Refractory immune thrombocytopenic purpura: current strategies for investigation and management

No abstract is available for this paper.

• Publication year

  2008

• Venue

  British Journal of Haematology

• Publication date

  2008-10-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1111/j.1365-2141.2008.07275.xPMID 18573111
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Efficacy of romiplostim in patients with chronic immune thrombocytopenic purpura: a double-blind randomised controlled trial.

  2008cited by this paper
• Heterogeneity of terminology and clinical definitions in adult idiopathic thrombocytopenic purpura: a critical appraisal from a systematic review of the literature

  2008cited by this paper
• Splenectomy for immune thrombocytopenic purpura: Surgery for the 21st century

  2008cited by this paper
• Self‐reported health‐related quality of life in adults with chronic immune thrombocytopenic purpura

  2008cited by this paper
• Phase 1/2 Study of AMG 531 in Thrombocytopenic Patients (pts) with Low-Risk Myelodysplastic Syndrome (MDS): Update Including Extended Treatment.

  2007cited by this paper
• Systematic Review: Efficacy and Safety of Rituximab for Adults with Idiopathic Thrombocytopenic Purpura

  2007cited by this paper
• The Role of Cytomegalovirus in Immune Thrombocytopenia Purpura.

  2007cited by this paper
• Long-Term Safety and Efficacy of Oral Eltrombopag for the Treatment of Subjects with Idiopathic Thrombocytopenic Purpura (ITP): Preliminary Data from the EXTEND Study.

  2007influential reference
• Rituximab for the treatment of autoimmune cytopenias

  2007cited by this paper
• Novel thrombopoietic agents: preliminary activity, potential benefit.

  2007cited by this paper
• Eltrombopag for thrombocytopenia in patients with cirrhosis associated with hepatitis C.

  2007cited by this paper
• Immune thrombocytopenic purpura in adults

  2007cited by this paper
• Eltrombopag for the treatment of chronic idiopathic thrombocytopenic purpura.

  2007influential reference
• Hemostasis, Thrombosis, and Vascular Biology

  2007cited by this paper
• New thrombopoietic growth factors.

  2007cited by this paper
• New therapeutic options for adult chronic immune thrombocytopenic purpura: a brief review

  2007cited by this paper
• Novel thrombopoietic agents.

  2007cited by this paper
• Should rituximab be used before or after splenectomy in patients with immune thrombocytopenic purpura?

  2007influential reference
• Multiagent induction and maintenance therapy for patients with refractory immune thrombocytopenic purpura (ITP).

  2007cited by this paper
• Activity and safety profile of low-dose rituximab for the treatment of autoimmune cytopenias in adults

  2007cited by this paper
• Current options for the treatment of idiopathic thrombocytopenic purpura.

  2007cited by this paper
• Picogram doses of lipopolysaccharide exacerbate antibody‐mediated thrombocytopenia and reduce the therapeutic efficacy of intravenous immunoglobulin in mice

  2007cited by this paper
• Thrombopoietin mimetic agents in the management of immune thrombocytopenic purpura.

  2007cited by this paper
• Long Term Follow-Up of Patients with Immune Thrombocytopenic Purpura (ITP) Whose Initial Response to Rituximab Lasted a Minimum of 1 Year.

  2006cited by this paper
• Management of patients with refractory immune thrombocytopenic purpura

  2006influential reference
• An open‐label, unit dose‐finding study of AMG 531, a novel thrombopoiesis‐stimulating peptibody, in patients with immune thrombocytopenic purpura

  2006cited by this paper
• Management of Evans syndrome

  2006cited by this paper
• Helicobacter pylori and Immune Thrombocytopenic Purpura: Unsolved Questions and Controversies

  2006cited by this paper
• Long-term dosing of AMG 531 in thrombocytopenic patients with immune thrombocytopenic purpura : 2-year update

  2006influential reference
• Direct infection of colony forming unit-megakaryocyte by human cytomegalovirus contributes the pathogenesis of idiopathic thrombocytopenic purpura

  2006cited by this paper
• AMG 531, a thrombopoiesis-stimulating protein, for chronic ITP.

  2006influential reference
• Prognostic relevance of large-platelet counts in patients with immune thrombocytopenic purpura.

  2005cited by this paper
• How I treat idiopathic thrombocytopenic purpura (ITP).

