RESEARCH ARTICLE Mechanism and Treatment of Renal Fibrosis Deletion of (cid:2) 1-integrin in collecting duct principal cells leads to tubular injury and renal medullary fibrosis

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• Integrins and integrin-related proteins in cardiac fibrosis.

  2016cited by this paper
• The αvβ1 integrin plays a critical in vivo role in tissue fibrosis

  2015cited by this paper
• Inactivation of integrin-β1 prevents the development of polycystic kidney disease after the loss of polycystin-1.

  2015cited by this paper
• Integrin α3β1 regulates kidney collecting duct development via TRAF6-dependent K63-linked polyubiquitination of Akt

  2015cited by this paper
• Collecting duct intercalated cell function and regulation.

  2015cited by this paper
• Adam10 mediates the choice between principal cells and intercalated cells in the kidney.

  2015cited by this paper
• Lithium causes G2 arrest of renal principal cells.

  2014cited by this paper
• β1 Integrin Inhibition Elicits a Prometastatic Switch Through the TGFβ–miR-200–ZEB Network in E-Cadherin–Positive Triple-Negative Breast Cancer

  2014cited by this paper
• Transforming growth factor-β1-mediated renal fibrosis is dependent on the regulation of transforming growth factor receptor 1 expression by let-7b.

  2014cited by this paper
• Vasopressin induces apical expression of caveolin in rat kidney collecting duct principal cells.

  2013cited by this paper
• Aqp2-expressing cells give rise to renal intercalated cells.

  2013cited by this paper
• Altered V-ATPase expression in renal intercalated cells isolated from B1 subunit-deficient mice by fluorescence-activated cell sorting.

  2013cited by this paper
• MiRNA-200b represses transforming growth factor-β1-induced EMT and fibronectin expression in kidney proximal tubular cells.

  2013cited by this paper
• Integrin-mediated regulation of TGFβ in fibrosis.

  2013cited by this paper
• Integrins in kidney disease.

  2013cited by this paper
• Aquaporin 2 promotes cell migration and epithelial morphogenesis.

  2012cited by this paper
• TGF-β and renal fibrosis: a Pandora's box of surprises.

  2012cited by this paper
• The Cell Biology of Vasopressin Action

  2012cited by this paper
• Novel biomarkers of acute kidney injury and failure: clinical applicability.

  2012cited by this paper
• New insights into the dynamic regulation of water and acid-base balance by renal epithelial cells.

  2012cited by this paper
• β1 Integrin NPXY Motifs Regulate Kidney Collecting-Duct Development and Maintenance by Induced-Fit Interactions with Cytosolic Proteins

  2012cited by this paper
• aV integrins and TGF-β-induced EMT: a circle of regulation

  2012cited by this paper
• Cellular and molecular mechanisms of renal fibrosis

  2011cited by this paper
• Molecular physiology of the medullary collecting duct.

  2011cited by this paper
• Integrin Signaling Modulates AQP2 Trafficking via Arg-Gly-Asp (RGD) Motif

  2011cited by this paper
• Evaluation of new acute kidney injury biomarkers in a mixed intensive care unit*

  2011cited by this paper
• TGFβ: a sleeping giant awoken by integrins.

  2011cited by this paper
• Diverse Roles of TGF-β/Smads in Renal Fibrosis and Inflammation

  2011cited by this paper
• Integrins modulate cellular fibrogenesis at multiple levels; Regulation of TGF-β signaling.

  2010cited by this paper
• Renal fibrosis: novel insights into mechanisms and therapeutic targets

  2010cited by this paper
• The Role of Kidney Biopsy in Heart Transplant Candidates With Kidney Disease

  2010cited by this paper
• β1 integrin is necessary for ureteric bud branching morphogenesis and maintenance of collecting duct structural integrity

  2009cited by this paper
• Constitutive Activation of Beta-Catenin in Uterine Stroma and Smooth Muscle Leads to the Development of Mesenchymal Tumors in Mice1

  2009cited by this paper
• TGF-beta signal transduction in chronic kidney disease.

  2009cited by this paper
• Beta1-integrin is required for kidney collecting duct morphogenesis and maintenance of renal function.

  2009influential reference
• Two novel VHL targets, TGFBI (BIGH3) and its transactivator KLF10, are up-regulated in renal clear cell carcinoma and other tumors.

  2008cited by this paper
• Conditional deletion of beta1-integrin from the developing lens leads to loss of the lens epithelial phenotype.

  2007cited by this paper
• Surgical septic complications in diabetic patients

  2007cited by this paper
• Impairment of sodium balance in mice deficient in renal principal cell mineralocorticoid receptor.

  2007cited by this paper
• Severe urinary concentrating defect in renal collecting duct-selective AQP2 conditional-knockout mice.

  2006cited by this paper
• Mouse model of inducible nephrogenic diabetes insipidus produced by floxed aquaporin-2 gene deletion.

  2006cited by this paper
• Methyl-beta-cyclodextrin induces vasopressin-independent apical accumulation of aquaporin-2 in the isolated, perfused rat kidney.

  2006cited by this paper
• Collecting duct-specific knockout of endothelin-1 alters vasopressin regulation of urine osmolality.

