Profibrotic Activities for Matrix Metalloproteinase-8 during Bleomycin-Mediated Lung Injury

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Journal of Immunology

• Publication date

  2013-04-15

• Fields of study

  Medicine

• Identifiers
  DOI 10.4049/jimmunol.1201043PMID 23487425PMCID PMC3639121
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Pulmonary Vaccination as a Novel Treatment for Lung Fibrosis

  2012cited by this paper
• Ly6Chi monocytes direct alternatively activated profibrotic macrophage regulation of lung fibrosis.

  2011cited by this paper
• Immunoglobulin Free Light Chains Are Increased in Hypersensitivity Pneumonitis and Idiopathic Pulmonary Fibrosis

  2011cited by this paper
• IL-1 and IL-23 Mediate Early IL-17A Production in Pulmonary Inflammation Leading to Late Fibrosis

  2011cited by this paper
• Cigarette smoke-induced lung emphysema in mice is associated with prolyl endopeptidase, an enzyme involved in collagen breakdown.

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• Cardiovascular , Pulmonary , and Renal Pathology Matrix Metalloproteinase 3 Is a Mediator of Pulmonary Fibrosis

  2011cited by this paper
• Antifibrotic properties of c-Ski and its regulation of cardiac myofibroblast phenotype and contractility.

  2011cited by this paper
• ANCA-Associated Lung Fibrosis

  2011cited by this paper
• New concepts of IL-10-induced lung fibrosis: fibrocyte recruitment and M2 activation in a CCL2/CCR2 axis.

  2011cited by this paper
• γδ T cells attenuate bleomycin-induced fibrosis through the production of CXCL10.

  2011cited by this paper
• TGF‐β interactions with IL‐1 family members trigger IL‐4‐independent IL‐9 production by mouse CD4+ T cells

  2010cited by this paper
• Resistance to Bleomycin-Induced Lung Fibrosis in MMP-8 Deficient Mice Is Mediated by Interleukin-10

  2010influential reference
• Expression of matrix metalloproteases by fibrocytes: possible role in migration and homing.

  2010cited by this paper
• MMP‐8 promotes polymorphonuclear cell migration through collagen barriers in obliterative bronchiolitis

  2010cited by this paper
• Repression of IP-10 by Interactions between Histone Deacetylation and Hypermethylation in Idiopathic Pulmonary Fibrosis

  2010cited by this paper
• Loss of matrix metalloproteinase-13 attenuates murine radiation-induced pulmonary fibrosis.

  2010cited by this paper
• Repetitive intratracheal bleomycin models several features of idiopathic pulmonary fibrosis.

  2010cited by this paper
• A Role of Matrix Metalloproteinase-8 in Atherosclerosis

  2009cited by this paper
• CD4+ T cells control the differentiation of Gr1+ monocytes into fibrocytes

  2009cited by this paper
• Matrix Metalloproteinase-8 Inactivates Macrophage Inflammatory Protein-1α To Reduce Acute Lung Inflammation and Injury in Mice

  2009cited by this paper
• Induction of epithelial-mesenchymal transition in primary airway epithelial cells from patients with asthma by transforming growth factor-beta1.

  2009cited by this paper
• Smoking-Dependent Reprogramming of Alveolar Macrophage Polarization: Implication for Pathogenesis of Chronic Obstructive Pulmonary Disease1

  2009cited by this paper
• Alternative activation of macrophages: immune function and cellular biology.

  2009cited by this paper
• Baseline BAL neutrophilia predicts early mortality in idiopathic pulmonary fibrosis.

  2008cited by this paper
• The bleomycin animal model: a useful tool to investigate treatment options for idiopathic pulmonary fibrosis?

  2008cited by this paper
• Characteristics of collagenase-2 from gingival crevicular fluid and peri-implant sulcular fluid in periodontitis and peri-implantitis patients: pilot study

  2008cited by this paper
• The Role of MIP-1α in the Development of Systemic Inflammatory Response and Organ Injury following Trauma Hemorrhage1

  2008cited by this paper
• Proteases as modulators of tumor-stromal interaction: primary tumors to bone metastases.

