A selective irreversible inhibitor targeting a PDZ protein interaction domain.

No abstract is available for this paper.

• Publication year

  2003

• Venue

  Journal of the American Chemical Society

• Publication date

  2003-09-11

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1021/JA035540LPMID 14518976
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Molecular recognition and docking algorithms.

  2003cited by this paper
• Treatment of Ischemic Brain Damage by Perturbing NMDA Receptor- PSD-95 Protein Interactions

  2002cited by this paper
• The PTEN, Mdm2, p53 tumor suppressor-oncoprotein network.

  2002cited by this paper
• Chemical Approaches for Functionally Probing the Proteome*

  2002cited by this paper
• Polyunsaturated fatty acid synthesis: what will they think of next?

  2002cited by this paper
• PDZ domains and the organization of supramolecular complexes.

  2001cited by this paper
• Magi-1c

  2001cited by this paper
• Energetic determinants of internal motif recognition by PDZ domains.

  2001cited by this paper
• Ten years of protein kinase B signalling: a hard Akt to follow.

  2001cited by this paper
• Evidence for regulation of the PTEN tumor suppressor by a membrane-localized multi-PDZ domain containing scaffold protein MAGI-2.

  2000cited by this paper
• Interaction of the Tumor Suppressor PTEN/MMAC with a PDZ Domain of MAGI3, a Novel Membrane-associated Guanylate Kinase*

  2000cited by this paper
• Membrane‐associated guanylate kinase with inverted orientation (MAGI)‐1/brain angiogenesis inhibitor 1‐associated protein (BAP1) as a scaffolding molecule for Rap small G protein GDP/GTP exchange protein at tight junctions

  2000cited by this paper
• PTEN: a tumour suppressor that functions as a phospholipid phosphatase.

  1999cited by this paper
• PDZ domains: fundamental building blocks in the organization of protein complexes at the plasma membrane.

  1999cited by this paper
• Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B.

  1997cited by this paper
• MAGI-1, a Membrane-associated Guanylate Kinase with a Unique Arrangement of Protein-Protein Interaction Domains*

  1997cited by this paper
• Crystal structures of a complexed and peptide-free membrane protein-binding domain: molecular basis of peptide recognition by PDZ.

  1996cited by this paper

• Peptide Targeting of PDZ-Dependent Interactions as Pharmacological Intervention in Immune-Related Diseases

  2021cites this paper
• Rational Design of PDZ Domain Inhibitors: Discovery of Small Organic Compounds Targeting PDZ Domains.

  2021cites this paper
• Targeting PDZ domains as potential treatment for viral infections, neurodegeneration and cancer

  2021cites this paper
• The electrostatic allostery could be the trigger for the changes in dynamics for the PDZ domain of PICK1

  2020cites this paper
• Structure-based optimization of a PDZ-binding motif within a viral peptide stimulates neurite outgrowth

  2019cites this paper
• Targeting PTEN in Colorectal Cancers.

  2018cites this paper
• Proteinaceous Regulators and Inhibitors of Protein Tyrosine Phosphatases

  2018cites this paper
• Cysteine modifiers suggest an allosteric inhibitory site on the CAL PDZ domain

  2018cites this paper
• Emerging Themes in PDZ Domain Signaling

  2018cites this paper
• Disruption of redox catalytic functions of peroxiredoxin-thioredoxin complex in Mycobacterium tuberculosis H37Rv using small interface binding molecules

  2017cites this paper
• Protein–Protein Interaction Inhibitors in Cancer

  2017cites this paper
• Affinity-guided protein conjugation: the trilogy of covalent protein labeling, assembly and inhibition

  2016cites this paper
• PDZ-Reactive Peptide Activates Ephrin-B Reverse Signaling and Inhibits Neuronal Chemotaxis.

  2016cites this paper
• PTEN-PDZ domain interactions: binding of PTEN to PDZ domains of PTPN13.

  2015cites this paper
• An efficient approach to 1,2,3-trisubstituted indole via rhodium catalyzed carbene C(sp(3))-H bond insertion.

  2015cites this paper
• PTEN: a yin-yang master regulator protein in health and disease.

  2015cites this paper
• Small Molecule Inhibition of the Na+/H+ Exchange Regulatory Factor 1 and Parathyroid Hormone 1 Receptor Interaction

  2014cites this paper
• 1 Ligand binding by PDZ domains

  2014cites this paper
• A site-selective, irreversible inhibitor of the DNA replication auxiliary factor proliferating cell nuclear antigen (PCNA).

  2014cites this paper
• Short linear motifs: ubiquitous and functionally diverse protein interaction modules directing cell regulation.

  2014cites this paper
• Accidental Interaction between PDZ Domains and Diclofenac Revealed by NMR-Assisted Virtual Screening

  2013cites this paper
• Interactions of native peptides and small molecules with the PDZ domains of PSD-95 and SAP97

  2013cites this paper
• Inhibition of PDZ domain-mediated interactions.

  2013cites this paper
• The schizophrenic faces of PICK 1

  2012cites this paper
• GABAB receptors-associated proteins: potential drug targets in neurological disorders?

  2012cites this paper
• Recent advances and new perspectives in targeting CFTR for therapy of cystic fibrosis and enterotoxin-induced secretory diarrheas.

