Prophylactic Efficacy of Hyperimmune Bovine Colostral Antiadhesin Antibodies Against Enterotoxigenic Escherichia coli Diarrhea: A Randomized, Double-Blind, Placebo-Controlled, Phase 1 Trial

No abstract is available for this paper.

• Publication year

  2017

• Venue

  Journal of Infectious Diseases

• Publication date

  2017-07-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1093/infdis/jix144PMID 28541500
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Characterization of Mucosal Immune Responses to Enterotoxigenic Escherichia coli Vaccine Antigens in a Human Challenge Model: Response Profiles after Primary Infection and Homologous Rechallenge with Strain H10407

  2015cited by this paper
• Characterization of Mucosal Immune Responses to Enterotoxigenic E. coli

  2015cited by this paper
• Maternal Vaccination with a Fimbrial Tip Adhesin and Passive Protection of Neonatal Mice against Lethal Human Enterotoxigenic Escherichia coli Challenge

  2015influential reference
• Burden and aetiology of diarrhoeal disease in infants and young children in developing countries (the Global Enteric Multicenter Study, GEMS): a prospective, case-control study.

  2013cited by this paper
• Preventing urinary tract infection: progress toward an effective Escherichia coli vaccine

  2012cited by this paper
• Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010.

  2012cited by this paper
• Randomized control trials using a tablet formulation of hyperimmune bovine colostrum to prevent diarrhea caused by enterotoxigenic Escherichia coli in volunteers

  2011cited by this paper
• Refinement of a Human Challenge Model for Evaluation of Enterotoxigenic Escherichia coli Vaccines

  2011cited by this paper
• The Two Variants of the Streptococcus pneumoniae Pilus 1 RrgA Adhesin Retain the Same Function and Elicit Cross-Protection In Vivo

  2010cited by this paper
• Roles of Minor Pilin Subunits Spy0125 and Spy0130 in the Serotype M1 Streptococcus pyogenes Strain SF370

  2010cited by this paper
• Structure of CFA/I fimbriae from enterotoxigenic Escherichia coli

  2009cited by this paper
• Pili in Gram-negative and Gram-positive bacteria — structure, assembly and their role in disease

  2009cited by this paper
• CfaE tip mutations in enterotoxigenic Escherichia coli CFA/I fimbriae define critical human intestinal binding sites

  2009cited by this paper
• Global etiology of travelers' diarrhea: systematic review from 1973 to the present.

  2009cited by this paper
• Preventing bacterial infections with pilus-based vaccines: the group B streptococcus paradigm.

  2009cited by this paper
• Donor strand complementation governs intersubunit interaction of fimbriae of the alternate chaperone pathway

  2007cited by this paper
• A Receptor-binding Site as Revealed by the Crystal Structure of CfaE, the Colonization Factor Antigen I Fimbrial Adhesin of Enterotoxigenic Escherichia coli*

  2007cited by this paper
• Immune Response, Ciprofloxacin Activity, and Gender Differences after Human Experimental Challenge by Two Strains of Enterotoxigenic Escherichia coli

  2006cited by this paper
• Crystallization and preliminary X-ray diffraction analysis of CfaE, the adhesive subunit of the CFA/I fimbriae from human enterotoxigenic Escherichia coli.

  2006cited by this paper
• The Major Subunit, CfaB, of Colonization Factor Antigen I from Enterotoxigenic Escherichia coli Is a Glycosphingolipid Binding Protein

  2006cited by this paper
• Serologic correlates of protection against enterotoxigenic Escherichia coli diarrhea.

  2005cited by this paper
• Enterotoxigenic Escherichia coli in Developing Countries: Epidemiology, Microbiology, Clinical Features, Treatment, and Prevention

  2005influential reference
• Antibody responses and protection from pyelonephritis following vaccination with purified Escherichia coli PapDG protein.

  2004cited by this paper
• Vaccination utilizing the FimCH complex as a strategy to prevent Escherichia coli urinary tract infections.

  2001cited by this paper
• Vaccination with FimH adhesin protects cynomolgus monkeys from colonization and infection by uropathogenic Escherichia coli.

  2000cited by this paper
• Lack of prophylactic efficacy of an enteric-coated bovine hyperimmune milk product against enterotoxigenic Escherichia coli challenge administered during a standard meal.

  1999cited by this paper
• A conserved residue in the tip proteins of CS1 and CFA/I pili of enterotoxigenic Escherichia coli that is essential for adherence.

  1999cited by this paper
• Milk immunoglobulin with specific activity against purified colonization factor antigens can protect against oral challenge with enterotoxigenic Escherichia coli.

  1998influential reference
• Prevention of mucosal Escherichia coli infection by FimH-adhesin-based systemic vaccination.

  1997cited by this paper
• Treatment of severe diarrhea caused by Cryptosporidium parvum with oral bovine immunoglobulin concentrate in patients with AIDS.

