SKF-83959 is not a highly-biased functionally selective D1 dopamine receptor ligand with activity at phospholipase C.

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Neuropharmacology

• Publication date

  2014-11-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/j.neuropharm.2014.05.042PMID 24929112PMCID PMC4188748
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Effects of the D1 Dopamine Receptor Agonist Dihydrexidine (DAR-0100A) on Working Memory in Schizotypal Personality Disorder

  2015cited by this paper
• Heteromeric Dopamine Receptor Signaling Complexes: Emerging Neurobiology and Disease Relevance

  2014cited by this paper
• D1-D2 Dopamine Receptor Synergy Promotes Calcium Signaling via Multiple Mechanisms

  2013cited by this paper
• Evaluation of D1 and D2 Dopamine Receptor Segregation in the Developing Striatum Using BAC Transgenic Mice

  2013cited by this paper
• SKF83959 Is a Potent Allosteric Modulator of Sigma-1 Receptor

  2013cited by this paper
• Ligand-Specific Roles for Transmembrane 5 Serine Residues in the Binding and Efficacy of Dopamine D1 Receptor Catechol Agonists

  2012cited by this paper
• Dopamine D1 receptors regulate type 1 inositol 1,4,5‐trisphosphate receptor expression via both AP‐1‐ and NFATc4‐mediated transcriptional processes

  2012cited by this paper
• The Dopamine D1–D2 Receptor Heteromer in Striatal Medium Spiny Neurons: Evidence for a Third Distinct Neuronal Pathway in Basal Ganglia

  2011cited by this paper
• A Dopamine D1 Receptor-Dependent β-Arrestin Signaling Complex Potentially Regulates Morphine-Induced Psychomotor Activation but not Reward in Mice

  2011cited by this paper
• Dopamine D1-D2 receptor heteromer signaling pathway in the brain: emerging physiological relevance

  2011cited by this paper
• Third generation antipsychotic drugs: partial agonism or receptor functional selectivity?

  2010cited by this paper
• The Dopamine D1-D2 Receptor Heteromer Localizes in Dynorphin/Enkephalin Neurons

  2010cited by this paper
• Assessment of jaw movements by magnetic sensor in relation to topographies of orofacial behaviour in freely moving rats: Studies with the dopamine D(1)-like receptor agonists SKF 83822 vs SKF 83959.

  2010cited by this paper
• Activation of Phosphatidylinositol-linked Novel D1 Dopamine Receptor Contributes to the Calcium Mobilization in Cultured Rat Prefrontal Cortical Astrocytes

  2009cited by this paper
• Functional selectivity of G protein-coupled receptor ligands : new opportunities for drug discovery

  2009cited by this paper
• Rapid, semi-automated, and inexpensive radioimmunoassay of cAMP: application in GPCR-mediated adenylate cyclase assays.

  2009cited by this paper
• Activation of Phosphatidylinositol-Linked D1-Like Receptor Modulates FGF-2 Expression in Astrocytes via IP3-Dependent Ca2+ Signaling

  2009cited by this paper
• Phosphatidylinositol-linked novel D(1) dopamine receptor facilitates long-term depression in rat hippocampal CA1 synapses.

  2009cited by this paper
• Calcium signaling cascade links dopamine D1–D2 receptor heteromer to striatal BDNF production and neuronal growth

  2009cited by this paper
• Neuroprotective effects of atypical D1 receptor agonist SKF83959 are mediated via D1 receptor‐dependent inhibition of glycogen synthase kinase‐3β and a receptor‐independent anti‐oxidative action

  2008cited by this paper
• GPCR functional selectivity has therapeutic impact.

  2007cited by this paper
• Neuronal Gq/11-coupled dopamine receptors: an uncharted role for dopamine.

  2007cited by this paper
• Functional Selectivity and Classical Concepts of Quantitative Pharmacology

  2007cited by this paper
• Collateral efficacy in drug discovery: taking advantage of the good (allosteric) nature of 7TM receptors.

  2007cited by this paper
• D1–D2 dopamine receptor heterooligomers with unique pharmacology are coupled to rapid activation of Gq/11 in the striatum

  2007cited by this paper
• Chronic SKF83959 induced less severe dyskinesia and attenuated L-DOPA-induced dyskinesia in 6-OHDA-lesioned rat model of Parkinson's disease.