  2008cited by this paper
• MMP 1 and MMP 7 as Potential Peripheral Blood Biomarkers in Idiopathic Pulmonary Fibrosis

  2008cited by this paper
• A Novel Proteolytic Cascade Generates an Extracellular Matrix-Derived Chemoattractant in Chronic Neutrophilic Inflammation12

  2008cited by this paper
• Roles of T lymphocytes in pulmonary fibrosis

  2008cited by this paper
• MMP1 and MMP7 as Potential Peripheral Blood Biomarkers in Idiopathic Pulmonary Fibrosis

  2008cited by this paper
• LPS Responsiveness and Neutrophil Chemotaxis In Vivo Require PMN MMP-8 Activity

  2007cited by this paper
• Important roles for macrophage colony-stimulating factor, CC chemokine ligand 2, and mononuclear phagocytes in the pathogenesis of pulmonary fibrosis.

  2007cited by this paper
• Essential roles of the CC chemokine ligand 3-CC chemokine receptor 5 axis in bleomycin-induced pulmonary fibrosis through regulation of macrophage and fibrocyte infiltration.

  2007cited by this paper
• Imbalance of receptor-regulated and inhibitory Smads in lung fibroblasts from bleomycin-exposed rats.

  2007cited by this paper
• Human rhinovirus induces robust IP‐10 release by monocytic cells, which is independent of viral replication but linked to type I interferon receptor ligation and STAT1 activation

  2006cited by this paper
• Increased and prolonged pulmonary fibrosis in surfactant protein C-deficient mice following intratracheal bleomycin.

  2005cited by this paper
• MIP‐1α[CCL3] acting on the CCR1 receptor mediates neutrophil migration in immune inflammation via sequential release of TNF‐α and LTB4

  2005cited by this paper
• MIP-1alpha[CCL3] acting on the CCR1 receptor mediates neutrophil migration in immune inflammation via sequential release of TNF-alpha and LTB4.

  2005cited by this paper
• Matrix Metalloproteinase-8 Deficiency Promotes Granulocytic Allergen-Induced Airway Inflammation 1

  2005cited by this paper
• IP-10 Mediates Selective Mononuclear Cell Accumulation and Activation in Response to Intrapulmonary Transgenic Expression and During Adenovirus-Induced Pulmonary Inflammation

  2005cited by this paper
• Repair after cholestatic liver injury correlates with neutrophil infiltration and matrix metalloproteinase 8 activity.

  2005cited by this paper
• Membrane-Bound Matrix Metalloproteinase-8 on Activated Polymorphonuclear Cells Is a Potent, Tissue Inhibitor of Metalloproteinase-Resistant Collagenase and Serpinase1

  2004cited by this paper
• Regulation of pulmonary fibrosis by chemokine receptor CXCR3.

  2004cited by this paper
• An Immune Basis for Lung Parenchymal Destruction in Chronic Obstructive Pulmonary Disease and Emphysema

  2004cited by this paper
• Inhibition of pulmonary fibrosis by the chemokine IP-10/CXCL10.

  2004cited by this paper
• IL-10 inhibits inflammation but does not affect fibrosis in the pulmonary response to bleomycin.

  2004cited by this paper
• Macrophage metalloelastase mediates acute cigarette smoke-induced inflammation via tumor necrosis factor-alpha release.

  2003cited by this paper
• Dual Roles of IL-4 in Lung Injury and Fibrosis1

  2003cited by this paper
• Neutrophil Restraint by Green Tea: Inhibition of Inflammation, Associated Angiogenesis, and Pulmonary Fibrosis1

  2003cited by this paper
• Bleomycin-induced pulmonary fibrosis is attenuated in γ-glutamyl transpeptidase-deficient mice

  2003cited by this paper
• Loss of collagenase-2 confers increased skin tumor susceptibility to male mice

  2003cited by this paper
• Bleomycin-induced pulmonary fibrosis is attenuated in gamma-glutamyl transpeptidase-deficient mice.

  2003cited by this paper
• The integrin alphaVbeta6 binds and activates latent TGFbeta3.

  2002cited by this paper
• The integrin αVβ6 binds and activates latent TGFβ3

  2002cited by this paper
• Matrilysin shedding of syndecan-1 regulates chemokine mobilization and transepithelial efflux of neutrophils in acute lung injury.

  2002cited by this paper
• Matrix metalloproteinase processing of monocyte chemoattractant proteins generates CC chemokine receptor antagonists with anti-inflammatory properties in vivo.

