Carcinogenicity, DNA adduct formation and K-ras activation by 7H-dibenzo[c,g]carbazole in strain A/J mouse lung.

No abstract is available for this paper.

• Publication year

  1996

• Venue

  Carcinogenesis

• Publication date

  1996-04-01

• Fields of study

  Medicine, Chemistry, Environmental Science

• Identifiers
  DOI 10.1093/CARCIN/17.4.865PMID 8625502
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Target Organ Specificity For N-Heterocyclic Aromatics

  1994cited by this paper
• Tumor multiplicity, DNA adducts and K-ras mutation pattern of 5-methylchrysene in strain A/J mouse lung.

  1994cited by this paper
• Tissue distribution of DNA adducts of 7H-dibenzo[c,g]carbazole and its derivatives in mice following topical application.

  1994cited by this paper
• Cyclopenta[cd]pyrene-induced tumorigenicity, Ki-ras codon 12 mutations and DNA adducts in strain A/J mouse lung.

  1994cited by this paper
• Carcinogenicity of 7H-dibenzo[c,g]carbazole, dibenz[a,j]acridine and benzo[a]pyrene in mouse skin and liver following topical application.

  1994cited by this paper
• Dose-dependent ras mutation spectra in N-nitrosodiethylamine induced mouse liver tumors and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone induced mouse lung tumors.

  1993cited by this paper
• Ki‐ras oncogene mutations in tumors and DNA adducts formed by benz[j]aceanthrylene and benzo[a]pyrene in the lungs of strain A/J mice

  1993cited by this paper
• Parental bias of Ki-ras oncogenes detected in lung tumors from mouse hybrids.

  1992cited by this paper
• Comparative tumor-initiating ability of 7H-dibenzo(c,g)carbazole and dibenz(a,j)acridine in mouse skin.

  1992cited by this paper
• Role of proto-oncogene activation in carcinogenesis.

  1992cited by this paper
• Analysis of point mutations in murine c‐Ha‐ras of skin tumors initiated with dibenz[a,j]anthracene and derivatives

  1992cited by this paper
• DNA adduct measurements and tumor incidence during chronic carcinogen exposure in animal models: implications for DNA adduct-based human cancer risk assessment.

  1992cited by this paper
• Protooncogene activation in spontaneously occurring and chemically induced rodent and human lung tumors.

  1992cited by this paper
• Comparative metabolism of 7H-dibenzo[c,g]carbazole and dibenz[a,j]acridine by mouse and rat liver microsomes.

  1992cited by this paper
• 32P-postlabelling and mass spectrometric methods for analysis of bulky, polyaromatic carcinogen-DNA adducts in humans.

  1992cited by this paper
• Environmental sources, carcinogenicity, mutagenicity, metabolism and DNA binding of nitrogen and sulfur heterocyclic aromatics

  1992cited by this paper
• Lung tumors in strain A mice as a bioassay for carcinogenicity of environmental chemicals.

  1991cited by this paper
• Activation of protooncogenes in mouse lung tumors.

  1991cited by this paper
• Detection and characterization of carcinogen-DNA adducts in exfoliated urothelial cells from 4-aminobiphenyl-treated dogs by 32P-postlabelling and subsequent thin-layer and high-pressure liquid chromatography.

  1990cited by this paper
• Binding of 7H-dibenzo[c,g]carbazole to polynucleotides and DNA in vitro.

  1989cited by this paper
• Molecular analysis of spontaneous mutations at the gpt locus in Chinese hamster ovary (AS52) cells.

  1989cited by this paper
• Rapid and sensitive detection of point mutations and DNA polymorphisms using the polymerase chain reaction.

  1989cited by this paper
• Activation of the Ki-ras protooncogene in spontaneously occurring and chemically induced lung tumors of the strain A mouse.

  1989cited by this paper
• Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase.

  1988cited by this paper
• The correlation between DNA adducts and chromosomal aberrations in the target organ of benzidine exposed, partially-hepatectomized mice.

  1987cited by this paper
• Comparative carcinogenic potencies of 7H-dibenzo[c,g]carbazole, dibenz[a,j]acridine and benzo[a]pyrene in mouse skin.

  1987cited by this paper
• 32P-postlabeling analysis of DNA adduction in mice by synthetic metabolites of the environmental carcinogen, 7H-dibenzo[c,g]carbazole: chromatographic evidence for 3-hydroxy-7H-dibenzo[c,g]carbazole being a proximate genotoxicant in liver but not skin.

