Quercetin and rutin ameliorates sulphasalazine‐induced spermiotoxicity, alterations in reproductive hormones and steroidogenic enzyme imbalance in rats

No abstract is available for this paper.

• Publication year

  2018

• Venue

  Andrologia

• Publication date

  2018-06-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1111/and.12981PMID 29512831
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2013cited by this paper
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  2012cited by this paper
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  2012cited by this paper
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  2012cited by this paper
• Liver Disorders in Inflammatory Bowel Disease

  2012cited by this paper
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  2012cited by this paper
• Effect of quercetin, rutin, naringenin and epicatechin on lipid peroxidation induced in human sperm.

  2012cited by this paper
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  2012cited by this paper
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  2012cited by this paper
• Sulfasalazine

  2012cited by this paper
• Antioxidant therapy in male infertility: fact or fiction?

  2011cited by this paper
• Flavonoids as anti-inflammatory agents: implications in cancer and cardiovascular disease

  2009cited by this paper
• Sulfasalazine induced oxidative stress: a possible mechanism of male infertility.

  2009influential reference
• Selenium: biochemical role as a component of glutathione peroxidase.

  2009cited by this paper
• Stimulating effects of quercetin on sperm quality and reproductive organs in adult male rats.

  2008cited by this paper
• Effect of T3 treatment on glutathione redox pool and its metabolizing enzymes in mitochondrial and post-mitochondrial fractions of adult rat testes.

  2007cited by this paper
• HISTOLOGICAL DETERMINATION OF SITE OF ANTIFERTILITY ACTION OF SULFASALAZINE IN MALE ALBINO RATS

  2007cited by this paper
• Early changes in sperm motility, acrosome reaction, and gene expression of reproductive organs in rats treated with sulfasalazine.

  2007cited by this paper
• Impact of Ca2+ flux inhibitors on acrosome reaction of hamster spermatozoa.

  2007cited by this paper
• Effects of sulfasalazine on sperm acrosome reaction and gene expression in the male reproductive organs of rats.

  2005cited by this paper
• Mechanisms of male infertility: role of antioxidants.

  2005cited by this paper
• Protein expression analysis of rat testes induced testicular toxicity with several reproductive toxicants.

  2005cited by this paper
• Frequently Asked Questions About the Public Health Service Policy on Humane Care and Use of Laboratory Animals

  2003cited by this paper
• Testicular and spermatotoxic effects of quinalphos in rats

  2003cited by this paper
• Anti-inflammatory effect of rutin on rat paw oedema, and on neutrophils chemotaxis and degranulation.

  2003cited by this paper
• Experimentally induced hypo‐ and hyper‐thyroidism influence on the antioxidant defence system in adult rat testis

  2003cited by this paper
• Anti‐ and pro‐oxidant activity of rutin and quercetin derivatives

  2003cited by this paper
• Sulphasalazine and mesalazine: serious adverse reactions re-evaluated on the basis of suspected adverse reaction reports to the Committee on Safety of Medicines

  2002cited by this paper
• [Therapy of inflammatory bowel disease].

  2002cited by this paper
• Lipid peroxidation and antioxidant enzymes in male infertility.

  2002cited by this paper
• Sulphasalazine and 5-aminosalicylic acid in long-term treatment of ulcerative colitis: report on tolerance and side-effects.

  2001cited by this paper
• Therapy of inflammatory bowel disease.

  2000cited by this paper
• Chemoprevention of 2-acetylaminofluorene-induced hepatotoxicity and lipid peroxidation in rats by kolaviron--a Garcinia kola seed extract.

  2000cited by this paper
• Dietary intake of subjects with alagille syndrome compared to normal subjects in the United States population

  2000cited by this paper
• On the ability of four flavonoids, baicilein, luteolin, naringenin, and quercetin, to suppress the fenton reaction of the iron-ATP complex

  2000cited by this paper
• Pentoxifylline-stimulated capacitation and acrosome reaction in hamster spermatozoa: involvement of intracellular signalling molecules.

  1999cited by this paper
• Effects of sulphapyridine on sperm transport through the rat epididymis and contractility of the epididymal duct.

  1999cited by this paper
• Sulfasalazine for treating rheumatoid arthritis

  1998cited by this paper
• Quercetin metabolites inhibit copper ion‐induced lipid peroxidation in rat plasma 1

  1998cited by this paper
• NTP Toxicology and Carcinogenesis Studies of Salicylazosulfapyridine (CAS No. 599-79-1) in F344/N Rats and B6C3F1 Mice (Gavage Studies).

