TGFβ1‐induced expression of caldesmon mediates epithelial–mesenchymal transition

No abstract is available for this paper.

• Publication year

  2018

• Venue

  Cytoskeleton

• Publication date

  2018-03-08

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/cm.21437PMID 29466836
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Cell-cell contact and matrix adhesion promote αSMA expression during TGFβ1-induced epithelial-myofibroblast transition via Notch and MRTF-A

  2016cited by this paper
• Current perspectives on cadherin-cytoskeleton interactions and dynamics

  2015cited by this paper
• SNAIL‐induced epithelial‐to‐mesenchymal transition produces concerted biophysical changes from altered cytoskeletal gene expression

  2015cited by this paper
• Cytoskeletal signaling in TGFβ‐induced epithelial–mesenchymal transition

  2015cited by this paper
• Matrix Rigidity Mediates TGFβ1‐induced Epithelial‐Myofibroblast Transition by Controlling Cytoskeletal Organization and MRTF‐A Localization

  2015cited by this paper
• Faculty Opinions recommendation of Cell adhesion. The minimal cadherin-catenin complex binds to actin filaments under force.

  2014cited by this paper
• The minimal cadherin-catenin complex binds to actin filaments under force

  2014cited by this paper
• Biomechanics of TGFβ-induced epithelial-mesenchymal transition: implications for fibrosis and cancer

  2014cited by this paper
• Epithelial-Mesenchymal Transition

  2014influential reference
• Integrin-β5 and zyxin mediate formation of ventral stress fibers in response to transforming growth factor β

  2013cited by this paper
• The Focal Adhesion Analysis Server: a web tool for analyzing focal adhesion dynamics

  2013influential reference
• Cell Adhesion and Shape Regulate TGF-Beta1-Induced Epithelial-Myofibroblast Transition via MRTF-A Signaling

  2013cited by this paper
• Hic-5 promotes invadopodia formation and invasion during TGF-b–induced epithelial–mesenchymal transition

  2012cited by this paper
• Quantifying traction stresses in adherent cells.

  2012cited by this paper
• Hic-5 promotes invadopodia formation and invasion during TGF-β–induced epithelial–mesenchymal transition

  2012cited by this paper
• Diversification of caldesmon-linked actin cytoskeleton in cell motility

  2011cited by this paper
• Myosin II isoform switching mediates invasiveness after TGF-β–induced epithelial–mesenchymal transition

  2011cited by this paper
• Dynamic actin remodeling during epithelial–mesenchymal transition depends on increased moesin expression

  2011cited by this paper
• Integrins and extracellular matrix in mechanotransduction.

  2010cited by this paper
• Caldesmon regulates the motility of vascular smooth muscle cells by modulating the actin cytoskeleton stability

  2010cited by this paper
• Preparation of Hydrogel Substrates with Tunable Mechanical Properties

  2010cited by this paper
• Fate-determining mechanisms in epithelial–myofibroblast transition: major inhibitory role for Smad3

  2010influential reference
• Mechanics, malignancy, and metastasis: The force journey of a tumor cell

  2009cited by this paper
• Contribution of epithelial-derived fibroblasts to bleomycin-induced lung fibrosis.

  2009cited by this paper
• The basics of epithelial-mesenchymal transition.

  2009cited by this paper
• Chapter 1: roles of caldesmon in cell motility and actin cytoskeleton remodeling.

  2009cited by this paper
• Mechanotransduction in development: a growing role for contractility

  2009cited by this paper
• Epithelial cell alpha3beta1 integrin links beta-catenin and Smad signaling to promote myofibroblast formation and pulmonary fibrosis.

  2008cited by this paper
• Foreign body reaction to biomaterials.

  2008cited by this paper
• Adherens and tight junctions: structure, function and connections to the actin cytoskeleton.

  2008cited by this paper
• Erk1/2 MAPK and caldesmon differentially regulate podosome dynamics in A7r5 vascular smooth muscle cells.

  2007cited by this paper
• Alpha-smooth muscle actin expression enhances cell traction force.

  2007cited by this paper
• Dual roles of myocardin-related transcription factors in epithelial–mesenchymal transition via slug induction and actin remodeling

  2007influential reference
• Formation and function of the myofibroblast during tissue repair.

  2007cited by this paper
• The myofibroblast: one function, multiple origins.

