Rare Germline Variants in ATM Are Associated with Chronic Lymphocytic Leukemia

Chronic lymphocytic leukemia (CLL) is a highly heritable cancer, with a 7.5-fold increased risk in first-degree relatives.1 However, inherited predisposition to CLL remains largely unexplained by traditional linkage or genome-wide association studies. Here, we hypothesized that CLL heritability might arise from rare coding variants not analyzed in previous studies.

• Publication year

  2017

• Venue

  Leukemia

• Publication date

  2017-06-13

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/leu.2017.201PMID 28652578PMCID 5628120
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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