Isatin derivatives with activity against apoptosis-resistant cancer cells.

No abstract is available for this paper.

• Publication year

  2016

• Venue

  Bioorganic & Medicinal Chemistry Letters

• Publication date

  2016-03-15

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1016/j.bmcl.2016.02.015PMID 26883150PMCID PMC4775416
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Sphaeropsidin A shows promising activity against drug-resistant cancer cells by targeting regulatory volume increase

  2015cited by this paper
• Design, synthesis and evaluation of thiohydantoin derivatives as potent topoisomerase I (Top1) inhibitors with anticancer activity.

  2015cited by this paper
• The pleiotropic profile of the indirubin derivative 6BIO overcomes TRAIL resistance in cancer.

  2014cited by this paper
• β-Lapachone induces programmed necrosis through the RIP1-PARP-AIF-dependent pathway in human hepatocellular carcinoma SK-Hep1 cells

  2014cited by this paper
• Rhodanine hydrolysis leads to potent thioenolate mediated metallo-β-lactamase inhibition.

  2014cited by this paper
• Indirubin core structure of glycogen synthase kinase-3 inhibitors as novel chemotype for intervention with 5-lipoxygenase.

  2014cited by this paper
• C1,C2-ether derivatives of the Amaryllidaceae alkaloid lycorine: retention of activity of highly lipophilic analogues against cancer cells.

  2014cited by this paper
• Therapeutic agents triggering nonapoptotic cancer cell death.

  2013cited by this paper
• Hydantoin based inhibitors of MMP13--discovery of AZD6605.

  2013cited by this paper
• Ophiobolin A induces paraptosis-like cell death in human glioblastoma cells by decreasing BKCa channel activity

  2013cited by this paper
• Glioblastoma, a Brief Review of History, Molecular Genetics, Animal Models and Novel Therapeutic Strategies

  2012cited by this paper
• In search of a cytostatic agent derived from the alkaloid lycorine: synthesis and growth inhibitory properties of lycorine derivatives.

  2011cited by this paper
• Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial.

  2009cited by this paper
• Why does cytotoxic chemotherapy cure only some cancers?

  2009cited by this paper
• The sodium pump α1 sub-unit: a disease progression–related target for metastatic melanoma treatment

  2009cited by this paper
• Anoikis resistance and tumor metastasis.

  2008cited by this paper
• 3'-Substituted 7-halogenoindirubins, a new class of cell death inducing agents.

  2006cited by this paper
• Present and potential future issues in glioblastoma treatment

  2006cited by this paper
• Indirubin derivatives inhibit Stat3 signaling and induce apoptosis in human cancer cells

  2005cited by this paper
• Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase-3 and cyclin-dependent kinases.

  2004cited by this paper
• Aryl hydrocarbon receptor-mediated induction of microsomal drug-metabolizing enzyme activity by indirubin and indigo.

  2004cited by this paper
• Development of a chemoresistant orthotopic human nonsmall cell lung carcinoma model in nude mice

  2004cited by this paper
• Syntheses of Indigoid Dye Precursors and Bioactive Compounds Via Condensation of 1,2- and 1,4-Diones with Thiohydantoins

  2002cited by this paper
• Evaluation of the efficiency of chemotherapy in in vivo orthotopic models of human glioma cells with and without 1p19q deletions and in C6 rat orthotopic allografts serving for the evaluation of surgery combined with chemotherapy

  2002cited by this paper
• Long-term survival rates of cancer patients achieved by the end of the 20th century: a period analysis.

  2002cited by this paper
• The synthesis and SAR of rhodanines as novel class C β-lactamase inhibitors

  2000cited by this paper
• The synthesis and SAR of rhodanines as novel class C beta-lactamase inhibitors.