  1987cited by this paper
• Statistics and experimental design for toxicologists

  1986cited by this paper
• Dibenz[a,j]acridine metabolism: identification of in vitro products formed by liver microsomes from 3-methylcholanthrene-pretreated rats.

  1986cited by this paper
• Mutagenesis of the Ha-ras oncogene in mouse skin tumors induced by polycyclic aromatic hydrocarbons.

  1986cited by this paper
• Structure and expression of amplified cKi‐ras gene sequences in Y1 mouse adrenal tumor cells.

  1985cited by this paper
• 32P-postlabeling analysis of DNA adducts persisting for up to 42 weeks in the skin, epidermis and dermis of mice treated topically with 7,12-dimethylbenz[a]anthracene.

  1985cited by this paper
• Polycyclic Aromatic Hydrocarbon-DNA Adducts: Formation, Detection, and Characterization

  1985cited by this paper
• Nonrandom binding of the carcinogen N-hydroxy-2-acetylaminofluorene to repetitive sequences of rat liver DNA in vivo.

  1984cited by this paper
• 32P-postlabeling analysis of non-radioactive aromatic carcinogen--DNA adducts.

  1982cited by this paper
• 32P-labeling test for DNA damage.

  1981cited by this paper
• Heterocyclic polycyclic aromatic hydrocarbon carcinogenesis: 7H-dibenzo[c,g]carbazole metabolism by microsomal enzymes from mouse and rat liver.

  1981cited by this paper
• Polycyclic organic matter (POM) and trace element contents of carbon black vent gas.

  1980cited by this paper
• The enzymatic preparation of [alpha-32P]ATP, [alpha-32P]GTP, [32P]cAMP, and [32P]cGMP, and their use in the assay of adenylate and guanylate cyclases and cyclic nucleotide phosphodiesterases.

  1979cited by this paper
• Carcinogenicity of 7H-dibenzo[c,g]carbazole in the respiratory tract of hamsters.

  1972cited by this paper
• The carcinogenic nitrogen heterocyclics in cigarette-smoke condensate.

  1960cited by this paper
• Induction of epithelial neoplasms in the urinary bladder of the dog by intravesical injection of a chemical carcinogen.

  1954cited by this paper
• Squamous Carcinoma of the Forestomach and other Lesions in Mice following Oral Administration of 3:4:5:6-Dibenzcarbazole

  1950cited by this paper
• The influence of methylation on carcinogenic activity; N-methyl-3 : 4 : 5 : 6-dibenzcarbazole.

  1946cited by this paper
• Hepatic Changes and Subcutaneous and Pulmonary Tumors Induced by Subcutaneous Injection of 3,4,5,6-Dibenzcarbazole

  1941cited by this paper
• Biologic Testing of Carcinogens. II. Pulmonary-Tumor-Induction Technique

  1940cited by this paper
• Induction of Tumors by 3:4:5:6-Dibenzcarbazole in Male Mice of the CBA Strain, which Develops Spontaneous Hepatoma *

  1938cited by this paper
• Mutagenesis of the Haras oncogene in mouse skin tumors induced by polycyclic aromatic hydrocarbons ( chemical carcinogenesis / carcinomas / DNA transfection / paplilomas / restriction fragment length polymorphism )

  year unknowncited by this paper

• 7H-Dibenzo[c,g]carbazole: Metabolic pathways and toxicity.

  2020cites this paper
• One-pot heterocyclic ring closure of 1,1′-bi-2-naphthol to 7H-dibenzo[c,g]carbazole

  2018cites this paper
• The additive to background assumption in cancer risk assessment: A reappraisal

  2018cites this paper
• Bitumens and Bitumen emissions, and some N - and S -Heterocyclic Polycyclic aromatic HydrocarBons

  2013influential citation
• SOME N- AND S-HETEROCYCLIC POLYCYCLIC AROMATIC HYDROCARBONS

  2013influential citation
• UvA-DARE ( Digital Academic Repository ) Toxicity of azaarenes : mechanisms and metabolism

  2012cites this paper
• Toxicity of azaarenes : mechanisms and metabolism

  2012cites this paper
• Polycyclic Aromatic Hydrocarbons : 15 Listings

  2011cites this paper
• Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis

  2009cites this paper
• Differences in DNA damage and repair produced by systemic, hepatocarcinogenic and sarcomagenic dibenzocarbazole derivatives in a model of rat liver progenitor cells.