  1996cited by this paper
• Efficacy of bovine milk immunoglobulin concentrate in preventing illness after Shigella flexneri challenge.

  1992cited by this paper
• Analysis of colonization factor antigen I, an adhesin of enterotoxigenic Escherichia coli O78:H11: fimbrial morphology and location of the receptor-binding site

  1991cited by this paper
• Passive immunisation of children with bovine colostrum containing antibodies to human rotavirus.

  1989cited by this paper
• Transplant or chemotherapy in acute myelogenous leukaemia

  1989cited by this paper
• Protection by milk immunoglobulin concentrate against oral challenge with enterotoxigenic Escherichia coli.

  1988influential reference
• Correlation between intestinal immune response to colonization factor antigen/I and acquired resistance to enterotoxigenicEscherichia coli diarrhea in an adult rabbit model

  1982cited by this paper
• ESCHERICHIA COLI STRAINS THAT CAUSE DIARRHŒA BUT DO NOT PRODUCE HEAT-LABILE OR HEAT-STABLE ENTEROTOXINS AND ARE NON-INVASIVE

  1978cited by this paper
• Escherichia coli strains that cause diarrhoea but do not produce heat-labile or heat-stable enterotoxins and are non-invasive.

  1978cited by this paper
• ALPHA-FETOPROTEIN DURING MID-TRIMESTER INDUCED ABORTION

  1975cited by this paper
• Three Characteristics Associated with Enterotoxigenic Escherichia coli Isolated from Man

  1973cited by this paper

• Parenteral vaccination with recombinant EtpA glycoprotein impairs enterotoxigenic E. coli colonization

  2025cites this paper
• Efficacy Evaluation of an Intradermally Delivered Enterotoxigenic Escherichia coli CF Antigen I Fimbrial Tip Adhesin Vaccine Coadministered with Heat-Labile Enterotoxin with LT(R192G) against Experimental Challenge with Enterotoxigenic E. coli H10407 in Healthy Adult Volunteers

  2024cites this paper
• Dietary Intervention with Whey Protein Concentrate Does Not Affect Toll-like Receptor Responses and Gene Expression Patterns in Peripheral Blood Mononuclear Cells of Healthy Volunteers

  2024cites this paper
• Immunogenic fusion proteins induce neutralizing SARS-CoV-2 antibodies in the serum and milk of sheep

  2023cites this paper
• A First in Human Clinical Trial Assessing the Safety and Immunogenicity of Two Intradermally Delivered Enterotoxigenic Escherichia coli CFA/I Fimbrial Tip Adhesin Antigens with and without Heat-Labile Enterotoxin with Mutation LT(R192G)

  2023cites this paper
• Developments in oral enterotoxigenic Escherichia coli vaccines.

  2023cites this paper
• The role of the minor colonization factor CS14 in adherence to intestinal cell models by geographically diverse ETEC isolates

  2023cites this paper
• Bioactivity and efficacy of a hyperimmune bovine colostrum product- Travelan, against shigellosis in a non-Human primate model (Macaca mulatta)

  2023cites this paper
• Colonization factors of human and animal-specific enterotoxigenic Escherichia coli (ETEC).

  2023cites this paper
• Immunogenic fusion proteins induce neutralizing SARS-CoV-2 antibodies in the serum and milk of sheep

  2022cites this paper
• The role of CFA/I in adherence and toxin delivery by ETEC expressing multiple colonization factors in the human enteroid model

  2022cites this paper
• Development of spirulina for the manufacture and oral delivery of protein therapeutics

  2022cites this paper
• Investigation of a monoclonal antibody against enterotoxigenic Escherichia coli, expressed as secretory IgA1 and IgA2 in plants

  2021cites this paper
• The Controlled Human Infection Model for Enterotoxigenic Escherichia coli.

  2021cites this paper
• Confronting Challenges to Enterotoxigenic Escherichia coli Vaccine Development

  2021cites this paper
• Development and Comparison of a Panel of Modified CS17 Fimbrial Tip Adhesin Proteins as Components for an Adhesin-Based Vaccine against Enterotoxigenic Escherichia coli

  2021cites this paper
• A One Health Perspective for Defining and Deciphering Escherichia coli Pathogenic Potential in Multiple hosts.

