Contributions to the NIH-NIGMS Protein Structure Initiative from the PSI Production Centers.

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Structure

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.str.2007.12.002PMID 18184575PMCID PMC2678832
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Quality of protein crystal structures.

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• The challenge of protein structure determination—lessons from structural genomics

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• Growth of novel protein structural data

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• Novel leverage of structural genomics

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• Protein structure space is much more than the sum of its folds

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• Structural genomics of protein phosphatases

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• Structural insight into repair of alkylated DNA by a new superfamily of DNA glycosylases comprising HEAT-like repeats

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• An expression vector tailored for large-scale, high-throughput purification of recombinant proteins.

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• A Virulence Locus of Pseudomonas aeruginosa Encodes a Protein Secretion Apparatus

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• HKL-3000: the integration of data reduction and structure solution--from diffraction images to an initial model in minutes.

  2006cited by this paper
• NMR data collection and analysis protocol for high-throughput protein structure determination.

  2005cited by this paper
• Protein production by auto-induction in high density shaking cultures.

  2005cited by this paper
• The Impact of Structural Genomics: Expectations and Outcomes

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• High-throughput Limited Proteolysis/Mass Spectrometry for Protein Domain Elucidation

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• Rapid refinement of crystallographic protein construct definition employing enhanced hydrogen/deuterium exchange MS.

  2004cited by this paper
• Systematic analysis of added-value in simple comparative models of protein structure.

  2004cited by this paper
• Crystal structure of thy1, a thymidylate synthase complementing protein from Thermotoga maritima at 2.25 Å resolution

  2002cited by this paper
• High throughput methods for gene cloning and expression.

  2002cited by this paper
• Completeness in structural genomics

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• Open-access data: A cornerstone for artificial intelligence approaches to protein structure prediction.

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• Fragment- and structure-based drug discovery for developing therapeutic agents targeting the DNA Damage Response

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• Exploring the understudied human kinome for research and therapeutic opportunities

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• How Structural Biologists and the Protein Data Bank Contributed to Recent FDA New Drug Approvals.

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• Dark Proteins Important for Cellular Function

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• Docking simulations between drugs and HLA molecules associated with idiosyncratic drug toxicity.

  2017cites this paper
• Protein structure determination using evolutionary information

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• Molecular Modeling of Human CCR2 Receptor within POPC Lipid Bilayer

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• Discovery of new selective antagonists of G-protein coupled receptors of therapeutic interest

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• What's the big deal about big data?

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• Identification of Small-Molecule Inhibitors against Meso-2, 6-Diaminopimelate Dehydrogenase from Porphyromonas gingivalis

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• Large-scale determination of previously unsolved protein structures using evolutionary information

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• A Novel Antimicrobial Drug Discovery Approach for the Periodontal Pathogen Porphyromonas gingivalis

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• Protein Structure Modeling in Drug Design

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• Biochemical functional predictions for protein structures of unknown or uncertain function

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• AMASS: a database for investigating protein structures

  2014cites this paper
• Coverage of protein domain families with structural protein-protein interactions: current progress and future trends.

  2014cites this paper
• Protein production for structural genomics using E. coli expression.

  2014cites this paper
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• How Many Protein-Protein Interactions Types Exist in Nature?

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• Structural genomics plucks high-hanging membrane proteins.

  2012cites this paper
• IMPROVING THE QUALITY OF PROTEIN NMR STRUCTURES BY ROSETTA REFINEMENT AND ITS APPLICATION IN MOLECULAR REPLACEMENT By

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  2011cites this paper
• Improved technologies now routinely provide protein NMR structures useful for molecular replacement.

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• Structures of domains I and IV from YbbR are representative of a widely distributed protein family

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• Internal organization of large protein families: Relationship between the sequence, structure, and function‐based clustering

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• Policy-Based Integration of Provenance Metadata

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• A new approach to assess and predict the functional roles of proteins across all known structures

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• Protein secondary structure appears to be robust under in silico evolution while protein disorder appears not to be

  2010cites this paper
• The Protein Structure Initiative

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• Structural Genomics, Its Application in Chemistry, Biology, and Drug Discovery

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• DNA base repair--recognition and initiation of catalysis.

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• Autoindexing the diffraction patterns from crystals with a pseudotranslation

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• Homology modeling in drug discovery: current trends and applications.

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• Unique opportunities for NMR methods in structural genomics

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• Structure and function of Pseudomonas aeruginosa protein PA1324 (21–170)

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• Structural genomics target selection for the New York consortium on membrane protein structure

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• Biomedical Informatics

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• Evaluating the efficacy of a structure-derived amino acid substitution matrix in detecting protein homologs by BLAST and PSI-BLAST

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• High-throughput crystallography for structural genomics.

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• New in protein structure and function annotation: hotspots, single nucleotide polymorphisms and the 'Deep Web'.

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• Predicting small ligand binding sites in proteins using backbone structure

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