  2007cited by this paper
• Oxidative stress reduces renal dopamine D1 receptor-Gq/11alpha G protein-phospholipase C signaling involving G protein-coupled receptor kinase 2.

  2007cited by this paper
• The role of the phosphatidyinositol-linked D1 dopamine receptor in the pharmacology of SKF83959.

  2005cited by this paper
• Seven-transmembrane receptor signaling through beta-arrestin.

  2005cited by this paper
• Seven-Transmembrane Receptor Signaling Through β-Arrestin

  2005cited by this paper
• Differential Activation of Adenylate Cyclase and Receptor Internalization by Novel Dopamine D1 Receptor Agonists

  2005cited by this paper
• The paradoxical effects of SKF83959, a novel dopamine D1-like receptor agonist, in the rat acoustic startle reflex paradigm.

  2005cited by this paper
• Dopamine Receptor Signaling

  2004cited by this paper
• Dopamine D1 and D2 Receptor Co-activation Generates a Novel Phospholipase C-mediated Calcium Signal*

  2004cited by this paper
• Desensitization of G protein-coupled receptors and neuronal functions.

  2004cited by this paper
• SK&F 83822 distinguishes adenylyl cyclase from phospholipase C-coupled dopamine D1-like receptors: behavioural topography.

  2004cited by this paper
• SKF83959 selectively regulates phosphatidylinositol‐linked D1 dopamine receptors in rat brain

  2003cited by this paper
• Aripiprazole, A Novel Atypical Antipsychotic Drug with a Unique and Robust Pharmacology

  2003cited by this paper
• Receptor affinities of dopamine D1 receptor-selective novel phenylbenzazepines.

  2003cited by this paper
• Lithocholylcholine, a Bile Acid/Acetylcholine Hybrid, Is a Muscarinic Receptor Antagonist

  2002cited by this paper
• Aripiprazole, a Novel Antipsychotic, Is a High-Affinity Partial Agonist at Human Dopamine D2 Receptors

  2002cited by this paper
• SKF83959 exhibits biochemical agonism by stimulating [35S]GTPγS binding and phosphoinositide hydrolysis in rat and monkey brain

  2001cited by this paper
• Dinapsoline: characterization of a D1 dopamine receptor agonist in a rat model of Parkinson's disease.

  2001cited by this paper
• Parkinson's disease and D1 dopamine receptors.

  2001cited by this paper
• SKF83959 exhibits biochemical agonism by stimulating [(35)S]GTP gamma S binding and phosphoinositide hydrolysis in rat and monkey brain.

  2001cited by this paper
• Phenotypical characterization of the neurons expressing the D1 and D2 dopamine receptors in the monkey striatum

  2000cited by this paper
• Sub-chronic administration of the dopamine D1 antagonist SKF 83959 in bilaterally MPTP-treated rhesus monkeys: stable therapeutic effects and wearing-off dyskinesia

  1999cited by this paper
• Functional comparison of muscarinic partial agonists at muscarinic receptor subtypes hM1, hM2, hM3, hM4 and hM5 using microphysiometry

  1999cited by this paper
• ABT‐431, a D1 receptor agonist prodrug, has efficacy in Parkinson's disease

  1999cited by this paper
• Interactions of the Novel Antipsychotic Aripiprazole (OPC-14597) with Dopamine and Serotonin Receptor Subtypes

  1999cited by this paper
• Effects of the Full Dopamine Dl Receptor Agonist Dihydrexidine in Parkinson's Disease

  1998cited by this paper
• D1-like dopaminergic activation of phosphoinositide hydrolysis is independent of D1A dopamine receptors: evidence from D1A knockout mice.

  1997cited by this paper
• Comparison of [3H]Phosphatidylinositol and [3H]Phosphatidylinositol 4,5‐Bisphosphate Hydrolysis in Postmortem Human Brain Membranes and Characterization of Stimulation by Dopamine D1 Receptors

  1997cited by this paper
• D1 agonist dihydrexidine releases acetylcholine and improves cognitive performance in rats.

  1997cited by this paper
• Positive cooperativity of acetylcholine and other agonists with allosteric ligands on muscarinic acetylcholine receptors.

