The influence of calcium, magnesium and cyclic adenosine 3',5'-monophosphate on the mixed lymphocyte reaction.

EDTA inhibits lymphocyte transformation in the mixed lymphocyte culture reaction as it does in PHA containing cultures. The effect is most likely due to binding of Ca++ and Mg++ required for the initiation and completion of the response since transformation does not occur in cultures deficient in these ions. Exogenous cyclic adenosine 3′,5′-monophosphate (cAMP) can potentiate or inhibit the mixed lymphocyte reaction depending on concentration and duration of exposure. The possible interaction of divalent cations and cAMP in lymphocyte transformation is discussed.

• Publication year

  1972

• Venue

  Journal of Immunology

• Publication date

  1972-05-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.4049/jimmunol.108.5.1179PMID 4337672
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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