Serotonin contributes to high pulmonary vascular tone in a sheep model of persistent pulmonary hypertension of the newborn.

No abstract is available for this paper.

• Publication year

  2013

• Venue

  American Journal of Physiology - Lung cellular and Molecular Physiology

• Publication date

  2013-06-15

• Fields of study

  Medicine

• Identifiers
  DOI 10.1152/ajplung.00043.2013PMID 23605003PMCID PMC3680750
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Selective serotonin reuptake inhibitors during pregnancy and risk of persistent pulmonary hypertension in the newborn: population based cohort study from the five Nordic countries

  2011cited by this paper
• Long-Term Maternal Hypoxia

  2011cited by this paper
• Pulmonary vascular effects of serotonin and selective serotonin reuptake inhibitors in the late-gestation ovine fetus.

  2011cited by this paper
• Persistent Pulmonary Hypertension of the Newborn Is Associated with Mode of Delivery and Not with Maternal Use of Selective Serotonin Reuptake Inhibitors

  2010cited by this paper
• Selective serotonin reuptake inhibitors and the incidence and outcome of pulmonary hypertension.

  2009cited by this paper
• RhoA and Rho kinase activation in human pulmonary hypertension: role of 5-HT signaling.

  2009cited by this paper
• Novel interactions between the 5‐HT transporter, 5‐HT1B receptors and Rho kinase in vivo and in pulmonary fibroblasts

  2008cited by this paper
• Converging Evidence in Support of the Serotonin Hypothesis of Dexfenfluramine-Induced Pulmonary Hypertension With Novel Transgenic Mice

  2008cited by this paper
• Chronic intrauterine pulmonary hypertension increases endothelial cell Rho kinase activity and impairs angiogenesis in vitro.

  2008cited by this paper
• Maternal use of selective serotonin re‐uptake inhibitors and persistent pulmonary hypertension of the newborn

  2008cited by this paper
• Prenatal exposure to fluoxetine induces fetal pulmonary hypertension in the rat.

  2007cited by this paper
• Endothelin-1 and Serotonin are Involved in Activation of RhoA/Rho Kinase Signaling in the Chronically Hypoxic Hypertensive Rat Pulmonary Circulation

  2007cited by this paper
• Rho Kinase-Mediated Vasoconstriction Is Important in Severe Occlusive Pulmonary Arterial Hypertension in Rats

  2007cited by this paper
• Transgenic Mice Overexpressing the 5-Hydroxytryptamine Transporter Gene in Smooth Muscle Develop Pulmonary Hypertension

  2006influential reference
• Rho kinase activation maintains high pulmonary vascular resistance in the ovine fetal lung.

  2006cited by this paper
• Cross Talk Between Endothelial and Smooth Muscle Cells in Pulmonary Hypertension: Critical Role for Serotonin-Induced Smooth Muscle Hyperplasia

  2006cited by this paper
• 5-hydroxytryptamine receptors in the human cardiovascular system.

  2006cited by this paper
• 5‐HYDROXYTRYPTAMINE IN THE CARDIOVASCULAR SYSTEM: FOCUS ON THE SEROTONIN TRANSPORTER (SERT)

  2006cited by this paper
• Treatment with selective serotonin reuptake inhibitors during pregnancy: deceleration of weight gain because of depression or drug?

  2006cited by this paper
• ACOG Committee Opinion No. 354: Treatment with selective serotonin reuptake inhibitors during pregnancy.

  2006cited by this paper
• Selective serotonin reuptake inhibitors and adverse pregnancy outcomes.

  2006cited by this paper
• Involvement of RhoA/Rho kinase signaling in pulmonary hypertension of the fawn-hooded rat.

  2006cited by this paper
• Selective serotonin reuptake inhibitor use and outcomes in pulmonary arterial hypertension.

  2006cited by this paper
• SERTRALINE PROTECTS AGAINST MONOCROTALINE‐INDUCED PULMONARY HYPERTENSION IN RATS

  2006cited by this paper
• Cross talk between endothelial and smooth muscle cells in pulmonary hypertension: critical role for serotonin-induced smooth muscle hyperplasia.

  2006cited by this paper
• Evidence for a Control of Plasma Serotonin Levels by 5-Hydroxytryptamine2B Receptors in Mice

  2006cited by this paper
• Selective Serotonin-Reuptake Inhibitors and Risk of Persistent Pulmonary Hypertension of the Newborn

  2006cited by this paper
• Inhibition of Rho-Kinase Attenuates Hypoxia-Induced Angiogenesis in the Pulmonary Circulation

  2005cited by this paper
• Perinatal Depression: A Systematic Review of Prevalence and Incidence

  2005cited by this paper
• Serotonin Transporter Inhibition Prevents and Reverses Monocrotaline-Induced Pulmonary Hypertension in Rats

  2005cited by this paper
• Functional Interactions between 5-Hydroxytryptamine Receptors and the Serotonin Transporter in Pulmonary Arteries

  2005cited by this paper
• Pathophysiologic mechanisms of persistent pulmonary hypertension of the newborn

  2005cited by this paper
• Chronic Maternal Fluoxetine Infusion in Pregnant Sheep: Effects on the Maternal and Fetal Hypothalamic-Pituitary-Adrenal Axes

  2004cited by this paper
• A pilot study of newer antidepressant concentrations in cord and maternal serum and possible effects in the neonate.

