Renal growth hormone--insulin-like growth factor-I system in acute renal failure.

The renal growth hormone--insulin-like growth factor-I system in acute ischemic renal failure. Recovery from acute tubular necrosis (ATN) is accelerated by IGF-I therapy. Furthermore, the local renal growth hormone-IGF-I system may participate in the natural repair. We examined the IGF-I system in rat kidneys subjected to 60 minute ischemia compared to sham operated controls. Two days after injury, growth hormone receptor mRNA and IGF-I mRNA levels fell approximately 9 to 33% of control values. This was associated with a reduction in kidney immunoreactive IGF-I levels. In contrast, IGF-I receptor mRNA abundance was unchanged. However, plasma membrane IGF-I receptor binding on day 2 and day 7 was near double the control values (P < 0.01). Scatchard analysis revealed a near twofold increase in receptor number. Since receptor mRNA levels were unchanged, this implies receptor protein up-regulation. In contrast to unchanged IGF-I receptor mRNA levels, the abundance of mRNA levels of insulin-like growth factor binding proteins (IGFBP) -2, -3, -4 and -5 fell approximately 14 to 62% of control levels day 2 after injury (P < 0.05), suggesting reduced IGFBP production. Thus, the renal response to ischemic ATN, namely, low IGFBP mRNA levels and high IGF-I receptor number, may function to increase IGF-I bioavailability and thereby enhance the reparative actions of local and circulating IGF-I in ischemic ATN.

• Publication year

  1995

• Venue

  Kidney International

• Publication date

  1995-06-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1038/KI.1995.230PMID 7543960
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The Polymerase Chain Reaction

  2019cited by this paper
• Distribution of IGF-I mRNA and IGF-I binding sites in the rat kidney

  2004cited by this paper
• Recovery from acute ischaemic renal failure is accelerated by des-(1-3)-insulin-like growth factor-1.

  1994cited by this paper
• Enhanced renal IGF-I expression following partial kidney infarction.

  1993cited by this paper
• Effects of rhGH and rhIGF-1 on renal growth and morphology.

  1993cited by this paper
• Recombinant human insulin-like growth factor-I accelerates recovery and reduces catabolism in rats with ischemic acute renal failure.

  1993cited by this paper
• Differential expression of messenger ribonucleic acids encoding insulin-like growth factors and their receptors in human uterine endometrium and decidua.

  1993cited by this paper
• Degradation of spectrin and ankyrin in the ischemic rat kidney.

  1993cited by this paper
• The role of insulin-like growth factors and IGF-binding proteins in the physiological and pathological processes of the kidney

  1992cited by this paper
• Anatomical relationships in the patterns of insulin-like growth factor (IGF)-I, IGF binding protein-1, and IGF-I receptor gene expression in the rat kidney.

  1992cited by this paper
• IGF-I binding and IGF-I mRNA expression in the post-ischemic regenerating rat kidney.

  1992cited by this paper
• Insulin-like growth factor I accelerates recovery from ischemic acute tubular necrosis in the rat.

  1992cited by this paper
• Comparison of extraction methods for insulin-like growth factor-I in rat serum.

  1992cited by this paper
• Insulin-like growth factors I and II are produced in the metanephros and are required for growth and development in vitro

  1991cited by this paper
• IGF-I and its variant, des-(1-3)IGF-I, enhance growth in rats with reduced renal mass.

  1991cited by this paper
• Tissue distribution, characterization, and regulation of messenger ribonucleic acid for growth hormone receptor and serum binding protein in the rat.

  1991cited by this paper
• Colocalization of insulin-like growth factor-binding protein with insulin-like growth factor I.

  1991cited by this paper
• Effects of transforming growth factor-beta, transforming growth factor-alpha, and other growth factors on renal proximal tubule cells.

  1991cited by this paper
• Identification and molecular characterization of insulin-like growth factor binding proteins (IGFBP-1, -2, -3, -4, -5 and -6).

  1991cited by this paper
• Insulin-like growth factor I gene expression in isolated rat renal collecting duct is stimulated by epidermal growth factor.

  1991cited by this paper
• Epidermal growth factor accelerates functional recovery from ischaemic acute tubular necrosis in the rat: role of the epidermal growth factor receptor.

  1990cited by this paper
• Growth hormone stimulates IGF I gene expression in isolated rat renal collecting duct.

  1990cited by this paper
• Changes in gene expression after temporary renal ischemia.

  1990cited by this paper
• The growth hormone-binding protein in rat serum is an alternatively spliced form of the rat growth hormone receptor.

  1989cited by this paper
• Epidermal growth factor enhances renal tubule cell regeneration and repair and accelerates the recovery of renal function in postischemic acute renal failure.