  2009cites this paper
• 7H-dibenzo[c,g]carbazole metabolism by the mouse and human CYP1 family of enzymes.

  2007cites this paper
• Impact of Cyp1a2 or Ahr gene knockout in mice: implications for biomonitoring studies.

  2006cites this paper
• Genetic alterations in cancer knowledge system: analysis of gene mutations in mouse and human liver and lung tumors.

  2006cites this paper
• DNA adduct formation by 7H‐dibenzo[c,g]carbazole and its tissue‐ and organ‐specific derivatives in Chinese hamster V79 cell lines stably expressing cytochrome P450 enzymes

  2004influential citation
• Clastogenicity of carbazole in mouse bone marrow cells in vivo.

  2002cites this paper
• A metabolic activation mechanism of 7H-dibenzo[c,g]carbazole via o-quinone. Part 2: covalent adducts of 7H-dibenzo[c,g]carbazole-3,4-dione with nucleic acid bases and nucleosides.

  2002cites this paper
• Mutagenicity of 7H-dibenzo[c,g]carbazole and its tissue specific derivatives in genetically engineered Chinese hamster V79 cell lines stably expressing cytochrome P450.

  2002cites this paper
• In vitro toxicity of 7H-dibenzo[c,g]carbazole in human liver cell lines.

  2002cites this paper
• THE EFFECTS OF A BINARY MIXTURE OF BENZO(a)PYRENE AND 7H-DIBENZO(c,g)CARBAZOLE ON LUNG TUMORS AND K-RAS ONCOGENE MUTATIONS IN STRAIN A/J MICE

  2001influential citation
• Comparison of Ha‐ras mutational spectra of N‐methyldibenzo[c,g]carbazole and 7H‐dibenzo[c,g]carbazole–induced mouse skin tumors

  2001influential citation
• The effects of a binary mixture of benzo(a)pyrene and 7H-dibenzo(c,g)carbazole on lung tumors and K-ras oncogene mutations in strain A/J mice.

  2001cites this paper
• Comparison of N-Heterocyclic Aromatics Dibenzo[c,g]Carbazole and Dibenz[a,j]Acridine : Metabolism, DNA Binding and Mutation

  2000cites this paper
• Comparative Oncogenic Activation of 7H-Dibenzo[C, G]Carbazole and Dibenz[A, J]Acridine

  2000cites this paper
• DNA adduct formation in northern pike (Esox lucius) exposed to a mixture of benzo[a]pyrene, benzo[k]fluoranthene and 7H-dibenzo[c, g]carbazole: time-course and dose-response studies.

  2000cites this paper
• Frequent Ha‐ras mutations in murine skin and liver tumors induced by 7H‐dibenzo[c,g]carbazole

  1999cites this paper
• Mutations in ras genes in experimental tumours of rodents.

  1999cites this paper
• DNA adduct formation and persistence in liver and extrahepatic tissues of northern pike (Esox lucius) following oral exposure to benzo[a]pyrene, benzo[k]fluoranthene and 7H-dibenzo[c,g]carbazole.

  1999cites this paper
• Toxicity of azaarenes: mechanisms and metabolism.

  1999cites this paper
• At least four loci and gender are associated with susceptibility to the chemical induction of lung adenomas in A/J x BALB/c mice.

  1998cites this paper
• Biological effect markers for exposure to carcinogenic compound and their relevance for risk assessment.

  1998cites this paper
• Modulation of ras p21 oncoprotein levels and DNA strand breakage in human cells with chemotherapeutic agents and/or deferoxamine.

  1998cites this paper
• Dimethylarsinic acid, a main metabolite of inorganic arsenics, has tumorigenicity and progression effects in the pulmonary tumors of A/J mice.

  1998cites this paper
• Tissue‐specific differences in adduct formation by hepatocarcinogenic and sarcomatogenic derivatives of 7H‐dibenzo[c,g]carbazole in mouse parenchymal and nonparenchymal liver cells

  1997cites this paper
• Combination of high-performance liquid chromatography and thin-layer chromatography separation of five adducted nucleotides isolated from liver resulting from intraperitoneal administration with 7H-dibenzo[c,g]carbazole to mice.

  1997cites this paper
• Comparative carcinogenicity, metabolism, mutagenicity, and DNA binding of 7H-dibenzo[c,g]carbazole and dibenz[a,j]acridine.

  1996cites this paper