  2004cited by this paper
• Overexpression of the 5-Hydroxytryptamine Transporter Gene: Effect on Pulmonary Hemodynamics and Hypoxia-Induced Pulmonary Hypertension

  2004influential reference
• Platelet Serotonin in Newborns and Infants: Ontogeny, Heritability, and Effect of In Utero Exposure to Selective Serotonin Reuptake Inhibitors

  2004cited by this paper
• Rho Kinase–Induced Nuclear Translocation of ERK1/ERK2 in Smooth Muscle Cell Mitogenesis Caused by Serotonin

  2004cited by this paper
• Serotonin transporter inhibitors protect against hypoxic pulmonary hypertension.

  2003cited by this paper
• Serotonin receptor antagonist inhibits monocrotaline-induced pulmonary hypertension and prolongs survival in rats.

  2003cited by this paper
• Expression of the serotonin 1b receptor in experimental pulmonary hypertension

  2003cited by this paper
• Intrauterine hypertension decreases lung VEGF expression and VEGF inhibition causes pulmonary hypertension in the ovine fetus.

  2003cited by this paper
• Birth outcomes after prenatal exposure to antidepressant medication.

  2003cited by this paper
• Effects of exposure to selective serotonin reuptake inhibitors during pregnancy on serotonergic symptoms in newborns and cord blood monoamine and prolactin concentrations.

  2003cited by this paper
• Function of the serotonin 5-hydroxytryptamine 2B receptor in pulmonary hypertension

  2002cited by this paper
• Effect of Maternal Fluoxetine Administration on Uterine Blood Flow, Fetal Blood Gas Status, and Growth

  2002cited by this paper
• Serotonin transporter overexpression is responsible for pulmonary artery smooth muscle hyperplasia in primary pulmonary hypertension.

  2001influential reference
• Activation of Erk Mitogen-Activated Protein Kinase Proteins by Vascular Serotonin Receptors

  2001cited by this paper
• Contribution of the 5-HT1B Receptor to Hypoxia-Induced Pulmonary Hypertension: Converging Evidence Using 5-HT1B-Receptor Knockout Mice and the 5-HT1B/1D-Receptor Antagonist GR127935

  2001cited by this paper
• 5-HT(2A) receptors stimulate mitogen-activated protein kinase via H(2)O(2) generation in rat renal mesangial cells.

  2000cited by this paper
• High Plasma Serotonin Levels in Primary Pulmonary Hypertension: Effect of Long-Term Epoprostenol (Prostacyclin) Therapy

  2000cited by this paper
• 5-HT2A receptors stimulate mitogen-activated protein kinase via H2O2 generation in rat renal mesangial cells

  2000cited by this paper
• 5‐hydroxytryptamine receptors mediating contraction in human small muscular pulmonary arteries: importance of the 5‐HT1B receptor

  1999cited by this paper
• Abnormal vasoreactivity in the pathophysiology of persistent pulmonary hypertension of the newborn.

  1999cited by this paper
• 5‐Hydroxytryptamine receptors mediating vasoconstriction and vasodilation in perinatal and adult rabbit small pulmonary arteries

  1998cited by this paper
• Treatment with 5-HT potentiates development of pulmonary hypertension in chronically hypoxic rats.

  1997cited by this paper
• Maternal tobacco smoke exposure and persistent pulmonary hypertension of the newborn.

  1997cited by this paper
• Persistent pulmonary hypertension of the newborn and smoking and aspirin and nonsteroidal antiinflammatory drug consumption during pregnancy.

  1996cited by this paper
• 5‐Hydroxytryptamine receptors mediating vasoconstriction in pulmonary arteries from control and pulmonary hypertensive rats

  1996cited by this paper
• Increased plasma serotonin in primary pulmonary hypertension.

  1995cited by this paper
• Role of endothelium-derived relaxing factor during transition of pulmonary circulation at birth.

  1990cited by this paper
• Responses of Small Intrapulmonary Arteries to Vasoactive Compounds in the Fetal and Neonatal Lamb: Norepinephrine, Epinephrine, Serotonin, and Potassium Chloride

  1989cited by this paper
• Failure of postnatal adaptation of the pulmonary circulation after chronic intrauterine pulmonary hypertension in fetal lambs.

  1989cited by this paper
• Acute hemodynamic response to the S2-serotonergic receptor antagonist, ketanserin, in patients with primary pulmonary hypertension.

  1987cited by this paper
• [Persistent pulmonary hypertension in the newborn infant].

  1986cited by this paper
• Distribution and regulation of blood flow in the fetal and neonatal lamb.

  1985cited by this paper
• Pulmonary vascular disease in fatal meconium aspiration.

  1985cited by this paper
• The Stractural Basis of PPHN

  1984cited by this paper
• The structural basis of PPHN.

  1984cited by this paper
• Maternal smoking causes fetal hypoxia: experimental evidence.

  1982cited by this paper
• Persistent pulmonary hypertension of the newborn infant.

