Structural insight into the mutual recognition and regulation between Suppressor of Fused and Gli/Ci

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Nature Communications

• Publication date

  2013-11-12

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/ncomms3608PMID 24217340PMCID PMC5842692
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Meteorological Influences on the Incidence of Aneurysmal Subarachnoid Hemorrhage – A Single Center Study of 511 Patients

  2013cited by this paper
• Gli proteins in development and disease.

  2011cited by this paper
• Structural basis for the recognition of Asef by adenomatous polyposis coli

  2011cited by this paper
• Transduction of the Hedgehog signal through the dimerization of Fused and the nuclear translocation of Cubitus interruptus

  2011cited by this paper
• The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins.

  2010cited by this paper
• A mechanism for vertebrate Hedgehog signaling: recruitment to cilia and dissociation of SuFu–Gli protein complexes

  2010cited by this paper
• Suppressor of fused and Spop regulate the stability, processing and function of Gli2 and Gli3 full-length activators but not their repressors

  2010cited by this paper
• Protein annotation and modelling servers at University College London

  2010cited by this paper
• Coordinated Translocation of Mammalian Gli Proteins and Suppressor of Fused to the Primary Cilium

  2010cited by this paper
• Suppressor of Fused inhibits mammalian Hedgehog signaling in the absence of cilia.

  2009cited by this paper
• Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved.

  2009cited by this paper
• Multiple Ser/Thr-rich degrons mediate the degradation of Ci/Gli by the Cul3-HIB/SPOP E3 ubiquitin ligase

  2009cited by this paper
• Identification of a SUFU germline mutation in a family with Gorlin syndrome

  2009cited by this paper
• Hedgehog signaling in development and cancer.

  2008cited by this paper
• Role and regulation of human tumor suppressor SUFU in Hedgehog signaling.

  2008cited by this paper
• Hedgehog regulates smoothened activity by inducing a conformational switch

  2007cited by this paper
• Phaser crystallographic software

  2007cited by this paper
• Protein–protein interaction through β-strand addition

  2006cited by this paper
• Roadkill attenuates Hedgehog responses through degradation of Cubitus interruptus

  2006cited by this paper
• A hedgehog-induced BTB protein modulates hedgehog signaling by degrading Ci/Gli transcription factor.

  2006cited by this paper
• Signaling from Smo to Ci/Gli: conservation and divergence of Hedgehog pathways from Drosophila to vertebrates

  2006cited by this paper
• Genetic elimination of Suppressor of fused reveals an essential repressor function in the mammalian Hedgehog signaling pathway.

  2006cited by this paper
• Lysine Methylation as a Routine Rescue Strategy for Protein Crystallization

  2006cited by this paper
• Protein-protein interaction through beta-strand addition.

  2006cited by this paper
• Divergence of hedgehog signal transduction mechanism between Drosophila and mammals.

  2006cited by this paper
• Negative regulation of Gli1 and Gli2 activator function by Suppressor of fused through multiple mechanisms.

  2005cited by this paper
• ConSurf 2005: the projection of evolutionary conservation scores of residues on protein structures

  2005cited by this paper
• Cardiac and CNS defects in a mouse with targeted disruption of suppressor of fused

  2005cited by this paper
• Suppressor of Fused Regulates Gli Activity through a Dual Binding Mechanism

  2004cited by this paper
• Tissue repair and stem cell renewal in carcinogenesis

  2004cited by this paper
• ElNémo: a normal mode web server for protein movement analysis and the generation of templates for molecular replacement

  2004cited by this paper
• Coot: model-building tools for molecular graphics.

  2004cited by this paper
• Macromolecular TLS refinement in REFMAC at moderate resolutions.

  2003cited by this paper
• Developmental roles and clinical significance of hedgehog signaling.

  2003cited by this paper
• Characterization of the Physical Interaction of Gli Proteins with SUFU Proteins*

  2003cited by this paper
• Consensus-derived structural determinants of the ankyrin repeat motif

  2002cited by this paper
• Suppressor of Fused represses Gli-mediated transcription by recruiting the SAP18-mSin3 corepressor complex

  2002cited by this paper
• Mutations in SUFU predispose to medulloblastoma

  2002cited by this paper
• Hedgehog signaling in animal development: paradigms and principles.

  2001cited by this paper
• Interactions with Costal2 and suppressor of fused regulate nuclear translocation and activity of cubitus interruptus.