  2012cites this paper
• The parathyroid hormone receptorsome and the potential for therapeutic intervention.

  2012cites this paper
• From laptop to benchtop to bedside: structure-based drug design on protein targets.

  2012cites this paper
• Ruthenium-catalyzed annulation of alkynes with amides via formyl translocation.

  2012cites this paper
• Ligand binding by PDZ domains

  2012cites this paper
• Hot Spots and Transient Pockets: Predicting the Determinants of Small-Molecule Binding to a Protein-Protein Interface

  2012cites this paper
• Functional regulation of cystic fibrosis transmembrane conductance regulator-containing macromolecular complexes: a small-molecule inhibitor approach.

  2011cites this paper
• Targeting the regulation of CFTR channels.

  2011cites this paper
• NMR evaluation of interactions between substituted-indole and PDZ1 domain of PSD-95.

  2011cites this paper
• Synthesis and evaluation of bidentate ligands designed to interact with PDZ domains.

  2011cites this paper
• A fluorescence polarization based screening assay for identification of small molecule inhibitors of the PICK1 PDZ domain.

  2011cites this paper
• Update 1 of: Beta-strand mimetics.

  2010cites this paper
• Dishevelled: The hub of Wnt signaling.

  2010cites this paper
• Development of small molecule RGS inhibitors as a mechanism to modulate G-protein signaling

  2010cites this paper
• Structure-activity relationships of a small-molecule inhibitor of the PDZ domain of PICK1.

  2010cites this paper
• Identification of a small-molecule inhibitor of the PICK1 PDZ domain that inhibits hippocampal LTP and LTD

  2009cites this paper
• Small Molecule Protein–Protein Interaction Inhibitors as CNS Therapeutic Agents: Current Progress and Future Hurdles

  2009influential citation
• Optimizing Dvl PDZ domain inhibitor by exploring chemical space

  2009cites this paper
• Protein-Protein Interactions: Recent Progress in the Development of Selective PDZ Inhibitors

  2009cites this paper
• Modified peptides as potent inhibitors of the postsynaptic density-95/N-methyl-D-aspartate receptor interaction.

  2008cites this paper
• Wnt signaling in development, disease and translational medicine.

  2008cites this paper
• Small-molecule inhibitors of protein-protein interactions.

  2008cites this paper
• Therapeutic use of PDZ protein-protein interaction antagonism.

  2008cites this paper
• Rational design of the first small-molecule antagonists of NHERF1/EBP50 PDZ domains.

  2008cites this paper
• Indole-2-amide based biochemical antagonist of Dishevelled PDZ domain interaction down-regulates Dishevelled-driven Tcf transcriptional activity.

  2008cites this paper
• PDZ Domains: Intracellular Mediators of Carboxy‐Terminal Protein Recognition and Scaffolding

  2008cites this paper
• Directed evolution of a beta -sheet scaffold for targeting proteins involved in human disease -- Thrombin and the vascular endothelial growth factor (VEGF)

  2007cites this paper
• PDZ domain protein-protein interactions: a case study with PICK1.

  2007cites this paper
• Diffusion-limited unbinding of small peptides from PDZ domains.

  2007cites this paper
• An antagonist of dishevelled protein-protein interaction suppresses beta-catenin-dependent tumor cell growth.

  2007cites this paper
• Duplex DNA as a Self-Assembling Template for the Identification of Bidentate Protein-Binding Agents

  2007cites this paper
• Rational design of a nonpeptide general chemical scaffold for reversible inhibition of PDZ domain interactions.

  2007cites this paper
• Bivalent Peptides as Models for Multimeric Targets of PDZ Domains

  2007cites this paper
• Design of a selective chemical probe for class I PDZ domains.

  2007cites this paper
• Scaffolds for blocking protein-protein interactions.

  2007cites this paper
• Targeting PDZ domain proteins for treating NMDA receptor-mediated excitotoxicity.

  2006cites this paper
• The schizophrenic faces of PICK1.

  2006cites this paper
• Beta strand peptidomimetics as potent PDZ domain ligands.

  2006cites this paper
• Targeting protein–protein interactions by rational design: mimicry of protein surfaces

  2006cites this paper
• β Strand Peptidomimetics as Potent PDZ Domain Ligands

  2006cites this paper
• Brief Communication b Strand Peptidomimetics as Potent PDZ Domain Ligands

  2006cites this paper
• Transition metals in organic synthesis: Highlights for the year 2003

  2006cites this paper
• Targeting protein-protein interactions with small molecules: challenges and perspectives for computational binding epitope detection and ligand finding.

  2006cites this paper
• Inhibiting protein-protein interactions using designed molecules.

  2005cites this paper
• Protein surface recognition and proteomimetics: mimics of protein surface structure and function.

  2005cites this paper
• The Kinetics of PDZ Domain-Ligand Interactions and Implications for the Binding Mechanism*

  2005cites this paper
• Making protein interactions druggable: targeting PDZ domains

  2004cites this paper
• Cysteine Modifiers Suggest an Allosteric Inhibitory Site on the Cysteine Modifiers Suggest an Allosteric Inhibitory Site on the CAL PDZ Domain CAL PDZ Domain

  year unknowncites this paper