MnSOD deficiency results in elevated oxidative stress and decreased mitochondrial function but does not lead to muscle atrophy during aging

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Aging Cell

• Publication date

  2011-06-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1111/j.1474-9726.2011.00695.xPMID 21385310PMCID PMC3094473
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Oxidative stress in skeletal muscle causes severe disturbance of exercise activity without muscle atrophy.

  2010influential reference
• Conditional knockout of Mn-SOD targeted to type IIB skeletal muscle fibers increases oxidative stress and is sufficient to alter aerobic exercise capacity.

  2009influential reference
• Principal component analysis reveals age-related and muscle-type-related differences in protein carbonyl profiles of muscle mitochondria.

  2008cited by this paper
• Resistance to Ca2+-induced opening of the permeability transition pore differs in mitochondria from glycolytic and oxidative muscles.

  2008cited by this paper
• Fatty acid oxidation in cardiac and skeletal muscle mitochondria is unaffected by deletion of CD36.

  2007cited by this paper
• Mitochondrial Dysfunction: Impact on Exercise Performance and Cellular Aging

  2007cited by this paper
• Denervation-induced skeletal muscle atrophy is associated with increased mitochondrial ROS production.

  2007cited by this paper
• Type II skeletal myofibers possess unique properties that potentiate mitochondrial H(2)O(2) generation.

  2006cited by this paper
• Investigation of drug-induced mitochondrial toxicity using fluorescence-based oxygen-sensitive probes.

  2006cited by this paper
• Oxidative Stress Causes Heart Failure with Impaired Mitochondrial Respiration*

  2006influential reference
• Alterations in mitochondrial function, hydrogen peroxide release and oxidative damage in mouse hind-limb skeletal muscle during aging.

  2006influential reference
• Genetic modifiers of the phenotype of mice deficient in mitochondrial superoxide dismutase.

  2006cited by this paper
• Reduced mitochondrial coupling in vivo alters cellular energetics in aged mouse skeletal muscle

  2005cited by this paper
• Decline in skeletal muscle mitochondrial function with aging in humans.

  2005cited by this paper
• Book Review

  2005cited by this paper
• A HIF1α Regulatory Loop Links Hypoxia and Mitochondrial Signals in Pheochromocytomas

  2005cited by this paper
• Evaluation of a quantitative magnetic resonance method for mouse whole body composition analysis.

  2004cited by this paper
• The contribution of reactive oxygen species to sarcopenia and muscle ageing.

  2004influential reference
• Redox-dependent modulation of aconitase activity in intact mitochondria.

  2003cited by this paper
• Mitochondrial complex I, aconitase, and succinate dehydrogenase during hypoxia-reoxygenation: modulation of enzyme activities by MnSOD.

  2003cited by this paper
• Quantitative magnetic resonance (QMR) method for bone and whole-body-composition analysis

  2003cited by this paper
• Endogenous mitochondrial oxidative stress: neurodegeneration, proteomic analysis, specific respiratory chain defects, and efficacious antioxidant therapy in superoxide dismutase 2 null mice

  2003influential reference
• Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging.

  2003cited by this paper
• Succinate dehydrogenase and fumarate reductase from Escherichia coli.

  2002cited by this paper
• 5-Diisopropoxyphosphoryl-5-methyl-1-pyrroline N-oxide, DIPPMPO, a crystalline analog of the nitrone DEPMPO: synthesis and spin trapping properties

  2002cited by this paper
• TnIfast IRE enhancer: Multistep developmental regulation during skeletal muscle fiber type differentiation

  2002cited by this paper
• Aconitase: sensitive target and measure of superoxide.

  2002cited by this paper
• Assaying mitochondrial respiratory complex activity in mitochondria isolated from human cells and tissues.

  2001cited by this paper
• Knockout mice heterozygous for Sod2 show alterations in cardiac mitochondrial function and apoptosis.

  2001cited by this paper
• What do mitochondrial diseases teach us about normal mitochondrial functions...that we already knew: threshold expression of mitochondrial defects.

  2001cited by this paper
• Mitochondrial DNA deletion mutations colocalize with segmental electron transport system abnormalities, muscle fiber atrophy, fiber splitting, and oxidative damage in sarcopenia

  2001cited by this paper
• Cellular phenotypes of age-associated skeletal muscle mitochondrial abnormalities in rhesus monkeys.

  2000cited by this paper
• Titrating the Effects of Mitochondrial Complex I Impairment in the Cell Physiology*

  1999cited by this paper
• Mitochondrial superoxide decreases yeast survival in stationary phase.

  1999influential reference
• Succinate: quinone oxidoreductases. Variations on a conserved theme.

  1997cited by this paper
• Requirement for superoxide in excitotoxic cell death.