  2005cited by this paper
• Efficacy and safety of splenectomy in immune thrombocytopenic purpura: long-term results of 402 cases.

  2005cited by this paper
• Management of Adult Patients with Persistent Idiopathic Thrombocytopenic Purpura Following Splenectomy

  2004cited by this paper
• Prospective screening of 205 patients with ITP, including diagnosis, serological markers, and the relationship between platelet counts, endogenous thrombopoietin, and circulating antithrombopoietin antibodies

  2004cited by this paper
• Pharmacodynamics and pharmacokinetics of AMG 531, a novel thrombopoietin receptor ligand

  2004cited by this paper
• Adult chronic idiopathic thrombocytopenic purpura (ITP) is the manifestation of a type-1 polarized immune response.

  2004cited by this paper
• Long-term outcomes in adults with chronic ITP after splenectomy failure.

  2004cited by this paper
• Enhancement of autoantibody pathogenicity by viral infections in mouse models of anemia and thrombocytopenia☆

  2004cited by this paper
• Unmasking Evans syndrome: T-cell phenotype and apoptotic response reveal autoimmune lymphoproliferative syndrome (ALPS).

  2004cited by this paper
• The efficacy and safety of B‐cell depletion with anti‐CD20 monoclonal antibody in adults with chronic immune thrombocytopenic purpura

  2004cited by this paper
• Immune thrombocytopenic purpura: investigation of the role of cytomegalovirus infection

  2004cited by this paper
• Splenectomy for adult patients with idiopathic thrombocytopenic purpura: a systematic review to assess long-term platelet count responses, prediction of response, and surgical complications.

  2004influential reference
• Adverse effects of estrogen therapy in a subset of women with ITP

  2004cited by this paper
• Exacerbation of autoantibody-mediated thrombocytopenic purpura by infection with mouse viruses.

  2004cited by this paper
• Ultrastructural study shows morphologic features of apoptosis and para-apoptosis in megakaryocytes from patients with idiopathic thrombocytopenic purpura.

  2004cited by this paper
• IgG antiplatelet immunity is dependent on an early innate natural killer cell-derived interferon-gamma response that is regulated by CD8+ T cells.

  2004cited by this paper
• Misdiagnosis of Chronic Thrombocytopenia in Childhood

  2003cited by this paper
• Immune thrombocytopenic purpura (ITP) plasma and purified ITP monoclonal autoantibodies inhibit megakaryocytopoiesis in vitro.

  2003cited by this paper
• The sympathetic nervous system is involved in variant Creutzfeldt-Jakob disease

  2003cited by this paper
• Long term follow‐up after splenectomy performed for immune thrombocytopenic purpura (ITP)

  2003cited by this paper
• Complete recovery from refractory immune thrombocytopenic purpura in three patients treated with etanercept

  2003cited by this paper
• Initial management of immune thrombocytopenic purpura in adults: A randomized controlled trial comparing intermittent anti‐D with routine care

  2003cited by this paper
• Does treatment with intermittent infusions of intravenous anti-D allow a proportion of adults with recently diagnosed immune thrombocytopenic purpura to avoid splenectomy?

  2002cited by this paper
• Prominent role of TGF-beta 1 in thrombopoietin-induced myelofibrosis in mice.

  2002cited by this paper
• Effects of pegylated recombinant human megakaryocyte growth and development factor in patients with idiopathic thrombocytopenic purpura.

  2002cited by this paper
• Plasma thrombopoietin levels in patients with aplastic anemia and idiopathic thrombocytopenic purpura.

  2002cited by this paper
• Cyclic immune thrombocytopenia responsive to thrombopoietic growth factor therapy

  2001cited by this paper
• Thrombocytopenia caused by the development of antibodies to thrombopoietin.

  2001cited by this paper
• Morbidity and mortality in adults with idiopathic thrombocytopenic purpura.

  2001cited by this paper
• Laparoscopic excision of accessory spleen.

  2000cited by this paper
• The Diagnostic Value of Thrombopoietin Level Measurements in Thrombocytopenia

  1998cited by this paper
• Intravenous anti-D treatment of immune thrombocytopenic purpura: experience in 272 patients.