  2007cited by this paper
• Hic‐5 contributes to epithelial‐mesenchymal transformation through a RhoA/ROCK‐dependent pathway

  2007cited by this paper
• Elevation of transforming growth factor beta (TGFbeta) and its downstream mediators in subcutaneous foreign body capsule tissue.

  2007cited by this paper
• Caldesmon transgene expression disrupts focal adhesions in HTM cells and increases outflow facility in organ-cultured human and monkey anterior segments.

  2006cited by this paper
• Renal fibrosis: new insights into the pathogenesis and therapeutics.

  2006cited by this paper
• Cellular and Molecular Dynamics in the Foreign Body Reaction

  2006cited by this paper
• Phosphorylation of caldesmon during smooth muscle contraction and cell migration or proliferation.

  2006influential reference
• Caldesmon effects on the actin cytoskeleton and cell adhesion in cultured HTM cells.

  2006influential reference
• Epithelial origin of myofibroblasts during fibrosis in the lung.

  2006cited by this paper
• The inflammatory cell influx and cytokines changes during transition from acute inflammation to fibrous repair around implanted materials

  2006cited by this paper
• Faculty Opinions recommendation of Focal adhesion size controls tension-dependent recruitment of alpha-smooth muscle actin to stress fibers.

  2006cited by this paper
• Modern pathogenetic concepts of liver fibrosis suggest stellate cells and TGF-β as major players and therapeutic targets

  2006cited by this paper
• Requirement of reversible caldesmon phosphorylation at P21-activated kinase-responsive sites for lamellipodia extensions during cell migration.

  2006influential reference
• Caldesmon is an integral component of podosomes in smooth muscle cells

  2006cited by this paper
• Focal adhesion size controls tension-dependent recruitment of α-smooth muscle actin to stress fibers

  2006cited by this paper
• The cardiac fibroblast: therapeutic target in myocardial remodeling and failure.

  2005cited by this paper
• α-Catenin Is a Molecular Switch that Binds E-Cadherin-β-Catenin and Regulates Actin-Filament Assembly

  2005cited by this paper
• Epithelial-mesenchymal transition

  2005cited by this paper
• Alpha-catenin is a molecular switch that binds E-cadherin-beta-catenin and regulates actin-filament assembly.

  2005cited by this paper
• The role of caldesmon in the regulation of endothelial cytoskeleton and migration

  2005influential reference
• Modes of Caldesmon Binding to Actin

  2004influential reference
• The role of epithelial-to-mesenchymal transition in renal fibrosis

  2004cited by this paper
• Activation of the Erk pathway is required for TGF-beta1-induced EMT in vitro.

  2004cited by this paper
• Induction by transforming growth factor-β1 of epithelial to mesenchymal transition is a rare event in vitro

  2004cited by this paper
• A critical role of tropomyosins in TGF-beta regulation of the actin cytoskeleton and cell motility in epithelial cells.

  2004influential reference
• Central role for Rho in TGF-beta1-induced alpha-smooth muscle actin expression during epithelial-mesenchymal transition.

  2003cited by this paper
• Transforming growth factor beta-regulated gene expression in a mouse mammary gland epithelial cell line

  2003cited by this paper
• Restricted expression of membrane type 1‐matrix metalloproteinase by myofibroblasts adjacent to human breast cancer cells

  2003cited by this paper
• Alpha-smooth muscle actin is crucial for focal adhesion maturation in myofibroblasts.

  2003cited by this paper
• BMP-7 counteracts TGF-β1–induced epithelial-to-mesenchymal transition and reverses chronic renal injury

  2003cited by this paper
• Central role for Rho in TGF-β1-induced α-smooth muscle actin expression during epithelial-mesenchymal transition

  2003cited by this paper
• Myofibroblasts and mechano-regulation of connective tissue remodelling

  2002cited by this paper
• Actin dynamics: tropomyosin provides stability.

  2002cited by this paper
• Transforming growth factor-beta-induced mobilization of actin cytoskeleton requires signaling by small GTPases Cdc42 and RhoA.

  2002cited by this paper
• The myofibroblast in pulmonary fibrosis.

  2002cited by this paper
• p38 mitogen-activated protein kinase is required for TGFbeta-mediated fibroblastic transdifferentiation and cell migration.

  2002cited by this paper
• Mechanical tension controls granulation tissue contractile activity and myofibroblast differentiation.

  2001cited by this paper
• Myosin IIB Is Required for Growth Cone Motility

  2001cited by this paper
• Transforming growth factor-beta1 mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependent mechanism.