  1976cited by this paper
• The vascular resistance of the foetal and newly ventilated lung of the lamb

  1964cited by this paper
• The vascular tone of the foetal lung

  1962cited by this paper
• Pulmonary and systemic vascular response to continuous infusion of 5-hydroxytryptamine (serotonin) in the dog.

  1957cited by this paper

• Microbiome Dysregulation and Inflammation: Key Players in Pulmonary Hypertension Pathophysiology

  2025cites this paper
• MicroRNA-210 Mediates Hypoxic Pulmonary Hypertension in the Newborn Lamb

  2025cites this paper
• Relationship Between Urine Serotonin and Persistent Pulmonary Hypertension of the Newborn.

  2024cites this paper
• Fetal ductal constriction caused by SSRI: A case report

  2024cites this paper
• A Review of Serotonin in the Developing Lung and Neonatal Pulmonary Hypertension

  2023cites this paper
• Activation of renal vascular smooth muscle TRPV4 channels by 5-hydroxytryptamine impairs kidney function in neonatal pigs.

  2023cites this paper
• Expression Patterns of Serotonin Receptors 5-HT1A, 5-HT2A, and 5-HT3A during Human Fetal Lung Development

  2023cites this paper
• Serotonin‐deficient neonatal mice are not protected against the development of experimental bronchopulmonary dysplasia or pulmonary hypertension

  2022cites this paper
• Investigation of Genes and Proteins Expression Associating Serotonin Signaling Pathway in Lung and Pulmonary Artery Tissues of Dogs with Pulmonary Hypertension Secondary to Degenerative Mitral Valve Disease: The Preliminary Study

  2022cites this paper
• Pathogenic Mechanisms of Pulmonary Arterial Hypertension

  2022cites this paper
• Pediatric Pulmonary Hypertension: Definitions, Mechanisms, Diagnosis, and Treatment.

  2021cites this paper
• Platelet activation in experimental murine neonatal pulmonary hypertension

  2020cites this paper
• The newborn sheep translational model for pulmonary arterial hypertension of the neonate at high altitude

  2020cites this paper
• Persistent Pulmonary Hypertension of the Newborn: Pathophysiological Mechanisms and Novel Therapeutic Approaches

  2020influential citation
• Brazilian Fetal Cardiology Guidelines - 2019

  2019cites this paper
• Pulmonary Vascular Development and the Neonatal Circulation

  2019cites this paper
• Gestational Hypoxia and Developmental Plasticity.

  2018cites this paper
• Serotonin 2A receptor inhibition protects against the development of pulmonary hypertension and pulmonary vascular remodeling in neonatal mice.

  2018cites this paper
• Pharmacotherapy for Pulmonary Hypertension: Future Directions

  2017cites this paper
• Impact of selective serotonin reuptake inhibitors on neural crest stem cell formation.

  2017cites this paper
• 155 – Pathophysiology of Persistent Pulmonary Hypertension of the Newborn

  2017cites this paper
• Drug-Induced Pulmonary Hypertension: The First 50 Years.

  2017cites this paper
• Selective serotonin reuptake inhibitor exposure constricts the mouse ductus arteriosus in utero.

  2016influential citation
• Advances in Neonatal Pulmonary Hypertension

  2016cites this paper
• Guidelines and Consensus: Statement on Pregnancy in Pulmonary Hypertension from the Pulmonary Vascular Research Institute

  2016cites this paper
• [Clinicopathological analysis of pulmonary vascular disease in 38 neonates died of respiratory failure].

  2016cites this paper
• Persistent pulmonary hypertension of the newborn

  2015cites this paper
• Statement on Pregnancy in Pulmonary Hypertension from the Pulmonary Vascular Research Institute

  2015cites this paper
• Translational Research in Acute Lung Injury and Pulmonary Fibrosis Ozone-induced airway hyperresponsiveness : roles of ROCK isoforms

  2015cites this paper
• Recent advances in the mechanisms of lung alveolarization and the pathogenesis of bronchopulmonary dysplasia.

  2015influential citation
• The pathophysiology of pulmonary hypertension in left heart disease.

  2015cites this paper
• Lifestyle Behaviours Add to the Armoury of Treatment Options for Panic Disorder: An Evidence-Based Reasoning

  2015cites this paper
• Oxidative Stress and the Perinatal Circulation

  2014cites this paper
• Developmental Physiology of the Pulmonary Circulation

  2014cites this paper
• Perinatal and Prenatal Disorders

  2014cites this paper
• Endothelial progenitor cells and pulmonary arterial hypertension.

  2014cites this paper
• Update on PPHN: mechanisms and treatment.

  2014cites this paper
• Role of Reactive Oxygen Species in Neonatal Pulmonary Vascular Disease

  2014cites this paper
• The Robyn Barst Memorial Lecture: Differences between the Fetal, Newborn, and Adult Pulmonary Circulations: Relevance for Age-Specific Therapies (2013 Grover Conference Series)

  2014cites this paper
• Prenatal Programming of Pulmonary Hypertension Induced by Chronic Hypoxia or Ductal Ligation in Sheep

  2013cites this paper