  1997cited by this paper
• The site of destruction of autologous 111In‐labelled platelets and the efficiency of splenectomy in children and adults with idiopathic thrombocytopenic purpura: a study of 578 patients with 268 splenectomies

  1997cited by this paper
• Identification and cloning of a megakaryocyte growth and development factor that is a ligand for the cytokine receptor MpI

  1994cited by this paper
• Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand

  1994cited by this paper
• c-Mpl ligand is a humoral regulator of megakaryocytopoiesis

  1994cited by this paper
• Identification and cloning of a megakaryocyte growth and development factor that is a ligand for the cytokine receptor Mpl.

  1994cited by this paper
• Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo

  1994cited by this paper
• Mechanisms of response to treatment in autoimmune thrombocytopenic purpura.

  1989cited by this paper
• Maintenance treatment of adults with chronic refractory immune thrombocytopenic purpura using repeated intravenous infusions of gammaglobulin.

  1988cited by this paper
• Mechanisms of thrombocytopenia in chronic autoimmune thrombocytopenic purpura. Evidence of both impaired platelet production and increased platelet clearance.

  1987cited by this paper
• Infection with the human immunodeficiency virus: clinical manifestations and their relationship to immune deficiency. A report from the Multicenter AIDS Cohort Study.

  1987cited by this paper
• Platelet‐associated complement in chronic ITP

  1985cited by this paper
• Platelet kinetics in patients with idiopathic thrombocytopenic purpura and moderate thrombocytopenia.

  1985cited by this paper
• Danazol therapy in myelodysplasia.

  1985cited by this paper
• Heterogeneity of human platelets. I. Metabolic and kinetic evidence suggestive of young and old platelets.

  1969cited by this paper

• Teclistamab‐Induced Remission of Chronic Immune Thrombocytopenia in a Patient With Multiple Myeloma

  2025cites this paper
• Успешный опыт применения даратумумаба при рефрактерной иммунной тромботической тромбоцитопенической пурпуре

  2025cites this paper
• Comparison of mean platelet component and mean platelet mass in immune thrombocytopenia versus hypoproductive thrombocytopenias.

  2025cites this paper
• Effectiveness and safety of eltrombopag in connective tissue disease patients with refractory immune thrombocytopenia: a retrospective study

  2024cites this paper
• Thrombopoietin receptor agonist and rituximab combination therapy in patients with refractory primary immune thrombocytopenia

  2024cites this paper
• A case report of refractory immune thrombocytopenia: Challenges in choice of therapies in resource limiting center

  2024cites this paper
• Treatment opportunities for refractory immune thrombocytopenia

  2024cites this paper
• Immune thrombocytopenia (ITP) - could it be part of autoimmune/inflammatory syndrome induced by adjuvants (ASIA)?

  2024cites this paper
• The Challenge for a Correct Diagnosis of Refractory Thrombocytopenia: ITP or MDS with Isolated Thrombocytopenia?

  2024cites this paper
• Efficacy and safety of mycophenolate mofetil in patients with immune thrombocytopenic purpura: a systematic review and meta-analysis

  2023cites this paper
• Novel Biomarkers for Diagnosis and Monitoring of Immune Thrombocytopenia

  2023cites this paper
• Un refroidissement lourd de conséquences

  2023cites this paper
• The Cause and Effect of Immune Thrombocytopenia (ITP) on Individuals

  2023cites this paper
• Involvement of the complement system in immune thrombocytopenia: review of the literature

  2023cites this paper
• Refractory splenectomized immune thrombocytopenic purpura: Does vincristine have a role after thrombopoietin receptor agonist failure?

  2022cites this paper
• Current therapeutic strategies and perspectives in refractory ITP: What have we learned recently?

  2022cites this paper
• Refractory primary immune thrombocytopenia (ITP): current clinical challenges and therapeutic perspectives

  2022cites this paper
• Retrospective Evaluation of Chronic Idiopathic Thrombocytopenia in Libyan Children

  2021cites this paper
• Management of pregnant women with Refractory Immune Thrombocytopenia Purpura (ITP) receiving eltrombopag therapy at Sanjiwani Hospital, Gianyar, Indonesia

  2021cites this paper
• REFRACTORY IMMUNE THROMBOCYTOPENIA WITH SUSPECTED EVANS SYNDROME REQUIRING QUADRUPLE THERAPY

  2020influential citation
• A prospective, multicenter study of low dose decitabine in adult patients with refractory immune thrombocytopenia

  2019cites this paper
• Idiopathic thrombocytopenic purpura (ITP) – new era for an old disease

  2019cites this paper
• Pathophysiology of Immune Thrombocytopenia

  2018cites this paper
• Efficacy and tolerability of old and new drugs used in the treatment of immune thrombocytopenia: Results from a long-term observation in clinical practice

  2018cites this paper
• Immune Hematology

  2018cites this paper
• Progranulin facilitates the increase of platelet count in immune thrombocytopenia.