  1997cited by this paper
• The D1 Agonist Dihydrexidine Releases Acetylcholine and Improves Cognition in Rats

  1996cited by this paper
• The role of dopamine in epilepsy

  1996cited by this paper
• Spare receptors and intrinsic activity: Studies with D1 dopamine receptor agonists

  1995cited by this paper
• Pharmacological characterization of behavioural responses to SK&F 83959 in relation to ‘D1‐like’ dopamine receptors not linked to adenylyl cyclase

  1995cited by this paper
• Stimulation of adenylate cyclase activity by benzazepine D-1 dopamine agonists with varying efficacies in the 6-hydroxydopamine lesioned rat--relationship to circling behaviour.

  1995cited by this paper
• 7-(4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butyloxy)-3,4-dihydro-2(1H)-quinolinone (OPC-14597), a new putative antipsychotic drug with both presynaptic dopamine autoreceptor agonistic activity and postsynaptic D2 receptor antagonistic activity.

  1995cited by this paper
• Differential anti-parkinsonian effects of benzazepine D1 dopamine agonists with varying efficacies in the MPTP-treated common marmoset

  1995cited by this paper
• D1 and D2 dopamine receptor gene expression in the rat striatum: Sensitive cRNA probes demonstrate prominent segregation of D1 and D2 mRNAS in distinct neuronal populations of the dorsal and ventral striatum

  1995cited by this paper
• Evidence for a Distinct D1Like Dopamine Receptor that Couples to Activation of Phosphoinositide Metabolism in Brain

  1994cited by this paper
• Effects of dihydrexidine, a full dopamine D-1 receptor agonist, on delayed response performance in chronic low dose MPTP-treated monkeys.

  1994cited by this paper
• Inhibition of Dopamine Agonist‐Induced Phosphoinositide Hydrolysis by Concomitant Stimulation of Cyclic AMP Formation in Brain Slices

  1994cited by this paper
• A common action of clozapine, haloperidol, and remoxipride on D1- and D2-dopaminergic receptors in the primate cerebral cortex.

  1994cited by this paper
• Dopamine D1 receptor mechanisms in the cognitive performance of young adult and aged monkeys

  1994cited by this paper
• Dopamine D1 receptors: efficacy of full (dihydrexidine) vs. partial (SKF38393) agonists in primates vs. rodents.

  1993cited by this paper
• Grooming and vacuous chewing induced by SK&F 83959, an agonist of dopamine 'D1-like' receptors that inhibits dopamine-sensitive adenylyl cyclase.

  1993cited by this paper
• Effects of repeated dopamine D1 receptor stimulation on rotation and c-fos expression.

  1993cited by this paper
• Selective dopaminergic mechanism of dopamine and SKF38393 stimulation of inositol phosphate formation in rat brain.

  1992cited by this paper
• Characterization of receptors involved in dopamine-induced activation of phospholipase-C in rat renal cortex.

  1992cited by this paper
• Partial and full dopamine D1 receptor agonists in mice and rats: relation between behavioural effects and stimulation of adenylate cyclase activity in vitro.

  1992cited by this paper
• Dihydrexidine, a full dopamine D1 agonist, reduces MPTP-induced parkinsonism in monkeys.

  1991cited by this paper
• Expression of striatal D1 dopamine receptors coupled to inositol phosphate production and Ca2+ mobilization in Xenopus oocytes.

  1990cited by this paper
• Stimulation of a dopamine D1 receptor enhances inositol phosphates formation in rat brain.

  1990cited by this paper
• Effects of dopamine on phosphoinositide hydrolysis in slices of rat striatum and cortex.

  1990cited by this paper
• D1 and D2 dopamine receptor-regulated gene expression of striatonigral and striatopallidal neurons.

  1990cited by this paper
• The dopamine-1 agonist, SKF 82526, stimulates phospholipase-C activity independent of adenylate cyclase.

  1989cited by this paper
• Dopamine-1-mediated stimulation of phospholipase C activity in rat renal cortical membranes.

  1989cited by this paper
• A rapid method for the regional dissection of the rat brain.

  1980cited by this paper
• The central effects of a novel dopamine agonist.

  1978cited by this paper
• Femtomole sensitive radioimmunoassay for cyclic AMP and cyclic GMP after 2'0 acetylation by acetic anhydride in aqueous solution.