  1997cited by this paper
• Short-term male reproductive toxicity study with sulfasalazine in the rat.

  1995cited by this paper
• Quercetin metabolites in plasma of rats fed diets containing rutin or quercetin.

  1995cited by this paper
• Sperm motility hyperactivation facilitates penetration of the hamster zona pellucida.

  1995cited by this paper
• Spermatozoal abnormalities and male infertility in the rat following sulfasalazine treatment.

  1994cited by this paper
• Neonatal goitrogen treatment increases adult testis size and sperm production in the mouse.

  1993cited by this paper
• Sulphasalazine in psoriatic arthritis: a double-blind placebo-controlled study.

  1990cited by this paper
• Reversible male infertility due to sulphasalazine: studies in man and rat.

  1984cited by this paper
• Sulphasalazine and male infertility: reversibility and possible mechanism.

  1981cited by this paper
• Incidence of sulphasalazine-induced male infertility.

  1981cited by this paper
• Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction.

  1979cited by this paper
• Male infertility due to sulphasalazine.

  1979cited by this paper
• Male infertility due to sulphasalazine.

  1979cited by this paper
• Glutathione S-transferases. The first enzymatic step in mercapturic acid formation.

  1974cited by this paper
• Bromobenzene-induced liver necrosis. Protective role of glutathione and evidence for 3,4-bromobenzene oxide as the hepatotoxic metabolite.

  1974cited by this paper
• Selenium: Biochemical Role as a Component of Glutathione Peroxidase

  1973cited by this paper
• The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase.

  1972influential reference
• New technique for assessing acrosomal characteristics of spermatozoa.

  1970influential reference
• 生殖腺のHydroxysteroid dehydrogenase(内分泌・生化学)

  1969cited by this paper

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• Anacyclus pyrethrum enhances fertility in cadmium-intoxicated male rats by improving sperm functions

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• Flavonoids as potential therapeutics in male reproductive disorders

  2024cites this paper
• Lotus seed (Nelumbo nucifera Gaertn.) extract at low dose ameliorates reproductive dysfunction in l-NAME-induced hypertension and oxidative stress in male rats

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• The antioxidant/anti‐inflammatory protective effects of rutin against ethanol‐induced testicular perturbation in rats: Involvement of the immunosuppressive indoleamine 2,3‐dioxygenase

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• Therapeutic potential of rutin in male infertility: A mini review.

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• Hesperidin Mitigates Cyclophosphamide-Induced Testicular Dysfunction via Altering the Hypothalamic Pituitary Gonadal Axis and Testicular Steroidogenesis, Inflammation, and Apoptosis in Male Rats

  2023cites this paper
• Potential health benefits of the plant Levisticum officinale (lovage) in relation to its polyphenolic content

  2023cites this paper
• Sulfasalazine exposure during pregnancy and lactation: reproductive outcomes in male rat offspring.

  2023cites this paper
• Quercetin Protects against Levetiracetam induced gonadotoxicity in rats.

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• Pharmacological Activity of Flavonoid Quercetin and Its Therapeutic Potential in Testicular Injury

  2023cites this paper
• Phytotherapeutic Potential of Rutin Against Xenobiotic-Induced Toxicities in Preclinical Models

  2023cites this paper
• Mediterranean Diet as a Shield against Male Infertility and Cancer Risk Induced by Environmental Pollutants: A Focus on Flavonoids

  2022cites this paper
• Sulfasalazine exposure during pregnancy and lactation induces alterations in reproductive behavior in adult female rat offspring.

  2022cites this paper
• Quercetin: Putative Effects on the Function of Cryopreserved Sperms in Domestic Animals.

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• The consequence and mechanism of dietary flavonoids on androgen profiles and disorders amelioration

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• Arrested Acetylene-Induced Pulmonary and Testicular Toxicity in Rats Through Treatment With Polyphenols

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• The Role of Selected Natural Biomolecules in Sperm Production and Functionality

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• Impact of Quercetin on Sperm Parameters, Testicular Tissue and Sex Hormone: a Systematic Review

  2021influential citation
• Cyclophosphamide‐induced testicular oxidative‐inflammatory injury is accompanied by altered immunosuppressive indoleamine 2, 3‐dioxygenase in Wister rats: Influence of dietary quercetin

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• Ginger reserves testicular spermatogenesis and steroidogenesis in difenoconazole‐intoxicated rats by conducting oxidative stress, apoptosis and proliferation

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  2020cites this paper
• Interplay between male reproductive system dysfunction and the therapeutic effect of flavonoids.

  2020cites this paper
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  2020cites this paper
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  2019cites this paper
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