The primary structure of the cytotoxin restrictocin.

No abstract is available for this paper.

• Publication year

  1984

• Venue

  European Journal of Biochemistry

• Publication date

  1984-09-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1111/J.1432-1033.1984.TB08415.XPMID 6479166
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The mechanism of action of the cytotoxic nuclease α-sarcin and its use to analyse ribosome structure

  1984cited by this paper
• Chemical and spectroscopic evidence on the homology of three antitumor proteins: α-sarcin, mitogillin, and restrictocin

  1983cited by this paper
• The primary structure of the cytotoxin alpha-sarcin.

  1983cited by this paper
• The site of action of alpha-sarcin on eukaryotic ribosomes. The sequence at the alpha-sarcin cleavage site in 28 S ribosomal ribonucleic acid.

  1982cited by this paper
• Amino acid sequence homologies in alfa-sarcin, restrictocin and mitogillin.

  1982cited by this paper
• The structure of the yeast ribosomal RNA genes. 4. Complete sequence of the 25 S rRNA gene from Saccharomyces cerevisae.

  1981cited by this paper
• The primary and secondary structure of yeast 26S rRNA.

  1981cited by this paper
• The rRNA operon from Zea mays chloroplasts: nucleotide sequence of 23S rDNA and its homology with E.coli 23S rDNA.

  1981cited by this paper
• A simple, rapid, manual peptide microsequencing procedure.

  1981cited by this paper
• Complete nucleotide sequence of a 23S ribosomal RNA gene from Escherichia coli.

  1980cited by this paper
• Viral infection permeabilizes mammalian cells to protein toxins.

  1980cited by this paper
• Protein toxins that catalytically inactivate ribosomes from eukaryotic microorganisms Studies on the mode of action of alpha sarcin, mitogillin and restrictocin: Response to alpha sarcin antibodies

  1978cited by this paper
• Polyquarternary amines prevent peptide loss from sequenators.

  1978cited by this paper
• Effects of some proteins that inactivate the eukaryotic ribosome

  1977cited by this paper
• Specific cleavage of ribosomal RNA caused by alpha sarcin.

  1977cited by this paper
• Fluorometric detection of peptides after column chromatography or on paper: o-phthalaldehyde and fluorescamine.

  1976cited by this paper
• Regeneration of amino acids from thiazolinones formed in the Edman degradation.

  1975cited by this paper
• Reaction of peptides with fluorescamine on paper after chromatography or electrophoresis.

  1975cited by this paper
• [10] Enzymatic hydrolysis with carboxypeptidases.

  1972cited by this paper
• Evaluation of mitogillin (NSC-69529) in the treatment of naturally occurring canine neoplasms.

  1971cited by this paper
• A protein sequenator.

  1967cited by this paper
• Thin-layer chromatography of PTH amino acids

  1967cited by this paper
• Alpha Sarcin, a New Antitumor Agent

  1965cited by this paper
• ALPHA SARCIN, A NEW ANTITUMOR AGENT. II. FERMENTATION AND ANTITUMOR SPECTRUM.

  1965cited by this paper
• EVIDENCE FOR NONIDENTICAL CHAINS IN THE BETA-GALACTOSIDASE OF ESCHERICHIA COLI K12.

  1965cited by this paper
• On the determination of cystine as cysteic acid.

  1963cited by this paper

• Aspergillus fumigatus and Its Allergenic Ribotoxin Asp f I: Old Enemies but New Opportunities for Urine-Based Detection of Invasive Pulmonary Aspergillosis Using Lateral-Flow Technology

  2020cites this paper
• Fungal proteinaceous compounds with multiple biological activities

  2016cites this paper
• Identification and characterization of an insect toxin protein, Bb70p, from the entomopathogenic fungus, Beauveria bassiana, using Galleria mellonella as a model system.

  2016influential citation
• Involvement of loop 5 lysine residues and the N-terminal β-hairpin of the ribotoxin hirsutellin A on its insecticidal activity

  2016cites this paper
• Ribotoxin restrictocin manifests anti-HIV-1 activity through its specific ribonuclease activity.

  2015cites this paper
• Hirsutellin A: A Paradigmatic Example of the Insecticidal Function of Fungal Ribotoxins

  2013cites this paper
• Capacidad antioxidante y antirradicalaria, y nuevas lectinas SELblo y ebulina blo presentes en las inflorescencias del saúco enano (Sambucus ebulus L)

  2013cites this paper
• The therapeutic potential of fungal ribotoxins.

  2008cites this paper
• Automated high-performance liquid chromatographic detection of VM-26 and mitogillin

  2008cites this paper
• Ribotoxin genes in isolates of Aspergillus section Clavati

  2008cites this paper
• Fungal ribotoxins: molecular dissection of a family of natural killers.