  2002cited by this paper
• Gene expression analysis reveals matrilysin as a key regulator of pulmonary fibrosis in mice and humans

  2002cited by this paper
• Role of Chemokines and Formyl Peptides in Pneumococcal Pneumonia-Induced Monocyte/Macrophage Recruitment2

  2001cited by this paper
• Expression of Neutrophil Collagenase (Matrix Metalloproteinase-8) in Human Atheroma: A Novel Collagenolytic Pathway Suggested by Transcriptional Profiling

  2001cited by this paper
• Characteristic elevation of matrix metalloproteinase activity in idiopathic interstitial pneumonias.

  2000cited by this paper
• Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesis.

  2000cited by this paper
• The cell biology of leukocyte‐mediated proteolysis

  1999cited by this paper
• Treatment of Bleomycin-Induced Pulmonary Fibrosis by Transfer of Urokinase-Type Plasminogen Activator Genes

  1999cited by this paper
• Chemokines IL-8, GROalpha, MCP-1, IP-10, and Mig are sequentially and differentially expressed during phase-specific infiltration of leukocyte subsets in human wound healing.

  1998cited by this paper
• Thrombospondin-1 Is a Major Activator of TGF-β1 In Vivo

  1998cited by this paper
• Differential Effects of Transforming Growth Factor-β on the Expression of Collagenase-1 and Collagenase-3 in Human Fibroblasts*

  1998cited by this paper
• Thrombospondin-1 is a major activator of TGF-beta1 in vivo.

  1998cited by this paper
• Matrix Metalloproteinase-8 Is Expressed in Rheumatoid Synovial Fibroblasts and Endothelial Cells

  1997cited by this paper
• Redox-mediated activation of latent transforming growth factor-beta 1.

  1996cited by this paper
• Bleomycin-induced pulmonary fibrosis in transgenic mice that either lack or overexpress the murine plasminogen activator inhibitor-1 gene.

  1996cited by this paper
• Actions of the chemotactic cytokines MCP-1, MCP-2, MCP-3, RANTES, MIP-1 alpha and MIP-1 beta on human monocytes.

  1995cited by this paper
• C-C chemokines, but not the C-X-C chemokines interleukin-8 and interferon-gamma inducible protein-10, stimulate transendothelial chemotaxis of T lymphocytes.

  1995cited by this paper
• Macrophage inflammatory protein-1 alpha mediates lung leukocyte recruitment, lung capillary leak, and early mortality in murine endotoxemia.

  1995cited by this paper
• Alpha and beta chemokines induce NK cell migration and enhance NK-mediated cytolysis.

  1995cited by this paper
• C‐C chemokines, but not the C‐X‐C chemokines interleukin‐8 and interferon‐γ inducible protein‐10, stimulate transendothelial chemotaxis of T lymphocytes

  1995cited by this paper
• Actions of the chemotactic cytokines MCP‐1, MCP‐2, MCP‐3, RANTES, MIP‐1α and MIP‐1β on human monocytes

  1995cited by this paper
• Recombinant human interferon-inducible protein 10 is a chemoattractant for human monocytes and T lymphocytes and promotes T cell adhesion to endothelial cells

  1993cited by this paper
• Direct activation of human neutrophil procollagenase by recombinant stromelysin.

  1993cited by this paper
• Hapten‐immune pulmonary interstitial fibrosis (HIPIF) in mice requires both CD4+ and CD8+ T lymphocytes

  1993cited by this paper
• Frequencies of T cells secreting IL-2 and/or IL-4 among unprimed CD4+ populations. Evidence that clones secreting IL-2 and IL-4 give rise to clones which secrete only IL-4.

  1990cited by this paper
• Characterization and activation of procollagenase from human polymorphonuclear leucocytes. N-terminal sequence determination of the proenzyme and various proteolytically activated forms.

  1990cited by this paper
• Upregulation of platelet-derived growth factor-A and -B gene expression in alveolar macrophages of individuals with idiopathic pulmonary fibrosis.

  1990cited by this paper
• Activation of latent rheumatoid synovial collagenase by human mast cell tryptase.

  1988cited by this paper
• Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction.

  1987cited by this paper
• The collagen substrate specificity of human neutrophil collagenase.

  1987cited by this paper
• Secreted forms of human neutrophil collagenase.

  1986cited by this paper
• Transforming growth factor-beta stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix.