  2021cites this paper
• Functional analysis of colonization factor antigen I positive enterotoxigenic Escherichia coli identifies genes implicated in survival in water and host colonization

  2021cites this paper
• Anti-CfaE nanobodies provide broad cross-protection against major pathogenic enterotoxigenic Escherichia coli strains, with implications for vaccine design

  2021cites this paper
• Delivery of Orally Administered Digestible Antibodies Using Nanoparticles

  2021cites this paper
• Evaluation of the Immunogenicity and Protective Efficacy of an Enterotoxigenic Escherichia coli CFA/I Adhesin–Heat-Labile Toxin Chimera

  2020cites this paper
• Inhibition of invasive salmonella by orally administered IgA and IgG monoclonal antibodies

  2020cites this paper
• Oral Vaccines for Enterotoxigenic Escherichia coli

  2020cites this paper
• Oral delivery of Hyperimmune bovine serum antibodies against CS6-expressing enterotoxigenic Escherichia coli as a prophylactic against diarrhea

  2020cites this paper
• Biochemical and immunological characterization of an ETEC CFA/I adhesin cholera toxin B subunit chimera

  2020cites this paper
• Vaccines against gastroenteritis, current progress and challenges

  2020cites this paper
• Oral administration of a single anti-CfaE nanobody provides broadly cross-protective immunity against major pathogenic Enterotoxigenic Escherichia coli strains

  2020cites this paper
• Cross-Reactivity, Epitope Mapping, and Potency of Monoclonal Antibodies to Class 5 Fimbrial Tip Adhesins of Enterotoxigenic Escherichia coli

  2020cites this paper
• Human Mucosal IgA Immune Responses against Enterotoxigenic Escherichia coli

  2020cites this paper
• Preclinical optimization of an enterotoxigenic Escherichia coli adjuvanted subunit vaccine using response surface design of experiments

  2020cites this paper
• A first in human clinical trial assessing the safety and immunogenicity of transcutaneously delivered enterotoxigenic Escherichia coli fimbrial tip adhesin with heat-labile enterotoxin with mutation R192G.

  2020cites this paper
• Cross-Reactivity, Epitope Mapping, and Potency of Monoclonal Antibodies to Class 5 Fimbrial Tip Adhesins of Enterotoxigenic <named-content content-type='genus-species'>Escherichia coli</named-content>

  2020cites this paper
• New Horizons in Food Science via Agricultural Immunity

  2020cites this paper
• Oral administration of an anti-CfaE secretory IgA antibody protects against Enterotoxigenic Escherichia coli diarrheal disease in a non-human primate model

  2019cites this paper
• Conservation and global distribution of non-canonical antigens in Enterotoxigenic Escherichia coli

  2019influential citation
• Evaluation of the reactogenicity, adjuvanticity and antigenicity of LT(R192G) and LT(R192G/L211A) by intradermal immunization in mice

  2019cites this paper
• animal based bioactives for health and wellness

  2019cites this paper
• Evaluation of transcutaneous immunization as a delivery route for an enterotoxigenic E. coli adhesin-based vaccine with CfaE, the colonization factor antigen 1 (CFA/I) tip adhesin.

  2019cites this paper
• Prevention and Treatment of Travelers' Diarrhea

  2019cites this paper
• Hyperimmune bovine colostral anti-CS17 antibodies protect against enterotoxigenic Escherichia coli diarrhea in a randomized, doubled-blind, placebo-controlled human infection model.

  2019cites this paper
• Therapeutic Approaches Targeting the Assembly and Function of Chaperone-Usher Pili

  2019cites this paper
• A roadmap for enterotoxigenic Escherichia coli vaccine development based on volunteer challenge studies

  2019influential citation
• Biochemical and Immunological Evaluation of Recombinant CS6-Derived Subunit Enterotoxigenic Escherichia coli Vaccine Candidates

  2019cites this paper
• Fermented, ultrasonicated, and dehydrated bovine colostrum: Changes in antimicrobial properties and immunoglobulin content.

  2019cites this paper
• Mycobacterium tuberculosis Primary Infection and Dissemination: A Critical Role for Alveolar Epithelial Cells

  2019cites this paper
• Intradermal or Sublingual Delivery and Heat-Labile Enterotoxin Proteins Shape Immunologic Responses to a CFA/I Fimbria-Derived Subunit Antigen Vaccine against Enterotoxigenic Escherichia coli

  2019cites this paper
• The TLR4 agonist adjuvant SLA-SE promotes functional mucosal antibodies against a parenterally delivered ETEC vaccine

  2019cites this paper
• Identification and Characterization of Human Monoclonal Antibodies for Immunoprophylaxis against Enterotoxigenic Escherichia coli Infection

  2018cites this paper
• Establishment, Validation, and Application of a New World Primate Model of Enterotoxigenic Escherichia coli Disease for Vaccine Development

  2018cites this paper
• Human Experimental Challenge With Enterotoxigenic Escherichia coli Elicits Immune Responses to Canonical and Novel Antigens Relevant to Vaccine Development

  2018cites this paper
• Evaluation of a conjugate vaccine platform against enterotoxigenic Escherichia coli (ETEC), Campylobacter jejuni and Shigella.

  2018cites this paper
• Effects of Bovine Immunoglobulins on Immune Function, Allergy, and Infection

  2018cites this paper
• A Role for Salivary Peptides in the Innate Defense Against Enterotoxigenic Escherichia coli

  2018cites this paper