Direct interaction of the human cytomegalovirus IE86 protein with the cis repression signal does not preclude TBP from binding to the TATA box

No abstract is available for this paper.

• Publication year

  1993

• Venue

  Journal of Virology

• Publication date

  1993-09-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1128/jvi.67.9.5595-5604.1993PMID 8394462PMCID PMC237963
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The 86-kilodalton IE-2 protein of human cytomegalovirus is a sequence-specific DNA-binding protein that interacts directly with the negative autoregulatory response element located near the cap site of the IE-1/2 enhancer-promoter

  1993cited by this paper
• An in vitro system for human cytomegalovirus immediate early 2 protein (IE2)-mediated site-dependent repression of transcription and direct binding of IE2 to the major immediate early promoter.

  1993cited by this paper
• Functional analysis of the true late human cytomegalovirus pp28 upstream promoter: cis-acting elements and viral trans-acting proteins necessary for promoter activation

  1992cited by this paper
• An isoform variant of the cytomegalovirus immediate-early auto repressor functions as a transcriptional activator.

  1992influential reference
• Interaction of TFIID in the minor groove of the TATA element.

  1991cited by this paper
• Enhancement of RNA polymerase II initiation complexes by a novel DNA control domain downstream from the cap site of the cytomegalovirus major immediate-early promoter

  1991cited by this paper
• The functionally active IE2 immediate-early regulatory protein of human cytomegalovirus is an 80-kilodalton polypeptide that contains two distinct activator domains and a duplicated nuclear localization signal

  1991cited by this paper
• Zinc fingers, zinc clusters, and zinc twists in DNA-binding protein domains.

  1991cited by this paper
• Human cytomegalovirus ie2 negatively regulates alpha gene expression via a short target sequence near the transcription start site

  1991influential reference
• A discrete cis element in the human immunodeficiency virus long terminal repeat mediates synergistic trans activation by cytomegalovirus immediate-early proteins

  1991cited by this paper
• TFIID binds in the minor groove of the TATA box.

  1991cited by this paper
• Molecular zippers in gene regulation.

  1991cited by this paper
• A cis-acting element in the major immediate-early (IE) promoter of human cytomegalovirus is required for negative regulation by IE2

  1991cited by this paper
• An inducible promoter mediates abundant expression from the immediate-early 2 gene region of human cytomegalovirus at late times after infection

  1991cited by this paper
• Human cytomegalovirus UL36-38 and US3 immediate-early genes: temporally regulated expression of nuclear, cytoplasmic, and polysome-associated transcripts during infection

  1991cited by this paper
• Functional domains and upstream activation properties of cloned human TATA binding protein.

  1990cited by this paper
• Mutational analysis of cis elements involved in E2 modulation of human papillomavirus type 16 P97 and type 18 P105 promoters

  1990cited by this paper
• Cloning of a transcriptionally active human TATA binding factor.

  1990cited by this paper
• Regulation and tissue-specific expression of human cytomegalovirus.

  1990cited by this paper
• The IE2 gene products of human cytomegalovirus specifically down-regulate expression from the major immediate-early promoter through a target sequence located near the cap site

  1990cited by this paper
• Analysis of the protein-coding content of the sequence of human cytomegalovirus strain AD169.

  1990cited by this paper
• Modulation of interleukin 1 beta gene expression by the immediate early genes of human cytomegalovirus.

  1990cited by this paper
• Human cytomegalovirus immediate-early two protein region involved in negative regulation of the major immediate-early promoter

  1990cited by this paper
• Promoter-specific trans activation and repression by human cytomegalovirus immediate-early proteins involves common and unique protein domains

  1990cited by this paper
• Transactivation of a human cytomegalovirus early promoter by gene products from the immediate-early gene IE2 and augmentation by IE1: mutational analysis of the viral proteins

  1990cited by this paper
• Human cytomegalovirus early gene expression.

  1990cited by this paper
• Characterization of the DNA-binding properties of herpes simplex virus regulatory protein ICP4

  1989cited by this paper
• A human cytomegalovirus early gene has three inducible promoters that are regulated differentially at various times after infection

  1989cited by this paper
• Transcriptional regulation in mammalian cells by sequence-specific DNA binding proteins.

  1989cited by this paper
• Regulated expression of the human cytomegalovirus pp65 gene: octamer sequence in the promoter is required for activation by viral gene products

  1989cited by this paper
• NF‐kappa B activation of the cytomegalovirus enhancer is mediated by a viral transactivator and by T cell stimulation.