  1986cited by this paper
• γ-Interferon transcriptionally regulates an early-response gene containing homology to platelet proteins

  1985cited by this paper
• Alveolar macrophages in idiopathic pulmonary fibrosis have glucocorticoid receptors, but glucocorticoid therapy does not suppress alveolar macrophage release of fibronectin and alveolar macrophage derived growth factor.

  1984cited by this paper
• Bleomycin-induced pulmonary fibrosis in hamsters: effect of neutrophil depletion on lung collagen synthesis.

  1982cited by this paper
• Production of fibronectin by the human alveolar macrophage: mechanism for the recruitment of fibroblasts to sites of tissue injury in interstitial lung diseases.

  1981cited by this paper
• The collagen substrate specificity of human skin fibroblast collagenase.

  1981cited by this paper
• The development of bleomycin-induced pulmonary fibrosis in neutrophil-depleted and complement-depleted rats.

  1981cited by this paper
• Secretory responses of human neutrophils: exocytosis of specific (secondary) granules by human neutrophils during adherence in vitro and during exudation in vivo.

  1979cited by this paper
• Granulocyte collagenase: selective digestion of type I relative to type III collagen.

  1977cited by this paper
• Specific degradation of the collagen molecule by tadpole collagenolytic enzyme.

  1965cited by this paper
• The determination of hydroxyproline in tissue and protein samples containing small proportions of this imino acid.

  1961cited by this paper
• The FASEB Journal • Research Communication Increased inflammation delays wound healing in mice deficient in collagenase-2 (MMP-8)

  year unknowncited by this paper

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• Exploring diagnostic gene markers and immune infiltration in idiopathic pulmonary fibrosis

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• The Roles of Neutrophil Cells in the Pathogenesis of Fibrosis: Mechanisms for Disease Progression

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• Neutrophil Heterogeneity in Airway Inflammatory Diseases

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• A Review of Proteases and Antiproteases for Immune Regulation and Potential Therapeutic Application in Pulmonary Fibrosis

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• Naltrexone reduces bleomycin-induced lung fibrosis in rats by attenuating fibrosis, inflammation, oxidative stress, and extracellular matrix remodeling.

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  2024cites this paper
• Immune mechanisms in fibrotic interstitial lung disease.

  2024cites this paper
• The Effect of Physalis angulata L. Administration on Gene Expressions Related to Lung Fibrosis Resolution in Mice-Induced Bleomycin

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• Matrix Metalloproteinases and Their Inhibitors in Pulmonary Fibrosis: EMMPRIN/CD147 Comes into Play

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• Matrix metalloproteinases inhibitors in idiopathic pulmonary fibrosis: Medicinal chemistry perspectives.

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• Matrix Metalloproteinases

  2021cites this paper
• Mechanotransduction in fibrosis: Mechanisms and treatment targets.

  2021cites this paper
• A Novel Protective Role for Matrix Metalloproteinase-8 in the Pulmonary Vasculature.

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• Distinct Metalloproteinase Expression and Functions in Systemic Sclerosis and Fibrosis: What We Know and the Potential for Intervention

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• Integrated computational and experimental pipeline for quantifying local cell–matrix interactions

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  2018cites this paper
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  2017cites this paper
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  2016cites this paper
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  2016cites this paper
• Development and Validation of a Small Single-domain Antibody That Effectively Inhibits Matrix Metalloproteinase 8.

  2016cites this paper
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  2015cites this paper
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  2015cites this paper
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  2015cites this paper
• Protective effects of desacyl ghrelin on diabetic cardiomyopathy

  2015cites this paper
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  2015cites this paper
• Matrix metalloproteinases as therapeutic targets for idiopathic pulmonary fibrosis.

  2015cites this paper
• Bidirectional role of IL-6 signal in pathogenesis of lung fibrosis

  2015cites this paper
• Matrix remodeling by MMPs during wound repair.

  2015cites this paper
• Neutrophil extracellular traps promote differentiation and function of fibroblasts

  2014cites this paper
• A glimpse of matrix metalloproteinases in diabetic nephropathy.

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  2014cites this paper
• ADAM9 Is a Novel Product of Polymorphonuclear Neutrophils: Regulation of Expression and Contributions to Extracellular Matrix Protein Degradation during Acute Lung Injury

  2014cites this paper
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  2014influential citation
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  2014influential citation
• Modeling the lung: Design and development of tissue engineered macro- and micro-physiologic lung models for research use

  2014cites this paper
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  2014cites this paper