Midkine Inhibits Inducible Regulatory T Cell Differentiation by Suppressing the Development of Tolerogenic Dendritic Cells

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Journal of Immunology

• Publication date

  2012-03-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.4049/jimmunol.1102346PMID 22323540
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Tumor necrosis factor‐α promotes granulocyte‐macrophage colony‐stimulating factor‐stimulated microglia to differentiate into competent dendritic cell‐like antigen‐presenting cells

  2011cited by this paper
• IL-9 Promotes Th17 Cell Migration into the Central Nervous System via CC Chemokine Ligand-20 Produced by Astrocytes

  2011cited by this paper
• Dendritic Cell (DC)-Specific Targeting Reveals Stat3 as a Negative Regulator of DC Function

  2010cited by this paper
• Circulating midkine in Crohn's disease: Clinical implications

  2010cited by this paper
• Discovery and development of therapeutic aptamers.

  2010cited by this paper
• LRP-1 Promotes Cancer Cell Invasion by Supporting ERK and Inhibiting JNK Signaling Pathways

  2010cited by this paper
• Transcription factors RUNX1 and RUNX3 in the induction and suppressive function of Foxp3+ inducible regulatory T cells

  2009cited by this paper
• Naturally occurring regulatory dendritic cells regulate murine cutaneous chronic graft-versus-host disease.

  2009cited by this paper
• Therapeutic approaches to allergy and autoimmunity based on FoxP3+ regulatory T-cell activation and expansion.

  2009cited by this paper
• Induction of Treg by monocyte‐derived DC modulated by vitamin D3 or dexamethasone: Differential role for PD‐L1

  2009cited by this paper
• Interleukin-25 Expressed by Brain Capillary Endothelial Cells Maintains Blood-Brain Barrier Function in a Protein Kinase Cϵ-dependent Manner*

  2009cited by this paper
• In vivo delivery of siRNA to immune cells by conjugation to a TLR9 agonist enhances antitumor immune responses

  2009cited by this paper
• PD-L1 regulates the development, maintenance, and function of induced regulatory T cells

  2009cited by this paper
• Th1, Th17, and Th9 Effector Cells Induce Experimental Autoimmune Encephalomyelitis with Different Pathological Phenotypes1

  2009cited by this paper
• Foxp3+ regulatory T cells in the control of experimental CNS autoimmune disease.

  2008cited by this paper
• Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancer

  2008cited by this paper
• IL-12– and IL-23–modulated T cells induce distinct types of EAE based on histology, CNS chemokine profile, and response to cytokine inhibition

  2008cited by this paper
• Inhibition of midkine alleviates experimental autoimmune encephalomyelitis through the expansion of regulatory T cell population

  2008cited by this paper
• Regulatory CD4 T cells: sensing the environment.

  2008cited by this paper
• 1,25-Dihydroxyvitamin D3 Selectively Modulates Tolerogenic Properties in Myeloid but Not Plasmacytoid Dendritic Cells1

  2007cited by this paper
• Immunosuppressive strategies that are mediated by tumor cells.

  2007cited by this paper
• Regulatory dendritic cells protect against cutaneous chronic graft-versus-host disease mediated through CD4+CD25+Foxp3+ regulatory T cells.

  2007cited by this paper
• A discoidin domain receptor 1/SHP-2 signaling complex inhibits alpha2beta1-integrin-mediated signal transducers and activators of transcription 1/3 activation and cell migration.

  2006cited by this paper
• Regulatory T‐cell physiology and application to treat autoimmunity

  2006cited by this paper
• Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

  2006cited by this paper
• “Alternatively Activated” Dendritic Cells Preferentially Secrete IL-10, Expand Foxp3+CD4+ T Cells, and Induce Long-Term Organ Allograft Survival in Combination with CTLA4-Ig1

  2006cited by this paper
• IL-23 drives a pathogenic T cell population that induces autoimmune inflammation

  2005cited by this paper
• The Neuropeptide Vasoactive Intestinal Peptide Generates Tolerogenic Dendritic Cells1

  2005cited by this paper
• STAT3 regulates NF-κB recruitment to the IL-12p40 promoter in dendritic cells

  2005cited by this paper
• STAT3 regulates NF-kappaB recruitment to the IL-12p40 promoter in dendritic cells.

  2005cited by this paper
• Activation of Dendritic Cells via Inhibition of Jak2/STAT3 Signaling1

  2005cited by this paper
• Midkine, a heparin-binding growth factor, is fundamentally involved in the pathogenesis of rheumatoid arthritis.

  2004cited by this paper
• Lack of the growth factor midkine enhances survival against cisplatin-induced renal damage.

