Cre‐dependent AAV vectors for highly targeted expression of disease‐related proteins and neurodegeneration in the substantia nigra

No abstract is available for this paper.

• Publication year

  2018

• Venue

  The FASEB Journal

• Publication date

  2018-03-07

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1096/fj.201701529RRPMID 29513569
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  1998cited by this paper
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  1997cited by this paper
• Alpha-synuclein in Lewy bodies.

  1997cited by this paper
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  1997cited by this paper

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