  2005cited by this paper
• Inhibition of endocytosis causes phosphorylation (S256)-independent plasma membrane accumulation of AQP2.

  2004cited by this paper
• Expression of the 56-kDa B2 subunit isoform of the vacuolar H(+)-ATPase in proton-secreting cells of the kidney and epididymis.

  2004cited by this paper
• Tyrosine phosphorylation-dependent PI 3 kinase/Akt signal transduction regulates TGFbeta-induced fibronectin expression in mesangial cells.

  2004cited by this paper
• The ins and outs of aquaporin-2 trafficking.

  2003cited by this paper
• Expression of TGF-beta-induced matrix protein betaig-h3 is up-regulated in the diabetic rat kidney and human proximal tubular epithelial cells treated with high glucose.

  2003cited by this paper
• Integrins: bidirectional, allosteric signaling machines.

  2002cited by this paper
• Role of connective tissue growth factor in fibronectin expression and tubulointerstitial fibrosis.

  2002cited by this paper
• Renal principal cell-specific expression of green fluorescent protein in transgenic mice.

  2002cited by this paper
• Cross talk between beta(1) and alpha(V) integrins: beta(1) affects beta(3) mRNA stability.

  2001cited by this paper
• Integrin beta 1 signaling is necessary for transforming growth factor-beta activation of p38MAPK and epithelial plasticity.

  2001cited by this paper
• Key Roles of Renal Aquaporins in Water Balance and Water-Balance Disorders.

  2000cited by this paper
• Conditional ablation of beta1 integrin in skin. Severe defects in epidermal proliferation, basement membrane formation, and hair follicle invagination.

  2000cited by this paper
• Role of transforming growth factor beta in human disease.

  2000cited by this paper
• Caspase activity is required for nephrogenesis in the developing mouse metanephros.

  1999cited by this paper
• Expression of the epithelial sodium channel (ENaC) during ontogenic differentiation of the renal cortical collecting duct epithelium

  1999cited by this paper
• Transforming growth factor-beta regulates tubular epithelial-myofibroblast transdifferentiation in vitro.

  1999cited by this paper
• Renal aquaporins: Key rols in watr balance and water balance disorders

  1998cited by this paper
• The Perinatal Expression of Aquaporin-2 and Aquaporin-3 in Developing Kidney

  1998cited by this paper
• Cellular apoptosis and proliferation in experimental renal fibrosis.

  1998cited by this paper
• Expression of an AQP2 Cre recombinase transgene in kidney and male reproductive system of transgenic mice.

  1998cited by this paper
• Regulation of survival and death of mesangial cells by extracellular matrix.

  1998cited by this paper
• Renal expression of transforming growth factor-beta inducible gene-h3 (beta ig-h3) in normal and diabetic rats.

  1998cited by this paper
• TGF-beta in kidney fibrosis: a target for gene therapy.

  1997cited by this paper
• Rapid onset of apoptosis in vitro follows disruption of beta 1-integrin/matrix interactions in human colonic crypt cells.

  1996cited by this paper
• Antigen retrieval in cryostat tissue sections and cultured cells by treatment with sodium dodecyl sulfate (SDS)

  1996cited by this paper
• Beta IG-H3, a novel secretory protein inducible by transforming growth factor-beta, is present in normal skin and promotes the adhesion and spreading of dermal fibroblasts in vitro.

  1995cited by this paper
• Fibronectin synthesis in tubular epithelial cells: up-regulation of the EDA splice variant by transforming growth factor beta.

  1995cited by this paper
• The alpha 5 beta 1 integrin supports survival of cells on fibronectin and up-regulates Bcl-2 expression.

  1995cited by this paper
• The emerging role of transforming growth factor-beta in kidney diseases.

  1994cited by this paper
• Transforming growth factor beta in tissue fibrosis.

  1994cited by this paper
• Type I and type III collagen mRNA levels in kidney regions of old and young rats.

  1993cited by this paper
• The alpha 5 beta 1 integrin fibronectin receptor, but not the alpha 5 cytoplasmic domain, functions in an early and essential step in fibronectin matrix assembly.

  1993cited by this paper
• cDNA cloning and sequence analysis of beta ig-h3, a novel gene induced in a human adenocarcinoma cell line after treatment with transforming growth factor-beta.

  1992cited by this paper
• Changes in PMN leukocyte migration activity and complement C3d levels in RA patients with high disease activity during steroid treatment.

  1989cited by this paper
• Morphologic heterogeneity along the rat inner medullary collecting duct.

  1989cited by this paper
• Relationship between structure and function in distal tubule and collecting duct.

  1988cited by this paper
• Transforming growth factor beta stimulates the expression of fibronectin and of both subunits of the human fibronectin receptor by cultured human lung fibroblasts.

  1988cited by this paper
• Prediction of creatinine clearance from serum creatinine.

  1975cited by this paper

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  2021cites this paper
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  2021cites this paper
• Interplay between extracellular matrix components and cellular and molecular mechanisms in kidney fibrosis.

  2021cites this paper
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  2020cites this paper
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  2020cites this paper
• Macrophage interactions with collecting duct epithelial cells are capable of driving tubulointerstitial inflammation and fibrosis in immunoglobulin A nephropathy.

  2020cites this paper
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  2020cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2018cites this paper
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  2018cites this paper