  2004cited by this paper
• Characterization of dendritic cells that induce tolerance and T regulatory 1 cell differentiation in vivo.

  2003cited by this paper
• Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain

  2003cited by this paper
• Oligodeoxynucleotide Studies in Primates: Antisense and Immune Stimulatory Indications

  2003cited by this paper
• RNA aptamers to initiation factor 4A helicase hinder cap-dependent translation by blocking ATP hydrolysis.

  2003cited by this paper
• Induction of Experimental Autoimmune Encephalomyelitis in IL-12 Receptor-β2-Deficient Mice: IL-12 Responsiveness Is Not Required in the Pathogenesis of Inflammatory Demyelination in the Central Nervous System1

  2003cited by this paper
• IL-12p35-Deficient Mice Are Susceptible to Experimental Autoimmune Encephalomyelitis: Evidence for Redundancy in the IL-12 System in the Induction of Central Nervous System Autoimmune Demyelination1

  2002cited by this paper
• Th1-type responses mediate spontaneous ileitis in a novel murine model of Crohn's disease.

  2001cited by this paper
• Toxicological evaluation of oligonucleotide therapeutics.

  2000cited by this paper
• Dissection of signaling cascades through gp130 in vivo: reciprocal roles for STAT3- and SHP2-mediated signals in immune responses.

  2000cited by this paper
• Engagement of the Pd-1 Immunoinhibitory Receptor by a Novel B7 Family Member Leads to Negative Regulation of Lymphocyte Activation

  2000cited by this paper
• Anti‐IL‐12 antibody prevents the development and progression of collagen‐induced arthritis in IFN‐γ receptor‐deficient mice

  1998cited by this paper
• Midkine, a retinoic acid-inducible heparin-binding cytokine in inflammatory responses: chemotactic activity to neutrophils and association with inflammatory synovitis.

  1997cited by this paper
• Accelerated collagen-induced arthritis in IFN-gamma receptor-deficient mice.

  1997cited by this paper
• Midkine, a retinoic acid-inducible heparin-binding cytokine in inflammatory responses : chemotactic activity to neutrophils and association with inflammatory synovitis

  1997cited by this paper
• Activation of the alternative pathway of complement by a phosphorothioate oligonucleotide: potential mechanism of action.

  1997cited by this paper
• Mice with a disrupted IFN-gamma gene are susceptible to the induction of experimental autoimmune encephalomyelitis (EAE).

  1996cited by this paper
• Effect of anti-interferon-γ and anti-interleukin-2 monoclonal antibody treatment on the development of actively and passively induced experimental allergic encephalomyelitis in the SJL/J mouse

  1992cited by this paper
• A new family of heparin-binding factors: strong conservation of midkine (MK) sequences between the human and the mouse.

  1991cited by this paper

• Data driven network inference and longitudinal transcriptomics unveil dynamic regulation in Chronic Lymphocytic Leukaemia models

  2026cites this paper
• Inflammation in a severe model of dystrophic cardiomyopathy contains a high proportion of T cells that contribute to onset of pathology.

  2026cites this paper
• Midkine (MDK) as a Central Regulator of the Tumor Microenvironment: From Developmental Cytokine to Therapeutic Target.

  2026cites this paper
• Significance of Midkine Signaling in Women’s Cancers: Novel Biomarker and Therapeutic Target

  2025cites this paper
• Systemic rewiring of dendritic cells by melanoma-secreted midkine impairs immune surveillance and response to immune checkpoint blockade

  2025cites this paper
• Time-series RNA-Seq and data-driven network inference unveil dynamics of cell activation, survival and crosstalk in Chronic Lymphocytic Leukaemia in vitro models

  2025cites this paper
• Midkine (MDK) in cancer and drug resistance: from inflammation to therapy

  2025influential citation
• Modulating Dendritic Cell function in Allergic Asthma with Toxoplasma gondii serine-protease inhibitor 1.

  2025cites this paper
• Single cell transcriptome profiling of infrapatellar fat pad highlights the role of interstitial inflammatory fibroblasts in osteoarthritis.

  2024cites this paper
• Identification of MDK as a Hypoxia- and Epithelial–Mesenchymal Transition-Related Gene Biomarker of Glioblastoma Based on a Novel Risk Model and In Vitro Experiments

  2024cites this paper
• The role of midkine in health and disease

  2023cites this paper
• Elevated Midkine Serum Levels Are Associated with Long-Term Survival in Critically Ill Patients

  2023influential citation
• Nasopharynx Battlefield: Cellular Immune Responses Mediated by Midkine in Nasopharyngeal Carcinoma and COVID-19

  2023cites this paper
• Targeted Delivery Platforms for the Treatment of Multiple Sclerosis.