  2001influential reference
• Alpha-smooth muscle actin expression upregulates fibroblast contractile activity.

  2001cited by this paper
• Association of fibroblast orientation around titanium in vitro with expression of a muscle actin.

  2000cited by this paper
• Caldesmon inhibits nonmuscle cell contractility and interferes with the formation of focal adhesions.

  1999cited by this paper
• TGF-(beta) type I receptor/ALK-5 and Smad proteins mediate epithelial to mesenchymal transdifferentiation in NMuMG breast epithelial cells.

  1999cited by this paper
• Stresses at the cell-to-substrate interface during locomotion of fibroblasts.

  1999cited by this paper
• The Tight Junction Protein ZO-1 Establishes a Link between the Transmembrane Protein Occludin and the Actin Cytoskeleton*

  1998cited by this paper
• Cell locomotion and focal adhesions are regulated by substrate flexibility.

  1997cited by this paper
• Rho-stimulated contractility drives the formation of stress fibers and focal adhesions

  1996cited by this paper
• Overexpression of microfilament-stabilizing human caldesmon fragment, CaD39, affects cell attachment, spreading, and cytokinesis.

  1996cited by this paper
• Messenger RNA for urokinase plasminogen activator is expressed in myofibroblasts adjacent to cancer cells in human breast cancer.

  1996cited by this paper
• Over-expression of smooth muscle caldesmon in mouse fibroblasts.

  1995influential reference
• The origin of the myofibroblasts in breast cancer. Recapitulation of tumor environment in culture unravels diversity and implicates converted fibroblasts and recruited smooth muscle cells.

  1995cited by this paper
• TGF-beta induced transdifferentiation of mammary epithelial cells to mesenchymal cells: involvement of type I receptors

  1994cited by this paper
• Tropomyosin‐troponin complex stabilizes the pointed ends of actin filaments against polymerization and depolymerization

  1990cited by this paper
• Tropomyosin stabilizes the pointed end of actin filaments by slowing depolymerization.

  1989cited by this paper
• The myofibroblast in pulmonary fibrosis.

  1983cited by this paper
• Kinetic analysis of actin assembly suggests that tropomyosin inhibits spontaneous fragmentation of actin filaments.

  1982cited by this paper
• Dynamic study of F-actin by quasielastic scattering of laser light.

  1971cited by this paper
• Transforming Growth Factor- (cid:1) –induced Mobilization of Actin Cytoskeleton Requires Signaling by Small GTPases Cdc42 and RhoA

  year unknowncited by this paper

• The senescence-like activity of BMS-470539 is associated with anti-fibrotic actions in models of dermal fibrosis

  2025cites this paper
• The gene expression of CALD1, CDH2, and POSTN in fibroblast are related to idiopathic pulmonary fibrosis

  2024cites this paper
• The Role of Caldesmon CaD, Integrin αV, Tissue Inhibitor of Metalloproteinases TIMP-1 in Molecular Mechanisms of Pulmonary Tuberculosis Development

  2024cites this paper
• Metastatic tumor cells in bone marrow differ from paired neuroblastoma tumor and contain subsets with therapy-resistant characteristics

  2024cites this paper
• CALD1 facilitates epithelial-mesenchymal transition progression in gastric cancer cells by modulating the PI3K-Akt pathway

  2024cites this paper
• Alterations of the m6A Methylation Induced by TGF-β2 in ARPE-19 Cells.

  2023cites this paper
• Immunohistochemical Expression Analysis of Caldesmon Isoforms in Colorectal Carcinoma Reveals Interesting Correlations with Tumor Characteristics

  2023cites this paper
• Alterations of the m 6 A Methylation Induced by TGF-β 2 in ARPE-19 Cells

  2023cites this paper
• Nitric-Oxide Synthase trafficking inducer (NOSTRIN) is an emerging negative regulator of colon cancer progression

  2022cites this paper
• Dissecting the Inorganic Nanoparticle-Driven Interferences on Adhesome Dynamics

  2021cites this paper
• Cyclooxygenase 2-Regulated Genes an Alternative Avenue to the Development of New Therapeutic Drugs for Colorectal Cancer

  2020cites this paper
• p130Cas induces bone invasion by oral squamous cell carcinoma by regulating tumor epithelial-mesenchymal transition and cell proliferation.

  2020cites this paper
• A Tale of Two States: Normal and Transformed, With and Without Rigidity Sensing.

  2019cites this paper