  2018cites this paper
• Guideline on immune thrombocytopenia in adults: Associação Brasileira de Hematologia, Hemoterapia e Terapia Celular. Project guidelines: Associação Médica Brasileira – 2018

  2018cites this paper
• Neutrophil lymphocyte ratio in estimating response to corticosteroid treatment in immune thrombocytopenia patients

  2018cites this paper
• Review: Umbilical Cord Stem Cells

  2018cites this paper
• Treatment of Children with Persistent and Chronic Idiopathic Thrombocytopenic Purpura: 4 Infusions of Rituximab and Three 4‐Day Cycles of Dexamethasone

  2017cites this paper
• Safety and efficacy of romiplostim in splenectomized and nonsplenectomized patients with primary immune thrombocytopenia

  2017cites this paper
• A new era in psychiatry: ECT and/or plasmapheresis? A new case of anti-NMDA antibodies with isolated psychiatric symptoms and review of previous cases

  2017cites this paper
• Patterns of Care and Association of Response with Rituximab among Patients of Immune Thrombocytopenia Purpura in a Rural Practice

  2017cites this paper
• Immune Thrombocytopenia and Obesity: Predictive Relationship.

  2017cites this paper
• A case of refractory immune thrombocytopenia in pregnancy managed with elthrombopag

  2016cites this paper
• Characteristics, outcome, and response to therapy of multirefractory chronic immune thrombocytopenia.

  2016cites this paper
• Does the site of platelet sequestration predict the response to splenectomy in adult patients with immune thrombocytopenic purpura?

  2015cites this paper
• Immune Thrombocytopenia in Two Unrelated Fanconi Anemia Patients – A Mere Coincidence?

  2015cites this paper
• Refractory immune thrombocytopenia. Successful treatment with repeated cyclosporine A: two case reports

  2015cites this paper
• PLATELETS AND THROMBOPOIESIS CD 8 1 T cells are predominantly protective and required for effective steroid therapy in murine models of immune thrombocytopenia

  2015influential citation
• CD8+ T cells are predominantly protective and required for effective steroid therapy in murine models of immune thrombocytopenia.

  2015cites this paper
• Sustained Partial Response to Thrombopoietin-Receptor Ago nist-Romiplo stim-in Therapy of Refractory Chronic Immune Thrombocytopenia

  2015cites this paper
• Acute and Chronic Infections

  2015cites this paper
• Cytomegalovirus: A possible cause of Persistent Refractory Immune Thrombocytopenic Purpura

  2014cites this paper
• Autoimmune thrombocytopenia: a complication of fludarabine therapy in the treatment of Waldenstrom's macroglobulinemia.

  2014cites this paper
• thrombocytopenia (ITP): study of 40 cases Intracranial hemorrhage (ICH) in children with immune

  2014cites this paper
• Adverse postoperative outcomes in surgical patients with immune thrombocytopenia

  2013cites this paper
• Idiopathic thrombocytopenic purpura during pregnancy

  2013cites this paper
• VINCRISTINE ROLE IN THE TREATMENT OF SPLENECTOMIZED REFRACTORY IDIOPATHIC THROMBOCYTOPENIC PURPURA (ITP)

  2013cites this paper
• Immune thrombocytopenia.

  2013cites this paper
• Parvovirus B19, rubella, Epstein-Barr, and cytomegalovirus and idiopathic thrombocytopenia in Egyptian children, single-center study

  2012cites this paper
• Therapeutic implications of disorders of cell death signalling: membranes, micro‐environment, and eicosanoid and docosanoid metabolism

  2012influential citation
• Childhood immune thrombocytopenia: Clinical presentation and management.

