Perforin expression is upregulated in the epidermis of psoriatic lesions

No abstract is available for this paper.

• Publication year

  2004

• Venue

  British Journal of Dermatology

• Publication date

  2004-10-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1111/j.1365-2133.2004.06168.xPMID 15491424
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Predominance of “memory” T cells (CD4+, CDw29+) over “naive” T cells (CD4+, CD45R+) in both normal and diseased human skin

  2004cited by this paper
• Systemic and local expression of perforin in lymphocyte subsets in acute and chronic rheumatoid arthritis.

  2003cited by this paper
• Perforin and granzyme B may contribute to skin inflammation in atopic dermatitis and psoriasis

  2001cited by this paper
• Granule exocytosis, and not the fas/fas ligand system, is the main pathway of cytotoxicity mediated by alloantigen-specific CD4(+) as well as CD8(+) cytotoxic T lymphocytes in humans.

  2000cited by this paper
• Assessment of perforin expression in peripheral blood lymphocytes in psoriatic patients during exacerbation of disease.

  2000cited by this paper
• Which T cells cause psoriasis?

  1999cited by this paper
• Cytotoxicity Is Mandatory for CD8+ T Cell–mediated Contact Hypersensitivity

  1999cited by this paper
• Apoptosis: definition, mechanisms, and relevance to disease.

  1999cited by this paper
• The immunologic and genetic basis of psoriasis.

  1999cited by this paper
• Apoptosis and the skin.

  1999cited by this paper
• Recent developments in the understanding of the pathogenesis of psoriasis

  1999cited by this paper
• Intraepidermal lymphocytes in psoriatic lesions are activated GMP‐17(TIA‐1)+CD8+CD3+ CTLs as determined by phenotypic analysis

  1998cited by this paper
• T‐cell‐mediated cytotoxicity against keratinocytes in sulfamethoxazol‐induced skin reaction

  1998cited by this paper
• Increased perforin expression in multiple sclerosis patients during exacerbation of disease in peripheral blood lymphocytes.

  1997cited by this paper
• Flow cytometric identification of proliferative subpopulations within normal human epidermis and the localization of the primary hyperproliferative population in psoriasis

  1993cited by this paper
• Role of perforin in lymphocyte-mediated cytolysis.

  1992cited by this paper
• Further characterization of the "incipient lesion of chronic stationary type psoriasis vulgaris in exacerbation". The CD4-positive lymphocytes are the prominent cell population infiltrating the dermis.

  1989cited by this paper
• Sequence of changes in psoriatic epidermis. Immunocompetent cell redistribution precedes altered expression of keratinocyte differentiation markers.

  1988cited by this paper
• Epidermal T lymphocytes and HLA‐DR expression in psoriasis

  1984cited by this paper
• Subpopulations of mononuclear cells in microscopic lesions of psoriatic patients. Selective accumulation of suppressor/cytotoxic T cells in epidermis during the evolution of the lesion.

  1984cited by this paper
• T‐cell subpopulations in the blood and skin of patients with psoriasis

  1984cited by this paper

• Potential marker genes for psoriasis revealed based on single-cell sequencing and Mendelian randomization analysis

  2025cites this paper
• Cellular Mechanisms of Psoriasis Pathogenesis: A Systemic Review

  2023cites this paper
• Gallic acid diminishes pro-inflammatory interferon-γ- and interleukin-17-producing sub-populations in vitro in patients with psoriasis

  2023cites this paper
• Inflammation and Psoriasis: A Comprehensive Review

  2023cites this paper
• The Role of Helper T Cells in Psoriasis

  2021cites this paper
• Current Concepts of Psoriasis Immunopathogenesis

  2021cites this paper
• Perforins Expression by Cutaneous Gamma Delta T Cells

  2020cites this paper
• Systemic and Local Increase of Granulysin Expression in Cytotoxic Lymphocytes in Severe Psoriasis.

  2019cites this paper
• Scanning the Immunopathogenesis of Psoriasis

  2018cites this paper
• بررسی درصد سلولهای کشندۀ طبیعی شبه لنفوسیت T در خون محیطی مواجههیافتگان با سولفور موستارد (مدتزمان طولانی بعد از مواجهه)

  2017cites this paper
• T Helper Cell Subsets in Clinical Manifestations of Psoriasis

  2016cites this paper
• Cytotoxic T lymphocytes as a potential brake of keratinocyte proliferation in psoriasis.

  2016cites this paper
• The Inflammatory Response in Psoriasis: a Comprehensive Review

  2016cites this paper
• Epigenetics in Psoriasis

  2015cites this paper
• Frequency and characteristics of circulating CD4+ CD28null T cells in patients with psoriasis

  2015cites this paper
• MANAGEMENT OF PSORIATIC ARTHRITIS: SHOULD THE INTERACTION BETWEEN DERMATOLOGISTS AND RHEUMATOLOGISTS IN CLINICAL PRACTICE BE INTENSIFIED?

  2015cites this paper
• Perforin Expression in Plaque Psoriasis: An Immunohistochemical Study

  2015influential citation
• Study on Certain Biomarkers of Inflammation in Psoriasis Through “OMICS” Platforms

  2014cites this paper
• Review: Skin and the Immune System

  2014cites this paper
• Paradoxes in dermatology

  2013cites this paper
• Epigenetics and psoriasis

  2012cites this paper
• New insights of T cells in the pathogenesis of psoriasis

  2012cites this paper
• Analysis of granulysin-mediated cytotoxicity in peripheral blood of patients with psoriatic arthritis

  2011cites this paper
• 4 – The psoriasiform reaction pattern

  2010cites this paper
• Molecular Dissection of Psoriasis: Integrating Genetics and

  2010cites this paper
• Natural killer cell/epithelial interactions

  2010cites this paper
• Molecular dissection of psoriasis: integrating genetics and biology.

  2010cites this paper
• A comparison of Ki-67 antigen presentation in acute generalized exanthematous pustulosis and pustular psoriasis

  2010cites this paper
• [The role of perforin mediated cell cytotoxicity in psoriasis].

  2010cites this paper
• Natural killer cell cytotoxicity and lymphocyte perforin expression in veterans with posttraumatic stress disorder.

  2010cites this paper
• Innate and acquired immunity in psoriasis

  2009cites this paper
• Apoptosis in psoriasis.

  2009cites this paper
• Determination of quantitative and site-specific DNA methylation of perforin by pyrosequencing

  2009cites this paper
• Immunopathogenesis of psoriasis: focus on natural killer T cells

  2009cites this paper
• Epigenetics in human autoimmunity

  2008cites this paper
• Immunopathogenetic mechanisms in psoriasis

  2007cites this paper
• Nature of cell kinetics in psoriatic epidermis

  2007cites this paper
• The role of telomerase activity in psoriatic skin lesions.

  2007cites this paper
• Analysis of perforin expression in peripheral blood and lesions in severe and mild psoriasis.

  2007cites this paper
• Apoptosis mediated by cytolytic molecules might be responsible for maintenance of psoriatic plaques.

  2006cites this paper
• Serine protease signaling of epidermal permeability barrier homeostasis.

  2006cites this paper