  1989cited by this paper
• The growth hormone-insulin-like growth factor axis in kidney.

  1989cited by this paper
• Evidence that insulin-like growth factor I increases renal plasma flow and glomerular filtration rate in fasted rats.

  1989cited by this paper
• Regulation by fasting of rat insulin-like growth factor I and its receptor. Effects on gene expression and binding.

  1989cited by this paper
• Distribution and regulation of rat insulin-like growth factor I messenger ribonucleic acids encoding alternative carboxyterminal E-peptides: evidence for differential processing and regulation in liver.

  1988cited by this paper
• Distinct receptors for insulin-like growth factor I in rat renal glomeruli and tubules.

  1988cited by this paper
• Risk factors and outcome of hospital-acquired acute renal failure. Clinical epidemiologic study.

  1987cited by this paper
• Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction.

  1987cited by this paper
• Analysis of serum insulin-like growth factor binding proteins using western blotting: use of the method for titration of the binding proteins and competitive binding studies.

  1986cited by this paper
• Isolation and characterization of rat and human glyceraldehyde-3-phosphate dehydrogenase cDNAs: genomic complexity and molecular evolution of the gene.

  1985cited by this paper
• The nature and regulation of the receptors for insulin-like growth factors.

  1985cited by this paper
• Tissue concentrations of somatomedin C: further evidence for multiple sites of synthesis and paracrine or autocrine mechanisms of action.

  1984cited by this paper
• Binding and Degradation of Insulin by Isolated Renal Brush Border Membranes

  1982cited by this paper
• THE ATTRACTIONS OF PROTEINS FOR SMALL MOLECULES AND IONS

  1949cited by this paper

• From renal development to pathology: An analysis of the multilevel role of insulin-like growth factor 2 (Review)

  2025cites this paper
• withdrawalof superoxide in apoptosis induced by growth factor

  2016cites this paper
• cultured mouse proximal tubular cells Graded ATP depletion can cause necrosis or apoptosis of

  2016cites this paper
• Insulin-like growth factor-1 (IGF-1) inhibits the basolateral Cl channels in the thick ascending limb of the rat kidney.

  2012cites this paper
• Insulin-like growth factors in normal and diseased kidney.

  2012cites this paper
• Beneficial effect of insulin-like growth factor-1 on hypoxemic renal dysfunction in the newborn rabbit

  2009cites this paper
• Indoleamine 2,3-dioxygenase expression promotes renal ischemia-reperfusion injury.

  2008cites this paper
• Growth hormone-mediated janus associated kinase-signal transducers and activators of transcription signaling in the growth hormone-resistant potassium-deficient rat.

  2004cites this paper
• Insulin-like growth factor binding protein-2 modulates podocyte mitogenesis

  2003cites this paper
• Acute renal failure in the surgical setting

  2003cites this paper
• Molecular mechanisms of recovery from acute renal failure

  2003cites this paper
• Effect of Prolonged Uremia on Insulin-Like Growth Factor-I Receptor Autophosphorylation and Tyrosine Kinase Activity in Kidney and Muscle

  2002cites this paper
• Transforming growth factor-beta1 (TGF-beta1): a potential recovery signal in the post-ischemic kidney.

  2002cites this paper
• OCTREOTIDENİN YENİDOĞAN STREPTOZOTOCIN DİYABETİK SIÇAN BÖBREĞİ VE IGF-1 DÜZEYLERİ ÜZERİNE ETKİLERİ

  2002cites this paper
• Serum and urinary insulin-like growth factor-1 and tumor necrosis factor in neonates with and without acute renal failure

  2002cites this paper
• TRANSFORMING GROWTH FACTOR-β1 (TGF-β1): A POTENTIAL RECOVERY SIGNAL IN THE POST-ISCHEMIC KIDNEY

  2002cites this paper
• Difficulties in understanding human "acute tubular necrosis": limited data and flawed animal models.

  2001cites this paper
• Expression of insulin-like growth factor-I and transforming growth factor-beta in hypokalemic nephropathy in the rat.

  2001cites this paper
• Effect of metabolic acidosis on the insulin-like growth factor-I system and cathepsins B and L gene expression in the kidney.

  2000cites this paper
• Acute renal failure. III. The role of growth factors in the process of renal regeneration and repair.

  2000cites this paper
• acute renal failure forum Acute renal failure. III. The role of growth factors in the process of renal regeneration and repair

  2000cites this paper
• acute renal failure forum Acute renal failure

  2000cites this paper
• Expression of apoptosis regulatory proteins in tubular epithelium stressed in culture or following acute renal failure.

  2000cites this paper
• Possible involvement of myofibroblasts in cellular recovery of uranyl acetate-induced acute renal failure in rats.

  2000cites this paper
• Renal expression of insulin-like growth factor-l in acute renal failure: a preliminary report.