  2000cited by this paper
• Suppressor of fused opposes hedgehog signal transduction by impeding nuclear accumulation of the activator form of Cubitus interruptus.

  2000cited by this paper
• Characterization of the human suppressor of fused, a negative regulator of the zinc-finger transcription factor Gli.

  1999cited by this paper
• Vertebrate homologs of Drosophila suppressor of fused interact with the gli family of transcriptional regulators.

  1999cited by this paper
• Mouse suppressor of fused is a negative regulator of sonic hedgehog signaling and alters the subcellular distribution of Gli1.

  1999cited by this paper
• Mammalian Suppressor-of-Fused modulates nuclear–cytoplasmic shuttling of GLI-1

  1999cited by this paper
• Suppressor of fused links fused and Cubitus interruptus on the hedgehog signalling pathway.

  1998cited by this paper
• [20] Processing of X-ray diffraction data collected in oscillation mode.

  1997cited by this paper
• Processing of X-ray diffraction data collected in oscillation mode.

  1997cited by this paper
• The CCP4 suite: programs for protein crystallography.

  1994cited by this paper
• The GLI gene is a member of the Kruppel family of zinc finger proteins

  1988cited by this paper

• The Role of the Hedgehog Pathway in Alcohol-Induced Birth Defects.

  2026cites this paper
• AlphaFold3 predictions of novel GLI-SUFU interfaces identify binding-defective SUFU missense variants from medulloblastoma and Gorlin Syndrome patients

  2026influential citation
• Morphogen-induced kinase condensates transduce Hh signal by allosterically activating Gli

  2025cites this paper
• Targeting MMA-induced USP36 methylmalonylation to suppress macrophage polarization and tumor progression in clear-cell renal cell carcinoma.

  2025cites this paper
• Hedgehog-stimulated phosphorylation at multiple sites activates Ci by altering Ci–Ci interfaces without full Suppressor of Fused dissociation

  2025cites this paper
• Physiological analysis of the mechanism of Ci transcription factor activation through multiple Fused phosphorylation sites in Hedgehog signal transduction

  2025cites this paper
• Regulatory mechanisms governing GLI proteins in hedgehog signaling

  2024cites this paper
• Hedgehog Signaling Pathway in Fibrosis and Targeted Therapies

  2024cites this paper
• Positive regulation of Hedgehog signaling via phosphorylation of GLI2/GLI3 by DYRK2 kinase

  2024cites this paper
• Increasing Sufu gene dosage reveals its unorthodox role in promoting polydactyly and medulloblastoma tumorigenesis

  2024cites this paper
• Cellular and molecular mechanisms of Hedgehog signalling

  2023cites this paper
• Hedgehog signaling in tissue homeostasis, cancers and targeted therapies

  2023cites this paper
• SUFU promotes GLI activity in a Hedgehog-independent manner in pancreatic cancer.

  2023cites this paper
• Exploring the hub mechanisms of ischemic stroke based on protein-protein interaction networks related to ischemic stroke and inflammatory bowel disease

  2023cites this paper
• Enhanced mitophagy driven by ADAR1-GLI1 editing supports the self-renewal of cancer stem cells in HCC

  2023cites this paper
• Dose-dependent phosphorylation and activation of Hh pathway transcription factors

  2022influential citation
• Ci/Gli Phosphorylation by the Fused/Ulk Family Kinases.

  2022cites this paper
• Hedgehog signaling mechanism and role in cancer.

  2021cites this paper
• ERK2 MAP kinase regulates SUFU binding by multisite phosphorylation of GLI1

  2021influential citation
• Regulation of Hedgehog Signal Transduction by Ubiquitination and Deubiquitination

  2021cites this paper
• Hedgehog/GLI Signaling Pathway: Transduction, Regulation, and Implications for Disease

  2021cites this paper
• A Knowledge-guided Mechanistic Model of Synthetic Lethality in the HCT116 Vorinostat-resistant Colon Cancer Xenograft Model Cell-line

  2021cites this paper
• A large disordered region confers a wide spanning volume to vertebrate Suppressor of Fused as shown in a trans-species solution study

  2021cites this paper
• Optimization of quantum-dot light source and detection of the simulants of chemical warfare agent

  2021cites this paper
• Constitutive GLI1 expression in chondrosarcoma is regulated by major vault protein via mTOR/S6K1 signaling cascade

  2021cites this paper
• Structural Analysis of an l-Cysteine Desulfurase from an Ssp DNA Phosphorothioation System

  2020cites this paper
• A novel multiplexed interactome proteomics approach for studying cellular signaling

  2020cites this paper
• Structural insight into the recognition between Sufu and Fused in the Hedgehog signal transduction pathway.

