation of neophobia.

  1994cited by this paper
• Requirement of a critical period of transcription for induction of a late phase of LTP.

  1994cited by this paper
• Latent inhibition of the rat eyeblink response: effect of hippocampal aspiration lesions.

  1994cited by this paper
• Inhibition of protein synthesis by the NMDA channel blocker MK-801.

  1994cited by this paper
• Information processing and attention dysfunctions in schizophrenia.

  1993cited by this paper
• Phencyclidine does not disrupt latent inhibition in rats: implications for animal models of schizophrenia.

  1992cited by this paper
• Forskolin Stimulation of Cyclic AMP Accumulation in Rat Brain Cortex Slices Is Markedly Enhanced by Endogenous Adenosine

  1992cited by this paper
• The neuropsychology of schizophrenia

  1991cited by this paper
• N-methyl-D-aspartate receptor activation increases cAMP levels and voltage-gated Ca2+ channel activity in area CA1 of hippocampus.

  1991cited by this paper
• In Vivo Measurement of Extracellular Cyclic AMP in the Brain: Use in Studies of β‐Adrenoceptor Function in Nonanesthetized Rats

  1990cited by this paper
• Autoradiographic mapping of a selective cyclic adenosine monophosphate phosphodiesterase in rat brain with the antidepressant [3H]rolipram.

  1989cited by this paper
• Pharmacokinetics of rolipram in the rhesus and cynomolgus monkeys, the rat and the rabbit. Studies on species differences.

  1988cited by this paper
• Influence of rolipram on the cyclic 3',5'-adenosine monophosphate response to histamine and adenosine in slices of guinea-pig cerebral cortex.

  1988cited by this paper
• Multiple isozymes of cyclic nucleotide phosphodiesterase.

  1988cited by this paper
• Hippocampal Lesions Attenuate Latent Inhibition and the Decline of the Orienting Response in Rats

  1987cited by this paper
• Stereospecific binding of the antidepressant rolipram to brain protein structures.

  1986cited by this paper
• Mutations affect storage and use of memory differentially in Drosophila.

  1983cited by this paper
• Brain cyclic AMP and memory in mice.

  1982cited by this paper
• Inhibitory effect of preirradiation saccharin habituation on conditioned avoidance behavior.

  1963cited by this paper

• Roflumilast and cognition enhancement: A translational perspective.

  2024cites this paper
• Neuronal lack of PDE7a disrupted working memory, spatial learning, and memory but facilitated cued fear memory in mice.

  2022cites this paper
• Pharmacokinetics and pharmacodynamics of nitric oxide mimetic agents.

  2019cites this paper
• A Nonhuman Primate PET Study: Measurement of Brain PDE4 Occupancy by Roflumilast Using (R)-[11C]Rolipram

  2018cites this paper
• An experimental medicine study of the phosphodiesterase-4 inhibitor, roflumilast, on working memory-related brain activity and episodic memory in schizophrenia patients

  2018cites this paper
• Mechanisms underlying executive function deficits

  2017cites this paper
• An examination of the roles of glutamate and sex in latent inhibition: Relevance to the glutamate hypothesis of schizophrenia?

  2017cites this paper
• Targeting phosphodiesterase type 4 for improving cognitive fronto-striatal functioning: a translational approach

  2017influential citation
• Specific Inhibition of Phosphodiesterase-4B Results in Anxiolysis and Facilitates Memory Acquisition

  2017cites this paper
• Specific Inhibition of Phosphodiesterase-4B Results in Anxiolysis and Facilitates Memory Acquisition

  2015cites this paper
• PDE and cognitive processing: beyond the memory domain.

  2015influential citation
• Effects of Selective Phosphodiesterases-4 Inhibitors on Learning and Memory: A Review of Recent Research

  2014cites this paper
• Disrupted-In-Schizophrenia-1 (DISC1) interactome and mental disorders: impact of mouse models.

  2014cites this paper
• The importance of glia in dealing with stress.

