The Role of Ceramide Synthases in the Pathogenicity of Cryptococcus neoformans

SUMMARY Cryptococcus neoformans (C. neoformans) is estimated to cause about 220,000 new cases every year in patients with AIDS, despite advances in antifungal treatments. C. neoformans possesses a remarkable ability to disseminate through an immunocompromised host, making treatment difficult. Here, we examine the mechanism of survival of C. neoformans under varying host conditions and find a role for ceramide synthase in C. neoformans virulence. This study also provides a detailed lipidomics resource for the fungal lipid research community in addition to discovering a potential target for antifungal therapy.

• Publication year

  2018

• Venue

  Cell Reports

• Publication date

  2018-02-06

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.celrep.2018.01.035PMID 29425496PMCID 5839121
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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