  1999cites this paper
• Intrarenal insulin-like growth factor-1 axis after unilateral nephrectomy in rat.

  1999cites this paper
• Role of PDGF B-chain and PDGF receptors in rat tubular regeneration after acute injury.

  1999cites this paper
• Response to growth hormone therapy in experimental ischemic acute renal failure.

  1999cites this paper
• Management of acute renal failure

  1999cites this paper
• Rekombinante Wachstumsfaktoren: Neue Therapeutische Perspektiven beim akuten Nierenversagen

  1998cites this paper
• The Growth Hormone Receptor

  1998cites this paper
• Role of superoxide in apoptosis induced by growth factor withdrawal.

  1998cites this paper
• Graded ATP depletion can cause necrosis or apoptosis of cultured mouse proximal tubular cells.

  1998cites this paper
• In vitro demonstration of a mitogenic activity in renal tissue extracts during regenerative hyperplasia.

  1998cites this paper
• [Use of insulin-like growth factor-I (IGF-I) in the treatment of acute renal insufficiency].

  1998cites this paper
• Graded ATP depletion can cause necrosis or apoptosis of cultured mouse proximal tubular cells.

  1998cites this paper
• Modulation of insulin-like growth factor (IGF) and IGF binding protein biosynthesis by hypoxia in cultured vascular endothelial cells.

  1998cites this paper
• High dosage growth hormone treatment and post-ischemic acute renal failure in the rat.

  1998cites this paper
• Expression of GH receptor, IGF-I receptor and IGF-I mRNA in the kidney and liver of rats recovering from unilateral renal ischemia.

  1998cites this paper
• IGF-I binding proteins, IGF-I binding protein mRNA and IGF-I receptor mRNA in rats with acute renal failure given IGF-I.

  1998influential citation
• Role of superoxide in apoptosis induced by growth factor withdrawal.

  1998cites this paper
• Purification from human plasma of a hexapeptide that potentiates the sulfation and mitogenic activities of insulin-like growth factors.

  1998cites this paper
• Cyclosporine A induces apoptosis in murine tubular epithelial cells: role of caspases.

  1998cites this paper
• Growth factors and apoptosis in acute renal injury

  1998cites this paper
• Insulin-like growth factor system and the kidney: physiology, pathophysiology, and therapeutic implications.

  1998cites this paper
• In vitro demonstration of a mitogenic activity in renal tissue extracts during regenerative hyperplasia

  1998influential citation
• The insulin-like growth factor-I axis in acute renal failure.

  1998cites this paper
• Growth factors and acute renal failure.

  1998cites this paper
• Acute renal failure in children and newborns: pathophysiology, clinical patterns and therapeutic approach

  1998cites this paper
• High dosage growth hormone treatment and post-ischemic acute renal failure in the rat.

  1998cites this paper
• The IGF-I axis in kidney and skeletal muscle of potassium deficient rats.

  1997cites this paper
• Participação de fatores de crescimento na regeneração celular pós-necrose tubular aguda

  1997cites this paper
• Effect of insulin-like growth factor binding proteins on the response of proximal tubular cells to insulin-like growth factor-I.

  1997cites this paper
• IGF-I receptor binding, autophosphorylation, and kinase activity in kidney and muscle of acutely uremic rats.

  1997cites this paper
• Insulin-like growth factor-I ameliorates delayed kidney graft function and the acute nephrotoxic effects of cyclosporine.

  1997cites this paper
• The Role of Growth Factors in the Treatment of Renal Failure

  1997cites this paper
• Growth Factors:Future Prospects in Renal Failure

  1997cites this paper
• Protein catabolism in acute renal failure.

  1997cites this paper
• Renal tubule regeneration after ischemic injury is coupled to the up-regulation and activation of cyclins and cyclin dependent kinases.

  1997cites this paper
• Regional changes in the intrarenal insulin-like growth factor-I axis in diabetes.

  1997cites this paper
• Response of the intrarenal insulin-like growth factor-I axis to acute ischemic injury and treatment with growth hormone and epidermal growth factor.

  1996cites this paper
• Growth hormone, the insulin-like growth factor system, and the kidney.

  1996cites this paper
• Acceleration of recovery in acute renal failure: from cellular mechanisms of tubular repair to innovative targeted therapies.

  1996cites this paper
• Mechanisms of apoptosis and its potential role in renal tubular epithelial cell injury.

  1996cites this paper
• Renal hypertrophy and kidney disease in diabetes.

  1996cites this paper
• Insulin resistance but IGF-I sensitivity in chronic renal failure.

  1996cites this paper
• Increased transforming growth factor-beta 1 expression in regenerating rat renal tubules following ischemic injury.

  1996cites this paper