  2014cites this paper
• Latent inhibition of a conditioned taste aversion in fetal rats.

  2014cites this paper
• Inhibition of Cyclic Nucleotide Phosphodiesterases to Regulate Memory

  2014cites this paper
• Dual inhibitor of PDE7 and GSK-3-VP1.15 acts as antipsychotic and cognitive enhancer in C57BL/6J mice.

  2013cites this paper
• PDE4 as a target for cognition enhancement

  2013cites this paper
• Leading compounds for the validation of animal models of psychopathology

  2013cites this paper
• Evaluating the links between schizophrenia and sleep and circadian rhythm disruption

  2012cites this paper
• The startle response as a measure in mouse models of mood disorders

  2012cites this paper
• Effect of the NMDA antagonist MK-801 on latent inhibition of fear conditioning.

  2012cites this paper
• Synergistic interactions between PDE4B and GSK-3: DISC1 mutant mice.

  2012influential citation
• PDE4 inhibition enhances hippocampal synaptic plasticity in vivo and rescues MK801-induced impairment of long-term potentiation and object recognition memory in an animal model of psychosis

  2012cites this paper
• Genetic and pharmacological evidence for schizophrenia‐related Disc1 interaction with GSK‐3

  2011cites this paper
• Parametric and pharmacological modulations of latent inhibition in mouse inbred strains.

  2011cites this paper
• Conditioned avoidance response in the development of new antipsychotics.

  2010cites this paper
• Advanced research on dopamine signaling to develop drugs for the treatment of mental disorders: biochemical and behavioral profiles of phosphodiesterase inhibition in dopaminergic neurotransmission.

  2010cites this paper
• Effects of Memantine on Latent Inhibition of Active Avoidance in Wistar Rats

  2009cites this paper
• Regulation of amygdalar PKA by β-arrestin-2/phosphodiesterase-4 complex is critical for fear conditioning

  2009cites this paper
• Behavioral and neurochemical characterization of mice deficient in the phosphodiesterase-4B (PDE4B) enzyme

  2008cites this paper
• Positive association of the PDE4B (phosphodiesterase 4B) gene with schizophrenia in the Japanese population.

  2008cites this paper
• Abnormally persistent latent inhibition induced by MK801 is reversed by risperidone and by positive modulators of NMDA receptor function: differential efficacy depending on the stage of the task at which they are administered

  2008cites this paper
• Distinct Roles of PDE4 and PDE10A in the Regulation of cAMP/PKA Signaling in the Striatum

  2008cites this paper
• The Role of Phosphodiesterases in Schizophrenia

  2008cites this paper
• Antipsychotic-Like Properties of Phosphodiesterase 4 Inhibitors: Evaluation of 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone (RO-20-1724) with Auditory Event-Related Potentials and Prepulse Inhibition of Startle

  2008cites this paper
• Title The Effect of Context and CS Preexposure on Acquisition of the Classically Conditioned Eyeblink Response in Rats Permalink

  2007cites this paper
• Signal transduction mechanisms within the entorhinal cortex that support latent inhibition of cued fear conditioning.

  2007influential citation
• Phosphodiesterase 10A inhibitors as a novel therapeutic approach for schizophrenia

  2007cites this paper
• Antipsychotic profile of rolipram: efficacy in rats and reduced sensitivity in mice deficient in the phosphodiesterase-4B (PDE4B) enzyme

  2007influential citation
• Rolipram: a specific phosphodiesterase 4 inhibitor with potential antipsychotic activity.

  2007cites this paper
• Constitutive Activation of Gαs within Forebrain Neurons Causes Deficits in Sensorimotor Gating Because of PKA-Dependent Decreases in cAMP

  2007cites this paper
• The Effect of Context and CS Preexposure on Acquisition of the Classically Conditioned Eyeblink Response in Rats

  2006cites this paper
• Coantagonism of glutamate receptors and nicotinic acetylcholinergic receptors disrupts fear conditioning and latent inhibition of fear conditioning.

  2005cites this paper