  2000cited by this paper
• Indirubin, the active constituent of a Chinese antileukaemia medicine, inhibits cyclin-dependent kinases

  1999cited by this paper
• Thiazolidinediones: a new class of antidiabetic drugs

  1999cited by this paper
• Étude de dérivés 5-arylidène-2-thiohydantoïnes à potentialité immunomodulatrice et anticancéreuse

  1992cited by this paper

• Recent Development in Hydantoins, Thiohydantoins, and Selenohydantoins as Anticancer Agents: Structure-activity Relationship and Design Strategies.

  2025cites this paper
• One step synthesis of tryptophan-isatin carbon nano dots and bio-applications as multifunctional nanoplatforms.

  2025cites this paper
• DESIGN AND COMPUTATIONAL ANALYSIS OF NEW ISATIN-IMINE HYBRIDS AS SELECTIVE HDAC6 INHIBITORS

  2025cites this paper
• Theoretical Study on the Prooxidant Activity of α‐ and β‐Lapachones in Aqueous Media

  2025cites this paper
• Affinity-driven functionalization of magnetic nanoparticles using tryptophan-isatin for potential bio-applications.

  2025cites this paper
• Hydantion indolinones as AANAT inhibitors.

  2025cites this paper
• Electronic, structural and nonlinear optical investigation of manganese carbonyl complexes of isatin derivatives by DFT

  2024cites this paper
• N-Glycosides of indigo, indirubin, and isoindigo: blue, red, and yellow sugars and their cancerostatic activity

  2024cites this paper
• Evaluation of Anticancer Potential of N(4)-Alkyl Substituted 5-Methoxyisatin Thiosemicarbazones: Synthesis, Characterization and Molecular Docking

  2023cites this paper
• Novel mitochondrial and DNA damaging fluorescent Calix[4]arenes bearing isatin groups as aromatase inhibitors: Design, synthesis and anticancer activity.

  2023cites this paper
• Evaluation of Rhodanine Indolinones as AANAT Inhibitors

  2023cites this paper
• Mechanistic insight and structure activity relationship of isatin-based derivatives in development of anti-breast cancer agents

  2023cites this paper
• A new reversible transformation of oxindolylidene derivatives of imidazothiazolotriazine into 3-[(imidazotriazin-3-yl)thio]-2-oxoquinoline-4-carboxylates.

  2023cites this paper
• Discovery of new quinoline and isatine derivatives as potential VEGFR-2 inhibitors: design, synthesis, antiproliferative, docking and MD simulation studies

  2023cites this paper
• 6-Bromoindirubin-3'-oxime derivatives are highly active colistin adjuvants against Klebsiella pneumoniae.

  2023cites this paper
• Synthesis of 7-oxindolylidene-3a,9a-diphenylimidazothiazolo[2,3-c][1,2,4]triazines by skeletal rearrangement of their [3,2-b]-fused isomers

  2022cites this paper
• 5‐Indolylidene‐2‐iminothiazolidin‐4‐ones – Convenient Starting Compounds for Stereoselective Synthesis of Novel Dispirooxindole Derivatives

  2022cites this paper
• The Anti-Breast Cancer Activity of Dihydroartemisinin-5-methylisatin Hybrids Tethered via Different Carbon Spacers

  2022cites this paper
• Synthesis and antiproliferative activity characterization of new imidazothiazolotriazine oxindolylidene derivatives containing various substituents in the oxindole ring

  2022cites this paper
• Design and synthesis of thiazolidine-2,4-diones hybrids with 1,2-dihydroquinolones and 2-oxindoles as potential VEGFR-2 inhibitors: in-vitro anticancer evaluation and in-silico studies

  2022cites this paper
• A Mini Review on Isatin, an Anticancer Scaffold with Potential Activities against Neglected Tropical Diseases (NTDs)

  2022cites this paper
• A convenient synthesis of 3-aryl-5-methylidene-2-thiohydantoins

  2022cites this paper
• Design, synthesis, anti-proliferative evaluation, docking, and MD simulations studies of new thiazolidine-2,4-diones targeting VEGFR-2 and apoptosis pathway