  2007cites this paper
• Involvement of loops L2 and L4 of ribonucleolytic toxin restrictocin in its functional activity.

  2007cites this paper
• Immunoconjugate generation between the ribosome inactivating protein restrictocin and an anti-human breast carcinoma MAB

  2004cites this paper
• Bassiacridin, a protein toxic for locusts secreted by the entomopathogenic fungus Beauveria bassiana.

  2004cites this paper
• Description, distribution, activity and phylogenetic relationship of ribosome-inactivating proteins in plants, fungi and bacteria.

  2004cites this paper
• Molecular biology of Aspergillus allergens.

  2003cites this paper
• A ubiquitin-like peptide from the mushroom Pleurotus sajor-caju exhibits relatively potent translation-inhibitory and ribonuclease activities.

  2002cites this paper
• Arginine 121 is a crucial residue for the specific cytotoxic activity of the ribotoxin alpha-sarcin.

  2001cites this paper
• Antiproliferative and antimitogenic activities in a peptide from puffball mushroom Calvatia caelata.

  2001cites this paper
• Arginine 121 is a crucial residue for the specific cytotoxic activity of the ribotoxin α‐sarcin

  2001cites this paper
• [Interactions between Asp-hemolysin from Aspergillus fumigatus and blood plasma components].

  2001cites this paper
• Mechanism of specific target recognition and RNA hydrolysis by ribonucleolytic toxin restrictocin.

  2001cites this paper
• Aspergillus fumigatus由来Asp-hemolysinと血漿成分の相互作用に関する研究

  2001cites this paper
• Assay for antitumor and lectin activity in RNase homologs.

  2001cites this paper
• Localization of the catalytic activity in restrictocin molecule by deletion mutagenesis.

  2000cites this paper
• Isolation of a novel ubiquitin-like protein from Pleurotus ostreatus mushroom with anti-human immunodeficiency virus, translation-inhibitory, and ribonuclease activities.

  2000cites this paper
• The highly refined solution structure of the cytotoxic ribonuclease alpha-sarcin reveals the structural requirements for substrate recognition and ribonucleolytic activity.

  2000cites this paper
• Role of histidine‐50, glutamic acid‐96, and histidine‐137 in the ribonucleolytic mechanism of the ribotoxin α‐sarcin

  1999cites this paper
• Biochemical characterization of an immunodominant allergen/antigen ofAspergillus fumigatus

  1999cites this paper
• Molecular Dissection of Mitogillin Reveals That the Fungal Ribotoxins Are a Family of Natural Genetically Engineered Ribonucleases*

  1999cites this paper
• Role of individual cysteine residues and disulfide bonds in the structure and function of Aspergillus ribonucleolytic toxin restrictocin.

  1999cites this paper
• Ribotoxins are a more widespread group of proteins within the filamentous fungi than previously believed.

  1999cites this paper
• Probing the active site of mitogillin, a fungal ribotoxin

  1998cites this paper
• Identification of Aspergillus fumigatus by PCR

  1998cites this paper
• Overproduction of soluble, extracellular cytotoxin alpha-sarcin in Escherichia coli.

  1998cites this paper
• Cloning and sequencing of cDNA of the insecticidal toxin hirsutellin A

  1998cites this paper
• Overproduction of soluble, extracellular cytotoxin α-sarcin inEscherichia coli

  1998cites this paper
• MOLECULAR BIOLOGY OF ASPERGILLUS ALLERGENS

  1998cites this paper
• Multiple Peaks in HPLC of Proteins: Bovine Serum Albumin Eluted in a Reversed‐Phase System

  1998cites this paper
• Construction, expression and characterization of chimaeric toxins containing the ribonucleolytic toxin restrictocin: intracellular mechanism of action.

  1997cites this paper
• Structure and Mechanism of Action of the Cytotoxic Ribonuclease α-Sarcin

  1997cites this paper
• Sequence determination and molecular characterization of gigantin, a cytotoxic protein produced by the mould Aspergillus giganteus IFO 5818.

  1997cites this paper
• Cytotoxic activity of ribonucleolytic toxin restrictocin‐based chimeric toxins targeted to epidermal growth factor receptor

  1997cites this paper
• Characterization of a new ribotoxin gene (c-sar) from Aspergillus clavatus.

  1997cites this paper
• A single amino acid substitution in ribonucleolytic toxin restrictocin abolishes its specific substrate recognition activity.

  1997cites this paper
• Asp-hemolysin Significance as a Virulence Factor with Biological Activities from Aspergillus fumigatus

  1997cites this paper
• The mode of action of hirsutellin A on eukaryotic cells.