  2012cites this paper
• Efficacy of rituximab in immune thrombocytopenic purpura: a retrospective survey

  2012cites this paper
• The burden of immune thrombocytopenia in adults: Evaluation of the thrombopoietin receptor agonist romiplostim

  2012cites this paper
• Thrombopoietin: too much or too little

  2012cites this paper
• [Guidelines for diagnosis, treatment and monitoring of primary immune thrombocytopenia].

  2012cites this paper
• TGFβ(1) and sCTLA-4 levels are increased in eltrombopag-exposed patients with ITP.

  2012cites this paper
• Chronic immune thrombocytopenia in a child responding only to thrombopoietin receptor agonist.

  2012cites this paper
• Childhood immune thrombocytopenia: Clinical presentation and management

  2012cites this paper
• Successful treatment with tacrolimus of a patient with severe idiopathic thrombocytopenic purpura after allogeneic bone marrow transplantation.

  2012cites this paper
• Crosstalk between Platelets and the Immune System: Old Systems with New Discoveries

  2012cites this paper
• Eltrombopag for management of chronic immune thrombocytopenia (RAISE): a 6-month, randomised, phase 3 study.

  2011cites this paper
• What’s New in the Management of Chronic Primary Immune Thrombocytopenia in Adults and the Use of Thrombopoietin Receptor Agonists

  2011cites this paper
• ITP: a historical perspective

  2011cites this paper
• Current treatment options for primary immune

  2011cites this paper
• Laparoscopic splenectomy for immune thrombocytopenic purpura at a teaching institution.

  2011cites this paper
• Guías clínicas para el manejo del paciente pediátrico con trombocitopenia inmune primaria (PTI)

  2011cites this paper
• Current treatment options for primary immune thrombocytopenia

  2011cites this paper
• Management of Immune Thrombocytopenic Purpura in Children

  2011cites this paper
• Immune thrombocytopenic pupura-induced reversible posterior leukoencephalopathy successfully treated by rituximab

  2011cites this paper
• Response of refractory immune thrombocytopenia after bone marrow transplantation to romiplostim

  2010cites this paper
• International consensus report on the investigation and management of primary immune thrombocytopenia.

  2010cites this paper
• Splenectomy for Children and Adults with Persistent and Chronic Immune Thrombocytopenia: Long term results.

  2010cites this paper
• Autoimmune complications in chronic lymphocytic leukaemia (CLL).

  2010cites this paper
• primary immune thrombocytopenia International consensus report on the investigation and management of

  2010cites this paper
• The Effectiveness and Safety of the Thrombopoetin Agonist Romiplostim in the Treatment of Adults with Chronic Idiopathic Thrombocytopenic Purpura

  2010cites this paper
• Long-term outcomes of a 5-year follow up of patients with immune thrombocytopenic purpura after splenectomy

  2010cites this paper
• Effects of Bisphosphonate Administration on the Bone Mass in Immune Thrombocytopenic Purpura Patients Under Treatment With Steroids

  2010cites this paper
• Chronic immune thrombocytopenic purpura

  2009cites this paper
• Traditional and new approaches to the management of immune thrombocytopenia: issues of when and who to treat.

  2009cites this paper
• Thrombopoietin receptor agonists in the treatment of thrombocytopenia

  2009cites this paper
• Intracranial hemorrhage (ICH) in children with immune thrombocytopenia (ITP): study of 40 cases.

  2009cites this paper
• Thrombopoietin agonists for the treatment of thrombocytopenia in liver disease and hepatitis C.

  2009cites this paper
• The ITP syndrome: pathogenic and clinical diversity.

  2009cites this paper
• Treatment of an infant with severe acute refractory immune thrombocytopenic purpura using combination therapy including rituximab

  2009cites this paper
• Infections, antigen-presenting cells, T cells, and immune tolerance: their role in the pathogenesis of immune thrombocytopenia.

  2009cites this paper
• Improved regulatory T-cell activity in patients with chronic immune thrombocytopenia treated with thrombopoietic agents.

  2009influential citation
• Cytomegalovirus can make immune thrombocytopenic purpura refractory

  2009cites this paper
• Finding a place for thrombopoietin receptor agonists in the treatment of chronic ITP

  2008cites this paper
• Mediterranean Journal of Hematology and Infectious Diseases Refractory Immune Thrombocytopenic Purpura and Cytomegalovirus Infection: a Call for a Change in the Current Guidelines

  year unknowncites this paper