  1975cited by this paper

• Intracellular GPCR modulators enable precision pharmacology

  2025cites this paper
• Receptor dimers and biased ligands: Novel strategies for targeting G protein-coupled receptors.

  2025cites this paper
• G Protein-Coupled Receptor Dimerization—What Next?

  2024cites this paper
• Effects of DPTQ, a novel positive allosteric modulator of the dopamine D1 receptor, on spontaneous eye blink rate and spatial working memory in the nonhuman primate

  2023cites this paper
• Ligand recognition and biased agonism of the D1 dopamine receptor

  2022cites this paper
• GPCR heteromers: An overview of their classification, function and physiological relevance

  2022cites this paper
• Structural insights into the human D1 and D2 dopamine receptor signaling complexes.

  2021cites this paper
• Functional Selectivity of Dopamine D1 Receptor Signaling: Retrospect and Prospect

  2021cites this paper
• Inhibition of striatal dopamine D5 receptor attenuates levodopa-induced dyskinesia in a rat model of Parkinson's disease.

  2021cites this paper
• A Complete Assessment of Dopamine Receptor- Ligand Interactions through Computational Methods

  2019influential citation
• Modulation and functions of dopamine receptor heteromers in drugs of abuse-induced adaptations.

  2019cites this paper
• Contrasting patterns of ERK activation in the tail of the striatum in response to aversive and rewarding signals

  2019cites this paper
• Cancer and the Dopamine D2 Receptor: A Pharmacological Perspective

  2019cites this paper
• Targeting the receptor-based interactome of the dopamine D1 receptor: looking for heteromer-selective drugs

  2019influential citation
• Dopaminergic Facilitation of Synaptic Transmission in Layer II of the Lateral Entorhinal Cortex

  2018cites this paper
• D1 dopamine receptors intrinsic activity and functional selectivity affect working memory in prefrontal cortex

  2018cites this paper
• Late effect of dopamine D1/5 receptor activation on stimulus‐induced BOLD responses in the hippocampus and its target regions depends on the history of previous stimulations

  2017cites this paper
• Extreme Vetting of Dopamine Receptor Oligomerization

  2017cites this paper
• Novel Dopamine Therapeutics for Cognitive Deficits in Schizophrenia.

  2017cites this paper
• Polypharmacology of dopamine receptor ligands.

  2016cites this paper
• Age-Dependent D1-D2 Receptor Coactivation in the Lateral Orbitofrontal Cortex Potentiates NMDA Receptors and Facilitates Cognitive Flexibility.

  2016cites this paper
• Regulation of Dopamine-Dependent Behaviors by G Protein-Coupled Receptor Kinases

  2016cites this paper
• The Role of the Dopamine D1-D2 Receptor Heteromer in Brain Reward Function: Relevance to Drug Addiction and Depression

  2015cites this paper
• Activation of D1-like receptor-dependent phosphatidylinositol signal pathway by SKF83959 inhibits voltage-gated sodium channels in cultured striatal neurons.

  2015cites this paper
• Regulation of c-fos expression by the dopamine D1-D2 receptor heteromer.

  2015cites this paper
• Activation of Phosphatidylinositol-Linked Dopamine Receptors Induces a Facilitation of Glutamate-Mediated Synaptic Transmission in the Lateral Entorhinal Cortex

  2015cites this paper
• Identification of G protein-biased agonists that fail to recruit β-arrestin or promote internalization of the D1 dopamine receptor.

  2015cites this paper
• Dopamine receptors – IUPHAR Review 13

  2015influential citation
• Evidence for limited D1 and D2 receptor coexpression and colocalization within the dorsal striatum of the neonatal mouse

  2015cites this paper
• NC-IUPHAR REVIEW Dopamine receptors - IUPHAR Review 13

  2015cites this paper
• The dopamine D1-D2 receptor heteromer exerts a tonic inhibitory effect on the expression of amphetamine-induced locomotor sensitization.

  2015cites this paper
• Evidence against dopamine D1/D2 receptor heteromers

  2014cites this paper
• Dopamine D1 Receptor Signaling: Does GαQ–Phospholipase C Actually Play a Role?

  2014influential citation