  1996cited by this paper
• Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase

  1995cited by this paper
• Superoxide Radical and Iron Modulate Aconitase Activity in Mammalian Cells (*)

  1995cited by this paper
• Aconitase is a sensitive and critical target of oxygen poisoning in cultured mammalian cells and in rat lungs.

  1994influential reference
• Myosin isoforms in mammalian skeletal muscle.

  1994cited by this paper
• Relationship between muscle fiber types and sizes and muscle architectural properties in the mouse hindlimb

  1994cited by this paper
• Variability in muscle fibre areas in whole human quadriceps muscle: effects of increasing age.

  1991cited by this paper
• Superoxide sensitivity of the Escherichia coli aconitase.

  1991cited by this paper
• The oxidative inactivation of mitochondrial electron transport chain components and ATPase.

  1990cited by this paper
• Fibre-type composition, structure and cytoskeletal protein location of fibres in anterior tibial muscle

  1990cited by this paper
• Cellular and molecular diversities of mammalian skeletal muscle fibers.

  1990cited by this paper
• Muscle fiber types identified by monoclonal antibodies to myosin heavy chains

  1986cited by this paper
• Muscle strength and speed of movement in relation to age and muscle morphology.

  1979cited by this paper
• Histochemical and biochemical changes in human skeletal muscle with age in sedentary males, age 22--65 years.

  1978cited by this paper
• Histochemical and Ultrastructural Changes in Senile Human Skeletal Muscle

  1977cited by this paper
• Interrelations of reconstitution activity, reactions with electron acceptors, and iron-sulfur centers in succinate dehydrogenase.

  1977cited by this paper
• Mitochondrial production of superoxide anions and its relationship to the antimycin insensitive respiration

  1975cited by this paper
• Histochemistry, Theoretical and Applied

  1960cited by this paper
• CYTOCHEMICAL DEMONSTRATION OF SUCCINIC DEHYDROGENASE BY THE USE OF A NEW p-NITROPHENYL SUBSTITUTED DITETRAZOLE

  1957influential reference
• The FASEB Journal • Research Communication Messenger RNA oxidation is an early event preceding cell death and causes reduced protein expression

  year unknowncited by this paper

• Impact of physical activity on physical function, mitochondrial energetics, ROS production, and Ca2+ handling across the adult lifespan in men

  2025cites this paper
• Molecular Framework of the Onset and Progression of Skeletal Muscle Aging

  2025cites this paper
• Anti-Aging Medicine: Mitochondria-Targeted Antioxidants and Physical Activity

  2024cites this paper
• Molecular Mechanisms and Potential Interventions During Aging-associated Sarcopenia.

  2024cites this paper
• Mitochondrial bioenergetics are not associated with myofibrillar protein synthesis rates

  2024cites this paper
• Pregnancy in obese women and mechanisms of increased cardiovascular risk in offspring

  2024cites this paper
• Anti-Aging Medicine: Mitochondrial-Directed Antioxidants and Physical Activity

  2024cites this paper
• Interplay between Protein Kinase C Epsilon and Reactive Oxygen Species during Myogenic Differentiation

  2023cites this paper
• The contribution of mitochondria to age-related skeletal muscle wasting: A sex-specific perspective.

  2023cites this paper
• Overexpression of thioredoxin‐2 attenuates age‐related muscle loss by suppressing mitochondrial oxidative stress and apoptosis

  2022cites this paper
• Epigallocatechin‐3‐gallate (EGCG) attenuates inflammatory responses and oxidative stress in lipopolysaccharide (LPS)‐induced endometritis via silent information regulator transcript‐1 (SIRT1)/nucleotide oligomerization domain (NOD)‐like receptor pyrin domain‐containing 3 (NLRP3) pathway

  2022cites this paper
• Jujuboside A Exhibits an Antiepileptogenic Effect in the Rat Model via Protection against Traumatic Epilepsy-Induced Oxidative Stress and Inflammatory Responses

  2022cites this paper
• Neuron-specific mitochondrial oxidative stress results in epilepsy, glucose dysregulation and a striking astrocyte response.

  2021cites this paper
• The ketogenic diet preserves skeletal muscle with aging in mice

  2021cites this paper
• Fission accomplished: Uncovering the role of Drp1 in regulating mitochondrial dysfunction and age‐related muscle atrophy

  2021cites this paper
• Cytosolic adaptation to mitochondria-induced proteostatic stress causes progressive muscle wasting

  2021cites this paper
• Cross-level analysis of molecular and neurobehavioral function in a prospective series of patients with germline heterozygous PTEN mutations with and without autism

  2021cites this paper
• The muscle to bone axis (and viceversa): an encrypted language affecting tissues and organs and yet to be codified?