  2022cites this paper
• Synthesis of 5-methylidene-2-thio- and 2-selenohydantoins from isothiocyanates or isoselenocyanates and l-serine

  2022cites this paper
• DFT Conformational, Wavefunction Based Reactivity Analysis, Docking and MD Simulations of a Carboxamide Derivative with Potential Anticancer Activity

  2022cites this paper
• Co-Inhibition of P-gp and Hsp90 by an Isatin-Derived Compound Contributes to the Increase of the Chemosensitivity of MCF7/ADR-Resistant Cells to Doxorubicin

  2021cites this paper
• Anticancer Compounds Based on Isatin-Derivatives: Strategies to Ameliorate Selectivity and Efficiency

  2021cites this paper
• Dispirooxindoles Based on 2-Selenoxo-Imidazolidin-4-Ones: Synthesis, Cytotoxicity and ROS Generation Ability

  2021cites this paper
• Design, synthesis, in silico molecular modelling studies and biological evaluation of novel indole-thiazolidinedione hybrid analogues as potential pancreatic lipase inhibitors

  2021cites this paper
• Design, Synthesis, Evaluation and Molecular Docking Studies of Novel Triazole Linked 1,4‐Dihydropyridine‐isatin Scaffolds as Potent Anticancer Agents

  2021cites this paper
• Metal-free oxidative ketonization–olefination of indoles by cross-coupling with 1,3-dicarbonyl substrate

  2021cites this paper
• Green Synthesis of Hydantoins and Derivatives

  2020cites this paper
• Study of Organic Radicals Generated upon Naphthoquinone-Hydantoins Reactions in Basic Aqueous Solution

  2020cites this paper
• Isatin: A Scaffold with Innumerable Biodiversity.

  2020cites this paper
• Design, synthesis and biological evaluation of novel 1,5-disubstituted isatin derivatives as antitumor agents

  2020cites this paper
• Current scenario of indole derivatives with potential anti-drug-resistant cancer activity.

  2020cites this paper
• 5-Fluoro-1H-indole-2,3-dione-triazoles- synthesis, biological activity, molecular docking, and DFT study

  2020cites this paper
• The anti-breast cancer potential of bis-isatin scaffolds.

  2020cites this paper
• Isatin dimers and their biological activities

  2020cites this paper
• Isatin–azole hybrids and their anticancer activities

  2020cites this paper
• Oxidative Assets Toward Biomolecules and Cytotoxicity of New Oxindolimine-Copper(II) and Zinc(II) Complexes

  2019cites this paper
• QSAR and Docking Study of Isatin Analogues as Cytotoxic Agents

  2019cites this paper
• Synthesis, anticancer, apoptosis-inducing activities and EGFR and VEGFR2 assay mechanistic studies of 5,5-diphenylimidazolidine-2,4-dione derivatives: Molecular docking studies

  2019cites this paper
• Benzofuran‐isatin conjugates as potent VEGFR‐2 and cancer cell growth inhibitors

  2019cites this paper
• The influence of substituents on the reactivity and cytotoxicity of imidazothiazolotriazinones

  2018cites this paper
• Cu–Catalyzed Tandem Oxidation of N ‐Substituted Indolines to Isatins

  2018cites this paper
• Base‐Catalyzed Formal [3+2] Cycloaddition of Diazooxindoles with Oxazol‐5‐(4H)‐ones

  2018cites this paper
• Novel isatin-derived molecules activate p53 via interference with Mdm2 to promote apoptosis

  2018cites this paper
• Recent Advances in the Synthesis of Hydantoins: The State of the Art of a Valuable Scaffold.

  2017cites this paper
• An efficient method based on indoles for the synthesis of isatins by taking advantage of I2O5 as oxidant

  2017cites this paper
• Semi-synthesis of indirubin-3′-oxime from Strobilanthes cusia leaves, its acute and sub-chronic toxicity, in vitro and in vivo antitumor activity in Lewis lung carcinoma bearing mice

  2016cites this paper