Ultrasound-targeted microbubble destruction combined with dual targeting of HSP72 and HSC70 inhibits HSP90 function and induces extensive tumor-specific apoptosis.

No abstract is available for this paper.

• Publication year

  2014

• Venue

  International Journal of Oncology

• Publication date

  2014-07-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.3892/ijo.2014.2388PMID 24736948
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Cancer statistics, 2014

  2014cited by this paper
• Hsp70 chaperone dynamics and molecular mechanism.

  2013influential reference
• Heat shock proteins 27, 40, and 70 as combinational and dual therapeutic cancer targets.

  2013influential reference
• Inhibition of androgen receptor and β-catenin activity in prostate cancer

  2013influential reference
• Cancer statistics for African Americans, 2013

  2013cited by this paper
• Targeting the PI3K/Akt/mTOR pathway in castration-resistant prostate cancer.

  2013cited by this paper
• Allostery in the Hsp70 chaperone proteins.

  2013cited by this paper
• A Modified HSP70 Inhibitor Shows Broad Activity as an Anticancer Agent

  2013cited by this paper
• Castration‐resistant prostate cancer: Many treatments, many options, many challenges ahead

  2012cited by this paper
• Inhibition of HSP70: a challenging anti-cancer strategy.

  2012influential reference
• A novel approach to attenuate proliferative vitreoretinopathy using ultrasound‐targeted microbubble destruction and recombinant adeno‐associated virus‐mediated RNA interference targeting transforming growth factor‐β2 and platelet‐derived growth factor‐B

  2012cited by this paper
• Targeted Delivery of PLK1-siRNA by ScFv Suppresses Her2+ Breast Cancer Growth and Metastasis

  2012cited by this paper
• Global cancer statistics

  2011cited by this paper
• Hsp70: anti-apoptotic and tumorigenic protein.

  2011cited by this paper
• Progress in the development of ultrasound-mediated gene delivery systems utilizing nano- and microbubbles.

  2011cited by this paper
• Heat shock protein Hsp72 plays an essential role in Her2-induced mammary tumorigenesis

  2011cited by this paper
• Peptides and aptamers targeting HSP70: a novel approach for anticancer chemotherapy.

  2011cited by this paper
• Phenethyl isothiocyanate (PEITC) promotes G2/M phase arrest via p53 expression and induces apoptosis through caspase- and mitochondria-dependent signaling pathways in human prostate cancer DU 145 cells.

  2011cited by this paper
• Heat shock protein 70 (hsp70) as an emerging drug target.

  2010cited by this paper
• Ultrasound microbubbles enhance recombinant adeno-associated virus vector delivery to retinal ganglion cells in vivo.

  2010cited by this paper
• Targeting heat shock protein 72 enhances Hsp90 inhibitor-induced apoptosis in myeloma

  2010cited by this paper
• Targeting membrane heat-shock protein 70 (Hsp70) on tumors by cmHsp70.1 antibody

  2010cited by this paper
• Targeting HSP70: The second potentially druggable heat shock protein and molecular chaperone?

  2010cited by this paper
• Ultrasound-targeted microbubble destruction enhances AAV-mediated gene transfection in human RPE cells in vitro and rat retina in vivo

  2009cited by this paper
• Dual targeting of HSC70 and HSP72 inhibits HSP90 function and induces tumor-specific apoptosis.

  2008cited by this paper
• The heat shock protein 70 family: Highly homologous proteins with overlapping and distinct functions

  2007cited by this paper
• Glucose-regulated protein GRP78 is up-regulated in prostate cancer and correlates with recurrence and survival.

  2007cited by this paper
• Cell type–specific delivery of siRNAs with aptamer-siRNA chimeras

  2006cited by this paper
• Prospects of RNA interference therapy for cancer

  2006cited by this paper
• Expression of Stress Response Protein Grp78 Is Associated with the Development of Castration-Resistant Prostate Cancer

  2006cited by this paper
• HSP90 and the chaperoning of cancer

  2005cited by this paper
• Heat shock proteins: their role in urological tumors.

  2003cited by this paper
• Heat Shock Proteins: Their Role in Urological Tumors

  2003influential reference
• HSP27 and HSP70: Potentially Oncogenic Apoptosis Inhibitors

  2003influential reference
• Identification of proteins in human prostate tumor material by two-dimensional gel electrophoresis and mass spectrometry

  2001influential reference
• Mammalian caspases: structure, activation, substrates, and functions during apoptosis.

  1999cited by this paper
• Induction of cell-membrane porosity by ultrasound.

  1999cited by this paper
• Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death.

  1996cited by this paper
• Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE

  1994cited by this paper
• Cancer statistics for african americans

  1992cited by this paper

• Heat shock cognate 70 protein is a novel target of nobiletin and its colonic metabolites in inhibiting colon carcinogenesis.

  2024cites this paper
• Advances in the study of HSP70 inhibitors to enhance the sensitivity of tumor cells to radiotherapy

  2022cites this paper
• Apoptotic changes and myofibrils degradation in post-mortem chicken muscles by ultrasonic processing

  2021cites this paper
• Metabolites profiling and pharmacokinetics of troxipide and its pharmacodynamics in rats with gastric ulcer

  2020cites this paper
• Oncolytic Adenovirus Expressing ST13 Increases Antitumor Effect of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Against Pancreatic Ductal Adenocarcinoma

  2020cites this paper
• GSEH: A Novel Approach to Select Prostate Cancer-Associated Genes Using Gene Expression Heterogeneity

  2018cites this paper
• The use of 5-fluorouracil-loaded nanobubbles combined with low-frequency ultrasound to treat hepatocellular carcinoma in nude mice

  2017cites this paper
• Suppression of human 8-oxoguanine DNA glycosylase (OGG1) augments ultrasound-induced apoptosis in cervical cancer cells.

  2016cites this paper
• Glucose-regulated protein 78 mediates the therapeutic efficacy of 17-DMAG in colon cancer cells

  2015cites this paper
• Non-invasive treatment of advanced atherosclerotic stenosis in the rabbit carotid artery using low-level combined dual- frequency ultrasonication

  2014cites this paper