  1989cited by this paper
• Regulated expression of early and late RNAs and proteins from the human cytomegalovirus immediate-early gene region

  1989influential reference
• Genetic assignment of multiple E2 gene products in bovine papillomavirus-transformed cells

  1989cited by this paper
• E2 polypeptides encoded by bovine papillomavirus type 1 form dimers through the common carboxyl-terminal domain: transactivation is mediated by the conserved amino-terminal domain.

  1989cited by this paper
• Three amino acids of the oestrogen receptor are essential to its ability to distinguish an oestrogen from a glucocorticoid-responsive element

  1989cited by this paper
• Human cytomegalovirus ie1 transactivates the alpha promoter-enhancer via an 18-base-pair repeat element

  1989cited by this paper
• The leucine zipper: a hypothetical structure common to a new class of DNA binding proteins.

  1988cited by this paper
• GAL4-VP16 is an unusually potent transcriptional activator

  1988cited by this paper
• Identification of sequence requirements and trans-acting functions necessary for regulated expression of a human cytomegalovirus early gene

  1988cited by this paper
• Biosynthesis and analysis of a genetically engineered HIV-1 reverse transcriptase/endonuclease polyprotein in Escherichia coli.

  1988influential reference
• trans-activation and autoregulation of gene expression by the immediate-early region 2 gene products of human cytomegalovirus

  1988influential reference
• An enhancer element in the short unique region of human cytomegalovirus regulates the production of a group of abundant immediate early transcripts.

  1988cited by this paper
• Direct correlation between a negative autoregulatory response element at the cap site of the herpes simplex virus type 1 IE175 (alpha 4) promoter and a specific binding site for the IE175 (ICP4) protein

  1988cited by this paper
• The bovine papillomavirus P2443 promoter is E2 trans‐responsive: evidence for E2 autoregulation.

  1988cited by this paper
• Distinct regions of Sp1 modulate DNA binding and transcriptional activation.

  1988cited by this paper
• Participation of two human cytomegalovirus immediate early gene regions in transcriptional activation of adenovirus promoters.

  1987cited by this paper
• Identification and characterization of the human cytomegalovirus immediate-early region 2 gene that stimulates gene expression from an inducible promoter

  1987cited by this paper
• Binding of transcription factors and creation of a large nucleoprotein complex on the human cytomegalovirus enhancer.

  1987cited by this paper
• Positive and negative regulation of transcription in vitro: enhancer-binding protein AP-2 is inhibited by SV40 T antigen.

  1987cited by this paper
• A novel rapid assay for chloramphenicol acetyltransferase gene expression

  1987cited by this paper
• An adenovirus E1a protein region required for transformation and transcriptional repression.

  1986cited by this paper
• Potential metal-binding domains in nucleic acid binding proteins.

  1986cited by this paper
• Multiple spliced and unspliced transcripts from human cytomegalovirus immediate-early region 2 and evidence for a common initiation site within immediate-early region 1

  1985influential reference
• Structural analysis of the major immediate early gene of human cytomegalovirus

  1984cited by this paper
• Predominant immediate-early transcripts of human cytomegalovirus AD 169

  1984cited by this paper
• Adenovirus-2 E1A products repress enhancer-induced stimulation of transcription

  1984cited by this paper
• Organization and expression of the immediate early genes of human cytomegalovirus

  1983cited by this paper
• SV40 T antigen binding site mutations that affect autoregulation.

  1983cited by this paper
• Temporal regulation of human cytomegalovirus transcription at immediate early and early times after infection

  1981cited by this paper
• Immediate-early proteins of human cytomegalovirus strains AD 169, Davis, and Towne differ in electrophoretic mobility.

  1981cited by this paper
• Patterns of Transcription of Human Cytomegalovirus in Permissively Infected Cells

  1980cited by this paper
• Structure of two spliced mRNAs from the transforming region of human subgroup C adenoviruses

  1979cited by this paper
• DNA sequencing with chain-terminating inhibitors.

  1977cited by this paper

• Human Cytomegalovirus IE2 Both Activates and Represses Initiation and Modulates Elongation in a Context-Dependent Manner

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• Phosphorylation by CK2 increases the SUMO-dependent activity of Cytomegalovirus transactivator IE2

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• Casein kinase-2–mediated phosphorylation increases the SUMO-dependent activity of the cytomegalovirus transactivator IE2

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• SUMOylation of IE2p86 is required for efficient autorepression of the human cytomegalovirus major immediate-early promoter.