  2021cites this paper
• Decreased Liver Tissue Wasting following High-Intensity Interval Training through Apoptosis Signaling Suppression in Breast Tumor–Bearing Female Mice

  2020cites this paper
• Palmitoyl Protein Thioesterase 1 Is Essential for Myogenic Autophagy of C2C12 Skeletal Myoblast

  2020cites this paper
• Single Nucleotide Resolution Analysis Reveals Pervasive, Long-Lasting DNA Methylation Changes by Developmental Exposure to a Mitochondrial Toxicant

  2020influential citation
• Discriminatory cytokine profiles predict muscle function, fatigue and cognitive function in patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)

  2020cites this paper
• Riding the tiger – physiological and pathological effects of superoxide and hydrogen peroxide generated in the mitochondrial matrix

  2020cites this paper
• Bilobalide protects against ischemia/reperfusion-induced oxidative stress and inflammatory responses via the MAPK/NF-휅B pathways in rats

  2020cites this paper
• Neutralizing mitochondrial ROS does not rescue muscle atrophy induced by hindlimb unloading in female mice.

  2020cites this paper
• The effects of high-intensity interval training and saffron aqueous extract supplementation on alterations of body weight and apoptotic indices in skeletal muscle of 4T1 breast cancer-bearing mice with cachexia.

  2020influential citation
• Cytosolic Adaptation to Mitochondrial Precursor Overaccumulation Stress Induces Progressive Muscle Wasting

  2019cites this paper
• The role of SIRT1 in skeletal muscle function and repair of older mice

  2019cites this paper
• Cytosolic Proteostatic Adaptation to Mitochondrial Stress Causes Progressive Muscle Wasting

  2019cites this paper
• Smooth muscle-specific deletion of MnSOD exacerbates diabetes-induced bladder dysfunction in mice.

  2019cites this paper
• Mitochondrial oxidative stress impairs contractile function but paradoxically increases muscle mass via fibre branching

  2019cites this paper
• Comparison of Whole Body SOD1 Knockout with Muscle-Specific SOD1 Knockout Mice Reveals a Role for Nerve Redox Signaling in Regulation of Degenerative Pathways in Skeletal Muscle

  2018cites this paper
• Reactive oxygen species upregulate expression of muscle atrophy-associated ubiquitin ligase Cbl-b in rat L6 skeletal muscle cells.

  2018cites this paper
• Heat stress prevents the decrease in succinate dehydrogenase activity in the extensor digitorum longus of streptozotocin-induced diabetic rats.

  2018cites this paper
• Superoxide dismutases: Dual roles in controlling ROS damage and regulating ROS signaling

  2018cites this paper
• Nrf2 deficiency exacerbates age-related contractile dysfunction and loss of skeletal muscle mass

  2018cites this paper
• Biological effects of adipocytes in sulfur mustard induced toxicity.

  2018cites this paper
• Manganese superoxide dismutase deficiency exacerbates the mitochondrial ROS production and oxidative damage in Chagas disease

  2018cites this paper
• Alterations in Sod2-Induced Oxidative Stress Affect Endocrine Cancer Progression

  2018cites this paper
• Modulation of age related protein expression changes by gelam honey in cardiac mitochondrial rats

  2018cites this paper
• Beneficial alterations in body composition, physical performance, oxidative stress, inflammatory markers, and adipocytokines induced by long‐term high‐intensity interval training in an aged rat model

  2018cites this paper
• Manganese influx and expression of ZIP8 is essential in primary myoblasts and contributes to activation of SOD2

  2018cites this paper
• Conserved and species-specific molecular denominators in mammalian skeletal muscle aging

  2017cites this paper
• Redox homeostasis and age‐related deficits in neuromuscular integrity and function

  2017cites this paper
• Sco2 deficient mice develop increased adiposity and insulin resistance.

  2017cites this paper
• Inhibition of NFE2L2-Antioxidant Response Element Pathway by Mitochondrial Reactive Oxygen Species Contributes to Development of Cardiomyopathy and Left Ventricular Dysfunction in Chagas Disease

  2017cites this paper
• SDHB downregulation facilitates the proliferation and invasion of colorectal cancer through AMPK functions excluding those involved in the modulation of aerobic glycolysis

  2017cites this paper
• Paradoxical Roles of Antioxidant Enzymes: Basic Mechanisms and Health Implications.

  2016cites this paper
• Exercise Promotes Healthy Aging of Skeletal Muscle.

  2016cites this paper
• ERK5/HDAC5-mediated, resveratrol-, and pterostilbene-induced expression of MnSOD in human endothelial cells.

  2016cites this paper
• Reactive oxygen species, health and longevity

  2016cites this paper
• Manganese Superoxide Dismutase (MnSOD) and Its Importance in Mitochondrial Function and Cancer

  2016cites this paper
• Centenarian ratio in selected Country in 2002

  2016cites this paper
• Mitochondrial ROS regulate oxidative damage and mitophagy but not age-related muscle fiber atrophy

  2016cites this paper
• Down-regulation of the mitochondrial matrix peptidase ClpP in muscle cells causes mitochondrial dysfunction and decreases cell proliferation.