  2020cites this paper
• Targeting the GLI family of transcription factors for the development of anti-cancer drugs

  2020cites this paper
• Hedgehog signaling in gastrointestinal carcinogenesis and the gastrointestinal tumor microenvironment

  2020cites this paper
• Proteostasis in the Hedgehog signaling pathway.

  2019cites this paper
• A proteomic approach identifies SAFB-like transcription modulator (SLTM) as a bidirectional regulator of GLI family zinc finger transcription factors

  2019cites this paper
• Molecular mechanisms of suppressor of fused in regulating the hedgehog signalling pathway.

  2018cites this paper
• Using Genomic Transgenes and the CRISPR/Cas9 Gene Editing System to Understand How Hedgehog Signaling Regulates Costal2 and Cubitus Interruptus in Drosophila melanogaster

  2017cites this paper
• Extra-mitochondrial prosurvival BCL-2 proteins regulate gene transcription by inhibiting the SUFU tumor suppressor

  2017cites this paper
• Suppressor of Fused restraint of Hedgehog activity level is critical for osteogenic proliferation and differentiation during calvarial bone development

  2017cites this paper
• Biophysical characterisation of the novel zinc binding property in Suppressor of Fused

  2017cites this paper
• Hedgehog Signaling: From Basic Biology to Cancer Therapy.

  2017cites this paper
• Multiple Hereditary Infundibulocystic Basal Cell Carcinoma Syndrome Associated With a Germline SUFU Mutation.

  2016cites this paper
• SCF (Fbxl17) ubiquitylation of Sufu regulates Hedgehog signaling and medulloblastoma development

  2016cites this paper
• Tumor-Derived Suppressor of Fused Mutations Reveal Hedgehog Pathway Interactions

  2016influential citation
• GLI1 modulation of the output of hedgehog signaling in human cancer

  2016cites this paper
• Suppressor of Fused Chaperones Gli Proteins To Generate Transcriptional Responses to Sonic Hedgehog Signaling

  2016cites this paper
• Structure of the TBC1D7-TSC1 complex reveals that TBC1D7 stabilizes dimerization of the TSC1 C-terminal coiled coil region.

  2016cites this paper
• Hedgehog signaling pathway: a novel model and molecular mechanisms of signal transduction

  2016cites this paper
• Structural mechanism for the arginine sensing and regulation of CASTOR1 in the mTORC1 signaling pathway

  2016cites this paper
• Members of the Rusc protein family interact with Sufu and inhibit vertebrate Hedgehog signaling

  2016cites this paper
• A Comparison of Ci/Gli Activity as Regulated by Sufu in Drosophila and Mammalian Hedgehog Response

  2015cites this paper
• Hedgehog Signaling Protocols

  2015cites this paper
• T396I Mutation of Mouse Sufu Reduces the Stability and Activity of Gli3 Repressor

  2015cites this paper
• Investigation of Protein-Protein Interactions and Conformational Changes in Hedgehog Signaling Pathway by FRET.

  2015cites this paper
• Structures of the APC–ARM domain in complexes with discrete Amer1/WTX fragments reveal that it uses a consensus mode to recognize its binding partners

  2015cites this paper
• Multisite interaction with Sufu regulates Ci/Gli activity through distinct mechanisms in Hh signal transduction

  2015influential citation
• Hedgehog

  2015cites this paper
• The FDA-approved natural product dihydroergocristine reduces the production of the Alzheimer’s disease amyloid-β peptides

  2015cites this paper
• A positive feedback loop between Gli1 and tyrosine kinase Hck amplifies shh signaling activities in medulloblastoma

  2015cites this paper
• Regulation of Sufu activity by p66β and Mycbp provides new insight into vertebrate Hedgehog signaling

  2014cites this paper
• Suppressor of fused impedes Ci/Gli nuclear import by opposing Trn/Kap&bgr;2 in Hedgehog signaling

  2014cites this paper
• Regulators of Shh Signaling in Limb Patterning and Development

  2014influential citation
• Canonical and Non-Canonical Hedgehog Signaling Pathways: Role of G Proteins

  2014cites this paper
• Trn/Kapβ2 in Hedgehog signaling

  2014cites this paper
• World Journal of Clinical Oncology

  year unknowncites this paper