  1996cites this paper
• Clavin, a Type‐1 Ribosome‐Inactivating Protein from Aspergillus clavatus IF0 8605

  1996cites this paper
• Expression of ribonucleolytic toxin restrictocin in Escherichia coli: purification and characterization

  1996cites this paper
• Aspergillus fumigatus peptides differentially express Th1 and Th2 cytokines.

  1996cites this paper
• Generation of active immunotoxins containing recombinant restrictocin.

  1996cites this paper
• Clavin, a type-1 ribosome-inactivating protein from Aspergillus clavatus IFO 8605. cDNA isolation, heterologous expression, biochemical and biological characterization of the recombinant protein.

  1996cites this paper
• Substitution of histidine-137 by glutamine abolishes the catalytic activity of the ribosome-inactivating protein alpha-sarcin.

  1995cites this paper
• Extraction and characterization of the insecticidal toxin hirsutellin A produced by Hirsutella thompsonii var. thompsonii.

  1995cites this paper
• Predictive study of the conformation of the cytotoxic protein alpha-sarcin: a structural model to explain alpha-sarcin-membrane interaction.

  1995cites this paper
• Fungal ribotoxins: a family of naturally engineered targeted toxins?

  1995cites this paper
• Hirsutellin A, a toxic protein produced in vitro by Hirsutella thompsonii.

  1995cites this paper
• Purification and characterization of a ribonuclease from Aspergillus giganteus IFO 5818, the gigantin. Immunological and enzymic comparison with alphasarcin.

  1994cites this paper
• Heterologous expression of the cytotoxin restriction in Aspergillus nidulans and Aspergillus niger.

  1994cites this paper
• Specific amplification of Aspergillus fumigatus DNA by polymerase chain reaction.

  1993cites this paper
• Structure, function and applications of ricin and related cytotoxic proteins

  1993cites this paper
• Ribosome-inactivating proteins from plants.

  1993cites this paper
• Selective expression of a major allergen and cytotoxin, Asp f I, in Aspergillus fumigatus. Implications for the immunopathogenesis of Aspergillus-related diseases.

  1992cites this paper
• Production and Characterization of a Monoclonal Antibody Against the Ribosome Inactivating Protein Alpha Sarcin

  1992cites this paper
• Effects of amino-terminal extensions and specific mutations on the activity of restrictocin.

  1992cites this paper
• Protein toxin inhibitors of protein synthesis.

  1992cites this paper
• Regulation of restrictocin production in Aspergillus restrictus.

  1992cites this paper
• Biochemical, cytotoxic and pharmacokinetic properties of an immunotoxin composed of a mouse monoclonal antibody Fib75 and the ribosome-inactivating protein alpha-sarcin from Aspergillus giganteus.

  1991cites this paper
• Crystallization and preliminary characterization of mitogillin, a ribosomal ribonuclease from Aspergillus restrictus.

  1991cites this paper
• Secretion of a potential virulence factor, a fungal ribonucleotoxin, during human aspergillosis infections

  1991cites this paper
• Isolation and nucleotide sequence of the Aspergillus restrictus gene coding for the ribonucleolytic toxin restrictocin and its expression in Aspergillus nidulans: the leader sequence protects producing strains from suicide.

  1991cites this paper
• Ultrastructural changes induced by alpha-sarcin in a human pulmonary tumor grown in naked mice.

  1991cites this paper
• Minireview: enzymatic properties of ribosome-inactivating proteins (RIPs) and related toxins.

  1991cites this paper
• Molecular action of tricholin, a ribosome‐inactivating protein isolated from Trichoderma viride

  1991cites this paper
• Expression of the chemically synthesized coding region for the cytotoxin alpha-sarcin in Escherichia coli using a secretion cloning vector.

  1990cites this paper
• The Aspergillus toxin restrictocin is a suitable cytotoxic agent for generation of immunoconjugates with monoclonal antibodies directed against human carcinoma cells

  1989cites this paper
• Conformational study of the antitumor protein α-sarcin

  1988cites this paper
• Alpha-sarcin causes a specific cut in 28 S rRNA when microinjected into Xenopus oocytes.

  1988cites this paper
• Conformational study of the antitumor protein alpha-sarcin.

  1988cites this paper
• Metabolism of protein anticancer agents.

  1987cites this paper
• Primary structure of the activation segment of procarboxypeptidase A from porcine pancreas.

  1986cites this paper
• Plant and fungal protein and glycoprotein toxins inhibiting eukaryote protein synthesis.

  1985cites this paper
• Sequential homologies between procarboxypeptidases A and B from porcine pancreas.

  1985cites this paper