  2016cites this paper
• Relationship of Mitochondrial Enzymes to Fatigue Intensity in Men With Prostate Cancer Receiving External Beam Radiation Therapy

  2016cites this paper
• MsrA Overexpression Targeted to the Mitochondria, but Not Cytosol, Preserves Insulin Sensitivity in Diet-Induced Obese Mice

  2015cites this paper
• Radical Oxygen Species, Exercise and Aging: An Update

  2015cites this paper
• In the idiopathic inflammatory myopathies (IIM), do reactive oxygen species (ROS) contribute to muscle weakness?

  2015cites this paper
• The histone deacetylase inhibitor butyrate improves metabolism and reduces muscle atrophy during aging

  2015cites this paper
• Role of Sod2 in Pancreatic Carcinogenesis

  2015cites this paper
• Neuronal redox imbalance results in altered energy homeostasis and early postnatal lethality

  2015cites this paper
• Redox Characterization of Functioning Skeletal Muscle

  2015cites this paper
• [Association between carbonyl proteins and tumor necrosis factor alpha with muscle strength in young and older women: exploratory study].

  2015cites this paper
• Understanding the susceptibility of dopamine neurons to mitochondrial stressors in Parkinson's disease

  2015cites this paper
• Bavachalcone-Induced Manganese Superoxide Dismutase Expression through the AMP-Activated Protein Kinase Pathway in Human Endothelial Cells

  2015cites this paper
• The peroxidase activity of mitochondrial superoxide dismutase (MnSOD/SOD2)

  2014cites this paper
• Melatonina y apoptosis en leucocitos humanos

  2014cites this paper
• Revisiting an age-old question regarding oxidative stress.

  2014cites this paper
• BIOGÊNESE MITOCONDRIAL E MARCADORES DE ESTRESSE OXIDATIVO EM RATOS TREINADOS E SUPLEMENTADOS COM L- ARGININA

  2014cites this paper
• Coping with Physical Activity and Inactivity

  2014cites this paper
• Peroxiredoxin 3 has a crucial role in the contractile function of skeletal muscle by regulating mitochondrial homeostasis.

  2014cites this paper
• Relationship of Mitochondrial Enzymes to Fatigue Intensity and Health-Related Quality of Life in Men with Prostate Cancer Receiving External Beam Radiation Therapy

  2014cites this paper
• Tissue-Specific Deletion of Manganese Superoxide Dismutase (Mn-SOD) in Mice

  2014cites this paper
• Exercice physique, marqueurs antioxydants et peroxydation lipidique : effets de l'âge et du niveau d'aptitude physique

  2014cites this paper
• Reduced mitochondrial ROS, enhanced antioxidant defense, and distinct age-related changes in oxidative damage in muscles of long-lived Peromyscus leucopus.

  2013cites this paper
• Mitochondrial pathways in sarcopenia of aging and disuse muscle atrophy

  2013cites this paper
• The peroxidase activity of mitochondrial superoxide dismutase.

  2013cites this paper
• Curbing cancer's sweet tooth: is there a role for MnSOD in regulation of the Warburg effect?

  2013influential citation
• The Akt–FoxO3a–manganese superoxide dismutase pathway is involved in the regulation of oxidative stress in diabetic nephropathy

  2013cites this paper
• Effect of oxygen tension on bioenergetics and proteostasis in young and old myoblast precursor cells☆

  2013cites this paper
• Mechanisms of skeletal muscle aging: insights from Drosophila and mammalian models

  2013cites this paper
• Mitochondrial redox metabolism in aging: Effect of exercise interventions

  2013cites this paper
• Neurodegeneration and early lethality in SOD2-deficient mice: a comprehensive analysis of the central and peripheral nervous systems

  2012cites this paper
• Mouse Models of Oxidative Stress Indicate a Role for Modulating Healthy Aging.

  2012cites this paper
• Oxidative Stress and Immunosenescence: Therapeutic Effects of Melatonin

  2012cites this paper
• Oxidative stress and condition-dependent sexual signals: more than just seeing red

  2012cites this paper
• Neurodegeneration and early lethality in superoxide dismutase 2-deficient mice: a comprehensive analysis of the central and peripheral nervous systems.

  2012cites this paper
• Forum on aging and skeletal health: Summary of the proceedings of an ASBMR workshop

  2011cites this paper
• Manganese Superoxide Dismutase: Guardian of the Powerhouse

  2011cites this paper
• Importance of SOD 2 in neuronal homeostasis : Study of a novel mouse model

  year unknowncites this paper