  2022cites this paper
• Midkine—A novel player in cardiovascular diseases

  2022cites this paper
• Aptamers Targeting Hallmark Proteins of Neurodegeneration

  2022cites this paper
• Nucleic Acids as Novel Therapeutic Modalities to Address Multiple Sclerosis Onset and Progression

  2021cites this paper
• HMOC, a chrysin derivative, induces tolerogenic properties in lipopolysaccharide-stimulated dendritic cells.

  2021cites this paper
• Disruption of Midkine gene reduces traumatic brain injury through the modulation of neuroinflammation

  2020cites this paper
• Plasma Midkine Is Associated With 28-Day Mortality and Organ Function in Sepsis

  2020influential citation
• Regulatory Dendritic Cells Induced by K313 Display Anti-Inflammatory Properties and Ameliorate Experimental Autoimmune Encephalitis in Mice

  2020influential citation
• Multiple pathophysiological roles of midkine in human disease.

  2020cites this paper
• Midkine: The Who, What, Where, and When of a Promising Neurotrophic Therapy for Perinatal Brain Injury

  2020cites this paper
• Study of Serum Midkine Level in Patients with Rheumatoid Arthritis

  2020cites this paper
• Connecting Metainflammation and Neuroinflammation Through the PTN-MK-RPTPβ/ζ Axis: Relevance in Therapeutic Development

  2019cites this paper
• The Role of Midkine in Arteriogenesis, Involving Mechanosensing, Endothelial Cell Proliferation, and Vasodilation

  2018cites this paper
• Involvement of midkine in autoimmune and autoinflammatory diseases

  2018cites this paper
• Serum Midkine Levels in Systemic Lupus Erythematosus

  2018cites this paper
• Growth Factor Midkine Promotes T-Cell Activation through Nuclear Factor of Activated T Cells Signaling and Th1 Cell Differentiation in Lupus Nephritis.

  2017cites this paper
• Tolerogenic Dendritic Cells Induced by BD750 Ameliorate Proinflammatory T cell Responses and Experimental Autoimmune Encephalitis in Mice

  2017cites this paper
• Nucleic acid aptamers for neurodegenerative diseases.

  2017cites this paper
• The growth factor midkine may play a pathophysiological role in rheumatoid arthritis

  2017cites this paper
• From top to bottom: midkine and pleiotrophin as emerging players in immune regulation

  2017cites this paper
• Full Reviews Midkine, a heparin-binding growth factor, and its roles in atherogenesis and in fl ammatory kidney diseases

  2016cites this paper
• Adipocytokines, Receptor Activator of Nuclear Factor-κB Ligand, and Midkine: Intricate Biomarkers Network Involved in Pathogenesis and Activity of Rheumatoid Arthritis in Egyptians

  2016cites this paper
• Midkine Is a Novel Regulator of Amphetamine-Induced Striatal Gliosis and Cognitive Impairment: Evidence for a Stimulus-Dependent Regulation of Neuroinflammation by Midkine

  2016cites this paper
• Midkine, a heparin-binding growth factor, and its roles in atherogenesis and inflammatory kidney diseases.

  2016cites this paper
• Tolerogenic Dendritic Cells Generated with Tofacitinib Ameliorate Experimental Autoimmune Encephalomyelitis through Modulation of Th17/Treg Balance

  2016cites this paper
• Elevated plasma midkine and pleiotrophin levels in patients with systemic lupus erythematosus

  2016cites this paper
• Inactivation of Protein Tyrosine Phosphatase Receptor Type Z by Pleiotrophin Promotes Remyelination through Activation of Differentiation of Oligodendrocyte Precursor Cells

  2015cites this paper
• Midkine and multiple sclerosis

  2014cites this paper
• Structure and function of midkine as the basis of its pharmacological effects

  2014influential citation
• Measuring midkine: the utility of midkine as a biomarker in cancer and other diseases

  2014cites this paper
• The heparin-binding growth factor midkine: the biological activities and candidate receptors.

  2013cites this paper
• Aptamer and its applications for midkine

  2013cites this paper
• Regulatory T cell kinetics in the peripheral blood of patients with Crohn's disease.

  2013cites this paper
• GM-CSF increases LPS-induced production of proinflammatory mediators via upregulation of TLR4 and CD14 in murine microglia

  2012cites this paper
• Cytokines as regulators of proliferation and survival of healthy and malignant peripheral B cells.

  2012cites this paper