  2018cites this paper
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  2010cites this paper
• Functional Properties of the Human Cytomegalovirus IE86 Protein Required for Transcriptional Regulation and Virus Replication

  2010cites this paper
• Effect of Inducible Expressed Human Cytomegalovirus Immediate Early 86 Protein on Cell Apoptosis

  2009cites this paper
• Analysis of key regions, roles, and interactions of the IE2 family of proteins throughout the human cytomegalovirus infection process

  2009cites this paper
• NF- (cid:2) B-Mediated Activation of the Chemokine CCL22 by the Product of the Human Cytomegalovirus Gene UL144 Escapes Regulation by Viral IE86 (cid:1)

  2008cites this paper
• The control of human cytomegalovirus latent and lytic gene expression by chromatin remodelling

  2008cites this paper
• NF-κB-Mediated Activation of the Chemokine CCL22 by the Product of the Human Cytomegalovirus Gene UL144 Escapes Regulation by Viral IE86

  2008cites this paper
• Functional roles of the human cytomegalovirus essential IE86 protein.

  2008cites this paper
• Dynamic Histone H3 Acetylation and Methylation at Human Cytomegalovirus Promoters during Replication in Fibroblasts

  2008cites this paper
• The Autoregulatory and Transactivating Functions of the Human Cytomegalovirus IE86 Protein Use Independent Mechanisms for Promoter Binding

  2007cites this paper
• Autorepression of the Human Cytomegalovirus Major Immediate-Early Promoter/Enhancer at Late Times of Infection Is Mediated by the Recruitment of Chromatin Remodeling Enzymes by IE86

  2006influential citation
• Struktur-Funktionsanalyse des Immediate-Early Proteins 2 (IE2) des humanen Zytomegalievirus

  2005influential citation
• Elimination of ie1 Significantly Attenuates Murine Cytomegalovirus Virulence but Does Not Alter Replicative Capacity in Cell Culture

  2005cites this paper
• Expression Differential Defects in Viral Gene Nonviable Recombinant Viruses with Cytomegalovirus IE 2 Gene Result in Small Internal Deletions in the Human

  2004cites this paper
• Small Internal Deletions in the Human Cytomegalovirus IE2 Gene Result in Nonviable Recombinant Viruses with Differential Defects in Viral Gene Expression

  2004cites this paper
• The Putative Zinc Finger of the Human Cytomegalovirus IE2 86-Kilodalton Protein Is Dispensable for DNA Binding and Autorepression, Thereby Demarcating a Concise Core Domain in the C Terminus of the Protein

  2004influential citation
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  2003cites this paper
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• Viable Human Cytomegalovirus Recombinant Virus with an Internal Deletion of the IE2 86 Gene Affects Late Stages of Viral Replication

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• Identification of Additional IE2-p86-Responsive cis-Repressive Sequences within the Human Cytomegalovirus Major Immediate Early Gene Promoter

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  2002cites this paper
• Identification of additional IE2-p86-responsive cis-repressive sequences within the human cytomegalovirus major immediate early gene promoter.

  2002cites this paper
• Absence of IE1 p72 Protein Function during Low-Multiplicity Infection by Human Cytomegalovirus Results in a Broad Block to Viral Delayed-Early Gene Expression

  2002influential citation
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  2002cites this paper
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  2001cites this paper
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  1999cites this paper
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  1999cites this paper
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  1998cites this paper
• Identification of Positive and Negative Regulatory Regions Involved in Regulating Expression of the Human Cytomegalovirus UL94 Late Promoter: Role of IE2-86 and Cellular p53 in Mediating Negative Regulatory Function

  1998cites this paper
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  1998cites this paper
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  1997cites this paper
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  1997cites this paper
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  1997influential citation
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  1997influential citation
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  1996cites this paper
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  1996cites this paper
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  1996cites this paper
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  1996cites this paper
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  1996cites this paper
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  1996cites this paper
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  1994cites this paper
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  1994cites this paper
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  1994cites this paper
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  1993influential citation
• Site-specific inhibition of RNA polymerase II preinitiation complex assembly by human cytomegalovirus IE86 protein

  1993cites this paper