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Autologous CD34+ and CD133+ stem cells transplantation in patients with end stage liver disease.

H. Salama,A. Zekri,A. Bahnassy,E. Medhat,H. A. Halim,Ola S Ahmed,G. Mohamed,Sheren A Al Alim,Ghada M. Sherif

Published 2010 in World Journal of Gastroenterology

ABSTRACT

AIM To assess the utility of an autologous CD34(+) and CD133(+) stem cells infusion as a possible therapeutic modality in patients with end-stage liver diseases. METHODS One hundred and forty patients with end-stage liver diseases were randomized into two groups. Group 1, comprising 90 patients, received granulocyte colony stimulating factor for five days followed by autologous CD34(+) and CD133(+) stem cell infusion in the portal vein. Group 2, comprising 50 patients, received regular liver treatment only and served as a control group. RESULTS Near normalization of liver enzymes and improvement in synthetic function were observed in 54.5% of the group 1 patients; 13.6% of the patients showed stable states in the infused group. None of the patients in the control group showed improvement. No adverse effects were noted. CONCLUSION Our data showed that a CD34(+) and CD133(+) stem cells infusion can be used as supportive treatment for end-stage liver disease with satisfactory tolerability.

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