Increased superoxide leads to decreased flow-induced dilation in resistance arteries of Mn-SOD-deficient mice.

No abstract is available for this paper.

• Publication year

  2005

• Venue

  American Journal of Physiology. Heart and Circulatory Physiology

• Publication date

  2005-05-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1152/AJPHEART.01036.2004PMID 15637112PMCID PMC4536920
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Limited Exercise Capacity in Heterozygous Manganese Superoxide Dismutase Gene–Knockout Mice: Roles of Superoxide Anion and Nitric Oxide

  2005cited by this paper
• Changes in NO bioavailability regulate cardiac O2 consumption: control by intramitochondrial SOD2 and intracellular myoglobin.

  2004cited by this paper
• Vasomotor responses in MnSOD-deficient mice.

  2004cited by this paper
• Bioavailability: In Vivo and Ex Vivo Evidence From ecSOD-Deficient Mice

  2003influential reference
• Voltage-dependent Anion Channels Control the Release of the Superoxide Anion from Mitochondria to Cytosol*

  2003cited by this paper
• Pivotal role of Cu,Zn-superoxide dismutase in endothelium-dependent hyperpolarization.

  2003influential reference
• Mitochondrial Sources of H2O2 Generation Play a Key Role in Flow-Mediated Dilation in Human Coronary Resistance Arteries

  2003cited by this paper
• Modeling the influence of superoxide dismutase on superoxide and nitric oxide interactions, including reversible inhibition of oxygen consumption.

  2003cited by this paper
• ADMA and oxidative stress.

  2003cited by this paper
• ADMA and oxidative stress are responsible for endothelial dysfunction in hyperhomocyst(e)inemia: effects of L-arginine and B vitamins.

  2003cited by this paper
• Endothelial Dysfunction Induced by Hyperhomocyst(e)inemia: Role of Asymmetric Dimethylarginine

  2003influential reference
• Role for Hydrogen Peroxide in Flow-Induced Dilation of Human Coronary Arterioles

  2003influential reference
• Postischemic Recovery of Contractile Function is Impaired in SOD2+/− but Not SOD1+/− Mouse Hearts

  2002cited by this paper
• Vascular Oxidative Stress and Endothelial Dysfunction in Patients With Chronic Heart Failure: Role of Xanthine-Oxidase and Extracellular Superoxide Dismutase

  2002influential reference
• Manganese Superoxide Dismutase Deficiency Exacerbates Cerebral Infarction After Focal Cerebral Ischemia/Reperfusion in Mice: Implications for the Production and Role of Superoxide Radicals

  2002cited by this paper
• Increased Superoxide and Vascular Dysfunction in CuZnSOD-Deficient Mice

  2002influential reference
• Superoxide and nitric oxide: consequences of varying rates of production and consumption: a theoretical treatment.

  2002cited by this paper
• Oxidation of the zinc-thiolate complex and uncoupling of endothelial nitric oxide synthase by peroxynitrite.

  2002cited by this paper
• Genetic modification of prenatal lethality and dilated cardiomyopathy in Mn superoxide dismutase mutant mice.

  2001cited by this paper
• Knockout mice heterozygous for Sod2 show alterations in cardiac mitochondrial function and apoptosis.

  2001cited by this paper
• Superoxide levels and function of cerebral blood vessels after inhibition of CuZn-SOD.

  2001influential reference
• Endothelial Regulation of Vasomotion in ApoE-Deficient Mice: Implications for Interactions Between Peroxynitrite and Tetrahydrobiopterin

  2001cited by this paper
• Increased mitochondrial oxidative stress in the Sod2 (+/−) mouse results in the age-related decline of mitochondrial function culminating in increased apoptosis

  2001cited by this paper
• Overexpression of copper/zinc superoxide dismutase does not prevent neonatal lethality in mutant mice that lack manganese superoxide dismutase.

  2000cited by this paper
• Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress.

  2000cited by this paper
• Vascular extracellular superoxide dismutase activity in patients with coronary artery disease: relation to endothelium-dependent vasodilation.

  2000influential reference
• Hydrogen peroxide is an endothelium-derived hyperpolarizing factor in mice.

  2000cited by this paper
• Mitochondrial Susceptibility to Oxidative Stress Exacerbates Cerebral Infarction That Follows Permanent Focal Cerebral Ischemia in Mutant Mice with Manganese Superoxide Dismutase Deficiency

  1998cited by this paper
• Ovarian function in superoxide dismutase 1 and 2 knockout mice.

  1998cited by this paper
• Vascular superoxide dismutase deficiency impairs endothelial vasodilator function through direct inactivation of nitric oxide and increased lipid peroxidation.

  1997influential reference
• Neurodegeneration, myocardial injury, and perinatal death in mitochondrial superoxide dismutase-deficient mice.

  1996cited by this paper
• A Role for Dietary Copper in Nitric Oxide‐Mediated Vasodilation

  1995influential reference
• NADH oxidoreductase is a major source of superoxide anion in bovine coronary artery endothelium.

  1994cited by this paper
• Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase.

  1974cited by this paper

• The role of NO, H2O2, and non-NO/H2O2 mechanisms in acetylcholine (ACh)-induced dilation of human arterioles in the absence and presence of coronary artery disease

  2025cites this paper
• Catalytic Antioxidants in the Kidney

  2021cites this paper
• Paradoxical Roles of Antioxidant Enzymes: Basic Mechanisms and Health Implications.

  2016cites this paper
• Mn-SOD-deficient mice Selective cerebral vascular dysfunction in

  2015cites this paper
• Vascular TRP channels: performing under pressure and going with the flow.

  2014cites this paper
• Hemodynamics Influence on Endothelial Function

  2014cites this paper
• Inducible nitric oxide synthase as a possible target in hypertension.

  2014cites this paper
• Molecular biology of atherosclerosis.

  2013cites this paper
• Oxidative stress induces gastric submucosal arteriolar dysfunction in the elderly.

  2013cites this paper
• Vascular Responses to Shear Stress: The Involvement of Mechanosensors in Endothelial Cells~!2009-12-23~!2010-04-27~!2010-08-06~!

  2012cites this paper
• Decreases in manganese superoxide dismutase expression and activity contribute to oxidative stress in persistent pulmonary hypertension of the newborn.

  2012cites this paper
• CYP2C29 Produces Superoxide in Response to Shear Stress

  2012cites this paper
• Ischemic postconditioning modified renal oxidative stress and lipid peroxidation caused by ischemic reperfusion injury in rats.

  2009cites this paper
• Mitochondrial reactive oxygen species-mediated signaling in endothelial cells.

  2007cites this paper
• Nitric oxide and peroxynitrite in health and disease.

  2007cites this paper
• signaling in endothelial cells Mitochondrial reactive oxygen species-mediated

  2007cites this paper
• Estrogen and mitochondria: a new paradigm for vascular protection?

  2006cites this paper
• Rho-kinase Contributes To Hypoxia/reoxygenation-induced Cerebral Endothelial Dysfunction

  2006cites this paper
• Novel isoforms of NADPH-oxidase in cerebral vascular control.

  2006cites this paper
• Selective cerebral vascular dysfunction in Mn-SOD-deficient mice.

  2006influential citation
• Effect of Aging on the Structure and Function of Skeletal Muscle Microvascular Networks

  2006cites this paper
• A Computational Model for Free Radicals Transport in the Microcirculation

  2006cites this paper